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- | Journal: Predictive Value of Annenxin A1 for Disease Severity and Prognosis in Patients with Community-Acquired Pneumonia. (Pubmed Central) - Feb 12, 2023
Kaplan-Meier analysis of 30-day mortality showed that AnxA1 level ?670.84 ng/mL was associated with a significantly higher survival rate than a level >670.84 ng/mL. These results indicate that AnxA1 is a useful biomarker for early diagnosis and prognostic assessment of CAP.
- | Journal: Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis. (Pubmed Central) - Feb 12, 2023
The depletion of peripheral neutrophils during lung melanoma metastasis development (anti-Gr1; i.p. every 48 h for 21 days) reduced the number of metastases and AnxA1 serum levels in mice. Our findings show that AnxA1 secreted by neutrophils favors melanoma metastasis evolution via FPR pathways, addressing AnxA1 as a potential biomarker for the detection or progression of melanoma.
- | Biomarker, Journal, Tumor microenvironment, IO biomarker: Mapping the tumor microenvironment in bladder cancer and exploring the prognostic genes by single-cell RNA sequencing. (Pubmed Central) - Feb 7, 2023
Weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) network mutual analysis, and the Kaplan-Meier survival prognosis analysis were used to identify six key genes associated with the prognosis of bladder cancer: VEGFA, ANXA1, HSP90B1, PSMA7, PRDX6, and PPP1CB. The dynamic change of the expression distribution of six genes on the pseudo-time axis was further verified by cell pseudo-time analysis.
- | Journal: In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression. (Pubmed Central) - Feb 7, 2023
The dynamic change of the expression distribution of six genes on the pseudo-time axis was further verified by cell pseudo-time analysis. C1GALT1 stably depleted ECC-1 cells mimic an EC aggressive phenotype observed in patients and might be useful for the identification and validation of EC markers of progression.
- | Journal: Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single-cell RNA sequencing. (Pubmed Central) - Feb 5, 2023
C1GALT1 stably depleted ECC-1 cells mimic an EC aggressive phenotype observed in patients and might be useful for the identification and validation of EC markers of progression. This work identifies intestinal fibrosis and related regulators in aganglionic segments of HSCR; hence, anti-fibrotic therapy may be considered to prevent HSCR-associated enterocolitis (HAEC), relieve intestinal stricture and improve cell therapy.
- Expression of annexin A1 and NLRNLRP3 inflamassome in Chron's disease (Poster exhibition) - Feb 1, 2023 - Abstract #ECCOIBD2023ECCO_IBD_736;
Counterstaining: Carazzi's Hematoxylin. Bars: 50 µm.
- | Journal, Tumor mutational burden, IO biomarker: A prognostic model based on necroptosis-related genes for prognosis and therapy in bladder cancer. (Pubmed Central) - Jan 29, 2023
In our study, DOK7 was chosen to further verify our prognosis model, and functional assays indicated that knockdown the expression of DOK7 could prompt bladder cancer proliferation and migration. Our work demonstrated the potential role of prognostic model based on necroptosis genes in the prognosis, immune landscape and response efficacy of immunotherapy of bladder cancer.
- | Preclinical, Journal, Metastases: Establishment of esophageal squamous carcinoma cell lines with different invasive metastatic potential and differential gene screening. (Pubmed Central) - Jan 26, 2023
The establishment of differential gene expression profiles for invasion and metastasis together with a bioinformatics analysis provided rich information for studies related to ESCC invasion and metastasis. HSP90α, 14-3-3β, and CXCR7 were highly expressed in ESCCs with high invasion and metastasis, while Annexin A1 was highly expressed in ESCCs with low metastasis.
- | Preclinical, Journal: Transcriptomic analysis of the upper lip and primary palate development in mice. (Pubmed Central) - Jan 24, 2023
Protein-protein interaction (PPI) network analysis identified a series of hub genes, including Col1a2, Fos, Bmp2, Shh, Col1a1, Wnt3a, Anxa1, Gem, etc. Overall, the results of this study provided a comprehensive analysis of the development of the upper lip and primary palate. Our work provides insight into future studies of normal upper lip and primary palate development and the etiology of CL/P.
- | Journal: Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway. (Pubmed Central) - Jan 22, 2023
Furthermore, ANXA1 antagonized the autophagic death of honokiol in colon cancer cells via stabilizing mitochondrial reactive oxygen species. Based on these results, we speculated that ANXA1 might be a druggable target to control colon cancer and overcome drug resistance.
- | Journal: Transcriptional and cell type profiles of cortical brain regions showing ultradian cortisol rhythm dependent responses to emotional face stimulation. (Pubmed Central) - Jan 21, 2023
Our results further indicate that specific cell types, including a specific NPY-expressing GABAergic neuronal cell type, and specific G protein signaling cascades underly the cerebral effects of a loss of ultradian cortisol rhythm. Our results provide a biological mechanistic underpinning of our fMRI findings, indicating specific cell types and cascades as a target for manipulation in future experimental studies.
- Targeting of Annexin-A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma (3F South Lounge) - Jan 20, 2023 - Abstract #APASL2023APASL_473;
Targeting of ANXA1 suppresses murine liver tumor growth through modulation of macrophage polarization, activation T cell antitumor immune response. The results demonstrate the translational potential of ANXA1 for anti-tumorigenesis therapies.
- || Review, Journal: Annexin A1 affects tumor metastasis through epithelial-mesenchymal transition: a narrative review. (Pubmed Central) - Jan 17, 2023
Both the abnormal expression of ANXA1 and the occurrence of EMT are closely related to the invasion and metastasis of tumors, and more interestingly, ANXA1 can impact EMT directly or indirectly by mediating signaling pathways and adhesion among cells. We need more studies to elucidate the effects of ANXA1 on tumor invasion, migration and metastasis through EMT in vitro and in vivo clearly, and ultimately in patients to identify more therapeutic targets.
- | Journal: Integrated transcriptome and proteome revealed that the declined expression of cell cycle-related genes associated with follicular atresia in geese. (Pubmed Central) - Jan 17, 2023
The cell cycle is an important pathway for the regulation of follicular atresia. Sodium outflow and high expression of MMP3 and MMP9 could be responsible for structural destruction and apoptosis of follicular cells.
- | Journal, Metastases: NTF4 plays a dual role in breast cancer in mammary tumorigenesis and metastatic progression. (Pubmed Central) - Jan 13, 2023
Our findings identified an unexpected dual role for NTF4 in breast cancer which contributes to early metastasis of the disease. Therefore, NTF4 may serve as a prognostic marker and a potential therapeutic target for breast cancer.
- | Journal: Bioinformatic analysis of molecular mechanism of IL-17 in regulating ulcerative colitis (Pubmed Central) - Jan 12, 2023
Ten hub genes such as IL-6, CXCL8, CXCL10, CXCL1, CXCL9, ANXA1, IL-1β, CCL20, CXCL2, and CXCL11 were screened out of the PPI network, which were located downstream of the signaling pathway regulated by IL-17. Conclusion The 10 hub genes related to the risk of UC were likely to be regulated by IL-17 during the occurrence and development of UC.
- | Journal: Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis. (Pubmed Central) - Jan 12, 2023
Loss of Annexin A1 randomises mitotic spindle orientation, which in turn disrupts epithelial architecture and luminogenesis in three-dimensional cultures of primary mammary epithelial cells. Our findings establish Annexin A1 as an upstream cortical cue that regulates LGN to direct planar cell divisions during mammalian epithelial morphogenesis.
- | PF-04217903 / Pfizer
Journal: Blocking the HGF-MET Pathway Induces Resolution of Neutrophilic Inflammation by Promoting Neutrophil Apoptosis and Efferocytosis. (Pubmed Central) - Jan 11, 2023
In human neutrophils, the combined use of LPS and HGF increased MET phosphorylation and provided a prosurvival signal, whereas blocking MET with PF-04217903 induced caspase-dependent neutrophil apoptosis. Taken together, these data demonstrate that blocking HGF/MET signalling may be a potential therapeutic strategy for inducing the resolution of neutrophilic inflammatory responses.
- | JQ-1 / Roche
Preclinical, Journal: The Role of Bromodomain and Extraterminal (BET) Proteins in Controlling the Phagocytic Activity of Microglia In Vitro: Relevance to Alzheimer's Disease. (Pubmed Central) - Jan 9, 2023
Further analysis of the mRNA level of other phagocytosis-related genes which were involved in the pathomechanism of Alzheimer's disease demonstrated that JQ1 significantly reduced the expression of Cd33, Trem2, and Zyx. Our results indicate the important role of BET proteins in controlling microglial phagocytosis; therefore, targeting BET may be the efficient method of modulating microglial activity.
- MiR-185-5p regulated cadherin binding proteins: A potential pathway involved in endometrial receptivity to implantation in humans? () - Jan 8, 2023 - Abstract #Fertility2023Fertility_446;
All transcripts were detected in the endometrium while expression of CSNK1D and TJP1 was lower in biopsies from the RIF group compared to the LB group (p=0.036 and p=0.079, respectively). These data provide preliminary evidence to support a regulatory role for miR-185-5p and its targets in contribution to endometrial function during implantation.
- | Journal: Detection of human annexin A1 as the novel N-terminal tag for separation and purification handle. (Pubmed Central) - Jan 6, 2023
The selected five colored proteins were efficient for detecting the applicability of the highly selective hanA1 for fusion separation and purification handle. The fused hanA1 tag will be potentially used for simple and cheap affinity separation of the target proteins in industry and diagnosis.
- || HCLv ( since annexin A1 neg). (Twitter) - Jan 4, 2023
- || Don’t remember the new name but HCL-V is BRaf negative and MapK + ve Annexin 1 and cd 25 neg (Twitter) - Jan 2, 2023
- ||||| Review: Hematology Board Review Difficult question as it has a new name! @sanamloghavi 63 yo male with massive splenomegaly and a WBC 53, Hgb 9, Plt 75, diff most lymphocytes. Flow = CD5-, CD10-, CD11c+, CD20+, CD25-, CD103+, CD123-, AnnexinA1-. (Twitter) - Jan 2, 2023
- || Review, Journal: Autoimmune complications of COVID-19 and potential consequences for long-lasting disease syndromes. (Pubmed Central) - Jan 1, 2023
This commentary focuses on the presence of various autoantibodies reported so far in Covid-19 diseases, exploring their association with the disease course and the durability of some related symptoms. Attempts are also made to further analyze the potential mechanism of actions and link the presence of antibodies with pathological complications.
- | Journal: Interplay of membrane crosslinking and curvature induction by annexins. (Pubmed Central) - Dec 30, 2022
Our data support a mechanistic model of PMR where ANXA4 induced membrane curvature and ANXA6 crosslinking promotes wound closure. The model now can be expanded to include ANXA1 and ANXA2 as specialist free edge membrane crosslinkers that act in concert with ANXA4 induced curvature and ANXA6 crosslinking.
- ||| Clinical data, Journal, Adverse events: Annexin A1 Is Associated with Adverse Clinical Outcomes in Patients with COVID-19. (Pubmed Central) - Dec 24, 2022
These findings might reflect an insufficient increase in AnxA1 as a response to the excessive hyperinflammation in COVID-19. Future studies should evaluate whether hyperinflammation could be reduced through the administration of human recombinant AnxA1 or Ac2-26 peptide.
- | Journal: Exosomes Released by Influenza-Virus-Infected Cells Carry Factors Capable of Suppressing Immune Defense Genes in Naïve Cells. (Pubmed Central) - Dec 24, 2022
Exosomes secreted by IAV-infected cells could reduce the immune response of neighboring intact cells, leading to more effective IAV replication. This may be associated both with regulatory functions of cellular miRNAs and mRNAs carried by exosomes, or with the presence of viral mRNAs encoding proteins with an immunosuppressive function.
- MUCOSAL EXPRESSION OF GENES PI3, ANXA1, AND VDR DESCRIMINATES CROHNS DISEASE FROM ULCERATIVE COLITIS IN INFLAMMATORY BOWEL DISEASE PATIENTS (Exhibit/Poster Hall (Aurora Halls 1/2) - Gaylord Resort) - Dec 23, 2022 - Abstract #CCCongress2023CCCongress_180;
We propose that the RT-qPCR assay could be used in a clinical routine setup for distinguishing UC from CD. Key words: IBDU, Multigene expression, Differential diagnosis, FFPE, RT-qPCR, Mucosal biopsies
- | Preclinical, Journal: Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro. (Pubmed Central) - Dec 22, 2022
Key words: IBDU, Multigene expression, Differential diagnosis, FFPE, RT-qPCR, Mucosal biopsies Taken together, this study provides evidence that the protective effect of ANXA1 (Ac2-26) on SI-AKI largely depends on the negative regulation of inflammation and apoptosis via the Fpr2 receptor.
- | Biomarker, Journal: Bile Proteome Analysis by High-Precision Mass Spectrometry to Examine Novel Biomarkers of Primary Sclerosing Cholangitis. (Pubmed Central) - Dec 19, 2022
A bile proteome analysis is a useful tool for elucidating the pathogenesis of PSC and developing new diagnostic approaches. Therefore, ANXA1 has potential as a bile biomarker for PSC.
- | Journal: Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1. (Pubmed Central) - Dec 16, 2022
Collectively, these data identify SIRT5 as a novel regulator of microglia-induced neuroinflammation and neuronal damage after cerebral ischaemia. Interventions targeting SIRT5 expression may represent a potential therapeutic target for ischaemic stroke.
- The role of gene expression of CD47 in colorectal cancer (CRC). (On Demand | Level 1, West Hall; Poster Board No. N2) - Dec 13, 2022 - Abstract #ASCOGI2023ASCO_GI_903;
Highly CD47-expressed CRC harbored activation of DAMPs and oncogenic signaling pathways that linked to aberrant tumor microenvironment and worse prognosis. Our results support intensive treatment strategies using CD47 inhibitors combined with cytotoxic agents and molecular targeted agents (such as anti-VEGF agents) in CD47-overexpressed CRC.
- | Preclinical, Journal: The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model. (Pubmed Central) - Dec 12, 2022
Moreover, P140 increased the production of the pro-resolving mediator annexin A1 and decreased the expression of the autophagy-related ATG5-ATG12 complex and HSPA8 chaperone protein. Overall, these findings suggest that P140 exerts a significant beneficial effect in a neutrophilic inflammation observed in the model of gout that can be of special interest in the design of new therapeutic strategies.
- | Journal: Integrated analysis of multiple microarray studies to establish differential diagnostic models of Crohn's disease and ulcerative colitis based on a metalloproteinase-associated module. (Pubmed Central) - Dec 9, 2022
The established Model_2 overcomes batch differences and has good clinical applicability. Subsequent in-depth research investigating how MMPs are involved in the development of different IBD subtypes is necessary.
- | Journal, Gene Signature: An Oxidative Stress-Related Gene Signature in Granulosa Cells Is Associated with Ovarian Aging. (Pubmed Central) - Dec 6, 2022
In GCs of reproductively aged (8-month-old) Kunming mice, upregulated expression of Mapk1, Stk24, Atg7, and Pon2 and downregulated expression of Anxa1 and Areg were observed (p < 0.01). We therefore here identify a six-gene GC signature associated with oxidative stress and ovarian aging.
- | Journal: Clinical and genetic characteristics of amyotrophic lateral sclerosis patients with ANXA11 variants. (Pubmed Central) - Dec 3, 2022
In addition, functional studies using amyotrophic lateral sclerosis-frontotemporal dementia patient fibroblasts revealed that the ANXA11 variants p.P36R and p.D40G impaired intracellular calcium homeostasis, stress granule disassembly and protein translation. This study suggests that the clinical manifestations of amyotrophic lateral sclerosis and amyotrophic lateral sclerosis-frontotemporal dementia spectrum patients with ANXA11 variants could be distinctively characterized depending upon the location of the variant.
- | Biomarker, Journal: Identification of potential diagnostic and prognostic biomarkers for papillary thyroid microcarcinoma (PTMC) based on TMT-labeled LC-MS/MS and machine learning. (Pubmed Central) - Nov 24, 2022
PDLIM4, ANXA1, PKM, NPC2, LMNA, and FN1 are potential diagnostic biomarkers. The five-protein nomogram could be a prognostic biomarker.
- | Journal: E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway. (Pubmed Central) - Nov 23, 2022
Co-overexpression of PRSS22 and ANXA1 could promote BC cell migration and invasion. We further demonstrated that PRSS22 promotes the cleavage of ANXA1 and in turn generates an N-terminal peptide, which initiates the FPR2/ERK signaling axis to increase BC aggressiveness.
- || Review, Journal: Implicative role of epidermal growth factor receptor and its associated signaling partners in the pathogenesis of Alzheimer's disease. (Pubmed Central) - Nov 22, 2022
Besides, Galectin-3, tissue-type activated plasminogen activator, and many more, which lineate the secretion of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-18) result in severe neuronal loss. Altogether, we emphasized the perspectives of cellular senescence up-regulated by EGFR and its associated membrane receptor molecules in the pathogenesis of AD as a target for a therapeutical alternative to intervene in AD.
- | rosuvastatin / Generic mfg.
Journal: Vitamin D and rosuvastatin alleviate type-II diabetes-induced cognitive dysfunction by modulating neuroinflammation and canonical/noncanonical Wnt/β-catenin signaling. (Pubmed Central) - Nov 22, 2022
The current findings have accentuated the neuroprotective potential of VitD and RSV and provide new incentives to expand their use in T2DM-induced cognitive and memory decline. This study also suggests a superior benefit of combining both treatments over either drug alone.
- | Journal: Relevance of the pyroptosis-related inflammasome drug targets in the Chuanxiong to improve diabetic nephropathy. (Pubmed Central) - Nov 20, 2022
This study also suggests a superior benefit of combining both treatments over either drug alone. The improvement of DN by Chuanxiong is related to the change of pyroptosis.
- || Review, Journal: Current uses of artificial intelligence in the analysis of biofluid markers involved in corneal and ocular surface diseases: a systematic review. (Pubmed Central) - Nov 18, 2022
Overall, most AI/bioinformatics tools were used to classify biofluids into diseases subgroups, distinguish between OSD, identify risk factors, or make predictions about treatment response, and/or prognosis. To conclude, AI models such as artificial neural networks, hierarchical clustering, random forest, etc., in conjunction with proteomic or metabolomic profiling using bioinformatics tools such as Gene Ontology or Kyoto Encylopedia of Genes and Genomes pathway analysis, were found to inform biomarker discovery, distinguish between OSDs, help define subgroups with OSDs and make predictions about treatment response in a clinical setting.
- | Journal: LncRNA Gm26917 regulates inflammatory response in macrophages by enhancing Annexin A1 ubiquitination in LPS-induced acute liver injury. (Pubmed Central) - Nov 18, 2022
LPS treatment dramatically increased the binding of FOXM1 to the promoter region of Gm26917 in macrophages. In summary, our findings suggest that lncRNA Gm26917 silencing protects against LPS-induced liver injury by regulating the TLR4/NF-κB signaling pathway in macrophages.
- | Biomarker, Journal: Identification of novel prognostic biomarkers for osteosarcoma: a bioinformatics analysis of differentially expressed genes in the mesenchymal stem cells from single-cell sequencing data set. (Pubmed Central) - Nov 18, 2022
Our bioinformatics analysis revealed 7 hub genes derived from the specific DEGs between the MSCs and osteoblastic cells. The 7 hub genes may serve as potential prognostic biomarkers for patients with OS.
- | Preclinical, Journal, IO biomarker: Extracellular vesicles from pristane-treated CD38-deficient mice express an anti-inflammatory neutrophil protein signature, which reflects the mild lupus severity elicited in these mice. (Pubmed Central) - Nov 16, 2022
These differences are likely to be related with the distinct inflammatory outcome shown by Cd38-/- vs WT mice in response to pristane treatment. Our results demonstrate the power of a hypothesis-free and data-driven approach to transform the heterogeneity of the peritoneal exudate EV from pristane-treated mice in valuable information about the relative proportion of different EV in a given sample and to identify potential protein markers specific for the different small EV subtypes, in particular those proteins defining EV involved in the resolution phase of chronic inflammation.
- | Biomarker, Journal: Salivary proteomic analysis in asymptomatic and symptomatic SARS-CoV-2 infection: innate immunity, taste perception and FABP5 proteins make the difference. (Pubmed Central) - Nov 16, 2022
Our results demonstrate the power of a hypothesis-free and data-driven approach to transform the heterogeneity of the peritoneal exudate EV from pristane-treated mice in valuable information about the relative proportion of different EV in a given sample and to identify potential protein markers specific for the different small EV subtypes, in particular those proteins defining EV involved in the resolution phase of chronic inflammation. The differentially abundant proteins involved in innate immunity (S100 proteins), taste (CA6 and cystatins), and viral binding to the host (FABP5), appear to be of interest for use as potential biomarkers and drugs targets.
- | Journal: GATA6 regulates expression of annexin A10 (ANXA10) associated with epithelial-mesenchymal transition of oral squamous cell carcinoma. (Pubmed Central) - Nov 9, 2022
In addition, annexin A10 (ANXA10) which is the largest type of Ca-regulated phospholipid-binding protein in eukaryotic cells was detected as a target gene for GATA6 and ANXA10 suppressed Vimentin expression in EMT in OSCC. Therefore, the GATA6/ANXA10 cascade may be a potential therapeutic approach for the treatment of lymph node metastases in OSCC patients.
- | Journal: Development of Annexin A1-surface-functionalized metal-complex multi-wall lipid core nanocapsules and effectiveness on experimental colitis. (Pubmed Central) - Nov 6, 2022
Only i.p. treatment with MLNC-AnxA1 reduced weight loss, diarrhea and disease activity index, and prevented loss of colonic structure integrity; induced the switch of macrophages into M2 phenotype in the lamina propria; recovered the colonic histoarchitecture by decreasing dysplasia of crypts, inflammation and ulcerations; restored the expression of claudin-1 Zonna-occludens-1 tight junctions in the inflamed gut; and induced stem cell proliferation in intestinal crypts. Associated, data highlight the functionalization of MLNC with AnxA1 as a tool to improve the local actions of such protein in the inflamed gut by inducing resolution of inflammation and tissue repair.
- Lipoxin A4, Maresin 1, and Resolvin D1 As Key Factors for the Actions of Plasminogen/Plasmin on Inflammation Resolution (Hall D (Ernest N. Morial Convention Center)) - Nov 4, 2022 - Abstract #ASH2022ASH_5566;
Moreover, the reciprocal modulation between the Plg/Pla system and SPMs pathways elucidated should be explored in future studies on candidate targets for therapies for inflammatory diseases. Financial support: FAPEMIG, CNPq, CAPES.