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- | simvastatin / Generic mfg.
Journal: Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation. (Pubmed Central) - Jul 9, 2020
These data are the first in vivo experimental validation of an atheroprotective role of endothelial Klf2 and Foxp1, which reveals a Klf2-Foxp1 transcriptional network in ECs as a novel regulator of endothelial inflammasome activation for atherogenesis, therefore provides opportunities for therapeutic intervention of atherosclerotic diseases and uncovers a novel atheroprotective mechanism for simvastatin.
- | Journal: Control of the inflammasome by the ubiquitin system. (Pubmed Central) - Jul 9, 2020
However, the mechanisms by which PTMs regulate the inflammasome is still not understood. This review aims to summarize our knowledge to date on how the ubiquitin system controls inflammasome activation and where this area of research is heading.
- || Review, Journal: The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney. (Pubmed Central) - Jul 9, 2020
Inflammasome-independent NLRP3 regulates apoptosis in tubular epithelial cells by interacting with mitochondria and mediating mitochondrial reactive oxygen species production and mitophagy. This review will summarize the mechanisms by which NLRP3 functions in the kidney in both inflammasome-dependent and inflammasome-independent ways and the role of NLRP3 and NLRP3 inhibitors in kidney diseases.
- | Preclinical, Journal: The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice. (Pubmed Central) - Jul 9, 2020
We further identified in vivo that Sirt1 repress the expression of IL-1β by the repression of NLR Family, Pyrin Domain Containing protein 3 (NLRP3) expression. In conclusion, this study confirms resveratrol acts against radiation-induced inflammatory bowel disease via NLRP-3 inflammasome repression in mice and supports Sirt1 as a potential biomarker and therapy target in intestinal radiation protection.
- || Clinical, Journal: Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure. (Pubmed Central) - Jul 9, 2020
Monocytes of individuals who carry CHIP-driver sequence variations and have cardiovascular disease appear to be primed for excessive inflammatory responses. Further studies are warranted to address potential adverse outcomes of coronavirus disease 2019 in patients with CHIP-driver sequence variations.
- | Journal: Altered monocyte response to the dengue virus in those with varying severity of past dengue infection. (Pubmed Central) - Jul 8, 2020
Further studies are warranted to address potential adverse outcomes of coronavirus disease 2019 in patients with CHIP-driver sequence variations. Monocytes from those with past SD appear to show marked differences in viral loads, viral sensing and production of inflammatory mediators in response to the DENV, when compared to those who experienced past NSD, suggesting that initial innate immune responses may influence the disease outcome.
- | Preclinical, Journal: Hydrogen sulfide improves endothelial dysfunction by inhibiting the vicious cycle of NLRP3 inflammasome and oxidative stress in spontaneously hypertensive rats. (Pubmed Central) - Jul 7, 2020
H2S could inhibit the vicious cycle of oxidative stress and inflammation in hypertension, and then improve endothelial function and ameliorated hypertension. Our results help to reveal the crucial role of H2S in regulating endothelial function, which might be a new tool for treating hypertension.
- | Review, Journal: CAPS and NLRP3. (Pubmed Central) - Jul 7, 2020
Several mechanisms have been identified that are important for the normal regulation of the cryopyrin inflammasome in order to prevent uncontrolled inflammation. Investigators have taken advantage of some of these pathways to develop and apply novel targeted therapies, which have resulted in improved quality of life for patients with this orphan disease.
- | Biomarker, Journal: Role of serum amyloid A in atherosclerosis. (Pubmed Central) - Jul 7, 2020
Investigators have taken advantage of some of these pathways to develop and apply novel targeted therapies, which have resulted in improved quality of life for patients with this orphan disease. SAA has many pro-inflammatory and pro-atherogenic activities, is clearly demonstrated to affect atherosclerosis development, and may be a candidate target for clinical trials in cardiovascular diseases.
- | allopurinol / Generic mfg.
Review, Journal: Gout. (Pubmed Central) - Jul 7, 2020
Low-dose anti-inflammatory therapies can reduce gout flares during initiation of urate-lowering therapy. Models of care, such as nurse-led strategies that focus on patient engagement and education, substantially improve clinical outcomes and now represent best practice for gout management.
- | Journal: Rutaecarpine derivative R3 attenuates atherosclerosis via inhibiting NLRP3 inflammasome-related inflammation and modulating cholesterol transport. (Pubmed Central) - Jul 7, 2020
Additionally, R3 significantly decreased total cholesterol in the serum and livers of Apoe mice and promoted cholesterol efflux in murine macrophages through upregulating protein expression of ATP-binding cassette subfamily A member 1 and scavenger receptor class B type I/human CD36 and lysosomal integral membrane protein-II analogous-1. Our results demonstrated that R3 prevented atherosclerotic progression via attenuating NLRP3 inflammasome-related inflammation and modulating cholesterol transport.
- | Journal: SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation. (Pubmed Central) - Jul 7, 2020
Interestingly, SENP3 deSUMOylates NLRP3 to attenuate ASC recruitment and speck formation, the NLRP3 inflammasome activation, as well as IL-1β cleavage and secretion. In conclusion, we reveal that SUMO1-catalyzed SUMOylation and SENP3-mediated deSUMOylation of NLRP3 orchestrate the inflammasome activation.
- | Journal: Cigarette smoke inhibits the NLRP3 inflammasome and leads to caspase-1 activation via the TLR4-TRIF-caspase-8 axis in human macrophages. (Pubmed Central) - Jul 7, 2020
Overall, our findings unveil novel pathways leading to immune-metabolic alterations in human macrophages exposed to cigarette smoke. These mechanisms may contribute to macrophage dysfunction and increased risk of infection in smokers.
- | Journal: Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation. (Pubmed Central) - Jul 7, 2020
Finally, inhibition of inflammasome prevented P. aeruginosa-induced acute lung injury. Our results suggest that targeting ENT1/2 and NLRP3 inflammasome may be novel strategies for prevention and treatment of P. aeruginosa-induced pneumonia and subsequent ARDS.
- || Clinical, Review, Journal: Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases. (Pubmed Central) - Jul 7, 2020
There are no evidence-based studies to establish which potential genotype analysis is the most appropriate in adult patients with clinical phenotypes suggestive of mAIDs. This review discusses genetic and clinical hints for an ideal diagnostic approach to mAIDs in adult patients, as their early identification is essential to prompt effective treatment and improve quality of life, and also highlights the most recent developments in the diagnostic work-up for the most frequent hereditary periodic febrile syndromes worldwide.
- | Journal: STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection. (Pubmed Central) - Jul 7, 2020
Second, STING interacts with NLRP3 and attenuates K48- and K63-linked polyubiquitination of NLRP3, thereby promoting the inflammasome activation. Collectively, we demonstrate that the cGAS-STING-NLRP3 signaling is essential for host defense against HSV-1 infection.
- | cyclosporine / Generic mfg.
Preclinical, Journal: Mycobacterium abscessus infection leads to enhanced production of type 1 interferon and NLRP3 inflammasome activation in murine macrophages via mitochondrial oxidative stress. (Pubmed Central) - Jul 7, 2020
Treatment of the infected macrophages with mtROS-modulating agents such as mito-TEMPO or cyclosporin A reduced cytosolic oxidized mtDNA, which inhibited the MAB-R strain-induced production of IL-1β and IFN-I...In conclusion, our data indicated that MAB-R strains enhanced IFN-I and IL-1β production by inducing mtROS as a pathogen-associated molecular pattern (PAMP). These events also enhance bacterial survival in macrophages and dampen inflammation, which contribute to the pathogenesis of MAB-R strains.
- | Journal: Cadmium induces mitophagy via AMP-activated protein kinases activation in a PINK1/Parkin-dependent manner in PC12 cells. (Pubmed Central) - Jul 7, 2020
These results suggest that Cd induces mitophagy via the PINK/Parkin pathway following AMPK activation in PC12 cells. Targeting the balanced activity of AMPK/PINK1/Parkin-mediated mitophagy signalling may be a potential therapeutic approach to treat Cd-induced neurotoxicity.
- || Review, Journal: Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: A review. (Pubmed Central) - Jul 7, 2020
In vitro and in vivo studies pointed out that the selected phytochemicals have inhibitory properties on NLRP3 inflammasome activity. However, neither the mechanism is clear, nor the study designs and doses are standardized.
- | Preclinical, Journal: Genistein Attenuates Acute Cerebral Ischemic Damage by Inhibiting the NLRP3 Inflammasome in Reproductively Senescent Mice. (Pubmed Central) - Jul 7, 2020
However, the overexpression of NLRP3 in microglia abrogated the Gen-induced inhibition of inflammatory factor release and reversed the neuroprotective effect of Gen. Taken together, the results suggest that Gen treatment could attenuate the acute injury induced by cerebral ischemia in reproductively senescent mice via the inhibition of the NLRP3 inflammasome in microglia, indicating that Gen could be a candidate drug for the treatment of stroke in postmenopausal women.
- [VIRTUAL] TREK-1 Activation Is Required for Inflammasome Activity Through Augmentation of Macrophage Membrane Polarization (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_7342;
Taken together, the results suggest that Gen treatment could attenuate the acute injury induced by cerebral ischemia in reproductively senescent mice via the inhibition of the NLRP3 inflammasome in microglia, indicating that Gen could be a candidate drug for the treatment of stroke in postmenopausal women. Our results suggest that TREK-1 is important in regulating macrophage membrane potential, and may be important in regulating potassium-efflux associated with inflammasome activity.
- [VIRTUAL] IL-1β Suppresses Prevents Type 2 Inflammation, ILC2 Expansion and Asthma Phenotype Development Following Early Life Rhinovirus Infection by Suppressing Epithelial Cell Innate Cytokine Expression (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6400;
RV infection induces inflammasome priming and activation in subepithelial and luminal macrophages. IL1RA amplifies RV-induced ILC2 expansion and mucous metaplasia, and IL-1β suppresses it, at least in part by decreasing epithelial cell innate cytokine expression.
- [VIRTUAL] Heightened ER Stress in Aged Lung Contributes to Dysregulated NLRP3 Inflammasome Activation During Influenza (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6387;
IL1RA amplifies RV-induced ILC2 expansion and mucous metaplasia, and IL-1β suppresses it, at least in part by decreasing epithelial cell innate cytokine expression. Data from this study provide new evidence as to why older persons are more susceptible to influenza and provide a possible therapeutic target to decrease morbidity and mortality in this population.
- [VIRTUAL] Innate Immunity of SP-A Was Involved in the Regulation of Both Acute Lung and Kidney Injuries in Pneumonia-Induced Sepsis (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6382;
SP-A is involved in the regulation of both ALI and AKI in the sepsis through modulating renal apoptosis,pyrotosis and inflammation activation. Supported by NIH R01HL136706
- [VIRTUAL] Evidence for Metabolic Reprogramming of Circulating Neutrophils in Gram-Negative Bacteremic Sepsis (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6380;
Metabolic intermediates may have a role as biomarkers in GNS. The NLRP3 inflammasome is the dominant processor of IL-1β in human neutrophils, is induced by LPS, and does not require a second signal in these cells.
- [VIRTUAL] Lipopolysaccharide Causes the Metabolic Flux to Glycolysis and Induces NLRP3 Inflammasome Activation and RIPK3-Mediated Necroptosis in the Lung (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5982;
The NLRP3 inflammasome is the dominant processor of IL-1β in human neutrophils, is induced by LPS, and does not require a second signal in these cells. Our findings indicate that LPS leads to altered metabolic flux to glycolysis in lung endothelium, which exacerbates lung ECs necroptosis and NLRP3-mediated inflammasome activation to aggravate lung inflammation and pulmonary vascular injury.This abstract is funded by CURE Grant No: 4100083087
- [VIRTUAL] Contrasting Effects of Stored Allogeneic Red Blood Cells and Their Supernatants on Permeability and Inflammatory Responses in Human Pulmonary Endothelial Cells (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5968;
RBC supernatants augmented LPS- and TNFα-induced EC inflammation reflected by increased production of IL-6, IL-8 and soluble ICAM1. CONCLUSIONS These findings demonstrate the deleterious effects of RBC supernatants on EC function which may have a major impact in pathological consequences associated with RBC transfusion.
- [VIRTUAL] Trim20/Pyrin Regulates Microparticulate Active GasderminD Mediated Cell Injury in Septic Patients (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5954;
Phosphorylated pyrin was detected along with serine/threonine kinase PKN1, active caspase-1 and GSDM-D in MPs derived from LPS stimulated THP1 cells. The protein interacting regulatory molecule 14-3-3, bound phosphorylated pyrin and this association was abrogated by knocking down upstream NLRP3 but not affected by inhibition of downstream caspase-1.
- [VIRTUAL] Exosomes Containing GBP2 in Macrophage Induced by Lipopolysaccharide Activate NLRP3 Inflammasome to Mediate the Pyroptosis of Alveolar Type II Cell: A New Mechanism of ALI (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5950;
Conclusions LPS-induced and GBP2 enriched exosomes from RAW264.7 triggers pyroptosis via activating NLRP3 inflammasome involved in ALI, Ang(1-7) could supressed the above mentioned changes by decreasing the levels of GBP2 in exosomes. Key words Acute lung injury; Exosomes; Pyroptosis; Angiotensin (1-7)
- [VIRTUAL] Melatonin Alleviates Radiation-Induced Lung Injury Via Regulation of Microrna-30e/NLRP3 Axis (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5943;
Meanwhile, melatonin exerted its protective effect through negatively regulating the NLRP3 inflammasome in macrophages. The melatonin-mediated miR-30e/NLRP3 signaling may provide novel therapeutic targets for radiation-induced injury.
- [VIRTUAL] Long Form of Thymic Stromal Lymphopoietin Aggravates Pyroptosis of Human Airway Epithelium on Virus-Induced Asthma Exacerbation (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_4864;
lfTSLP aggravated the activation of NLRP3 inflammasome ,the cleavage of GSDMD and the release of mature IL-1β in HDM-sensitized epithelial cells induced by poly(I:C),thus promoting epithelium pyroptosis. Consistent with this observation, Mouse TSLP expression, the ortholog of human lfTSLP, was found to be critical for the dysfunction of bronchial epithelial barrier and airway inflammation in murine model of viral asthma exacerbation, which could be suppressed by administration of TSLP mAb or human short form of thymic stromal lymphopoietin(sfTSLP).
- bleomycin / Generic mfg., BMS, sildenafil / Generic mfg.
[VIRTUAL] Targeting the NLRP3 Inflammasome as a Novel Approach to Treat Pulmonary Hypertension (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_4705;
Interventions commenced at day 14 (SuHx) or 7 (BLM) and included: NLRP3 inflammasome inhibitor MCC950 (10mgkg/day [low] or 20mg/kg/day [high]; s.c.), current therapy sildenafil (SILD; 30mg/kg/day; p.o.) or combination therapy (MCC950 10mg/kg/day + SILD)...Further, initial evidence suggests that IL-18 receptor signalling may be vital for SuHx-induced increases in RVSP. This highlights a previously unrecognised therapeutic option whereby selective targeting of the NLRP3 inflammasome, or its downstream cytokine IL-18, may provide a novel adjunct to current pulmonary vasodilator therapy.
- bleomycin / Generic mfg., BMS
[VIRTUAL] Deletion of Cannabinoid 1 Receptor (CB 1 R) in Myeloid Cells Prevents Lung Inflammation and Neutrophil Infiltration in Bleomycin-Induced Pulmonary Fibrosis in Mice (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_3758;
Myeloid CB 1 Rs regulated the infiltration of neutrophils by inducing their production of chemoattractants and PAF-like bioactive lipids. These findings endorse myeloid CB 1 R as a therapeutic target in lung inflammation and fibrosis.
- [VIRTUAL] Increased NLRP3 and AIM2 Activation in IPF Alveolar Macrophages Is Associated with mtROS (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_3611;
In lung fibrosis, mitochondrial dysfunction is associated with increased NLRP3 and AIM2 activation. Multiple insults in the fibrotic lungs could activate the Inflammasome and through IL-1b release, which could be associated with disease progression or acute exacerbations.
- [VIRTUAL] Sphingosine-1-Phosphate Induces Pulmonary Vascular Inflammation by Activating the Canonical NF-κB and Inflammasome Pathway (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_2322;
Conclusion : These findings suggest that S1P induces pulmonary vascular pro-inflammatory signaling via activation of NF-κB and the inflammasome, and that the S1P/Sphk1/miR-1 signaling axis may be involved in this activation. Targeted activation of the inflammasome may be an important mechanism underlying PAH pathogenesis and may represent a novel pathway to target in PAH treatment.
- [VIRTUAL] The Role of the NLRP3 Inflammasome and Macrophages in Right Ventricular Failure in Pulmonary Arterial Hypertension (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_2318;
Macrophages are an important but not exclusive source of NLRP3 in the MCT-RV. Further functional experiments will be required to evaluate the therapeutic value of targeting macrophages and NLRP3 activation and assembly in PAH.
- [VIRTUAL] Human Surfactant Protein B Variants Differentially Regulate Surfactant Activity and Cell Death Signaling in Acute Lung Injury of Pseudomonas Aeruginosa Pneumonia (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_2160;
Further functional experiments will be required to evaluate the therapeutic value of targeting macrophages and NLRP3 activation and assembly in PAH. hSP-B variants differentially regulate susceptibility through modulating surface activity of surfactant, cell death and inflammatory signaling in bacterial pneumonia.
- [VIRTUAL] Modulation of NLRP3 Inflammasome Activity by Endo-Lysosomal Proteins (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_2146;
NLRP3 is a poly-ubiquitinated protein. Modulation of STAMBP abundance and activity impacts the ubiquitination of NLRP3 to decrease NLRP3 abundance and inflammasome activity.
- [VIRTUAL] Role of PAD2 Regulated Inflammasome Signaling in Arsenic Induced Airway Inflammation and Remodeling (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1246;
Sodium arsenite exposed mice have increased airway reactivity and airway remodeling. PAD2 regulates inflammasome activation in macrophages and contributes to airway remodeling in sodium arsenite exposed mice.
- [VIRTUAL] NLRP3 Inflammasome Mediates Chronic Intermittent Hypoxia-Induced Renal Injury Implication of the Microrna-155/FOXO3a Signaling Pathway (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1015;
Collectively, we demonstrated that miR‐155 might be a positive‐regulator of NLRP3 pathway by inhibiting the targeted FOXO3a gene. These results established a link between the miR‐155/FOXO3a pathway and the NLRP3 inflammasome, suggesting pharmacological blockage of NLRP3 as a potential therapeutic strategy for OSA‐associated chronic kidney disease.
- [VIRTUAL] NLRP3 Deficiency Alleviates Chronic Intermittent Hypoxia-Induced Neuroinflammation and Oxidative Stress Via Parkin-Mediated Mitophagy (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1014;
In summary, these results revealed NLRP3 deficiency acted as a protective promotor through enhancing Parkin-depended mitophagy in CIH-induced neuroinflammation. Thus, NLRP3 gene knockout or pharmacological blockage could be as a potential therapeutic strategy for OSA-associated neurocognitive impairment.
- [VIRTUAL] The NLRP3 Inflammasome in the Cystic Fibrosis Macrophage (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_970;
The variant was associated with greater IL-6 production in response to lipopolysaccharide, suggesting the possibility of crosstalk between inflammasome and non-inflammasome-mediated pathways. Our finding identifies a subset of people with CF who could benefit most from host-directed therapeutics targeting inflammasome pathways.
- [VIRTUAL] Gasdermin D: A New Biomarker for Critically Ill Patients (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_901;
Furthermore, GSDMD correlates with other pyroptotic effector molecules, namely IL-18. These results suggest pyroptosis, through interaction with other cell death pathways, may play a critical role in the dysregulated immune response in sepsis.
- [VIRTUAL] Importance of the Mitochondrial Permeability Transition Pore (MPTP) for Initiation of NLRP3 Inflammasome Activation During Influenza (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_756;
Along with reduced inflammatory cytokine expression, mice with impaired MPTP had decreased expression of multiple anti-viral genes, impaired mROS production, dysregulated immune cell infiltration, and decreased viral clearance. Conclusion Data from this study sheds light on the critical role of MPTP in NLRP3 inflammasome activation and activation of the innate immune response to influenza.
- [VIRTUAL] Enhanced dsDNA Release in Sting Deficient Lung Contributes to Increased ROS and cGAMP Mediated Inflammasome Priming and Activation (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_749;
Conclusions : In response to influenza infection, increased mtDNA release contributes to upregulated cGAS mediated production of cGAMP. In the absence of STING, cGAMP binds directly to NLRP3, which contributed to increased inflammasome activation and overly heightened production of IL1β in response to influenza.
- | doxorubicin hydrochloride / Generic mfg.
Journal, IO Biomarker: Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway. (Pubmed Central) - Jul 5, 2020
When H9c2 cells were treated by Ex527 (Sirt1 inhibitor), the effect of CA on expressions of NLRP3 and thioredoxin-interacting protein was suppressed. In conclusion, the results suggested that CA might be a cotreatment with DOX to ameliorate cardiotoxicity by Sirt1-NLRP3 pathway.
- | Preclinical, Journal: Study on therapeutic effect and its related mechanism of anemoside B4 on ischemia reperfusion injury induced by renal artery and vein ligation in rats (Pubmed Central) - Jul 5, 2020
This study showed that anemoside B4 could alleviate renal ischemia-reperfusion injury in rats. And its mechanism may be related to the inhibition of inflammatory factors related to response mediated by NLRP3 pathway and TLR4/NF-κB pathway by anemoside B4.
- | Journal: The activation of IL-17 signaling pathway promotes pyroptosis in pneumonia-induced sepsis. (Pubmed Central) - Jul 5, 2020
Moreover, the release of IL-1β and IL-18 and the levels of the molecules (NLRP3, NLRC4, Cleaved caspase-1, and Cleaved GSDMD) associated with caspase-1-dependent pyroptosis were up-regulated in pneumonia-induced sepsis. As NK-κB activation can promote the development of caspase-1-dependent pyroptosis, these findings suggested that the activation of the IL-17 signaling pathway could promote pyroptosis in pneumonia-induced sepsis.
- | Review, Journal: P2X7 receptor in cardiovascular disease: The heart side. (Pubmed Central) - Jul 4, 2020
Recent studies demonstrated that the P2X7 could modulate the assembly of the NLRP3 inflammasome, leading to the secretion of pro-inflammatory factors and worsen the cardiac disease phenotypes. This review discusses the critical molecular function of P2X7 in the modulation of the onset, progression and resolution of cardiovascular diseases and analyses the putative future use of P2X7-based therapies that modulate the IL-1β secretion arm and direct P2X7 antagonists.
- | Preclinical, Journal: Discovery of Quinazolin-4(3H)-ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-free Synthesis and In-vitro Biological Evaluation. (Pubmed Central) - Jul 4, 2020
Reaction relies on the C-N bond formation along with C-C bond cleavage under metal-free conditions. The nitro-substituted quinazolin-4(3H)-one 2k inhibited NLRP3-inflammasome (IC50 5 µM) via suppression of IL-1β release from ATP-stimulated J774A.1 cells.