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- || losartan potassium / Generic mfg.
Clinical, Journal: Antihypertensive treatment guided by genetics: PEARL-HT, the randomized proof-of-concept trial comparing rostafuroxin with losartan. (Pubmed Central) - Jan 27, 2022
Chinese patients had a similar drop in OSBP to Caucasians with losartan but no change in OSBP with rostafuroxin. These results show that genetics may guide drug treatment for primary hypertension in Caucasians.
- | Journal: Three novel genetic variants in the FAM110D, CACNA1A and NLRP12 genes are associated with susceptibility to hypertension among Dai people. (Pubmed Central) - Dec 16, 2021
These results show that genetics may guide drug treatment for primary hypertension in Caucasians. These findings indicate that there may be different molecular pathogeneses of hypertension among Dai people, which should be noted in future studies.
- | Journal: Dysregulated protein phosphorylation as main contributor of granulovacuolar degeneration at the first stages of NFT pathology. (Pubmed Central) - Nov 11, 2021
Markers of impaired ubiquitin-protesome system, abnormal reticulum stress response, and altered endocytic and autophagic pathways occur in a subpopulation of neurons containing cytoplasmic granules, and they appear later. These observations suggest early phosphorylation of kinases leading to their activation, and resulting in the abnormal phosphorylation of various substrates, including tau, as a main alteration at the first stages of GVD.
- | Retrospective data, Journal: Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis. (Pubmed Central) - Oct 27, 2021
Software STATA 12.0 (StataCorp, College Station, TX, USA) was used for the meta-analysis and 26 studies with 5,776 cases and 8,025 controls were included. The results indicated significantly higher risk of ischemic stroke associated with TBXA2R variant rs768963 in all genetic models (C vs T: OR=1.27, 95% CI=1.13-1.42, P.
- [VIRTUAL] Genome-Wide Association Study of Obsessive-Compulsive Symptoms and Hoarding Symptoms in the General Population () - Oct 3, 2021 - Abstract #WCPG2021WCPG_393;
The SNP with the lowest p-value for HS was rs117321479 (P = 1.26x10-07) on chromosome 12, which is associated with SOX5 which has been implicated in a variety of psychiatric disorders in the cross-disorder study of the PGC. Gene-based analysis with MAGMA/FUMA did not reveal any significant associations.
- | Aduhelm (aducanumab) / Eisai, Biogen
Preclinical, Journal: Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease. (Pubmed Central) - Sep 29, 2021
Gene-based analysis with MAGMA/FUMA did not reveal any significant associations. We identified novel proteomic patterns of SPs and surrounding tissue indicating that chronic treatment with aducanumab could inhibit Aβ toxicity and increase phagocytosis and cell viability.
- [VIRTUAL] Excessive accumulation of candidate gene polymorphisms in young hypertensive patients as a factor of increasing incidence of arterial hypertension at a young age () - Jul 6, 2021 - Abstract #ESC2021ESC_4099;
Conclusions. The research has revealed a significantly higher accumulation of gene polymorphisms associated with AH at a young age compared to hypertensive patients of an older age and non-hypertensive patients, which is a strong factor influencing on the increasing incidence of AH at a young age and in the future can be used for the prognosis of the disease progress and early prevention.
- || Clinical, Journal: The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population. (Pubmed Central) - Jun 1, 2021
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used for ADD1 Gly460Trp-polymorphism genotyping. The ADD1 Gly460Trp-polymorphic locus is an important predictor of arterial hypertension development in the Ukrainian population, but other nongenetic factors should be considered in further studies.
- | Preclinical, Journal: miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease. (Pubmed Central) - Apr 13, 2021
Blocking the phosphorylation of Ser726 on Add1 with a membrane-permeable peptide effectively rescues the memory impairments in AD mice. Taken together, these findings demonstrate that synaptic-related miR-135a-5p mediates synaptic/memory deficits in AD via the Rock2/Add1 signaling pathway, illuminating a potential therapeutic strategy for AD.
- | Journal: The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies? (Pubmed Central) - Feb 26, 2021
Treatment of hEECs with bovine CAPG increased expression of transcripts previously known to interact with CAPG in different systems (CAPZB, CAPZA2, ADD1, and ADK) compared with vehicle controls (P < .05). In conclusion, we have demonstrated that CAPG, a highly conserved protein in eutherian mammals, elicits a transcriptional response in the endometrial epithelium in species with different implantation strategies that may contribute to pregnancy success.
- || Review, Journal: Genetically, Dietary Sodium Intake Is Causally Associated with Salt-Sensitive Hypertension Risk in a Community-Based Cohort Study: a Mendelian Randomization Approach. (Pubmed Central) - Dec 2, 2020
MR analysis revealed that the odds ratio for hypertension per 1 mg/day increment of dietary sodium intake was 2.24 in participants with the PRKG1 rs12414562 AA genotype. Our findings suggest that dietary sodium intake may be causally associated with hypertension risk.
- || Clinical, Journal: Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific. (Pubmed Central) - Nov 18, 2020
Results demonstrate alternative splicing and sexually dimorphic expression of most putative risk genes in stroke patients' blood. Since expression was also often cause-specific, sex, and etiology are factors to consider in stroke treatment trials and genetic association studies as society trends toward more personalized medicine.
- | Journal: The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation. (Pubmed Central) - Nov 12, 2020
Surprisingly, costimulatory signals through CD28 were completely abrogated in the absence of Add1. This study is the first to examine the role of actin-capping in T cells, and it reveals a previously unappreciated role for the actin cytoskeleton in regulating costimulation.
- | Journal: Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration. (Pubmed Central) - Nov 2, 2020
Likewise, depletion of ADD1 suppressed the effects of EGF on lamellipodia formation, cell migration, and invasion, all of which were restored by FLAG-ADD1 WT and the T724D mutant, but not the T724A mutant. Together, our results suggest that phosphorylation of ADD1 at T724 by Cdk5 is important for EGF-induced cell migration and invasion.
- || Clinical, Review, Journal: Genetic Risk Factors of Intracranial Atherosclerosis. (Pubmed Central) - Oct 21, 2020
We review the available evidences on the candidate genes and SNPs associated with genetic susceptibility to ICAS, and point out future developments of this field. Genetic discoveries could have clinical implications for intracranial atherosclerotic disease.
- | Journal: 25-Hydroxycholesterol Inhibits Adipogenic Differentiation of C3H10T1/2 Pluripotent Stromal Cells. (Pubmed Central) - Oct 2, 2020
Our observations showed that 25-HC was the most potent oxysterol in inhibiting adipogenesis and the expression of key adipogenic transcripts in C3H10T1/2 cells among the tested oxysterols, suggesting its potential application in providing an intervention in osteoporosis and obesity. We also report that the inhibitory effects of 25-HC on adipogenic differentiation in C3H10T1/2 cells are not mediated by hedgehog signaling and LXR.
- [VIRTUAL] Features of the Candidate Genes Polymorphisms Accumulation in Population of Hypertensive Patients of Different Age Groups (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_2430;
It was revealed in the research the accumulation of pathological genetic polymorphisms in the population of hypertensive patients through generations. It was found the strong significant difference in the proportion of 'pathological' GP between young and older patients.
- || Biomarker, Clinical, Journal: The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population. (Pubmed Central) - Aug 29, 2020
The Roma population seems to be genetically less susceptible to EH than the general one. These results support preventive efforts to lower the risk of developing hypertension by encouraging a healthy lifestyle.
- || Review, Journal: The role of DNA methylation and histone modifications in blood pressure: a systematic review. (Pubmed Central) - Aug 23, 2020
In summary, the most convincing evidence has been reported from candidate-gene studies, which show reproducible epigenetic changes in the interconnected renin-angiotensin and inflammatory systems. Our study highlights gaps in the literature on the role of histone modifications in blood pressure and the need to conduct high-quality studies, in particular, hypothesis-generating studies that may help to elucidate new molecular mechanisms.
- | Journal, IO Biomarker: Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach. (Pubmed Central) - Aug 8, 2020
We identified seven core genes that represent potential molecular biomarkers for the diagnosis of atherosclerosis and might serve as a platform for developing therapeutics against both FH and atherosclerosis. However, functional studies are further needed to validate their role in the pathogenesis of FH and atherosclerosis.
- [VIRTUAL] Genetically, dietary sodium intake is causally associated with salt-sensitive hypertension risk in a community-based cohort study: A Mendelian randomization approach () - Jul 30, 2020 - Abstract #ESC2020ESC_3008;
MR analysis revealed that the odds ratio for hypertension per 1 mg/day increment of dietary sodium intake was 2.24 in participants with the PRKG1 rs12414562 AA genotype. Our findings suggest that dietary sodium intake may be causally associated with hypertension risk.
- [VIRTUAL] Integrative assessment of candidate gene polymorphisms distribution by forming a gene modification index in arterial hypertension with and without obesity: a new perspective in cardiology management () - Jul 30, 2020 - Abstract #ESC2020ESC_2497;
There was a moderate significant difference between hypertensive patients, depending on the presence of obesity. Evaluation of GMI is a perspective direction in the diagnosis and prevention of AH and can be used in practical management.
- | Journal: Hypertension in High School Students: Genetic and Environmental Factors: The HYGEF Study. (Pubmed Central) - Jul 29, 2020
Urinary protein tests showed a greater excretion of IL1β (interleukin 1β) and interleukin 10 (P<0.0001) in carriers of the ADD1 rs4961 T allele. In conclusion, 3 missense gene variants already implicated in adult hypertension impact BP or Na excretion among adolescents, and, together with activated pro-inflammatory pathways, might predispose to early cardiovascular damage.
- || Review, Journal: Sexually dimorphic DNA-methylation in cardiometabolic health: A systematic review. (Pubmed Central) - Jul 19, 2020
Our findings suggest that DNAm might be a promising molecular strategy for understanding sex differences in the pathophysiology of cardiometabolic diseases and that future studies should investigate the effects of sex on epigenetic mechanisms in cardiometabolic risk. In addition, we emphasize the gap between the translational potential and the clinical utilization of cardiometabolic epigenetics.
- | Journal: Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function. (Pubmed Central) - Jul 2, 2020
However, loss of adducin-1 blocked APC-induced Akt signaling. These studies define distinct thrombin and APC dynamic signaling profiles and a rich array of proteins and biological pathways that engender PAR1 biased signaling in endothelial cells.
- | Journal: Alpha adducin (ADD1) gene polymorphism and new onset of diabetes under the influence of selective antihypertensive therapy in essential hypertension. (Pubmed Central) - May 21, 2020
Variant T allele of ADD1 gene may be considered as the risk factor for development of diabetes in hypertensive patients. Diuretics as mono therapy and in combination with BBs may be considered as the risk factor for new onset of diabetes in EH patients carrying variant T allele (either as TG or TT).
- || Review, Journal, IO Biomarker: DNA Methylation of Candidate Genes (ACE II, IFN-γ, AGTR 1, CKG, ADD1, SCNN1B and TLR2) in Essential Hypertension: A Systematic Review and Quantitative Evidence Synthesis. (Pubmed Central) - Apr 3, 2020
The aberrant epigenomic modulation of ACE II, TLR2, IFN-γ, AGTR1, and GCK correlated with essential HTN. Transforming the environments resulting from these epigenomic lesions will facilitate early intervention mapping in reducing HTN in the US population, especially among socially disadvantaged individuals, particularly racial/ethnic minorities.
- | Journal: Association of CYP11B2 Gene Polymorphism with Preeclampsia in North East of Iran (Khorasan province). (Pubmed Central) - Mar 28, 2020
Our results showed a significant association between CYP11B2 -344C > T gene polymorphism with PE. This finding suggests that mentioned polymorphism may be associated with susceptibility to PE at least in IRAN.
- | Journal: Effect of Fabomotizole on Brain Gene Expression in MR Rats in the Open Field Test. (Pubmed Central) - Mar 22, 2020
The analysis of the effect of fabomotizole on the gene expression profile in the brain of MR (Maudsley Reactive) rats was carried out when modeling emotional stress in the open field test. A change in the expression of 14 genes was found, the results of the functional annotation of which showed that the mechanisms of action of fabomotizole may be associated with the regulation of translation of proteins (Rpl5, Rpl15, Ncl, and Ybx1), synaptic functions (Cplx2, Dlg4, Syngap1, Add1, Rab8b, Klc1, and Chn1), and cellular metabolism (Akr1d1, Bcat1, and Pkm).
- | Journal: AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression. (Pubmed Central) - Feb 28, 2020
Multivariate Cox regression analysis indicated that combined p-AKT and p-ZNF expression profile was an independent factor to predict the clinical outcome in lung cancer patients. Our results reveal a new mechanism of AKT signaling in promoting ZNF322A protein stability and transcriptional activity in lung cancer cell, xenograft, and clinical models.
- Genetic and epigenetic risk factors in patients with severe preeclampsia (HALL 9 GALEN) - Feb 20, 2020 - Abstract #ISGE2020ISGE_407;
Our results support that the combination of >2 mutant alleles of genes-candidate for arterial hypertension or their combination with the mutant gene(s) of ADD1-1378TT, GNB3-825TT or cytochrome P-450 (CYP11B2-304TT) and heterozygous genotypes FVL-1691GA or FII-20210GA can be considered as a genetic predictor of SPE. Maternal systemic infectious and/or lower genital tract infections, tobacco smoking, history of >2 surgical abortions are associated with increased risk of SPE.
- | Preclinical, Journal: Anti-obesity effect of Yangkyuksanwha-tang in high-fat diet-induced obese mice. (Pubmed Central) - Jan 1, 2020
The results imply that YST has anti-obesity effects in obesity-induced mice. Although the number of experimental animals was limited and the drug effects concern mice, rather than humans, which have different constitutions, the study has valuable implications with respect to the general effects of YST.
- | Journal: The underlying regulated mechanisms of adipose differentiation and apoptosis of breast cells after weaning. (Pubmed Central) - Dec 21, 2019
In addition, hormones, especially the estrogen and pituitary hormone, play a vital role in the whole reproductive processes. In this review, we mainly focus on the underlying regulated mechanisms of differentiation of adipose tissue and apoptosis of breast cell to provide a specific insight into the physiological changes during weaning.
- | Journal: Effects of Dietary Supplementation of Alpha-Ketoglutarate in a Low-Protein Diet on Fatty Acid Composition and Lipid Metabolism Related Gene Expression in Muscles of Growing Pigs. (Pubmed Central) - Oct 25, 2019
The experimental trial lasted 35 d. The results showed that compared with the NP and LP diets, supplementation with AKG in a low-protein diet increased the intramuscular fat (IMF), oleic acid (C18:1n-9), and monounsaturated fatty acid (MUFA) contents (p < 0.05), and tended to increase the percentage of palmitoleic acid (C16:1) and stearic acid (C18:0) (p < 0.10) in the biceps femoris and longissimus dorsi muscles of growing pigs. These effects may be associated with increased relative mRNA expression levels of fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), adipocyte determination and differentiation factor 1 (ADD1), fatty acid binding protein 4 (FABP4), and stearoyl-CoA desaturase (SCD) in skeletal muscle, indicating that AKG might be involved in the differential regulation of some key lipogenic genes in skeletal muscles of pigs.
- Hypertension and Obesity in High School Students: Genetic and Environmental Factors in the HYGEF Study (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_3334;
Conclusion In this young Italian population we detected specific environmental factors (such as high salt intake) and gene polymorphisms linked to higher BP values. This help to create the basis for future interventions in educational, clinical and/or pharmacological studies
- The Perspective of Using the Genetic Risk Score in Prediction of Cardiovascular Risk in Patients With Arterial Hypertension (Zone 2, Science and Technology Hall) - Sep 20, 2019 - Abstract #AHA2019AHA_8008;
Thus, proposed GRS based on evaluation of proportion of "pathological" genotypes of candidate genes, has a significantly high correlation with traditional stratification of CVR and can be used with prognostic purpose in patients with AH. GRS can have obvious benefits for the purposes of primary prevention of AH.
- | Journal: Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression. (Pubmed Central) - Sep 12, 2019
By contrast, the accelerated migration of ADD1 and ADD3-depleted NSCLC cells was ECM adhesion-independent and was driven by the upregulated expression of pro-motile cadherin-11. Overall, our findings reveal a novel function of adducins as negative regulators of NSCLC cell migration and invasion, which could be essential for limiting lung cancer progression and metastasis.
- | Journal: Genetic Variants in ADD1 Gene and their Associations with Growth Traits in Cattle. (Pubmed Central) - Aug 1, 2019
The statistical analyses indicated that the some SNPs are associated with the growth traits (body length, body height, chest circumference, and hucklebone width) in Chinese Jiaxian cattle population. Our results provide evidence that polymorphisms in the ADD1 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program.
- | Journal: Improvement of the Concrete Permeability by Using Hydrophilic Blended Additive. (Pubmed Central) - Jul 31, 2019
Its effectiveness as a water permeability reducing additive has shown encouraging results having reduced the water permeability by approximately 50% during testing. The action mechanism of the studied additive seems to be related to hydration reactions in the presence of water, producing new solid amorphous phases in the concrete bulk.
- | Clinical, Review, Journal: A Review of the Epidemiological Evidence for Adducin Family Gene Polymorphisms and Hypertension. (Pubmed Central) - Jul 6, 2019
Animal model experiments and clinical studies suggest that changes in single-nucleotide polymorphisms (SNPs) at part of the adducin family gene increase the Na-K-ATPase activity of the renal tubular basement membrane and increase the reabsorption of Na by renal tubular epithelial cells, which may cause hypertension. This review makes a summary on the structure, function, and mechanism of adducin and the role of adducin on the onset of EH, providing a basis for the early screening, prevention, and treatment of EH.
- | Journal: Adducin-1 is essential for spindle pole integrity through its interaction with TPX2. (Pubmed Central) - May 15, 2019
Moreover, the phosphorylation of ADD1 at S726 is crucial for its interaction with TPX2, which is essential for spindle pole integrity. Together, our findings unveil a novel function of ADD1 in maintaining spindle pole integrity through its interaction with TPX2.
- | Clinical, Journal: Genetic Polymorphisms Associated with the Onset of Arterial Hypertension in a Portuguese Population (Pubmed Central) - May 7, 2019
Through a multivariate analysis, it was concluded that these two last genetic variants together with four of the traditional risk factors (smoking, alcohol consumption, obesity and diabetes) are associated in a significant and independent way with essential hypertension. In a predictive model of hypertension, the introduction of genetic variants slightly increases the predictive value of the model.
- | U0126 / Promega
Journal: Salt Induces Adipogenesis/Lipogenesis and Inflammatory Adipocytokines Secretion in Adipocytes. (Pubmed Central) - Apr 9, 2019
Using the inhibitors of MAPK/ERK, U0126, we found that the crosstalk among the signaling pathways of MAPK/ERK, Akt-mTOR, and the inflammatory adipogenesis can be the possible mechanism of salt-linked obesity. The possibilities of whether the defense mechanisms against high dose of intracellular salts provoke signaling for adipocytes differentiation or interact with surrounding tissues through other pathways will be explored in future research.