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29 Diseases | |
11 Trials |  |
763 News |  |
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- || Review, Journal: Hidden Aspects of Valency in Immune System Regulation. (Pubmed Central) - Jul 25, 2020
We discuss some of the ways in which valency itself is regulated through transcriptional, post-transcriptional, and post-translational modifications. Finally, we propose that the valency model can be applied at the whole cell level to study differences in individual cell responses with relevance to putative therapeutic applications.
- | Journal: Oncogenic Kras causes myeloproliferation via NLRP3 inflammasome activation. (Pubmed Central) - Jul 24, 2020
Our findings indicate that oncogenic KRAS not only act via its canonical oncogenic driver function, but also enhances the activation of the pro-inflammatory RAC1/ROS/NLRP3/IL-1β axis. This paves the way for a therapeutic approach based on immune modulation via NLRP3 blockade in KRAS-mutant myeloid malignancies.
- | glibenclamide / Generic mfg.
Preclinical, Journal: Glibenclamide attenuates 2,5-hexanedione-induced neurotoxicity in the spinal cord of rats through mitigation of NLRP3 inflammasome activation, neuroinflammation and oxidative stress. (Pubmed Central) - Jul 24, 2020
Collectively, our findings suggested that NLRP3 inflammasome activation contributed to HD-induced neurotoxicity by enhancing microglial M1 polarization and oxidative damage. Inhibition of NLRP3 inflammasome by glibenclamide might a potential avenue to combat n-hexane-induced neuropathy.
- || Review, Journal: Pro-inflammatory Actions of Heme and Other Hemoglobin-Derived DAMPs. (Pubmed Central) - Jul 24, 2020
The contribution of oxidized Hb forms is much less studied, but some evidence show that these species might play distinct roles in intravascular hemolysis-associated pathologies independently of heme release. This review aims to summarize our current knowledge about the formation and pro-inflammatory actions of heme and other Hb-derived DAMPs.
- | Journal: Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells. (Pubmed Central) - Jul 24, 2020
Furthermore, the elevated IL-1β could be restored by silencing of TLR4, indicating soluble uric acid induces inflammation via the TLR4/NLRP3 pathway. Soluble uric acid exerted detrimental effect on intestinal epithelial cells through the TLR4/NLRP3 pathway.
- | Journal, IO Biomarker: Aggravated MRSA pneumonia secondary to influenza A virus infection is derived from decreased expression of IL-1β. (Pubmed Central) - Jul 24, 2020
These results contributed to our understanding of the detailed activity of the NLRP3 inflammasome, IL-1β and their relationship with aggravation of MRSA pneumonia secondary to IAV infection. Immunotherapy targeting the IL-1β signaling pathway could be possible therapeutic strategy for secondary MRSA pneumonia.
- | Journal: LDL, LDL receptors, and PCSK9 as modulators of the risk for type 2 diabetes: a focus on white adipose tissue. (Pubmed Central) - Jul 24, 2020
This supports a central role for upregulated pathway of LDLR and/or other receptors regulated by PCSK9 such as cluster of differentiation 36 (CD36) in LDL-induced anomalies. Targeting receptor-mediated uptake of LDL into WAT may reduce WAT inflammation, WAT dysfunction, and related risk for T2D without increasing the risk for CVD.
- Herceptin (trastuzumab) / Roche, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca, doxorubicin hydrochloride / Generic mfg.
[VIRTUAL] The SGLT2 inhibitor dapagliflozin enhanced anticancer activities and exerts cardioprotective effects against doxorubicin and trastuzumab toxicity through TLR4, MyD88, NF-kB signaling and NLRP3 inflammasome pathway (On-Demand) - Jul 24, 2020 - Abstract #ESMO2020ESMO_2698;
Legal entity responsible for the study: The authors. Funding: Italian Ministry of Health; Ricerca corrente “Cardiotossicità dei trattamenti antineoplastici: Identificazione precoce e strategie di cardioprotezione ”Codice progetto: M1/5-C.
- Opdivo (nivolumab) / Ono Pharma, BMS
[VIRTUAL] Hyperglycemia increased nivolumab-induced cardiotoxicity, enhanced immunoresistance of ERɑ+, PR+, HER2- breast cancer cells modulating growth factors and NLRP3 expression (On-Demand) - Jul 24, 2020 - Abstract #ESMO2020ESMO_2673;
Legal entity responsible for the study: The authors. Funding: Ministry of Health; Ricerca corrente “Cardiotossicità dei trattamenti antineoplastici: Identificazione precoce e strategie di cardioprotezione ”Codice progetto: M1/5-C.
- ||| Obesity and SARS-CoV-2 drive activation of the NLRP3 inflammasome, perhaps the only inflammasome to integrate endogenous and endogenous danger signals. BTK inhibitors block NLRP3i and may be best drugs here (Twitter) - Jul 22, 2020
- | Preclinical, Journal: Fastigial nucleus stimulation ameliorates cognitive impairment via modulating autophagy and inflammasomes activation in a rat model of vascular dementia. (Pubmed Central) - Jul 22, 2020
Funding: Ministry of Health; Ricerca corrente “Cardiotossicità dei trattamenti antineoplastici: Identificazione precoce e strategie di cardioprotezione ”Codice progetto: M1/5-C. FNS treatment exerted a therapeutic effect during VD treatment by suppressing the autophagy process and by inhibiting inflammatory responses, thus alleviating neuron cell apoptosis and reducing the severity of VD.
- | Journal: Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation. (Pubmed Central) - Jul 22, 2020
Our data suggest that ERS induces macrophages to produce mature IL-1β during infection with virulent M. bovis through a positive feedback loop between mitochondrial damage and inflammasome activation. To the best of our knowledge, this is the first evidence of the involvement of ERS and mitochondrial damage in inflammasome activation during M. bovis infection.
- || Clinical, Journal: Evidence of Different IL-1β Activation Pathways in Innate Immune Cells From Indeterminate and Cardiac Patients With Chronic Chagas Disease. (Pubmed Central) - Jul 22, 2020
We suggest some distinct molecular mechanisms for production of IL-1β in innate immune cells from patients with different clinical forms of Chagas disease. MMP-2 and MMP-9 gelatinases are associated with distinct disease outcomes and IL-1β production.
- | Journal: Pharmacological inhibition of the NLRP3 inflammasome as a potential target for cancer-induced bone pain. (Pubmed Central) - Jul 22, 2020
Chronic administration with MCC950 restored the protein expression of NLRP3 inflammasome and significantly suppressed the upregulation of IL-1β. Spinal NLRP3 inflammasome might be a novel therapeutic target for treatment of CIBP.
- | Journal: Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1. (Pubmed Central) - Jul 22, 2020
Moreover, coptisine prevented LPS-mediated IL-1β production and MSU-mediated mice paw edema by blocking NLRP3 inflammasome activation in vivo. Coptisine blocks NLRP3 inflammasome activation by inhibiting caspase-1 and may be useful for treating NLRP3 inflammasome-involved gouty arthritis.
- | Journal: Contrasting Effects of Stored Allogeneic Red Blood Cells and Their Supernatants on Permeability and Inflammatory Responses in Human Pulmonary Endothelial Cells. (Pubmed Central) - Jul 22, 2020
RBC supernatants augmented LPS- and TNFα-induced EC inflammation reflected by increased production of IL-6, IL-8 and soluble ICAM1. These findings demonstrate the deleterious effects of RBC supernatants on EC function which may have a major impact in pathological consequences associated with RBC transfusion.
- | Journal: Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-κB pathway after Mycoplasma pneumoniae infection. (Pubmed Central) - Jul 21, 2020
Overexpression of NLRP3 reversed the protective effect of PD against MP-induced injury of BEAS-2B cells. Taken together, these results indicate that PD treatment suppressed the inflammatory response and the development of pulmonary fibrosis by inhibiting the NLRP3 inflammasome and NF-κB pathway after MP infection.
- | Journal: Adiponectin alleviates NLRP3-inflammasome-mediated pyroptosis of aortic endothelial cells by inhibiting FoxO4 in arteriosclerosis. (Pubmed Central) - Jul 21, 2020
Specifically, APN reduced propidium-iodide-positive cells, NLRP3 inflammasomes, apoptosis-related speck-like protein containing caspase recruitment domains, and pro-inflammation factors IL-1β and IL-18, all of which was reversed by overexpression of FoxO4. In conclusion, our study suggests that APN might play an essential role in NLRP3 inflammasome-modulated pyroptosis by regulating FoxO4 in human aortic epithelial cells, providing a novel therapy for atherosclerosis.
- | Preclinical, Journal: Interleukin-1β Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes. (Pubmed Central) - Jul 21, 2020
No adverse effect were observed. Thus, IL-1β contributes to the progression of chronic kidney disease in type 2 diabetes and might therefore be a valuable therapeutic target, potentially in combination with drugs with different mechanisms-of-action such as RAS and SGLT2 inhibitors.
- | Retrospective data, Journal: Potential Interplay Between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome, to Modulate Insulin Resistance and Diabetes Risk: insights from a Meta-Analysis of 19,005 Individuals. (Pubmed Central) - Jul 21, 2020
Two NLRP3-related SNPs showed potential novel interaction with dietary SFA to modulate fasting insulin. Greater dietary SFA intake accentuates T2D risk, which subject to functional validation, may be further elaborated depending on NLRP3 inflammasome related genetic variants.
- || Review, Journal: Current status of terpenoids as inflammasome inhibitors. (Pubmed Central) - Jul 21, 2020
Thus, terpenoids represent an interesting pharmacological approach for the treatment of inflammatory diseases as they are endowed with a dual mechanism of inhibition of NF-KB transcription factor and inflammasome activation, both critically involved in their anti-inflammatory effects. This work provides an overview of the current knowledge on the therapeutic potential of terpenoids as NLRP3 inflammasome inhibitors.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Preclinical, Journal: Circadian Pharmacological Effects of Berberine on Chronic Colitis in Mice: Role of the Clock Component Rev-erbα. (Pubmed Central) - Jul 21, 2020
Chronic colitis was induced by feeding mice with dextran sulfate sodium in drinking water...In conclusion, circadian pharmacological effects of berberine on chronic colitis were mainly contributed by diurnal rhythms of both disease severity and Rev-erbα (as a drug target). The findings may have implications for chronotherapeutic practice on colitis or related diseases.
- | doxorubicin hydrochloride / Generic mfg.
Journal, IO Biomarker: Dexmedetomidine reduces the inflammation and apoptosis of doxorubicin-induced myocardial cells. (Pubmed Central) - Jul 21, 2020
However, those above changes could be reversed by Compound C. In conclusion, this study indicated that DEX could reduce the inflammation and apoptosis of DOX-induced myocardial cells through activating the AMPK-GSK3β signaling pathway. Because of the above effects of DEX, it may be beneficial for surgical patients with heart problems.
- | Journal: DDX3X Sits at the Crossroads of Liquid-Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells. (Pubmed Central) - Jul 21, 2020
We recently reported that DDX3X modulates this crosstalk by acting as a common essential factor for NLRP3 inflammasome activation and stress granule assembly. Here, we discuss the role of DDX3X in modulating the liquid-liquid phase separation and prionoid phase transition required for making cell fate decisions under stress conditions.
- | Journal: N-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. (Pubmed Central) - Jul 19, 2020
Lack of NLRP3 inflammasome adaptor named apoptosis-associated speck-like protein containing a CARD (ASC) abrogated N4A-induced HMGB1 expression, NFκB activation, and NLRP3 expression. Taken together, our results reveal a novel role of N4A in activation of NLRP3 inflamasome via HMGB1 feedback.
- | Journal: Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. (Pubmed Central) - Jul 19, 2020
The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death.
- | Journal: miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock. (Pubmed Central) - Jul 19, 2020
In addition, by analyzing published miRNA expression profiles in the Gene Expression Omnibus database, we found that the miR-21 levels in peripheral blood from patients with septic shock were elevated. Thus, miR-21 may serve as a potential treatment target in patients with septic shock.
- | Journal: ATP/P2X7 axis mediates the pathological process of allergic asthma by inducing M2 polarization of alveolar macrophages. (Pubmed Central) - Jul 19, 2020
Activating P2X7r induced polarization of M2-type AMs and inhibited polarization of M1-type AMs, while blockage of P2X7r had the opposite effect. The ATP/P2X7r axis may participate in the pathogenesis of asthma by mediating the M2-type AM polarization.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Preclinical, Journal: Effects of sDR5-Fc fusion protein on infant mice with ulcerative colitis via the TRAIL-DR5 pathway. (Pubmed Central) - Jul 19, 2020
To explore effects of the sDR5-Fc fusion protein on ulcerative colitis of infant mice via the TRAIL-DR5 pathway, 50 female mice were randomly divided into 5 groups, i.e., control group (group A), dextran sulfate sodium group (group B), hIgG group (group C), 10 mg/kg sDR5-Fc group (group D), and 20 mg/ kg sDR5-Fc group (group E)...Thus, sDR5-Fc could inhibit the activation of NLRP3 inflammasomes induced by TRAIL, thereby decreasing the apoptosis of NCM460 cells. In conclusion, the sDR5-Fc fusion protein could block the TRAIL-DR5 pathway to reduce the expression of NLRP3 inflammasomes, thereby improving ulcerative colitis.
- | Journal: The NLRP3-Mediated Neuroinflammatory Responses to CdTe Quantum Dots and the Protection of ZnS Shell. (Pubmed Central) - Jul 19, 2020
Even though the milder immune responses and neurotoxicity of CdTe@ZnS QDs compared with CdTe QDs indicated the protective role of ZnS coating, the inhibitions of NLRP3 expression and ROS production completely reduced the IL-1ß-mediated inflammation. This provided valuable information that inhibiting target molecules is an effective and efficient way to alleviate the toxicity of cadmium-containing QDs, so it is important to evaluate QDs through a mechanism-based risk assessment.
- | Journal, IO biomarker: Interleukin-35 pretreatment attenuates lipopolysaccharide-induced heart injury by inhibition of inflammation, apoptosis and fibrotic reactions. (Pubmed Central) - Jul 19, 2020
Similar cardioprotective effects of IL-35 pretreatment were observed in mouse myocardial fibroblasts challenged with LPS in vitro. In summary, IL-35 pretreatment can attenuate cardiac inflammation, apoptosis, and fibrotic reactions induced by LPS, implicating IL-35 as a promising therapeutic target in sepsis-related cardiac injury.
- [VIRTUAL] NLRP3 INFLAMMASOME INHIBITOR CY-09 IMPROVES HEPATIC STEATOSIS IN EXPERIMENTAL NAFLD MICE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4875;
CY-09 is a potential drug for treatment of NAFLD. However, more researches on pharmacokinetics and pharmacodynamics is needed, as well as studies on the bioavailability of the human body, especially the liver, to prove whether it can be effectively applied to humans.
- [VIRTUAL] SLEEVE GASTROPLASTY COMBINED WITH NLRP3 INFLAMMASOME INHIBITOR CY-09 REDUCE BODY WEIGHT, IMPROVE THE INSULIN RESISTANCE AND ALLEVIATE HEPATIC STEATOSIS IN MICE MODEL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4873;
The surgery imitating ESG combined with CY-09 reduces body weight, improves insulin resistance and alleviates hepatic steatosis. The combination therapy may be a promising method for treating obesity and NAFLD.
- [VIRTUAL] OXIDATIVE STRESS DRIVES MYOGENIC ALTERATIONS IN DIVERTICULAR DISEASE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4834;
These myogenic perturbations might impair colonic compliance and potentially increase intraluminal pressure, key factors in DD pathogenesis. The evidence of an oxidative stress contribution in myogenic impairment could open new possible therapeutic strategies.
- [VIRTUAL] SUCNR1 DEFICIENCY IMPAIRS INFLAMMASOME ACTIVATION AND AMELIORATES CHRONIC DSS COLITIS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4360;
In CD patients, the expression of inflammasome components is significantly increased. In addition, the expression of SUCNR1 positively correlates with the expression of the inflammasome components Nlrp3, IL18, Caspase1 and ASC.
- [VIRTUAL] NLRP3 INFLAMMASOME INHIBITOR CY-09 IMPROVES HEPATIC STEATOSIS IN EXPERIMENTAL NAFLD MICE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2899;
CY-09 is a potential drug for treatment of NAFLD. However, more researches on pharmacokinetics and pharmacodynamics is needed, as well as studies on the bioavailability of the human body, especially the liver, to prove whether it can be effectively applied to humans.
- [VIRTUAL] SLEEVE GASTROPLASTY COMBINED WITH NLRP3 INFLAMMASOME INHIBITOR CY-09 REDUCE BODY WEIGHT, IMPROVE THE INSULIN RESISTANCE AND ALLEVIATE HEPATIC STEATOSIS IN MICE MODEL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2897;
The surgery imitating ESG combined with CY-09 reduces body weight, improves insulin resistance and alleviates hepatic steatosis. The combination therapy may be a promising method for treating obesity and NAFLD.
- [VIRTUAL] OXIDATIVE STRESS DRIVES MYOGENIC ALTERATIONS IN DIVERTICULAR DISEASE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2858;
These myogenic perturbations might impair colonic compliance and potentially increase intraluminal pressure, key factors in DD pathogenesis. The evidence of an oxidative stress contribution in myogenic impairment could open new possible therapeutic strategies.
- [VIRTUAL] SUCNR1 DEFICIENCY IMPAIRS INFLAMMASOME ACTIVATION AND AMELIORATES CHRONIC DSS COLITIS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2384;
In CD patients, the expression of inflammasome components is significantly increased. In addition, the expression of SUCNR1 positively correlates with the expression of the inflammasome components Nlrp3, IL18, Caspase1 and ASC.
- [VIRTUAL] NLRP3 INFLAMMASOME INHIBITOR CY-09 IMPROVES HEPATIC STEATOSIS IN EXPERIMENTAL NAFLD MICE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_915;
CY-09 is a potential drug for treatment of NAFLD. However, more researches on pharmacokinetics and pharmacodynamics is needed, as well as studies on the bioavailability of the human body, especially the liver, to prove whether it can be effectively applied to humans.
- [VIRTUAL] SLEEVE GASTROPLASTY COMBINED WITH NLRP3 INFLAMMASOME INHIBITOR CY-09 REDUCE BODY WEIGHT, IMPROVE THE INSULIN RESISTANCE AND ALLEVIATE HEPATIC STEATOSIS IN MICE MODEL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_913;
The surgery imitating ESG combined with CY-09 reduces body weight, improves insulin resistance and alleviates hepatic steatosis. The combination therapy may be a promising method for treating obesity and NAFLD.
- [VIRTUAL] OXIDATIVE STRESS DRIVES MYOGENIC ALTERATIONS IN DIVERTICULAR DISEASE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_874;
These myogenic perturbations might impair colonic compliance and potentially increase intraluminal pressure, key factors in DD pathogenesis. The evidence of an oxidative stress contribution in myogenic impairment could open new possible therapeutic strategies.
- [VIRTUAL] SUCNR1 DEFICIENCY IMPAIRS INFLAMMASOME ACTIVATION AND AMELIORATES CHRONIC DSS COLITIS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_400;
In CD patients, the expression of inflammasome components is significantly increased. In addition, the expression of SUCNR1 positively correlates with the expression of the inflammasome components Nlrp3, IL18, Caspase1 and ASC.
- | Journal: Inflammation-Induced Intra-Amniotic inflammation induces preterm birth by Activating the NLRP3 inflammasome. (Pubmed Central) - Jul 18, 2020
Collectively, these results provide a causal link between NLRP3 inflammasome activation and spontaneous preterm labor and birth in the context of intra-amniotic inflammation. We also showed that, by targeting the NLRP3 inflammasome, adverse pregnancy and neonatal outcomes can be significantly reduced.
- ||| Journal, Adverse events: Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth and adverse neonatal outcomes. (Pubmed Central) - Jul 18, 2020
In conclusion, the data presented herein indicate that the alarmin S100B can induce sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes by activating the NLRP3 inflammasome, which can be prevented by inhibiting such a pathway. These findings provide evidence that sterile intra-amniotic inflammation could be treated by targeting the NLRP3 inflammasome.
- | Journal: Glyburide, a NLRP3 inhibitor, decreases inflammatory response and is a candidate to reduce pathology in Leishmania braziliensis infection. (Pubmed Central) - Jul 18, 2020
These findings provide evidence that sterile intra-amniotic inflammation could be treated by targeting the NLRP3 inflammasome. No abstract available
- | Preclinical, Journal: Choline Supplementation Ameliorates Behavioural Deficits and Alzheimer's Disease-Like Pathology in Transgenic APP/PS1 Mice. (Pubmed Central) - Jul 18, 2020
No abstract available These findings reveal a beneficial effect of CS on AD progression during adulthood and provide a likely therapeutic intervention for AD patients.
- | metformin / Generic mfg.
Journal: AMPK as a potential pharmacological target for alleviating LPS-induced acute lung injury partly via NLRC4 inflammasome pathway inhibition. (Pubmed Central) - Jul 18, 2020
The results demonstrated that the efficacy of metformin was reduced when using the AMPK pharmacological inhibitor compound C or AMPKα expression was knocked down in RAW 264.7 cells. In conclusion, our data indicated that metformin may inhibit NLRC4 inflammasome activation in LPS-induced ALI in old mice through AMPK signaling, and further understanding of the AMPK/NLRC4 axis may provide a novel therapeutic strategy for LPS-induced ALI in the future.
- | Journal: Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway. (Pubmed Central) - Jul 18, 2020
Additionally, melatonin inhibits pyroptosis, production of mitochondrial and cytosolic reactive oxygen species (ROS) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling. The beneficial effects of melatonin on NLRP3 inflammasome activation were associated with nuclear factor erythroid 2-related factor 2 (Nrf2) and Silent information regulator 2 homolog 1 (SIRT1) activation, which were reversed by Nrf2 siRNA and SIRT1 inhibitor treatment.
- | Journal, IO Biomarker: Epigallocatechin-3-Gallate Attenuates Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Non-Canonical Inflammasome via TLR4/NF-κB Pathway. (Pubmed Central) - Jul 18, 2020
The beneficial effects of melatonin on NLRP3 inflammasome activation were associated with nuclear factor erythroid 2-related factor 2 (Nrf2) and Silent information regulator 2 homolog 1 (SIRT1) activation, which were reversed by Nrf2 siRNA and SIRT1 inhibitor treatment. EGCG attenuated microglial inflammation and neurotoxicity by inhibition of canonical NLRP3 and non-canonical caspase-11-dependent inflammasome activation via TLR4/NF-κB pathway.