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- | Journal, IO biomarker: Integrated Bioinformatics-Based Analysis of Hub Genes and the Mechanism of Immune Infiltration Associated With Acute Myocardial Infarction. (Pubmed Central) - Apr 26, 2022
TLR2, IL1B, LILRB2, FCER1G, FPR1, and MMP9 are involved in the process of AMI, which can be used as molecular biomarkers for the screening and diagnosis of AMI. In addition, the immune system plays a vital role in the occurrence and progression of AMI.
- | Journal: Bioinformatics Analysis Identified the Hub Genes, mRNA-miRNA-lncRNA Axis, and Signaling Pathways Involved in Rheumatoid Arthritis Pathogenesis. (Pubmed Central) - Apr 19, 2022
The immunohistochemical results showed that ITGB2 expression was significantly upregulated in RA. The hub genes, mRNA-miRNA-lncRNA axes, and signaling pathways related to RA pathogenesis identified in this study provide a new research direction for the mechanism, diagnosis, and treatment of RA.
- | Biomarker, Journal: Comprehensive analysis of immunocyte infiltration and the key genes associated with intraplaque hemorrhage in carotid atherosclerotic plaques. (Pubmed Central) - Apr 7, 2022
The hub genes, mRNA-miRNA-lncRNA axes, and signaling pathways related to RA pathogenesis identified in this study provide a new research direction for the mechanism, diagnosis, and treatment of RA. Eight genes were found to be involved in IPH, and four genes (ITGB2, VAV1, ITGAM, TYROBP) may be an important biomarkers for IPH.
- | Biomarker, Journal: Identification of Key Biomarkers and Pathways for Maintaining Cognitively Normal Brain Aging Based on Integrated Bioinformatics Analysis. (Pubmed Central) - Apr 1, 2022
CD44, CD93, and CD 163 are considered as potential biomarkers. This study provides more molecular evidence for maintaining cognitively normal brain aging.
- | Biomarker, Journal: Identification of diagnostic markers and immune cell infiltration characteristics in antineutrophil cytoplasmic antibody-associated vasculitis by weighted gene co-expression network analysis. (Pubmed Central) - Mar 23, 2022
This study provides more molecular evidence for maintaining cognitively normal brain aging. The present study is that the initial to spot immune cell infiltration with microarray data of glomeruli in AAV, which provides novel proof and clues for additional analysis of the molecular mechanisms.
- Transcriptome analysis reveals intrinsic pro-inflammatory signaling in healthy African American skin (Poster Presentation Center 1) - Mar 21, 2022 - Abstract #AAD2022AAD_2372;
Conclusions. Overall, these findings suggest the existence of intrinsic pro-inflammatory circuits in AA keratinocytes/skin that may account for disease disparities and will help to build a foundation for the development of targeted skin disease prevention and treatment.
- | Journal: Comprehensive Analysis to Identify Key Genes Involved in Advanced Atherosclerosis. (Pubmed Central) - Mar 15, 2022
Our study suggests that the key genes related to immune and inflammatory responses are involved in the development of AA. This may deepen our understanding of the mechanisms of and provide valuable therapeutic targets for AA.
- | Biomarker, Journal, PD(L)-1 Biomarker, IO biomarker: Prognostic modeling of patients with metastatic melanoma based on tumor immune microenvironment characteristics. (Pubmed Central) - Mar 15, 2022
Overall, a prognostic model for metastatic melanoma based on the tumor immune microenvironment characteristics was established, which left plenty of space for further studies. It could function well in helping people to understand characteristics of the immune microenvironment in metastatic melanoma.
- | Preclinical, Journal: Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice. (Pubmed Central) - Mar 12, 2022
Furthermore, treatment with polySia avDP20 prevented the loss of dopaminergic neurons in the substantia nigra pars compacta induced by lipopolysaccharide challenge in both SIGLEC11 transgenic and wild type mice on day 19. Thus, our data demonstrate that polySia avDP20 ameliorates inflammatory dopaminergic neurodegeneration and therefore is a promising drug candidate to prevent Parkinson's disease-related inflammation and neurodegeneration.
- | Opdivo (nivolumab) / Ono Pharma, BMS
Biomarker, Journal, PD(L)-1 Biomarker: FCER1G positively relates to macrophage infiltration in clear cell renal cell carcinoma and contributes to unfavorable prognosis by regulating tumor immunity. (Pubmed Central) - Mar 11, 2022
High expression of FCER1G in ccRCC is closely related to TAMs infiltration and suppression of T cell activation and proliferation. Combining the expression levels of FCER1G and macrophage biomarker CD68 may be a promising postoperative prognostic index for patients with ccRCC.
- DYSREGULATED EXPRESSION LEVELS OF APH1B IN PERIPHERAL BLOOD ARE ASSOCIATED WITH BRAIN ATROPHY AND AMYLOID-Β DEPOSITION IN ALZHEIMER’S DISEASE () - Mar 9, 2022 - Abstract #ADPD2022ADPD_1445;
Combining the expression levels of FCER1G and macrophage biomarker CD68 may be a promising postoperative prognostic index for patients with ccRCC. An integrative analysis of genetics, blood-based transcriptomic profiles, and imaging biomarkers suggests that APH1B expression levels in blood might play a role in the pathogenesis of AD.
- In vivo programming of myeloid cells by mRNA mediated delivery of novel Fc alpha fusion receptor activates anti-tumor immunity (Section 17) - Mar 9, 2022 - Abstract #AACR2022AACR_2335;
Furthermore, in the B16 syngeneic melanoma model, treatment with the melanoma antigen GP75 targeted Fc-alpha Receptor Fusion Constructs was also associated with the initiation of broad systemic immune responses, characterized by tumoral accumulation of activated CD8+ T cells, reduced tumor associated Tregs and activation of antigen presenting cells in spleen. Together these studies highlight the potential of Fc-alpha Receptor Fusion Construct delivered directly in vivo to program myeloid cells to recognize and kill cancer.
- | Biomarker, Journal: The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration. (Pubmed Central) - Mar 4, 2022
The SPI1-TYROBP-FCER1G network were potentially initiated by transcription factor SPI1 and would lead to the upregulated CD86, MHC-II, CCL4/CXCL10/CX3CL1 and hence increased immune infiltrations. With this study, we could better explore the mechanism of OS oncogenesis and metastasis for developing new therapies.
- | Journal: Enabling chemical protein (semi)synthesis via reducible solubilizing tags (RSTs). (Pubmed Central) - Mar 1, 2022
Both the protein 2B4 cytoplasmic tail and FCER1G protein have been successfully synthesized via this strategy. Of particular note, the RST strategy could be used for solubilizing the expressed protein segment for protein semi-synthesis of the HMGB1 protein.
- | Journal: The Expression Quantitative Trait Loci in Immune Response Genes Impact the Characteristics and Survival of Colorectal Cancer. (Pubmed Central) - Feb 26, 2022
We also demonstrated that FCER1G and co-expressed genes in TME were related to the aggregation of leukocytes via pathway analysis. By analyzing the eQTL from the cancer genome using germline variants and TME-based RNA sequencing, we identified the eQTL in immune response genes that impact colorectal cancer characteristics and survival.
- | Journal, Gene Signature, IO biomarker: A novel immune-related gene signature predicts survival in esophageal squamous cell carcinoma. (Pubmed Central) - Feb 5, 2022
The novel immune-related prognostic signature we constructed has a good prognostic, predictive ability and can be used as an independent prognostic indicator. Our study provides clinicians with a quantitative tool to predict the probability of individual survival time and helps clinicians select targets for immunotherapies and individualized treatment strategies for ESCC patients.
- | Journal: Atlas of genetic effects in human microglia transcriptome across brain regions, aging and disease pathologies. (Pubmed Central) - Feb 4, 2022
Our study provides clinicians with a quantitative tool to predict the probability of individual survival time and helps clinicians select targets for immunotherapies and individualized treatment strategies for ESCC patients. In summary, we have built the most comprehensive catalog to date of genetic effects on the microglia transcriptome and propose molecular mechanisms of action of candidate functional variants in several neurological and neuropsychiatric diseases.
- | Journal: Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides. (Pubmed Central) - Feb 3, 2022
Furthermore, loss of tyrosine hydroxylase positive (TH+) and NeuN positive neurons in the substantia nigra pars compacta upon repeated systemic LPS application were attenuated in NOX-2 KO mice. Thus, our data demonstrate that loss of dopaminergic neurons in the substantia nigra pars compacta after repeated systemic challenge with LPS is associated with a microglial phagocytosis-related gene activation profile involving the NADPH oxidase subunit Cybb/gp91phox.
- DONOR KLRC2 DELETION GENOTYPE IS ASSOCIATED WITH UPREGULATION OF ALLOREACTIVITY PATHWAYS WITH INCREASED GVHD AND NRM FOLLOWING T-REPLETE HAPLOIDENTICAL HCT (ePoster Area [VIRTUAL]) - Jan 30, 2022 - Abstract #EBMT2022EBMT_1610;
While KLRC2 del donor strongly correlated with acute GVHD and NRM, but not relapse, KLRC2wt donor with high D-ANK was associated with low incidences of GVHD, NRM as well as relapse, suggesting that incorporation of KLRC2 genotype and ANK cell repertoire in the algorithm for selection of haploidentical donors, might improve transplant outcomes. Clinical Trial Registry: NA
- | Journal, Gene Signature: A Unique Immune-Related Gene Signature Represents Advanced Liver Fibrosis and Reveals Potential Therapeutic Targets. (Pubmed Central) - Jan 26, 2022
Overall, we identified an immune gene signature that reliably predicts advanced fibrosis in chronic liver disease. This signature revealed potential immune therapeutic targets to ameliorate liver fibrosis.
- | Journal: Tianma Formula Alleviates Dementia via ACER2-Mediated Sphingolipid Signaling Pathway Involving Aβ. (Pubmed Central) - Jan 26, 2022
Also, the results of network pharmacology analysis and molecular docking were consistent with those of RNA-seq analysis. TF alleviates dementia by reducing Aβ deposition via the ACER2-mediated sphingolipid signaling pathway.
- || Clinical, Journal, Heterogeneity: Personal Network Inference Unveils Heterogeneous Immune Response Patterns to Viral Infection in Children with Acute Wheezing. (Pubmed Central) - Dec 27, 2021
The ratio of interferon- and FCER1G-associated gene network responses was able to predict recurrence, with low interferon being associated with increased risk of readmission. These findings demonstrate the applicability of personal network inference for biomarker discovery and therapeutic target identification in the context of acute asthma which focuses on variations in network structure.
- || Biomarker, Clinical, Journal, Tumor Mutational Burden, Tumor microenvironment: Identification of Prognostic Related Genes of Tumor Microenvironment Derived From Esophageal Cancer Patients. (Pubmed Central) - Dec 25, 2021
We identified a set of stromal and immune score-related prognostic differentially expressed genes that could influence the complexity of the TME. C1QA and FCER1G were identified and validated with respect to their role in the progression of ESCA.
- | Biomarker, Journal: Identification of novel genetic biomarkers and treatment targets for arteriosclerosis-related abdominal aortic aneurysm using bioinformatic tools. (Pubmed Central) - Dec 16, 2021
The construction of a PPI network and key modules resulted in the identification of five hub genes (SPI1, TYROBP, TLR2, FCER1G, and MMP9) as candidate diagnostic biomarkers and treatment targets for patients with AS-related AAA. AS and AAA are indeed correlated; SPI1, TYROBP, TLR2, FCER1G and MMP9 genes are potential new genetic biomarkers for AS-related AAA.
- | Journal: Identification of increased expression of activating Fc receptors and novel findings regarding distinct IgE and IgM receptors in Kawasaki disease. (Pubmed Central) - Nov 24, 2021
This is the first study indicating that IgA, IgE, IgG, and IgM receptors are associated with KD. We highlighted potential biomarkers related to Fc receptors and their regulation.
- | Biomarker, Journal: Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease. (Pubmed Central) - Nov 21, 2021
We highlighted potential biomarkers related to Fc receptors and their regulation. An integrative analysis of genetics, blood-based transcriptomic profiles, and imaging biomarkers suggests that APH1B expression levels in the blood might play a role in the pathogenesis of AD.
- Single Cell RNA-Seq Characterization of an Adaptive Population of NK Cells after Primary CMV Infection in Rhesus Macaques (GWCC - B211-B212, Level 2) - Nov 5, 2021 - Abstract #ASH2021ASH_1494;
This may be analogous to the dedifferentiation of effector CD8 T cells into memory T cells proposed by Youngblood et al. Confirmatory experiments to analyze the reconstitution of the CD16 + compartment after treatment with a depleting antibody are on-going.
- | Journal: Rhesus Macaque Activating Killer Immunoglobulin-Like Receptors Associate With Fc Receptor Gamma (FCER1G) and Not With DAP12 Adaptor Proteins Resulting in Stabilized Expression and Enabling Signal Transduction. (Pubmed Central) - Oct 31, 2021
This association with FcRγ results in increased and substantially stabilized surface expression of KIR3DS05. In addition, we demonstrate that binding of specific ligands of KIR3DS05, Mamu-A1*001 and A1*011, resulted in signal transduction in the presence of FcRγ in contrast to DAP12.
- | Journal: Identification of TYROBP and FCER1G as Key Genes with Prognostic Value in Clear Cell Renal Cell Carcinoma by Bioinformatics Analysis. (Pubmed Central) - Sep 30, 2021
Among them, CD53 was newly identified, and Kaplan-Meier survival curves suggested that high expression of CD53 was significantly associated with poor survival in ccRCC patients (log-rank P < 0.01). The present results may provide new insight into the understanding of molecular mechanisms and the clinical prognosis of ccRCC.
- | dexamethasone / Generic mfg.
Journal, IO biomarker: The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis. (Pubmed Central) - Sep 19, 2021
Immune genes such as SRC, RHOA, CD40LG, CSF1, TNFRSF1A, FCER1G, ICAM1, LAT, LCN2, PLAU, CXCL10, ICAM1, CD40, IRF7, and B2M were predicted to be the hub genes in the cytokine storm. Furthermore, we inferred that resveratrol, acetaminophen, dexamethasone, estradiol, statins, curcumin, and other compounds are potential target drugs in the treatment of COVID-19.
- | Journal: GP6 promotes the development of cerebral ischemic stroke induced by atherosclerosis via the FYN-PKA-pPTK2/FAK1 signaling pathway. (Pubmed Central) - Sep 2, 2021
Furthermore, we inferred that resveratrol, acetaminophen, dexamethasone, estradiol, statins, curcumin, and other compounds are potential target drugs in the treatment of COVID-19. GP6 can promote the development of CIS by activating the FYN-PKA-pPTK2/FAK1 signaling pathway.
- | MK-0752 / Merck (MSD), volasertib (BI 6727) / Oncoheroes
Journal: PLK1 and NOTCH Positively Correlate in Melanoma and their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways. (Pubmed Central) - Aug 14, 2021
We identified the modulations of several key genes relevant to melanoma progression/metastasis, including MAPK, PI3K, and RAS, as well as some new genes such as Apobec3G, BTK and FCER1G which have not been well-studied in melanoma. In conclusion, our study demonstrated a synergistic anti-proliferative response of a concomitant targeting of PLK1 and NOTCH in melanoma, unraveling a potential novel therapeutic approach for detailed preclinical/clinical evaluation.
- | Biomarker, Journal: FCER1G and PTGS2 Serve as Potential Diagnostic Biomarkers of Acute Myocardial Infarction Based on Integrated Bioinformatics Analyses. (Pubmed Central) - Aug 14, 2021
The area under ROC curve of FCER1G and PTGS2 was 77.6% and 80.7%, respectively. Moreover, the micro (mi)RNA-messenger (m)RNA network was also visualized; the results showed that miRNA-143, miRNA-144, and miRNA-26 could target PTGS2 in AMI progression.
- ||||| Preclinical: FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in MM https://t.co/LZFoBrnXUP #mmsm #myeloma (Twitter) - Aug 7, 2021
- |||| Preclinical: Awesome collaboration! Wonderful to work with the Indapta team and collaborators @StatAustin @apwiita @ninashah33 FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myeloma (Twitter) - Aug 7, 2021
- |||| Preclinical: Nuthin’ like a H-town/Bay Area collab! Check out our paper on a novel allogeneic memory NK cell product: FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myeloma #mmsm @apwiita https://t.co/xmmGS50R5r (Twitter) - Aug 6, 2021
- [VIRTUAL] Profiling microglial nodules in MS: possible implications for MS lesion formation (Stream 4 Pathogenesis) - Aug 3, 2021 - Abstract #ECTRIMS2021ECTRIMS_1317;
In MS tissue, the number of HLA-DR+ nodules was higher compared to stroke tissue (p<0.05). In MS nodules vs MS peri-nodular tissue, 325 differentially expressed (DE) genes were upregulated, involved in immune response (FCGR3A, IRF8, TNFSF13B, CD276, MHC class II, FCER1G), phagocytosis (AXL, CD13, SLC11A1), and nitric oxide metabolism (TLR2, TLR6).
- Atlas of genetic effects in human microglia transcriptome across brain regions, aging and disease pathologies (Convention Ctr - 601/603) - Aug 2, 2021 - Abstract #AAIC2021AAIC_1510;
In MS nodules vs MS peri-nodular tissue, 325 differentially expressed (DE) genes were upregulated, involved in immune response (FCGR3A, IRF8, TNFSF13B, CD276, MHC class II, FCER1G), phagocytosis (AXL, CD13, SLC11A1), and nitric oxide metabolism (TLR2, TLR6). In summary, we have built the most comprehensive catalog to date of genetic effects on the microglia transcriptome and propose molecular mechanisms of action of candidate functional variants in several neurological and neuropsychiatric diseases.
- | Journal: Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. (Pubmed Central) - Jul 30, 2021
Single microglia sequencing confirms that Aβ, not TAU, pathology induces marked transcriptional changes in microglia, including increased proportions of activated microglia. We conclude that genetic risk of AD functionally translates into different microglia pathway responses to Aβ pathology, placing AD genetic risk downstream of the amyloid pathway but upstream of TAU pathology.
- || Clinical, Journal, Gene Signature: Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9. (Pubmed Central) - Jul 16, 2021
This study revealed the significance of 10-gene signature in the development of osteosarcoma. Besides, drug candidates identified in this study provided a solid basis on MMP9 inhibitors' development.
- | Journal: Bioinformatics analysis reveals novel hub gene pathways associated with IgA nephropathy. (Pubmed Central) - Jul 7, 2021
We identified key genes along with the pathways that were most closely related to IgAN initiation and progression. Our results provide a more detailed molecular mechanism for the development of IgAN and novel candidate gene targets of IgAN.
- || Clinical, Journal: Identification of Key Genes and Pathways in Myeloma side population cells by Bioinformatics Analysis. (Pubmed Central) - Jul 7, 2021
The predictive value of the prognostic model including TFF3, EPDR1, MACROD1, ARHGEF12, AMMECR1, NFATC2, HES6, PLEK2 and SNCA was identified, and validated in another external dataset (MMRF-CoMMpass cohort from TCGA). In conclusion, this study provides reliable molecular biomarkers for screening, prognosis, as well as novel therapeutic targets for myeloma LC/SP cells.
- || Clinical, Journal: A Novel Inflammatory Dendritic Cell That Is Abundant and Contiguous to T Cells in the Kidneys of Patients With Lupus Nephritis. (Pubmed Central) - Jun 30, 2021
Importantly, IF identified CD3 T cells to be adjacent to these infDCs in the PG space of the LN kidney, whereas both cell types are minimally present in the healthy kidney. Thus, we have identified a previously undescribed DC in lupus kidneys that may interact with intrarenal T cells and play a role in the pathogenesis of kidney injury during LN flare.
- | Journal: Identification of Potential Key Genes Involved in the Carotid Atherosclerosis. (Pubmed Central) - Jun 30, 2021
The present study identified key DEGs in atheroma plaque compared with control samples. The key genes involved in the development of carotid atherosclerosis may provide valuable therapeutic targets for carotid atherosclerosis.
- | Journal: Assessment of changes in genetic transcriptome in nasal epithelial cells exposed to ozone-aged black carbon and pollen allergen by high-throughput transcriptomics. (Pubmed Central) - May 25, 2021
The key genes involved in the development of carotid atherosclerosis may provide valuable therapeutic targets for carotid atherosclerosis. OBC and pollen allergen combined exposure may induce innate immune and allergic inflammation in hNECs, and therefore potentially exacerbate the symptoms of AR in affected individuals.
- | Journal: Novel Insight Into the Role of Immune Dysregulation in Amyotrophic Lateral Sclerosis Based on Bioinformatic Analysis. (Pubmed Central) - May 20, 2021
This gene signature could differentiate ALS patients from non-neurological controls (p < 0.001) and predict disease occurrence (AUC = 0.829 in training set; AUC = 0.862 in test set). In conclusion, our study provides potential biomarkers of ALS for disease diagnosis and therapeutic monitoring.
- || Biomarker, Clinical, Journal, Tumor microenvironment, IO biomarker: Development and validation of nomogram with tumor microenvironment-related genes and clinical factors for predicting overall survival of endometrial cancer. (Pubmed Central) - May 20, 2021
TME-related hub genes of prognostic value identified in our study may provide references for the mechanisms underlying EC development and the immunotherapy for EC. The prediction model may help assess the prognosis of EC patients.
- | Journal: Transcriptome of airway neutrophils reveals an interferon response in life-threatening respiratory syncytial virus infection. (Pubmed Central) - May 15, 2021
Our data indicate that airway neutrophils regulate their function at the transcriptional level in response to viral infection. It also suggests that local interferon drives the neutrophil response of severe RSV bronchiolitis.
- | Preclinical, Journal: Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse. (Pubmed Central) - Apr 30, 2021
As a result, segregation of human NK cell-mediated ADCC from mouse cell-mediated ADCC was possible in the NOG-FcγR-hIL-15 Tg mice. Our results suggest that NOG-FcγR-hIL-15 Tg mice are useful for validating the in vivo function of antibody drug candidates.
- | Journal: Key genes associated with non-alcoholic fatty liver disease and acute myocardial infarction. (Pubmed Central) - Apr 29, 2021
RESULTS To obtain the pathogenesis associated with both NAFLD and AMI, protein-protein interaction (PPI) network was constructed and the top ten hub genes (TLR2, LILRB2, CXCL1, FPR1, TLR4, TYROBP, MMP9, FCER1G, CLEC4D and CCR2) were selected with CONCLUSIONS The results of this study suggesting some novel genes may play an important role in the occurrence and progression NAFLD and AMI. But more experimental researches and clinical trials need to verify.