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- | Journal: Crucial role of lncRNA NONHSAG037054.2 and GABPA, and their related functional networks, in ankylosing spondylitis. (Pubmed Central) - Apr 17, 2024
In conclusion, NONHSAG037054.2 and GABPA are associated with AS. GABPA was downregulated in AS, and it could serve as a novel diagnostic factor for AS.
- Molecular Mechanisms Underlying Abnormal Activation of T Cells in Idiopathic Aplastic Anemia and Hypoplastic Myelodysplastic Neoplasms (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_1745;
Furthermore, our analyses revealed novel pathways, such as oxidative phosphorylation, as well as candidates ( TLR2 , and CDC42-IT1) for functional studies. The deregulation of multiple lncRNAs in the patients indicates their implication in the molecular pathogenesis and thus their roles in bone marrow failure need to be explored.
- | Preclinical, Journal: Arf6 is required for endocytosis and filamentous actin assembly during angiogenesis in vitro. (Pubmed Central) - Sep 26, 2023
The deregulation of multiple lncRNAs in the patients indicates their implication in the molecular pathogenesis and thus their roles in bone marrow failure need to be explored. Our findings highlight that endothelial Arf6 is a potent mediator of both actin regulation and endocytosis and is required for proper sprout formation.
- | Journal, IO biomarker: Development of a novel angiogenesis-related lncRNA signature to predict the prognosis and immunotherapy of glioblastoma multiforme. (Pubmed Central) - Feb 11, 2023
Furthermore, the sensitivity of 28 potential chemotherapeutic drugs differed significantly between the high- and low-risk groups. A novel angiogenesis-related lncRNA signature could be used to predict the prognosis and treatment of GBM.
- | Journal: Comprehensive Analysis of Metabolome and Transcriptome in Fruits and Roots of Kiwifruit. (Pubmed Central) - Jan 22, 2023
The expression profiles of these TFs were similar to those of the genes related to flavonols and dihydrochalcones, suggesting they are key candidate genes controlling the flavonoid accumulation in kiwifruit. Our results provided an insight into the functional metabolites and their regulatory mechanism in kiwifruit root.
- | Journal: LncRNA RPL34-AS1 sponges miR-3656 to suppress cell proliferation in colorectal cancer. (Pubmed Central) - Jul 27, 2022
RPL34-AS1 positively regulated the expression of ACAP2 at both mRNA and protein levels. Therefore, RPL34-AS1 is downregulated in CRC and may sponge miR-3656 to suppress cell proliferation in CRC.
- | Journal: Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. (Pubmed Central) - Apr 9, 2022
Finally, we demonstrate that Rab35 overexpression prevents the amyloidogenic trafficking of APP and BACE1 induced by high GC levels. These studies identify Rab35 as a key regulator of APP processing and suggest that its downregulation may contribute to stress-related and AD-related amyloidogenesis.
- | dactinomycin / Generic mfg.
Journal, IO biomarker: CircRNA ACAP2 induces myocardial apoptosis after myocardial infarction by sponging miR-29. (Pubmed Central) - Mar 24, 2022
These studies identify Rab35 as a key regulator of APP processing and suggest that its downregulation may contribute to stress-related and AD-related amyloidogenesis. The expression of circ ACAP2 increased in cardiomyocytes after MI and promoted apoptosis by binding to miR-29.
- | Journal: Circ-ACAP2 facilitates the progression of colorectal cancer through mediating miR-143-3p/FZD4 axis. (Pubmed Central) - Mar 17, 2022
The expression of circ ACAP2 increased in cardiomyocytes after MI and promoted apoptosis by binding to miR-29. Circ-ACAP2 contributed to the development and radioresistance of CRC partly through targeting miR-143-3p/FZD4 axis, which provided novel potential diagnostic and therapeutic targets for CRC.
- | Journal: Genome-wide analysis of AP2/ERF transcription factors in pineapple reveals functional divergence during flowering induction mediated by ethylene and floral organ development. (Pubmed Central) - Feb 23, 2022
ERF and RAV subfamily genes might play important roles in the process of ethylene response of pineapple; ERF and DREB subfamily genes had particular functions in the floral organ development. This study is the first to provide detailed information on the features of AP2/ERFs in pineapple, provide new insights into the potential functional roles of the AP2/ERF superfamily members, and will facilitate a better understanding of the molecular mechanism of flower in pineapple.
- | Journal: Cancer-associated fibroblasts-derived exosomal miR-3656 promotes the development and progression of esophageal squamous cell carcinoma via the ACAP2/PI3K-AKT signaling pathway. (Pubmed Central) - Feb 19, 2022
Additionally, the downregulation of ACAP2 triggered by exosomal-derived miR-3656 further promotes the activation of the PI3K/AKT and β-catenin signaling pathways and ultimately improves the growth of ESCC cells both in vitro and in xenograft models. These results may represent a potential therapeutic target for ESCC and provide a new basis for clinical treatment plans.
- | Journal: CircRNA-ACAP2 contributes to the invasion, migration, and anti-apoptosis of neuroblastoma cells through targeting the miRNA-143-3p-hexokinase 2 axis. (Pubmed Central) - Jan 26, 2022
Rescue of miR-143-3p in ACAP2-overexpressing cells effectively mitigated the influence of ACAP2 on neuroblastoma cell processes. Our study revealed biological roles and molecular mechanisms for circ-ACAP2 in the oncogenic characteristics of neuroblastoma, facilitating the development of circRNA-based treatment approaches for anti-brain tumor therapy.
- | Journal: CircRNA ACAP2 is overexpressed in myocardial infarction and promotes the maturation of miR-532 to induce the apoptosis of cardiomyocyte. (Pubmed Central) - Jan 18, 2022
In addition, miR-532 inhibitor reduced the effects of ACAP2 overexpression. ACAP2 is overexpressed in MI and may promote the maturation of miR-532 to induce the apoptosis of cardiomyocyte.
- | Journal: Effects of Current Annealing on Thermal Conductivity of Carbon Nanotubes. (Pubmed Central) - Jan 12, 2022
The high-level thermal diffusivity of CNTB2 and CNTF are 2.28-2.46 times and 1.65-3.85 times higher than the lower one. The results show that the decrease of the thermal diffusivity for CNTB2 and CNTF is mainly caused by enhanced Umklapp scattering, the high thermal resistance and torsional sliding during high temperature heating.
- || Review, Journal: Long noncoding RNAs: functions and mechanisms in colon cancer. (Pubmed Central) - Aug 29, 2021
In addition, we briefly highlight the functions of circRNAs in colon tumorigenesis and progression, including circPPP1R12A, circPIP5K1A, circCTIC1, circ_0001313, circRNA_104916 and circRNA-ACAP2. This review provides the rationale for anticancer therapy via modulation of lncRNAs and circular RNAs (circRNAs) in colon carcinoma.
- || Clinical, Journal: Identification and validation of lncRNAs involved in m6A regulation for patients with ovarian cancer. (Pubmed Central) - Jul 10, 2021
Based on the four LI-m6As (AC010894.3, ACAP2-IT1, CACNA1G-AS1, and UBA6-AS1), the risk model we identified can independently predict the OS and therapeutic value of OC. CACNA1G-AS1 was preliminarily proved to be a malignant lncRNA.
- | Journal: Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells. (Pubmed Central) - Jan 5, 2021
Furthermore, our data indicates that Rab35-GTP, ACAP2, ARF6-GDP and EHD1 act in a cascade mechanism to promote TNT formation. Interestingly, MICAL-L1 overexpression, shown to be necessary for the action of Rab35 on neurite outgrowth, showed no effect on TNTs, indicating that TNT formation and neurite outgrowth may be processed through similar but not identical pathways, further supporting the unique identity of these cellular protrusions.
- | Preclinical, Journal: Rab35-GEFs, DENND1A and folliculin differentially regulate podocalyxin trafficking in two- and three-dimensional epithelial cell cultures. (Pubmed Central) - Dec 18, 2020
By contrast, FLCN-knockdown cells specifically accumulated PODXL in actin-rich structures similar to the Rab35-knockdown cells in 2D cell cultures. Our findings indicate that two distinct functional cascades of Rab35, the FLCN-Rab35-OCRL and the DENND1A-Rab35-ACAP2 axes, regulate PODXL trafficking in 2D and 3D MDCK II cell cultures, respectively.
- | Journal: The plasma peptides of sepsis. (Pubmed Central) - Jul 9, 2020
Specific proteins and peptides that vary between diseases might be discovered by the random and independent sampling of multiple disease and control plasma from different hospital and clinics by LC-ESI-MS/MS for storage in a relational SQL Server database and analysis with the R statistical system that will be a powerful tool for clinical research. The processing of SAA1 may play an unappreciated role in the inflammatory response to Sepsis.
- | testosterone (ARG101) / arGentis
Journal: Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase. (Pubmed Central) - Jun 10, 2020
The structural analysis allows us to design specific Rab35 mutants capable of eliminating Rab35/ACAP2 and Rab35/RUSC2 interactions, but not interfering with other effector bindings. The atomic structures also offer possible explanations to disease-associated mutants identified at the Rab35-effector interfaces.
- | Preclinical, Journal: Identification of Differentially Expressed Gene Transcripts in Porcine Endometrium during Early Stages of Pregnancy. (Pubmed Central) - May 22, 2020
Microarray validation experiment on selected candidate genes showed complementarity to significant endometrial DEG-transcript-probes responsible for the regulation of immune response (IL1B, S100A11), lipid metabolism (FABP3, PPARG), cell-adhesion (ITGAV), angiogenesis (IL1B), intercellular transmission (NMB), cell-adhesion (OPN) and response to stimuli (RBP4) was confirmed by RT-PCR. This study provides a clue that identified pregnancy-stage specific microarray transcript probes could be considered as candidate genes for recognition and establishment of early pregnancy in the pig.
- | Journal: CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis. (Pubmed Central) - Feb 15, 2020
Elevated expression of circACAP2 in breast cancer tissues leads to malignant phenotype upon cancerous cells. CircACAP2-miR-29a/b-3p-COL5A1 axis leads to breast cancer tumorigenesis and could hopefully be a novel method for diagnosis and treatment for breast cancer.
- | Journal: Effector Specificity Mechanisms of Rab35 GTPase. (Pubmed Central) - Dec 23, 2019
In this issue of Structure, Lin et al. (2019) present crystal structures of Rab35 in complex with two effectors, ACAP2 and RUSC2, respectively, unraveling the molecular basis for the exquisite mutual specificity between Rab35 and these effectors.
- | Journal: The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells. (Pubmed Central) - Oct 18, 2018
This was probably due to the fact that circRNA-ACAP2 could act as a miRNA sponge to regulate Tiam1 expression by removing the inhibitory effect of miR-21-5p on Tiam1 expression. The results from this study have revealed new insights into the pathogenicity of colon cancer and may provide novel therapeutic targets for the treatment of colon cancer.