 |
7 Companies | 6 Products |
|
|
6 Products | |
29 Diseases | |
11 Trials |  |
763 News |  |
| «12...90919293949596979899100...134135» |
- | Journal: Nano-Antagonist Alleviates Inflammation and Allows for MRI of Atherosclerosis. (Pubmed Central) - Jun 28, 2020
In summary, our work demonstrates for the first time that a short peptide fragment presented on a nanoparticle surface exhibit potent receptor-targeted antagonist effects, which are not seen with the peptide alone. Unlike commonly used cargo-carrying, vector-directed drug delivery vehicles, CCTV nanoparticles may act as therapeutics/theranostics themselves, particularly in inflammatory conditions with CCL2/CCR2 pathogenesis, including cardiovascular disease and cancer.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Journal: Synthetic Imine Resveratrol Analog 2-Methoxyl-3,6-Dihydroxyl-IRA Ameliorates Colitis by Activating Protective Nrf2 Pathway and Inhibiting NLRP3 Expression. (Pubmed Central) - Jun 28, 2020
The anticolitis action of C33 was assessed in a mouse model of colitis induced by dextran sulfate sodium (DSS)...In conclusion, the novel IRA, C33, has stronger anticolitis effects than RSV. Further studies are warranted to evaluate C33 as a potential therapeutic agent for inflammatory bowel disease and cancer chemoprevention.
- | Journal: Molecular regulative mechanisms of NLRP3 inflammasome activation in diabetic nephropathy and interventional effects of Chinese herbal medicine (Pubmed Central) - Jun 28, 2020
Some extracts of Chinese herbal medicines(CHMs)such as quercetin, curcumin, cepharanthine, piperine and salidroside, as well as Chinese herbal compound prescriptions such as Wumei Pills both could treat NLRP3 inflammasome to ameliorate inflammatory renal damage in DN. Therefore, accurately clarifying the targets of anti-inflammatory CHMs and Chinese herbal compound prescriptions delaying DN progression by targeting the molecular regulative mechanisms of NLRP3 inflammasome activation will be one of the development directions in the future.
- | Decadron (dexamethasone) / Merck (MSD)
Journal, IO Biomarker: Expression characteristics of inflammatory and apoptosis factors and regulatory effect of anemoside B4 in mice with acute kidney injury (Pubmed Central) - Jun 28, 2020
The results suggested that B4 had a certain protective effect on cisplatin-induced acute kidney injury, and could activate p53 signaling pathway related apoptotic factors. B4 renal protective effect was mainly related to the regulation of p53 signaling pathway, while NLRP3 inflammasome and related inflammatory factors had no obvious response in this model.
- | Journal: Baicalin attenuates lipopolysaccharide-induced renal tubular epithelial cell injury by inhibiting the TXNIP/NLRP3 signalling pathway via increasing miR-223-3p expression. (Pubmed Central) - Jun 28, 2020
The mechanism may be associated with the inhibition of activation of the TXNIP/NLRP3 inflammatory pathway, which might be mediated by increased expression of miR-223-3p. Thus, NLRP3 is a regulatory target of miR-223-3p.
- | telmisartan / Generic mfg.
Preclinical, Journal, IO Biomarker: Regulation of NLRP3 inflammasome by CD38 through cADPR-mediated Ca release in vascular smooth muscle cells in diabetic mice. (Pubmed Central) - Jun 28, 2020
Thus, NLRP3 is a regulatory target of miR-223-3p. Our data suggested that CD38/cADPR-mediated Ca signaling contributed to the mitochondrial damage, consequently released mtDNA to the cytosol, which was related with NLRP3 inflammasome activation and VSMCs remodeling in diabetic mice.
- | gemcitabine / Generic mfg.
Journal: NLRP3 augmented resistance to gemcitabine in triple-negative breast cancer cells(TNBCC) via EMT/IL-1β/Wnt/β-catenin signaling pathway. (Pubmed Central) - Jun 27, 2020
Our data suggested that CD38/cADPR-mediated Ca signaling contributed to the mitochondrial damage, consequently released mtDNA to the cytosol, which was related with NLRP3 inflammasome activation and VSMCs remodeling in diabetic mice. NLRP3 could enhance resistance to gemcitabine via IL-1β/EMT/Wnt/β-catenin signaling, which suggested that NLRP3 antagonist CY-09 might be incorporated into gemcitabine treatment for TNBC.
- || Clinical, Review, Journal: Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke. (Pubmed Central) - Jun 27, 2020
In this mini review article, we will summarize the structure, assembly, and regulation of NLRP3 inflammasome, the role of NLRP3 inflammasome in ischemic stroke, and several treatments targeting NLRP3 inflammasome in ischemic stroke. The further understanding of the mechanism of NLRP3 inflammasome in patients with ischemic stroke will provide novel targets for the treatment of cerebral ischemic stroke patients.
- | Journal: Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition. (Pubmed Central) - Jun 27, 2020
Taken together, we suggested the renal protective effects of PT in urate nephropathy and proved that PT induces autophagy leading to restraining TGF-β-mediated NLRP3 inflammasome activation and EMT. This study is also the first one to provide a clinical potential application of PT for a better management of CKD through its autophagy inducing effects.
- [VIRTUAL] PAD4-Dependent Assembly of NLRP3 Inflammasome Promotes NET Formation Resulting in Venous Thrombus Progression (Virtual Meeting Room 3) - Jun 27, 2020 - Abstract #ISTH2020ISTH_3203;
We show that NLRP3 signaling is a strong contributor to NETosis and is implicated in thrombus progression in stenosis-induced deep vein thrombosis. Thus, NLRP3 inhibitors attenuating NETosis could be beneficial to curtail NET-mediated inflammatory and thrombotic diseases.
- | Journal: Impact of trimethylamine N-oxide (TMAO) metaorganismal pathway on cardiovascular disease. (Pubmed Central) - Jun 27, 2020
Further, we discuss the latest advances of preclinical models targeting the gut microbiota trimethylamine lyase of the TMAO metaorganismal pathway for CVD intervention, as well as the catalog of gut microbiota TMA lyase genes and microbes in the human gut as the prerequisite for potential clinical intervention. In-depth characterization of TMAO metaorganismal pathway holds great promise for CVD clinical metagenomics, diagnostics and therapeutics.
- | Preclinical, Journal: Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells. (Pubmed Central) - Jun 26, 2020
• Novel selective NLRP3 inhibitors are effective in human and murine RPE cells. • Promising compounds for pharmaceutical intervention in atrophic AMD.
- | Journal: Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer's Disease Brain. (Pubmed Central) - Jun 26, 2020
Together, these findings suggest that TXNIP, an upstream promising new therapeutic target, is a molecular link between inflammation and AD. The significant contribution of TXNIP to AD pathology suggests that strategies focusing on specific targeting of the TXNIP-NLRP3 inflammasome may lead to novel therapies for the management of AD and other age-related dementias.
- | Journal: Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization. (Pubmed Central) - Jun 26, 2020
When the same ST131 strain was engineered to overexpress high HlyA levels, macrophage cell death occurred even when NLRP3 function was abrogated, and bladder colonization was significantly increased. Thus, variation in HlyA expression in UPEC affects mechanisms by which macrophages die, as well as host susceptibility vs. resistance to colonization.-Murthy, A. M. V., Sullivan, M. J., Nhu, N. T. K., Lo, A. W., Phan, M.-D., Peters, K. M., Boucher, D., Schroder, K., Beatson, S. A., Ulett, G. C., Schembri, M. A., Sweet, M. J. Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization.
- | Gemiglo (gemigliptin) / Sanofi, LG Chem
Journal: Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome. (Pubmed Central) - Jun 26, 2020
Thus, variation in HlyA expression in UPEC affects mechanisms by which macrophages die, as well as host susceptibility vs. resistance to colonization.-Murthy, A. M. V., Sullivan, M. J., Nhu, N. T. K., Lo, A. W., Phan, M.-D., Peters, K. M., Boucher, D., Schroder, K., Beatson, S. A., Ulett, G. C., Schembri, M. A., Sweet, M. J. Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization. The present study shows that activation of the NLRP3 inflammasome contributes to UUO-induced renal fibrosis and the renoprotective effect of gemigliptin is associated with attenuation of NLRP3 inflammasome activation.
- | Journal: NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1β processing during Streptococcus pneumoniae infection. (Pubmed Central) - Jun 26, 2020
Additionally, neutrophil serine proteases also participate in IL-1β secretion by mediating ASC oligomerization and caspase-1 activation. Taken together, these findings indicated that both the NLRP3 inflammasome-related pathway and neutrophil serine protease mediate IL-1β processing upon S. pneumoniae infection.
- | Journal: Cardiac arrhythmias after renal I/R depend on IL-1β. (Pubmed Central) - Jun 26, 2020
Taken together, these results corroborate the hypothesis that IL-1β is produced after sensing renal injury through NRLP3-CASP1, and IL-1β on its turn triggers longer ventricular repolarization and increase susceptibility to cardiac arrhythmias. Still, they offer a therapeutic approach to treat cardiac arrhythmias that arise after renal I/R.
- | Preclinical, Journal: Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats. (Pubmed Central) - Jun 26, 2020
These results provided compelling evidence that α7nAChR played a pivotal role in regulating the activation and expression of NLRP3 inflammasome in neurons after cerebral I/R. These findings highlighted a novel anti-inflammatory mechanism of EA stimulus by α7nAChR modulating the inhibition of NLRP3 inflammasome, suggesting that α7nAChR-dependent cholinergic anti-inflammatory system and NLRP3 inflammasome in neurons might act as potential therapeutic targets in EA induced neuroprotection against cerebral ischemic injury.
- | Journal: Acetate attenuates inflammasome activation through GPR43-mediated Ca-dependent NLRP3 ubiquitination. (Pubmed Central) - Jun 26, 2020
In vivo, acetate protects mice from NLRP3 inflammasome-dependent peritonitis and LPS-induced endotoxemia. Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases.
- | imipramine / Generic mfg.
Journal: Salvianolic acid B abolished chronic mild stress-induced depression through suppressing oxidative stress and neuro-inflammation via regulating NLRP3 inflammasome activation. (Pubmed Central) - Jun 26, 2020
Treatment group rats were induced with CMS for 6 weeks but received either 20 or 40 mg/kg of SB or 20 mg/kg imipramine (CMS+IMP) from the 4th week to 6th week...The outcome of the current study has confirmed the anti-depressant activity by abolishing oxidative stress, and neuroinflammatory response in the hippocampus through inhibiting NLRP3 inflammasome activation. Hence, SB can be prescribed to major depression patients with standard anti-depressant agents to abolish oxidative stress, neuro-inflammatory response, and related neurological changes.
- || Clinical, Journal: Somatic mosaicism in adult-onset TNF receptor-associated periodic syndrome (TRAPS). (Pubmed Central) - Jun 26, 2020
Hence, SB can be prescribed to major depression patients with standard anti-depressant agents to abolish oxidative stress, neuro-inflammatory response, and related neurological changes. These data provide additional information about somatic mosaicism in autoinflammatory conditions and provide new insights regarding cellular players that are indispensable for the phenotypic expression of TRAPS.
- | Journal: Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis. (Pubmed Central) - Jun 26, 2020
The administration of inflammasome-related cytokines partially rescued the impairment of pathogenesis of EAE in GSDMD KO mice. Collectively, these findings provide the first demonstration of GSDMD in peripheral myeloid cells driving neuroinflammation during EAE pathogenesis.
- | Journal: Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency Against Acute Gouty Arthritis. (Pubmed Central) - Jun 25, 2020
Among them, we further show that 68 (LT052) mediates BRD4/NF-κB/NLRP3 signaling inflammatory pathways with comparable protein expression and significantly improves symptoms of gout arthritis in a rat model. Therefore, selective pharmacological modulation of individual bromodomains could represent a strategy for the treatment of acute gouty arthritis.
- | U0126 / Promega
Preclinical, Journal: MicroRNA-155 promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the ERK1/2 pathway in THP-1 macrophages and aggravates atherosclerosis in ApoE-/- mice. (Pubmed Central) - Jun 25, 2020
Therefore, selective pharmacological modulation of individual bromodomains could represent a strategy for the treatment of acute gouty arthritis. MiR-155 aggravates the carotid AS lesion in ApoE-/- mice and exerts a regulatory effect on NLRP3 inflammasome activation in ox-LDL-induced macrophages via the ERK1/2 pathway.
- | Journal: Knockdown of long non-coding RNAs of maternally expressed 3 (lncRNA-MEG3) alleviates hyperoxia-induced lung injury via inhibiting thioredoxin-interacting protein (TXNIP)-mediated pyroptosis by binding to microRNA miR-18a. (Pubmed Central) - Jun 25, 2020
In vivo knockdown of MEG3 and overexpression of miR-18a relieved hyperoxia-induced lung injury via restraining NLRP3 inflammasome-mediated pyroptosis, whereas miR-18a inhibition reversed these effects. In conclusion, knockdown of MEG3 inhibits pyroptosis to alleviate hyperoxia lung injury by suppressing NLRP3 inflammasome and caspase-1 signaling via regulating miR-18a-TXNIP axis.
- | Journal: Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway. (Pubmed Central) - Jun 23, 2020
Importantly, the expression of FOXO3a was upregulated by UMSC-Exo but was reduced when si-circHIPK3 was present. Using loss/gain-of function method, we demonstrated that miR-421/FOXO3a is the direct target of circHIPK3, and UMSC-Exo prevent ischemic injury by releasing circHIPK3, which in turn down regulate miR-421, resulting in increased expression of FOXO3a, leading to inhibition of pyroptosis and release of IL-1β and IL-18.
- | Journal: Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation. (Pubmed Central) - Jun 23, 2020
In vitro and ex vivo experiments indicated that increased NF-κB pathway activity might have been associated with the IVD degeneration observed in CST mice. This study suggests the role of CST in mitochondrial ROS and activation of the NLRP3 inflammasome in IVD degeneration, which might shed light on therapeutic targets for IVD degeneration.
- | Journal: Jiaweishaoyao Decoction Alleviates DSS-Induced Ulcerative Colitis via Inhibiting Inflammation. (Pubmed Central) - Jun 23, 2020
In addition, JWSYD suppressed the NF-κB pathway in vitro and in vivo. JWSYD alleviated DSS-induced UC via inhibiting the NLRP3 inflammasome and NF-κB pathway.
- | Preclinical, Journal: Oridonin Attenuates Myocardial Ischemia/Reperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice. (Pubmed Central) - Jun 23, 2020
Importantly, NLRP3 inflammasome pathway was also inhibited by ORI, as reflected by the lower protein levels of NLRP3, caspase-1, and IL-1β. In conclusion, ORI alleviates myocardial injury induced by I/R via inhibiting the oxidative stress and NLRP3 inflammasome pathway.
- | Journal: Long non-coding RNA SNHG7 inhibits NLRP3-dependent pyroptosis by targeting the miR-34a/SIRT1 axis in liver cancer. (Pubmed Central) - Jun 23, 2020
SNHG7 knockdown-induced effects were enhanced by miR-34a upregulation. In summary, the present study indicated that the SNHG7/miR-34a/SIRT1 axis contributed to NLRP3-dependent pyroptosis during liver cancer.
- [VIRTUAL] The CARD8 rs2043211 genetic variant and IL-33 plasma levels are associated with TB-HIV/IRIS onset in Brazilian individuals (Abstract Sessions On-Demand Channel) - Jun 22, 2020 - Abstract #AIDS2020AIDS_1768;
The functional role of such molecules in IRIS pathogenesis is still to be demonstrated. These results, associated with previous data of HLA and KIR polymorphisms in this study group, contribute to the discussion of the impact of host genes in TB-HIV individuals and the IRIS outcome.
- [VIRTUAL] Broad Spectrum Effects of a Ketogenic Diet Delivered by Remote Continuous Care on Inflammation and Immune Modulators in Type 2 Diabetes and Prediabetes () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_888;
CRP reductions were nonetheless significant in T2D/CCI statin users, suggesting added benefit of the WFKD. We conclude that improvements in IMs induced by a combination of nutritional ketosis and weight loss contribute to the beneficial effects of the CCI in the management of T2D.
- azathioprine orodispersible / Generic mfg.
[VIRTUAL] Whole Exome Sequencing Identifies Several Variants Associated with Immune Deficiency, Inflammasomopathy and Non-Ischemic Dilated Cardiomyopathy in a Complex Case of Acquired Generalized Lipodystrophy () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_765;
As we are yet beginning to understand the molecular mechanisms behind the so-called “acquired fat loss” and its relation to inflammatory and complex immune system diseases, further efforts are critical to better recognize different AGL phenotypes and phenotype-genotype correlations. Additional efforts should be placed on WES for AGL patients and functional validation of identified VUSs.
- [VIRTUAL] The combination therapy of pembrolizumab and trastuzumab exerts cardiotoxic and pro-fibrotic properties in preclinical models: the role of TLR4/MyD88/NF-kB signaling and NLRP3 pathway () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_1217;
Additional efforts should be placed on WES for AGL patients and functional validation of identified VUSs. Pembrolizumab associated to Trastuzumab leads to strong cardiac pro-inflammatory effects mediated by overexpression of Arachidonate/Leukotrienes and TLR4/MyD88/NF-?B pathways.
- [VIRTUAL] RBP4 induces pyroptosis in cardiomyocytes via activating NLRP3/Caspase-1/GSDMD pathway in acute myocardial infarction () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_1154;
Pembrolizumab associated to Trastuzumab leads to strong cardiac pro-inflammatory effects mediated by overexpression of Arachidonate/Leukotrienes and TLR4/MyD88/NF-?B pathways. RBP4 is presented in cardiomyocytes and induces cardiac pyroptosis via activating NLRP3/Caspase-1/GSDMD pathway in acute MI.
- Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
[VIRTUAL] Hyperglycemia increases ipilimumab and nivolumab-induced cardiotoxicity modulating growth factors and NLRP3 expression () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_1007;
RBP4 is presented in cardiomyocytes and induces cardiac pyroptosis via activating NLRP3/Caspase-1/GSDMD pathway in acute MI. The results obtained are, to our knowledge, the first evidence demonstrating that hyperglycemia exacerbates ICI-induced cardiotoxicity and set the stage to preclinical and clinical trials aimed to decrease glucose through dietary or lifestyle changes or through new pharmacological treatments (gliflozins).
- | Preclinical, Journal: Inhibition of protein kinase R protects against palmitic acid-induced inflammation, oxidative stress, and apoptosis through the JNK/NF-kB/NLRP3 pathway in cultured H9C2 cardiomyocytes. (Pubmed Central) - Jun 20, 2020
Our study reports, for the first time, that PKR-mediated harmful effects of PA in cultured cardiomyocytes via activation of JNK, NF-kB, and NLRP3 pathways. Inhibition of PKR is one of the possible mechanistic approaches to inhibit inflammation, oxidative stress, and apoptosis in lipotoxicity-induced cardiomyocyte damage.
- | Journal: Pannexin 1 channels contribute to IL-1β expression via NLRP3/Caspase-1 inflammasome in Aspergillus fumigatus keratitis. (Pubmed Central) - Jun 19, 2020
Inhibition of PKR is one of the possible mechanistic approaches to inhibit inflammation, oxidative stress, and apoptosis in lipotoxicity-induced cardiomyocyte damage. Pannexin 1 channels play important roles in the regulation of progression and leucocytes aggregation during corneal A. fumigatus infection via the NLRP3/Caspase-1/IL-β pathway.
- | Journal: Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin. (Pubmed Central) - Jun 19, 2020
Melatonin enhanced lactate production, recovered mitochondria, inhibited tubular aggregates formation, reduced apoptosis, and normalized frailty index. The fewer sarcopenic changes as well as the highly detectable prophylactic effects of melatonin treatment reported here in the muscle of NLRP3-knockout mice comparing with that previously detected in wild-type mice, confirming NLRP3 inflammasome implication in muscular aging and sarcopenia onset and progression.
- | cisplatin / Generic mfg.
Journal: NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation. (Pubmed Central) - Jun 19, 2020
The fewer sarcopenic changes as well as the highly detectable prophylactic effects of melatonin treatment reported here in the muscle of NLRP3-knockout mice comparing with that previously detected in wild-type mice, confirming NLRP3 inflammasome implication in muscular aging and sarcopenia onset and progression. Inhibition of NLRP3 inflammasome attenuates renal fibrosis due to repeated cisplatin injections, and might be identified as a potential target for attenuating cisplatin-induced chronic kidney disease.
- | Preclinical, Journal: NLRP3 upregulation in A549 cells co-cultured with THP-1 macrophages under hypoxia via deregulated TGF-β signaling. (Pubmed Central) - Jun 19, 2020
The analysis of downstream molecules of TGF-β signaling in A549 cells co-cultured with THP-1 macrophages under hypoxia showed that TGFBR1 was upregulated and SMAD7 was downregulated. Taken together, these results suggest that the upregulation of NLRP3 in A549 cells is associated with deregulated TGF-β signaling and that the interaction between NLRP3 and TGF-β signaling plays a fundamental role in fibrogenesis.
- | Journal: The protective effects of Thalictrum minus L. on lipopolysaccharide-induced acute lung injury. (Pubmed Central) - Jun 19, 2020
Taken together, these results suggest that the upregulation of NLRP3 in A549 cells is associated with deregulated TGF-β signaling and that the interaction between NLRP3 and TGF-β signaling plays a fundamental role in fibrogenesis. These results suggested that TML ameliorated LPS-induced acute lung injury by inhibiting the release of inflammatory cytokines and reducing oxidative damage associated with the MAPKs p38-NLRP3/caspase-1 and COX2 signaling pathways, AMPK-Nrf2/KEAP signaling pathways, as well as apoptosis and autophagy.
- | Review, Journal: Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. (Pubmed Central) - Jun 19, 2020
This article summarizes the current understanding of neurological symptoms of COVID-19 and hypothesizes that affected patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. A structured prospective evaluation should analyze the likelihood, time course, and severity of cognitive impairment following the COVID-19 pandemic.
- | Journal: Shen-Ling-Bai-Zhu-San Improves Dextran Sodium Sulfate-Induced Colitis by Inhibiting Caspase-1/Caspase-11-Mediated Pyroptosis. (Pubmed Central) - Jun 19, 2020
In this paper, we demonstrate that SLBZS attenuates DSS-induced ulcerative colitis injury in mice via the MAPK/NF-κB and pyroptosis signaling pathway. These results indicate that SLBZS is a potential drug for the treatment of UC.
- | Journal: NLRP3 and CARD8 polymorphisms influence risk for asbestos-related diseases. (Pubmed Central) - Jun 19, 2020
However, when testing interactions with asbestos exposure, a decreased risk of asbestosis was found for NLRP3 CA+AA genotypes (OR = 0.09, 95% CI 0.01-0.60, p = 0.014). The results of our study suggest that NLRP3 and CARD8 polymorphisms could affect the risk of asbestos-related diseases.
- | Journal: The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion. (Pubmed Central) - Jun 18, 2020
The susceptibility of atp6v0d2 knockout mice to DSS-induced colitis and Salmonella typhimurium-induced death, highlights the in vivo significance of ATP6V0D2-mediated autophagosome-lysosome fusion. Together, our data identify ATP6V0D2 as a key component of macrophage-specific autophagosome-lysosome fusion machinery maintaining macrophage organelle homeostasis and, in turn, limiting both inflammation and bacterial infection.
- | Preclinical, Journal: NLRP3 inhibition improves heart function in GPER knockout mice. (Pubmed Central) - Jun 18, 2020
Both ANF and BNP mRNA levels were also significantly reduced by chronic MCC950 treatment. The findings from this study point toward a new understanding for the increased occurrence of heart diseases in women following loss or absence of estrogenic protection and GPER activation that involves cardiac NLRP3 inflammatory pathways.
- | Journal: Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways. (Pubmed Central) - Jun 18, 2020
The findings from this study point toward a new understanding for the increased occurrence of heart diseases in women following loss or absence of estrogenic protection and GPER activation that involves cardiac NLRP3 inflammatory pathways. Our results demonstrated that Ori exerted protective effects on LPS-induced ALI via Nrf2-independent anti-inflammatory and Nrf2-dependent antioxidative activities.
- | Journal: Gain-of-function CEBPE mutation causes non-canonical autoinflammatory inflammasomopathy. (Pubmed Central) - Jun 18, 2020
The mechanism, including widely dysregulated transcription, is likely not unique for C/EBPε. Similar multiomics approaches should as well be utilized in studying other transcription factor-associated diseases.
- | Journal: Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. (Pubmed Central) - Jun 18, 2020
Mice with a deletion of the granulocyte specific miR-223 gene showed a similarly impaired resolution profile that could be reversed by restoring miR-223 levels using a miR-223 3p mimic or infusing neutrophils from wildtype animals. Collectively, our findings reveal a novel role for neutrophils in the liver as resolving effector cells that induce pro-inflammatory macrophages into a restorative phenotype, potentially via miR-223.