- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Journal: Randomized Trial of SGLT2 Inhibitor Identifies Target Proteins in Diabetic Kidney Disease. (Pubmed Central) - Feb 12, 2024 They were treated with 10 mg of dapagliflozin for 12 weeks...Biological processes relating to inflammation, wound healing, and kidney fibrosis were enriched. The current study discovers the urinary proteome impacted by the SGLT2i, thereby providing new potential target sites and pathways, especially relating to wound healing and inflammation.
- |||||||||| Journal: Serum proteomics analysis of drug-na (Pubmed Central) - Jan 22, 2024
These proteins had a functional association with immune inflammation. The development of generalised anxiety disorder might be closely linked to the immune inflammatory stress response.
- |||||||||| Journal: Quantitative Proteomics of Maternal Blood Plasma in Isolated Intrauterine Growth Restriction. (Pubmed Central) - Dec 17, 2023
Our findings highlight the complex interplay of immune and coagulation factors in IUGR and the differences between early- and late-onset IUGR and other placenta-related conditions like PE. Understanding these mechanisms is crucial for developing targeted interventions and improving outcomes for pregnancies affected by IUGR.
- |||||||||| pevonedistat (MLN4924) / Takeda
Extracellular vesicles as a pharmacodynamic reporter in glioblastoma (Exhibit Hall A/B) - Nov 11, 2023 - Abstract #SNO2023SNO_429; Future efforts are focused on evaluating immunoprecipitated GBM-EVs from longitudinally collected patient biofluids. Overall, we anticipate that the results of this study will lead to development of a clinical test that reflects BBB penetration and tumor response, which will likely aid in novel drug development efforts.
- |||||||||| Journal: Evaluation of the differences in proteomics of high-quality bovine colostrum and low-quality bovine colostrum. (Pubmed Central) - Sep 19, 2023
It was detected that the proteome contents of high- and low-quality bovine colostrums were different from each other. As new functions are added to the protein databases regarding these proteins detected in colostrums, the interactions of proteins with each other and with other molecules will be detailed and the effects of high-quality colostrums on passive transfer immunity and calf health will be understood in full detail.
- |||||||||| Journal: Impact of Rehydration Following Systemic Dehydration on Vocal Fold Gene Expression. (Pubmed Central) - Jun 22, 2023
This study provides molecular evidence for a transcriptional response to rehydration following acute systemic dehydration in the vocal folds. These data are the first to study gene expression following realistic dehydration and rehydration paradigms and provide biological data to support clinical recommendations to increase water intake after acute dehydration.
- |||||||||| In vitro model of liver ischemia/reperfusion injury identifies iRhom2 as new target of disease (Poster Area) - Apr 12, 2023 - Abstract #EASLILC2023EASL_ILC_1046;
These data are the first to study gene expression following realistic dehydration and rehydration paradigms and provide biological data to support clinical recommendations to increase water intake after acute dehydration. Taken together, these data suggest that iRhom2, in response to IRI, could regulate secretion of these proteins post-transcriptionally, by a mechanism that might be independent from TNF pathway.
- |||||||||| Journal, Epigenetic controller: Epigenome-wide analysis of maternal exposure to green space during gestation and cord blood DNA methylation in the ENVIRONAGE cohort. (Pubmed Central) - Nov 19, 2022
Furthermore, a bagged-trees-based ensemble model with superior classifier performance is integrated with the sensing platform to categorize diseased and healthy conditions, which could be helpful in precise decision making for end users. Our results demonstrate that maternal exposure to green space during pregnancy is associated with cord blood DNA methylation, mainly at loci organized in regions, in genes playing important roles in neurological development (e.g., HTR2A).
- |||||||||| Biomarker, Journal: A novel classification of HCC basing on fatty-acid-associated lncRNA. (Pubmed Central) - Nov 9, 2022
Three subtypes were obtained, which presented with differences in prognosis, clinical information, mutation features, pathway traits, immune characteristics, and drug sensitivity. The seven key lncRNAs identified in this study might serve as promising biomarkers for predicting prognosis in patients with HCC, and the three HCC subtypes classified according to lncRNA expression profiles could improve HCC classification.
- |||||||||| Journal: Differentially Represented Proteins in Response to Infection with Mycobacterium tuberculosis Identified by Quantitative Serum Proteomics in Asian Elephants. (Pubmed Central) - Sep 24, 2022
Protective mechanisms included defense against infection (Alpha-1-B glycoprotein A1BG, Serpin family A member 1 SERPINA1, Transthyretin TTR), neuroprotection (TTR), and reduced risks of inflammation, infections, and cancer (SERPINA1, Keratin 10 KRT10). Using a translational biotechnology approach, the results provided information for the identification of candidate diagnostic, prognostic, and protective antigens for monitoring and control of tuberculosis in Asian elephants.
- |||||||||| Biomarker, Journal: Validation of Serotransferrin in the Serum as Candidate Biomarkers for the Diagnosis of Pulmonary Tuberculosis by Label-Free LC/MS. (Pubmed Central) - Jul 27, 2022
Furthermore, the AUC value of TRF was 0.647 with 90.22% sensitivity and 42.86% specificity in discriminating the TB group from the pneumonia group, 0.702 with 93.48% sensitivity and 47.16% specificity in discriminating the TB group from the lung cancer group, 0.894 with 91.30% sensitivity and 71.62% specificity in discriminating the TB group from all HCs, and 0.792 with 91.30% sensitivity and 58.90% specificity in discriminating the TB group from the non-TB controls. This study obtained the proteomic profiles of neutrophils in the TB patients and HCs, which contribute to a better understanding of the pathogenesis molecules existing in the neutrophils of pulmonary tuberculosis and provide candidate biomarkers for the diagnosis of pulmonary tuberculosis.
- |||||||||| Journal: Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis. (Pubmed Central) - May 15, 2022
Although the significant changes in any protein in Group PC were absent, significant changes were observed in Alpha-1B-glycoprotein (A1BG), Zinc transporterZIP11 (S39AB), Cathelicidin-1 (CTHL1), Actin_ cytoplasmic-1 (ACTB), and Apolipoprotein A-IV (APOA4) proteins in Group PCOL and Alpha-1-antiproteinase (A1AT), Serum amyloid A protein (SAA), Actin-cytoplasmic-2 (ACTG), Protein HP-20 homolog (HP20) proteins in Group PBCOL with colostral treatment, which indicated that the use of colostrum had an effect on calf serum proteomes. The more pronounced healing and shorter clinical improvement time in the colostrum groups especially colostrum with sodium bicarbonate revealed that these proteomes have positive effects in the treatment with their systemic and local effects in the intestines.
- |||||||||| Preclinical, Journal, Heterogeneity: Proteomic Analysis Identifies FNDC1, A1BG, and Antigen Processing Proteins Associated with Tumor Heterogeneity and Malignancy in a Canine Model of Breast Cancer. (Pubmed Central) - Dec 13, 2021
Finally, an independent validation showed FNDC1, A1BG, PDIA3, HSPA5, and calnexin as significant prognostic markers for human breast cancer patients. Thus, through a spatially correlated characterization of spontaneous carcinomas, we described key proteins which can be further validated as potential prognostic biomarkers.
- |||||||||| Journal: Quality-Related Properties of Equine Immunoglobulins Purified by Different Approaches. (Pubmed Central) - Jun 24, 2021
AC and CEX remarkably affected drug's venom-neutralization activity, in contrary to the CAP procedure, that preserved protective efficacy of the IgG fraction. Presented data might improve the process of designing and establishing novel downstream processing strategies and give guidance for optimization of the current ones by providing information on potency-protecting and purity-increasing properties of each purification principle.
- |||||||||| carbimazole / Generic mfg.
Biomarker, Clinical, Journal: Proteomics Profiling of the Urine of Patients with Hyperthyroidism after Anti-Thyroid Treatment. (Pubmed Central) - May 25, 2021 Urine samples were collected from nine age-matched patients before and after carbimazole treatment...The notable upregulated urinary proteins were serotransferrin, transthyretin, serum albumin, ceruloplasmin, alpha-1B-glycoprotein, syntenin-1, and glutaminyl peptide cyclotransferase, whereas the three notable downregulated proteins were plasma kallikrein, protein glutamine gamma-glutamyl transferase, and serpin B3 (SERPINB3). Bioinformatic analysis using ingenuity pathway analysis (IPA) identified the dysregulation of pathways associated with cellular compromise, inflammatory response, cellular assembly, and organization and identified the involvement of the APP and AKT signaling pathways via their interactions with interleukins as the central nodes.
- |||||||||| carbimazole / Generic mfg.
Clinical, Journal: Plasma-Based Proteomics Profiling of Patients with Hyperthyroidism after Antithyroid Treatment. (Pubmed Central) - Feb 20, 2021 Plasma from 10 age-matched subjects at baseline (hyperthyroid) and post treatment with carbimazole (euthyroid) was compared by difference gel electrophoresis (DIGE) and matrix-assisted laser desorption/ionization time of flight (MALDI TOF) mass spectrometry (MS)...The plasma proteome of patients with hyperthyroidism revealed differences in the abundance of proteins involved in acute phase response signaling, and development of a hypercoagulable and hypofibrinolytic state. Our findings enhance our existing knowledge of the altered proteins and associated biochemical pathways in hyperthyroidism.
- |||||||||| Biomarker, Journal: Proteomic study of advanced cirrhosis based on HCV to reveal potential biomarkers. (Pubmed Central) - Feb 17, 2021
According to network analysis, ALB has been introduced as a key protein, which may play an important role in pathogenesis. Integration of the proteomics with protein interaction data led to the identification of several novel key proteins related to the immune system that may reflect the long-term effects of hepatitis C virus on the liver, and can introduce as therapeutic targets for advanced HCV- cirrhosis.
- |||||||||| Biomarker, Clinical, Journal: Analysis of plasma protein biomarkers in childhood onset multiple sclerosis. (Pubmed Central) - Dec 16, 2020
Plasma protein changes observed in our study were related to the inflammation, coagulation and oxidative stress pathways. If confirmed and validated in larger groups, these results may indicate potential biomarker(s) for demyelinating diseases at proteome level and could encourage studies for the development of novel diagnostic kits.
- |||||||||| Journal: Revelation of Proteomic Indicators for Colorectal Cancer in Initial Stages of Development. (Pubmed Central) - Nov 12, 2020
Due attention should be paid to Apolipoprotein E (APOE), Apolipoprotein C1 (APOC1), and Apolipoprotein B-100 (APOB) because of their impact on the malfunction of DNA repair and their capability to regulate mTOR and PI3K pathways. The contribution of the observed PTMs is still equivocal, but a significant decrease in the likelihood between modified and native proteins was not detected confidently.
- |||||||||| [VIRTUAL] Molecular analysis of atopic dermatitis pathogenesis in NC/NgaTnd mice () - Jul 1, 2020 - Abstract #SID2020SID_636;
Importantly, APR signaling and several others identified in our proteomics analysis (A1bg, Myh13, Mocs3, Pcdh15, Lrg1; all >5-fold change) have not been linked to AD thus far. Further studies are needed to validate how interactions of these modulated proteins are involved in AD development and progression.
- |||||||||| Journal: Unraveling the LRC evolution in mammals: IGSF1 and A1BG provide the keys. (Pubmed Central) - Nov 6, 2019
The only family member retained in all the three mammalian lineages is a collagen-binding receptor OSCAR. Strong sequence conservation of a transmembrane domain known to associate with FcRγ suggests an adaptive role of this domain subtype in the LRC evolution.
- |||||||||| Journal: A comparison of the uterine proteome of mares in estrus and diestrus. (Pubmed Central) - May 5, 2019
In conclusion, ten differentially abundant proteins were identified in the uterine flush fluid of mares in estrus and diestrus. Targeted studies on these proteins could elucidate their role in uterine defense mechanisms during estrous cycle in the mare.
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