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- | Journal: A Novel Prognostic Model for Oral Squamous Cell Carcinoma: The Functions and Prognostic Values of RNA-Binding Proteins. (Pubmed Central) - Aug 17, 2021
The internal validation cohort results showed a reliable predictive capability of the nomogram for OSCC. We established a novel 10-RBP-based model for OSCC that could enable precise individual treatment and follow-up management strategies in the future.
- | Journal: Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase. (Pubmed Central) - May 29, 2020
Together, our findings suggest that hsp90 works in concert with cochaperons (Hsp70, Aha1, Aarsd1, STIP1, and Cdc37) and an active sGC-cGMP signaling pathway to promote heme insertion into immature apo-Mb, and thus generate functional Mb during muscle myotube formation. This fills gaps in our understanding and suggests new ways to potentially control these processes.-Ghosh, A., Dai, Y., Biswas, P., Stuehr, D. J. Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase.
- | Clinical, Journal, IO Biomarker: Novel cancer gene variants and gene fusions of triple-negative breast cancers (TNBCs) reveal their molecular diversity conserved in the patient-derived xenograft (PDX) model. (Pubmed Central) - Aug 7, 2019
Finally, western blot analysis of oncogenic signaling proteins supporting molecular diversity of TNBC PDXs. Overall, our report provides a molecular basis for the usefulness of the TNBC PDX model in preclinical study.