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7 Companies | 6 Products |
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6 Products | |
29 Diseases | |
11 Trials |  |
763 News |  |
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- | Journal: Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via NF-κB Signaling. (Pubmed Central) - Sep 11, 2020
Importantly, Tisp40 overexpression significantly increased TECs pyroptosis via p-p65 activation, however, the effects of Tisp40 overexpression were partially blocked by parthenolide (PTL). Collectively, our findings provide insight into the mechanism of how Tisp40 regulated GSDMD-mediated pyroptosis in renal IRI.
- | Journal: Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation. (Pubmed Central) - Sep 11, 2020
This study demonstrated that NAR targeted microglial NLRP3 inflammasome to protect DA neurons against LPS-induced neurotoxicity. These findings suggest NAR might hold a promising therapeutic potential for PD.
- | paclitaxel / Generic mfg.
Journal: Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation. (Pubmed Central) - Sep 10, 2020
This suggestion was supported by the observations that paclitaxel treatment caused robust IL-1β production in macrophages in the presence of cell-free medium derived from growth of injured cells and also in the spleen of mice. Collectively, our data strongly indicate that paclitaxel is able to facilitate the activation of NLRP3 inflammasome signaling in a certain physiological environment.
- | Journal: Dexmedetomidine exerts dual effects on human annulus fibrosus chondrocytes depending on the oxidative stress status. (Pubmed Central) - Sep 10, 2020
However, Dex decreased the amount of NEDD4 adhering to XIAP, thus protecting XIAP protein from NEDD4-mediated ubiquitination and degradation. Given that surgery inevitably causes oxidative stress and inflammation, the protective effect of Dex on chondrocytes during oxidative stress is noteworthy and warrants further study.
- | Journal: NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium. (Pubmed Central) - Sep 10, 2020
Given that surgery inevitably causes oxidative stress and inflammation, the protective effect of Dex on chondrocytes during oxidative stress is noteworthy and warrants further study. Our study identifies NFAT5 as a new and essential transcription factor that is required for the early activation of NLRP3-inflammasome-mediated endothelium innate immunity, contributing to the formation of atherosclerosis under hypertonic stress induction.
- | Journal: IgA1 deposition may induce NLRP3 expression and macrophage transdifferentiation of podocyte in IgA nephropathy. (Pubmed Central) - Sep 10, 2020
Dys-glycosylated IgA1 isolated from IgAN patient serum could induce NLRP3 expression in podocytes and initiate podocyte macrophage transdifferentiation (PMT). After PMT, podocytes secrete proinflammatory cytokines that can contribute to the inflammation cascade and renal fibrosis changes associated with IgAN.
- | Journal: Nonlinear dose-time-response functions and health-protective exposure limits for inflammation-mediated diseases. (Pubmed Central) - Sep 10, 2020
Key conclusions are that (i) For RCS, but not asbestos, limiting average (TWA) exposure concentrations also tightly constrains internal doses and ability to trigger chronic inflammation and resulting increases in disease risks (ii) For asbestos, excursions (i.e., spikes in concentrations); and especially the times between them are crucial drivers of internal doses and time until chronic inflammation; and hence (iii) These dynamic aspects of exposure, which are not addressed by current occupational safety regulations, should be constrained to better protect worker health. Adjusting permissible average exposure concentration limits (PELs) and daily excursion limits (ELs) is predicted to have little impact on reducing mesothelioma risks, but increasing the number of days between successive excursions is predicted to be relatively effective in reducing worker risks, even if it has little or no impact on TWA average concentrations.
- [VIRTUAL] LSC - 2020 - Caspase-1 activation by cigarette smoke occurs via TLR4/TRIF/caspase-8 axis leading to metabolic alterations in human macrophages (Pre-congress content) - Sep 10, 2020 - Abstract #ERS2020ERS_6000;
Active caspase-1 impairs glycolytic flux. Overall, herein we unveil novel mechanism of immune-metabolic alteration leading to macrophage dysfunction upon exposure to cigarette smoke.
- | Journal: Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner. (Pubmed Central) - Sep 10, 2020
Finally, CypA inhibitor TMN355 attenuated liver steatosis and injury and inhibited NF-κB/NLRP3 signaling pathway. Therefore, our results suggest that CD147 played a vital role in NASH pathogenesis by regulating the inflammatory response, and CypA/CD147 could be attractive therapeutic targets for NASH treatment.
- | Journal: Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4. (Pubmed Central) - Sep 10, 2020
Of note, the IL-1β induction is not affected in the S. mitis-treated THP-1 cells with the silence of NLRP3, Caspase-1, and Caspase-4 genes. NLRP3/Caspase-4 and NLRP3/Caspase-1 dependent IL-1β production may crucially contribute to the dysregulated immuno-inflammatory response in periodontal pathogenesis.
- | Ocuvia (elamipretide) / Stealth BioTherapeutics
Preclinical, Journal: Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice. (Pubmed Central) - Sep 10, 2020
Remarkably, treatment with the mitochondrial-targeted peptide elamipretide not only had protective effects against mitochondrial dysfunction but also attenuated surgery-induced pyroptosis and cognitive deficits. Our results provide a promising strategy for the treatment of PND involving mitochondrial dysfunction and pyroptosis.
- | Journal: NLRP3 Blockade Suppresses Pro-Inflammatory and Pro-Angiogenic Cytokine Secretion in Diabetic Retinopathy. (Pubmed Central) - Sep 10, 2020
Our results suggest NLRP3 inflammasome as the potential cross-point between inflammation and pro-angiogenesis in DR and support the effectiveness of NLRP3-targeted shRNA administrated by intravitreal injection in animal models of DR. The protective effect of NLRP3-targeted shRNA may stem from the inhibition of both pro-inflammatory cytokines and HIF-1α/VEGF axis.
- | Journal: Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival. (Pubmed Central) - Sep 10, 2020
However, further expression quantitative trait loci (eQTL) analysis showed no evidence for correlations between the two SNPs and mRNA expression levels of corresponding genes. These results indicated that genetic variants in the NLRP3 imflammasome pathway gene-sets might be predictors of NSCLC survival, but the molecular mechanisms underlying the observed associations warrant further investigations.
- | FTY720, fingolimod / Generic mfg.
Journal: Activation of sphingosine-1-phosphate receptor 1 in the spinal cord produces mechano-hypersensitivity through the activation of inflammasome and IL-1β pathway. (Pubmed Central) - Sep 9, 2020
PERSPECTIVE: This is the first study to link the activation of NLRP3 and IL-1β signaling in the spinal cord and S1PR1 signaling in astrocytes to the development of S1PR1-evoked mechano-allodynia. These findings provide critical basic science insights to support the development of therapies targeted toward S1PR1.
- | Journal: IL-1RA is part of the inflammasome-regulated immune response in bladder epithelial cells and influences colonization of uropathogenic E. coli. (Pubmed Central) - Sep 9, 2020
A targeted protein analysis of inflammation-related proteins showed that the basal expression of 23 proteins and the UPEC-induced expression of 10 proteins were significantly altered in IL-1RA deficient bladder epithelial cells compared to Cas9 control cells. This suggests that IL-1RA has a broad effect on the inflammatory response in bladder epithelial cells.
- | Journal: Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome. (Pubmed Central) - Sep 9, 2020
Further, our findings reveal that the IL-1β production by EDIII protein is mediated through caspase-1 and NLRP3 inflammasome activation. In conclusion this study unearths the role of DENV EDIII protein in modulating innate inflammatory responses, which might provide possible mechanism of pathogenesis and open-up new avenues for the development of therapeutics against DENV.
- | Journal: A polymorphism in the IL1B gene (rs16944 T/C) is associated with cutaneous leishmaniasis caused by Leishmania guyanensis and plasma cytokine interleukin receptor antagonist. (Pubmed Central) - Sep 9, 2020
The rs16944 C/C genotype shows a tendency to correlate with lower levels of the IL-1Ra cytokine. Low levels of IL-1Ra cytokine and rs16944 C/C genotype seem to confer susceptibility to L. guyanensis-infection in the Amazonas.
- | Journal: The presence of P2RX7 single nuclear polymorphism is associated with a gain of function in P2X7 receptor and inflammasome activation in SLE complicated with pericarditis. (Pubmed Central) - Sep 9, 2020
Our results suggest that 489 C>T polymorphism of the P2RX7 gene is associated with activation of inflammasome NLRP3 and an increased release of IL-1β and IL-18. The EB uptake increase in macrophages of LE+PCS subjects carrying 489C>T displays the functional upregulation of P2RX7, which may be involved in the pathogenesis of SLE complicated with pericarditis in the presence of P2RX7 SNP 489C>T.
- | Journal: Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. (Pubmed Central) - Sep 9, 2020
Mechanistically, miR-335 inhibitor reversed the effects of downregulated LncRNA-XIST on ROS levels and cell pyroptosis, which were abrogated by synergistically knocking down SOD2. Taken together, knock-down of LncRNA-XIST inhibited NSCLC progression by triggering miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death.
- || Clinical, Journal: Anti-inflammatory therapy may ameliorate the clinical picture of COVID-19. (Pubmed Central) - Sep 9, 2020
Taken together, knock-down of LncRNA-XIST inhibited NSCLC progression by triggering miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. No abstract available
- | Journal: Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome. (Pubmed Central) - Sep 9, 2020
No abstract available Our findings reveal that puerarin plays a protective role against retinal I/R injury by alleviating RGC damage, and is beneficial for the treatment of I/R injury-caused ophthalmic diseases.
- | Journal: Dexmedetomidine Ameliorates Renal Ischemia Reperfusion-Mediated Activation of the NLRP3 Inflammasome in Alveolar Macrophages. (Pubmed Central) - Sep 9, 2020
In conclusion, our study demonstrated that the protective action of DEX in AMs is induced through amelioration of HMGB1-NLRP3 inflammasome-AMPK signaling. Our results suggest that the anesthetic reagent DEX exerts beneficial effects to ameliorate rI/R-induced ALI.
- | Journal: 3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations. (Pubmed Central) - Sep 8, 2020
3D also induces the priming of the NLRP3 inflammasome resulting in an increased IL-1β and IL-6 secretion. These results give the molecular basis for assessing collagen induced immunomodulation of human macrophages in various physiological and pathological contexts such as cancer.
- | Review, Journal: Autophagy and Inflammatory Diseases. (Pubmed Central) - Sep 8, 2020
It is found that the aberrant autophagy is closely related to inflammatory diseases, including infections, adaptive immune-associated inflammation and inflammatory bowel disease. Autophagy plays critical roles in the activation of NLRP3 inflammasome, the clearance of bacterial and viral infections and what is more, the function of adaptive immune cells.
- | Review, Journal: Autophagy and Immune-Related Diseases. (Pubmed Central) - Sep 8, 2020
It also plays a key role in the development of viral hepatitis. Therefore, autophagy might be a promising regulatory target for the treatment of immune-related diseases.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: Dietary emulsifier polysorbate-80 induces small-intestinal vulnerability to indomethacin-induced lesions via dysbiosis. (Pubmed Central) - Sep 5, 2020
Polysorbate-80 enhances the vulnerability of the small intestine to indomethacin-induced injury by inducing ileal dysbiosis. Direct enhancement of the motility of specific flagellated microbiota by P80 might be related to dysbiosis and intestinal injury.
- | Preclinical, Journal: Txnip mediates glucocorticoid-activated NLRP3 inflammatory signaling in mouse microglia. (Pubmed Central) - Sep 5, 2020
Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1β. It is therefore likely that Txnip-activated NLRP3 inflammasome contributes to corticosterone-caused neuroinflammation.
- | Journal: The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. (Pubmed Central) - Sep 5, 2020
By knocking down DrNLRP3 in zebrafish embryos and generating a DrASC-knockout (DrASC fish clone, we characterized the function of the DrNLRP3 inflammasome in anti-bacterial immunity in vivo The results of our study disclosed the origin of the NLRP3 inflammasome in teleost fish, providing a cross-species understanding of the evolutionary history of inflammasomes. Our findings also indicate that the NLRP3 inflammasome may coordinate inflammatory cytokine processing and secretion through a GSDME-mediated pyroptotic pathway, uncovering a previously unrecognized regulatory function of NLRP3 in both inflammation and cell pyroptosis.
- | epirubicin / Generic mfg.
Journal: Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines. (Pubmed Central) - Sep 5, 2020
These anti-inflammatory effects were not mediated by the induction of autophagy or altered MAPK signaling, but as the result of a global transcriptional suppression of LPS-dependent genes. Epirubicin-treated macrophages displayed reduced acetylation of histone 3 lysine 9 (H3K9ac), suggesting anti-inflammatory epigenetic imprinting as one underlying mechanism.
- | Journal, IO Biomarker: Increased inflammation with crude E. coli LPS protects against acute leptospirosis in hamsters. (Pubmed Central) - Sep 5, 2020
Our results indicate that increased inflammation induced by LPS derived from Escherichia coli (E. coli) protects against leptospirosis in hamsters.
- | Journal, IO Biomarker: HDAC6 inhibitor Cay10603 inhibits high glucose-induced oxidative stress, inflammation and apoptosis in retinal pigment epithelial cells via regulating NF-κB and NLRP3 inflammasome pathway. (Pubmed Central) - Sep 5, 2020
Cay decreased the expression of phospho (p)-NF-κB p65, p-IκB-α, NLRP3, cleaved caspase-1 and ASC while increased the expression of NF-κB p65 (cytoplasm). Taken together, these findings demonstrated that Cay suppressed HG-induced oxidative stress, inflammation and apoptosis via regulating NF-κB and NLRP3 inflammasome pathway in HG-induced ARPE-19 cells, suggesting that Cay might be a therapeutic agent for the treatment of diabetic retinopathy.
- | Journal: Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging. (Pubmed Central) - Sep 4, 2020
On the other hand, NRF2 activation in EPCs from aged mice protected these cells against oxidative stress, ameliorated their biological dysfunction and downregulated the NLRP3 inflammasome. These findings suggest NRF2 can prevent the functional damage of EPCs and downregulate the NLRP3 inflammasome through NF-κB signaling.
- | acarbose / Generic mfg.
Preclinical, Journal: Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats. (Pubmed Central) - Sep 4, 2020
Taken together, our data indicated that acarbose ameliorated endothelial barrier dysfunction by directly inhibiting NLRP3 inflammasome which was dependent on inhibiting Nox4 oxidase-dependent O production. These properties might carry a potential significance for acarbose in cardiovascular protection in diabetic patients.
- || Review, Journal: Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes. (Pubmed Central) - Sep 4, 2020
The diversity of an individual's gut microbiome and the resultant microbial metabolites determines the extent of their involvement in the physiological and pathological mechanisms within the gut. As such, further study of the interaction between the NLRP3 inflammasome and the complex intestinal environment in disease development is warranted to discover novel therapies for the treatment of diabetes.
- [VIRTUAL] ß2-microglobulin induces the activation of the NLRP3 inflammasome in myeloma-associated macrophages and promotes cell growth in multiple myeloma (Abstract video presentations) - Sep 3, 2020 - Abstract #DGHO2020DGHO_2135;
Treatment of 5TMM mice with MCC950, a selective NLRP3 inhibitor, reduced tumor progression and thus attenuated the severity of MM. Our findings shed new light on β2m as macrophagic NLRP3 inflammasome activator which contributes to MM cell progression, and open a potential novel avenue for therapies of this severe malignancy.
- [VIRTUAL] ß2-microglobulin induces the activation of the NLRP3 inflammasome in myeloma-associated macrophages and promotes cell growth in multiple myeloma (Abstract video presentations) - Sep 3, 2020 - Abstract #DGHO2020DGHO_1526;
Treatment of 5TMM mice with MCC950, a selective NLRP3 inhibitor, reduced tumor progression and thus attenuated the severity of MM. Our findings shed new light on β2m as macrophagic NLRP3 inflammasome activator which contributes to MM cell progression, and open a potential novel avenue for therapies of this severe malignancy.
- [VIRTUAL] ß2-microglobulin induces the activation of the NLRP3 inflammasome in myeloma-associated macrophages and promotes cell growth in multiple myeloma (Abstract video presentations) - Sep 3, 2020 - Abstract #DGHO2020DGHO_732;
Treatment of 5TMM mice with MCC950, a selective NLRP3 inhibitor, reduced tumor progression and thus attenuated the severity of MM. Our findings shed new light on β2m as macrophagic NLRP3 inflammasome activator which contributes to MM cell progression, and open a potential novel avenue for therapies of this severe malignancy.
- Ilaris (canakinumab) / Novartis
[VIRTUAL] Clonal hematopoiesis, cardiovascular risk and autoimmune diseases - new connections (Osaka) - Sep 3, 2020 - Abstract #DGHO2020DGHO_429;
The Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) study underlines the clinical relevance of this finding...Novel insights on the role of the innate immunity in patients with CHIP closes the gap between the biology of myeloid neoplasms, SIAMs and other inflammatory conditions, including CVD. Novel treatment options may emerge that abrogate the common, inflammatory, seeding ground for disease evolution.
- | Journal: MicroRNA Profiling in Adipose Before and After Weight Loss Highlights the Role of miR-223-3p and the NLRP3 Inflammasome. (Pubmed Central) - Sep 2, 2020
Novel treatment options may emerge that abrogate the common, inflammatory, seeding ground for disease evolution. This is the first report detailing genome-wide miRNA profiling of omental adipose before and after gastric bypass, and it further highlights the association of miR-223-3p and the NLRP3 inflammasome with obesity.
- | Biomarker, Journal: Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: Potential biomarkers in multicomponent models comprising IL-1beta. (Pubmed Central) - Sep 2, 2020
Multiparameter models of UA and UCR that included IL-1β were able to correctly classify 86% and 90% of cases, respectively. We suggest that UA might be a useful biomarker when combined with IL-1β, while UCR might be even more informative and useful in overall COPD assessments.
- | Nourianz (istradefylline) / Kyowa Hakko Kirin
Preclinical, Journal: Inactivation of endothelial adenosine receptor 2A protects mice from cerebral ischemia-induced brain injury. (Pubmed Central) - Sep 2, 2020
Our data demonstrate for the first time that endothelial Adora2a inactivation mitigates ischemic brain injury and improves post-stroke outcomes, at least partially, through its anti-inflammatory effects via blockage of Nlrp3 inflammasome activity. Our findings may open a new avenue for vascular protection following an ischemic stroke.
- | Journal, IO Biomarker: Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation. (Pubmed Central) - Sep 1, 2020
Our study demonstrated that S100A9 promotes cellular senescence of bone marrow stromal cells via TLR4, NLRP3 inflammasome formation, and IL-1β secretion for its effects. Our findings deepen the understanding of the molecular mechanisms involved in MDS reprogramming of MSCs and indicated the essential role of S100A9 in tumor-environment interactions in bone marrow.
- | hydroxychloroquine / Generic mfg.
Journal: Hydroxychloroquine inhibits IL-1β production from amyloid-stimulated human neutrophils. (Pubmed Central) - Sep 1, 2020
Treatment with HCQ was associated with impaired production of IL-1β in SAA-stimulated human neutrophils without affecting the priming process of the NLRP3 inflammasome such as pro-IL-1β or NLRP3 induction. These findings suggest that HCQ affects the NLRP3 activation process, resulting in the impaired IL-1β production in human neutrophils, as representative innate immune cells.
- | Journal, BRCA Biomarker: The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models. (Pubmed Central) - Sep 1, 2020
Besides, inhibition of BRCC3 blocked the increased secretion of IL-1β. Together, these results suggest that Cdk5-mediated BRCC3 expression may play a critical role in neuronal inflammation by regulating the NLRP3 inflammasome in PD.
- | Journal: NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling. (Pubmed Central) - Sep 1, 2020
In conclusion, NEK7 interacts with NLRP3 to modulate NLRP3 inflammasome activation, therefore modulating the pyroptosis in MODE-K cells and DSS-induced chronic colitis in mice. We provide a novel mechanism of NEK7-NLRP3 interaction affecting IBD via pyroptosis.
- | spironolactone / Generic mfg.
Journal: NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus. (Pubmed Central) - Sep 1, 2020
Spironolactone also reduced active caspase-1-positive macrophages in db/db mice, events that contribute to diabetes-associated vascular changes. These data clearly indicate that MR and NLRP3 activation contribute to diabetes-associated vascular dysfunction and pro-inflammatory phenotype.
- | metformin / Generic mfg.
Journal: The anti-periodontitis action of metformin via targeting NLRP3 inflammasome. (Pubmed Central) - Sep 1, 2020
These data clearly indicate that MR and NLRP3 activation contribute to diabetes-associated vascular dysfunction and pro-inflammatory phenotype. Our study provided novel insights into the anti-inflammatory effects of metformin against NLRP3 inflammasome activity, which could potentially be used for the prevention and treatment of P. gingivalis-related periodontal diseases.
- | dimethyl fumarate / Generic mfg.
Biomarker, Journal: Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway. (Pubmed Central) - Sep 1, 2020
DMF also mitigated diabetes-induced fibrous tissue proliferation in aortic tunica media. Collectively, these findings demonstrate that DMF offered vasculoprotective influences on diabetic aortas via attenuation of ROS-TXNIP-NLRP3 inflammasome pathway.
- | cyclophosphamide intravenous / Generic mfg.
Journal: Ameliorate effect of pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway. (Pubmed Central) - Sep 1, 2020
Collectively, these findings demonstrate that DMF offered vasculoprotective influences on diabetic aortas via attenuation of ROS-TXNIP-NLRP3 inflammasome pathway. Our results suggest that PQQ protects against CTX-induced nephrotoxicity, probably by activating the Nrf2-mediated antioxidant pathway and inhibiting the NLRP3 inflammatory pathway.
- | Journal: Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy. (Pubmed Central) - Sep 1, 2020
Moreover, we verified that inhibition of miR-223 could suppress the NLRP3 inflammasome activation, and alleviate myocardial fibrosis and apoptosis of the DCM model rats. In conclusion, our results suggested that miR-223 might be an underlying therapeutic target for DCM by reducing NLRP3 inflammasome activation, fibrosis, and apoptosis.