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11 Trials |  |
763 News |  |
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- || Review, Journal: The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease. (Pubmed Central) - Oct 20, 2020
NFTs can also activate the Nlrp3 inflammasome leading to enhanced tau-associated pathology. Here, we will review the role of microglia and the activation of the inflammasome in the innate immune response to AD.
- | Preclinical, Journal: The Protective Effect of Crataegus aronia Against High-Fat Diet-Induced Vascular Inflammation in Rats Entails Inhibition of the NLRP-3 Inflammasome Pathway. (Pubmed Central) - Oct 16, 2020
However, protein levels of LOX-1 were not affected by C. aronia in unstimulated cells. In conclusion, C. aronia inhibits the NLRP-3 inflammasome pathway, induced by HFD feeding in the aorta of rats, mainly by its hypolipidemic effect and in vitro, in LPS-stimulated macrophages, by its antioxidant effect.
- | Journal: Novel Insights Into the NLRP 3 Inflammasome in Atherosclerosis. (Pubmed Central) - Oct 16, 2020
In conclusion, C. aronia inhibits the NLRP-3 inflammasome pathway, induced by HFD feeding in the aorta of rats, mainly by its hypolipidemic effect and in vitro, in LPS-stimulated macrophages, by its antioxidant effect. No abstract available
- | Journal: Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts. (Pubmed Central) - Oct 16, 2020
Key findings were reinvestigated in human monocyte-derived macrophages. In cardiac fibroblasts, mTOR inhibition selectively favors pro-IL-1β synthesis while proteasomal degradation and not autophagy is the major catabolic anti-inflammatory mechanism for degradation of this cytokine.
- | Journal: The Secreted Virulence Factor NADase of Group A Streptococcus Inhibits P2X7 Receptor-Mediated Release of IL-1β. (Pubmed Central) - Oct 16, 2020
Further, our data indicate that in the absence of NADase, IL-1β is released through both P2X7-dependent and -independent pathways, although the precise mechanisms of how this occur are still unclear. This study adds information about the mechanism by which NADase regulates inflammasome-dependent IL-1β release, which may in part explain why increased NADase expression correlates with bacterial virulence.
- | Journal: Mitochondrial dysfunction/NLRP3 inflammasome axis contributes to angiotensin II-induced skeletal muscle wasting via PPAR-γ. (Pubmed Central) - Oct 16, 2020
Finally, the PPAR-γ agonist protected against Ang II-induced muscle wasting by preventing MtD, oxidative stress, and NLRP3 inflammasome activation in vitro and in vivo. This work suggests a potential role of MtD/NLRP3 inflammasome pathway in the pathogenesis of Ang II-induced skeletal muscle wasting, and targeting the PPAR-γ/MtD/NLRP3 inflammasome axis may provide a therapeutic approach for muscle wasting.
- | Journal: Novel therapeutic targets for SARS-CoV-2-induced acute lung injury: Targeting a potential IL-1β/neutrophil extracellular traps feedback loop. (Pubmed Central) - Oct 15, 2020
Considering such assertions, we propose potential drug candidates that could be used to alleviate such pathologies. Considering that recent efforts to ascertain effective treatments of COVID-19 in severe patients has been less than successful, investigating novel avenues of treating this virus are essential.
- | lamivudine / Generic mfg.
Journal: Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development. (Pubmed Central) - Oct 15, 2020
Meanwhile, an NRTI, lamivudine, improves insulin sensitivity and reduces inflammasome activation in diabetic and insulin resistance-induced human cells, as well as in mice fed with high-fat chow; mechanistically, inflammasome-activating short interspersed nuclear element (SINE) transcripts are elevated, whereas SINE-catabolizing DICER1 is reduced, in diabetic cells and mice. These data suggest the possibility of repurposing an approved class of drugs for prevention of diabetes.
- | Journal: In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression Analysis. (Pubmed Central) - Oct 15, 2020
This study is the first to propose Astragaloside IV as a new drug candidate for alleviating hyper-inflammation in COVID-19 patients. Besides, the key targets and pathways may reveal the main pharmacological mechanism of Astragaloside IV in the treatment of COVID-19.
- | Preclinical, Journal: Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies. (Pubmed Central) - Oct 15, 2020
In vivo, in a LPS-induced rat model, PA-induced protective effects in intestinal barrier dysfunction could be detected. In summary, our findings clarify the role of PA in intestinal barrier dysfunction and suggest that it is promising for the treatment of LPS-related intestinal diseases.
- | Preclinical, Journal: Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo. (Pubmed Central) - Oct 15, 2020
Collectively, these results suggested that HCK plays a critical role in NLRP3 inflammasome activation. Our results will enhance current understanding regarding the effectiveness of HCK inhibitors for treating acute inflammatory diseases.
- | sirolimus / Generic mfg.
Journal: Astragaloside IV prevents myocardial hypertrophy induced by mechanical stress by activating autophagy and reducing inflammation. (Pubmed Central) - Oct 15, 2020
Our results will enhance current understanding regarding the effectiveness of HCK inhibitors for treating acute inflammatory diseases. As-IV prevents myocardial hypertrophy induced by mechanical stress by activating autophagy and reducing inflammation.
- | Journal, IO Biomarker: CD38 triggers inflammasome-mediated pyroptotic cell death in head and neck squamous cell carcinoma. (Pubmed Central) - Oct 15, 2020
Reduced expression of calcium ion regulator CD38 functions could prevent inflammasome-induced pyroptosis in HNSCC. CD38 may function as a tumor suppressor in HNSCC progression.
- |||| Clinical: People with CHIP had driver gene-specific elevations in their inflammatory markers. Individuals with TET2 CHIP had activation of the NLRP3 inflammasome with greater IL-1beta and IL-6 elevation. Meanwhile, JAK2 had a stronger association with IL-18 and P-selectin. 6/n (Twitter) - Oct 14, 2020
- [VIRTUAL] Genetic Variant in NOD, LRR and Pyrin Domain-Containing Protein 3 Gene is Associated With Generalized Anxiety Disorder in Young Adults Exposed to Childhood Trauma () - Oct 13, 2020 - Abstract #WCPG2020WCPG_571;
No association was found between genotype distribution and GAD (p=0.530). After sex stratification a significant association between the G-allele as a risk factor for GAD in men was observed (p=0.015), even after adjusted analysis for possible confounders as age and skin color [OR= 2.328 (1.136 – 4.773); p=0.021].
- [VIRTUAL] Genetic Variant in NOD, LRR and Pyrin Domain-Containing Protein 3 Gene is Associated With Generalized Anxiety Disorder in Young Adults Exposed to Childhood Trauma () - Oct 13, 2020 - Abstract #WCPG2020WCPG_403;
No association was found between genotype distribution and GAD (p=0.530). After sex stratification a significant association between the G-allele as a risk factor for GAD in men was observed (p=0.015), even after adjusted analysis for possible confounders as age and skin color [OR= 2.328 (1.136 – 4.773); p=0.021].
- GYY4137 / National University of Singapore
[VIRTUAL] H2S May Inhibit Peritoneal Dialysis-Related Fibrosis Through the Sulfhydrylation Regulation of PSMA7 (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2983;
Rat peritoneal mesothelial cells were randomly assigned into different groups, 4.5% peritoneal dialysate group (PD group), PD+H2S supplement GYY4137 group and PD+H2S inhibitor PAG group... H2S has a protective effect on PD-related fibrosis through the PSMA7 sulfhydryl sulfhydrylation regulation, and further break the pathological changes of "pyroptosis- inflammation-fibrosis" axis and avoid the occurrence of inflammatory cascade reaction.
- [VIRTUAL] Indoxyl Sulfate Reduces the Inducibility of NLRP3 Inflammasome in Hemodialysis Patients (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2368;
The low stimulation response of the NLRP3 inflammasome attributed to indoxyl sulfate probably constitutes a breach of the immune defense system, which may explain the high infection risk in HD patients. Funding: Clinical Revenue Support
- Interleukin 22 subunit alpha receptor / Merck (MSD)
[VIRTUAL] Anti-Interleukin 22 Antibody Relieves Angiotensin II-Induced Renal Injury in Mice Through Inhibiting NLRP3 Inflammasome Activation (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_1213;
IL-22, IL-22R expression and renal pathology Funding: Government Support - Non-U. S.
- [VIRTUAL] STC1 Prevents Lipopolysaccharide-Induced AKI via TGF-β (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_823;
STC 1 has protective effects on LPS-induced acute renal tubular injury in mice, possibly by targeting TGF β, enhencing TLR4 expression, regulating the TGF β/STC1 signaling pathway, and inhibiting the expression of downstream inflammatory factors. Funding: Government Support - Non-U.
- [VIRTUAL] Hematopoietic Aging: Mechanisms and Consequences - Live Q&A (Channel 6 (Virtual Meeting)) - Oct 11, 2020 - Abstract #ASH2020ASH_213;
Geiger's talk will present novel data and concepts on causes and consequences of aging of hematopoietic stem cells, and implications for the clinic. Sponsor: Scientific Committee on Hematopoiesis
- | Preclinical, Journal: Milk Fat Globule Membrane Inhibits NLRP3 Inflammasome Activation and Enhances Intestinal Barrier Function in a Rat Model of Short Bowel. (Pubmed Central) - Oct 11, 2020
Sponsor: Scientific Committee on Hematopoiesis Supplementation of MFGM helps to modulate NLRP3 inflammasome activation and enhances gut barrier integrity in rats after massive small-bowel resection, which provides experimental support for potential applications of MGFM in intestinal barrier dysfunction, although further studies are needed.
- | Journal: Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome. (Pubmed Central) - Oct 11, 2020
Furthermore, oral administration of GlcN reduced peritoneal neutrophils influx and lavage fluids concentrations of IL-1β, IL-6 MCP-1 and TNF-α in uric acid crystal-injected mice. These results indicated that GlcN might be a novel dietary supplement for the amelioration of NLRP3 inflammasome-associated complications.
- [VIRTUAL] COPPER DEFICIENCY IS AN INDEPENDENT RISK FACTOR FOR DECREASED SURVIVAL IN PATIENTS WITH CIRRHOSIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1745;
In cirrhosis, Cu deficiency is not uncommon and its presence is independently associated with worse patient survival. Given the multifaceted role of Cu in mammalian physiology, the mechanism of Cu deficiency and whether it represents a potential therapeutic target warrant further study.
- selonsertib (GS-4997) / Gilead
[VIRTUAL] REDUCTION OF HEPATOCYTE INJURY BY SRT-015, A NOVEL INHIBITOR OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1). () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1692;
Antiapoptotic activity of SRT-015 and other ASK1 inhibitors, including selonsertib (SEL), was investigated in HepG2 cells exposed to H2O2-induced oxidative stress... These results demonstrate a robust hepatoprotective mechanism of action of novel ASK1 inhibitor SRT-015, and support its development for NASH and other hepatic indications.
- [VIRTUAL] ASC SPECKS REQUIRE NLRP3 TO AMPLIFY INFLAMMATION IN ALCOHOLIC HEPATITIS IN A CELL-SPECIFIC MANNER () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1297;
The presence of NLRP3 in the exASC specks or in the recipient cell is required for this amplification effect. Our novel findings indicate that NLRP3 can be explored as a therapeutic target in AH.
- tamoxifen / Generic mfg.
[VIRTUAL] SINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF LIVERS DURING NLRP3 INFLAMMASOME ACTIVATION REVEALS A NOVEL IMMUNE NICHE () - Oct 11, 2020 - Abstract #AASLD2020AASLD_302;
Using single cell transcriptomics, we defined and characterized the immune cell subsets within the inflamed liver microenvironment induced by NLRP3 inflammasome activation, which was corroborated with IHC and RNA-seq. These results have important implications for dissecting the mechanisms of liver injury in NLRP3-driven pathologies such as NASH and may aid in identifying novel therapeutic targets.
- [VIRTUAL] ROLE OF NEUTROPHIL-SPECIFIC NLRP3 ACTIVATION ON LIVER PATHOBIOLOGY: DISSOCIATION BETWEEN LIVER INFLAMMATION AND COLLAGEN TURNOVER () - Oct 11, 2020 - Abstract #AASLD2020AASLD_301;
Neutrophil-specific NLRP3 overactivation resulted in shortened survival, poor growth, and severe liver inflammation while decreased collagen deposition and HSC activation in the liver at least in part via neutrophil specific MMP-8 overexpression. This data provides novel insights into the complex relationship between liver neutrophil-driven inflammation, collagen turnover and HSC biology.
- | Preclinical, Journal: Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice. (Pubmed Central) - Oct 11, 2020
These data demonstrate that this novel LMP limits T1D development by inducing caecal homeostasis to shape pancreatic immune environment. This finding opens a realistic option for gut microbiota manipulation and prevention of T1D in humans.
- || Clinical, Journal: IL-23/IL-17 Axis Activates IL-1β-Associated Inflammasome in Macrophages and Generates an Auto-Inflammatory Response in a Subgroup of Patients With Bullous Pemphigoid. (Pubmed Central) - Oct 11, 2020
Subsequently, this opens up alternative therapeutic strategies targeting IL-1β pathway in the aim to control the early, pre-blistering inflammatory phase. Ultimately, this could also help in reducing the detrimental effects associated with high doses of corticosteroids treatment.
- | Journal: Activation of Human NK Cells by Bordetella pertussis Requires Inflammasome Activation in Macrophages. (Pubmed Central) - Oct 11, 2020
Our data provides a better understanding of the underlying mechanisms involved in the induction of innate immune responses against B. pertussis. These findings contribute to the knowledge required for the development of improved intervention strategies to control this highly contagious disease.
- | Journal: The Association of Major Depressive Disorder with Activation of NLRP3 Inflammasome, Lipid Peroxidation, and Total Antioxidant Capacity. (Pubmed Central) - Oct 11, 2020
In contrast, there was no significant difference between the treated and non-treated groups in terms of oxidative stress (P = 0.6, P = 0.1). Our results suggested that inflammasome signaling pathway is a therapeutic potential for MDD.
- | Biomarker, Journal: Cardiolipin inhibitor ameliorates the non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation. (Pubmed Central) - Oct 10, 2020
Our results suggested that inflammasome signaling pathway is a therapeutic potential for MDD. Our study showed that the upregulation of NLRP3 inflammasome activated by cardiolipin is crucial in NASH pathogenesis, which might provide a novel potential role of cardiolipin blockade in the treatment of NASH.
- | Preclinical, Journal: Eriodictyol ameliorates lipopolysaccharide-induced acute lung injury by suppressing the inflammatory COX-2/NLRP3/NF-κB pathway in mice. (Pubmed Central) - Oct 10, 2020
Moreover, eriodictyol inhibited the COX-2/NLRP3/NF-κB signaling pathway in the lung tissues of ALI mice. In conclusion, our observations validated that eriodictyol processed the protective effects on ALI mice, which was related to the regulation of the COX-2/NLRP3/NF-κB signaling pathway.
- | Preclinical, Journal: α-Bisabolol protects against β-adrenergic agonist-induced myocardial infarction in rats by attenuating inflammation, lysosomal dysfunction, NLRP3 inflammasome activation and modulating autophagic flux. (Pubmed Central) - Oct 10, 2020
The findings of the present study clearly demonstrate that α-bisabolol attenuates oxidative stress and inflammation by inhibiting NLRP3 inflammasome activation and TLR4-NFκB/MAPK signaling pathways along with correcting lysosomal dysfunction and impaired autophagic flux. The underlying pharmacological and molecular mechanism of cardioprotection was attributed to its antioxidant, free radical scavenging and anti-inflammatory properties.
- | Journal: Immunometabolism: a key target to improve microcirculation in ageing. (Pubmed Central) - Oct 10, 2020
The underlying pharmacological and molecular mechanism of cardioprotection was attributed to its antioxidant, free radical scavenging and anti-inflammatory properties. No abstract available
- | Journal: Mitochondrial membrane protein mitofusin 2 as a potential therapeutic target for treating free fatty acid-induced hepatic inflammation in dairy cows during early lactation. (Pubmed Central) - Oct 10, 2020
In the cell culture model, we were able to replicate our findings in cows with moderate fatty liver: 1.2 mM exogenous FFA decreased the abundance of MFN2 and upregulated phosphorylation levels of the inhibitor of NF-κB (IκB) α and NF-κB p65, the IκB kinase β activity, and the abundance of NLRP3, caspase-1, IL-1β, IL-6, and TNF-α. Whereas MFN2 knockdown potentiated the FFA-induced activation of these inflammatory pathways, overexpression of MFN2 attenuated the detrimental effect of excess exogenous FFA by improving mitochondrial function and decreasing the release of reactive oxygen species, suggesting that MFN2 may be a potential therapeutic target for FFA-induced hepatic inflammation in dairy cows during early lactation.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Preclinical, Journal: Protective effect of Lachnum polysaccharide on dextran sulfate sodium-induced colitis in mice. (Pubmed Central) - Oct 9, 2020
In addition, LEP also inhibited (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, endoplasmic reticulum (ER) stress and oxidative/nitrosative stress induced by DSS. These results provided a scientific basis for LEP as a potential natural agent for protecting mice from DSS-induced IBD.
- | fluorouracil topical / Generic mfg.
Preclinical, Journal, IO Biomarker: Lactobacillus rhamnosus FLRH93 protects against intestinal damage in mice induced by 5-fluorouracil. (Pubmed Central) - Oct 9, 2020
In conclusion, Lb. rhamnosus FLRH93 has positive effects on body injury and could be used to prevent intestinal damage caused by cancer chemotherapy.
- || Review, Journal: The Nlrp3 inflammasome as a "rising star" in studies of normal and malignant hematopoiesis. (Pubmed Central) - Oct 9, 2020
The Nlrp3 inflammasome is also involved in certain hematological pathologies, including (i) myelodysplastic syndrome, (ii) myeloproliferative neoplasms, (iii) leukemia, and (iv) graft-versus-host disease (GvHD) after transplantation. The aim of this review is to shed more light on this intriguing intracellular protein complex that has become a "rising star" in studies focused on both normal steady-state and pathological hematopoiesis.
- | Journal: Mangiferin inhibits lipopolysaccharide-induced epithelial-mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non-small cell lung cancer cells. (Pubmed Central) - Oct 9, 2020
In addition, mangiferin markedly mediated protein levels of PER1 and NLRP3 in LPS-induced NSCLC cells and reduced the secretion of IL-1β. These results indicate that mangiferin is not only a remarkable anti-inflammatory compound but also an antitumor agent; thus, it has the potential for being developed into anti-inflammatory and antitumor drugs in the future.
- | Journal: Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers. (Pubmed Central) - Oct 9, 2020
These findings provide an insight into how NETs communicate with other cells in the vicinity (e.g. macrophages) to exacerbate the inflammatory response. Most importantly, they provide novel avenues to improve wound healing process such as diabetic foot ulcers (DFUs) by targeting NETs.
- | Preclinical, Journal, IO Biomarker: TLR9 mediates the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation. (Pubmed Central) - Oct 9, 2020
Similarly, in the in vitro study, we found that knockdown of TLR9 markedly suppressed S.aureus-induced activation of NLRP3 inflammasome and oxidative stress in Raw264.7 cells. Collectively, our findings indicated that TLR9 may mediate allergic airway inflammation via activating NLRP3 inflammasome and oxidative stress.
- | Journal: PM2.5 compromises antiviral immunity in influenza infection by inhibiting activation of NLRP3 inflammasome and expression of interferon-β. (Pubmed Central) - Oct 9, 2020
Thus, our study revealed that PM2.5 could alter macrophage inflammatory responses by suppressing LPS-induced activation of NLRP3 inflammasome and expression of IFN-β during influenza infection. These findings provided us new insights in understanding that PM2.5 combining with influenza infection could enhance the severity of pneumonia.
- | Preclinical, Journal: Allicin reduces inflammation by regulating ROS/NLRP3 and autophagy in the context of A.fumigatus infection in mice. (Pubmed Central) - Oct 9, 2020
These findings provided us new insights in understanding that PM2.5 combining with influenza infection could enhance the severity of pneumonia. These results support that allicin reduces inflammation and autophagy resistance to A. fumigatus infection, It also provides a possible treatment for Aspergillus infectious diseases, i.e. early anti-inflammation, antibiotics or drugs that inhibit excessive autophagy.
- [VIRTUAL] PERIPHERAL INFLAMMATION, COGNITIVE IMPAIRMENT AND AD-RELATED HIPPOCAMPAL NEURODEGENERATION IN PRODROMAL AD PATIENTS () - Oct 9, 2020 - Abstract #CTAD2020CTAD_251;
Altered expression of proinflammatory factors are associated to hippocampal neurodegeneration and worse cognitive performance in prodromal AD patients. These preliminary results suggest that non-invasive peripheral inflammatory biomarkers could represent possible biomarkers to support the early diagnosis of AD.
- | Preclinical, Journal, IO Biomarker: Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice. (Pubmed Central) - Oct 8, 2020
Furthermore, with NLRP3 overexpression, the expression of fibrotic factors in ovarian cells was dramatically increased, such as TGF-β, CTGF, α-SMA, β-catenin, collagen I and collagen IV. These findings suggest that hyperandrogen stimulates chronic low-grade inflammation in the ovary to activate the NLRP3 inflammasome, further inducing a series of pathologies including ovarian GC pyroptotic death, follicular dysfunction and ovarian interstitial cell fibrosis.
- | Journal: The effects of maternal separation stress experienced by parents on male reproductive potential in the next generation. (Pubmed Central) - Oct 8, 2020
Finally, the mean percentage of caspase-1 and NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) positive cells was significantly higher in first-generation group. MS experienced by parents may negatively affect the reproduction of first generation offspring.
- | Preclinical, Journal: Nlrp3 inflammasome inhibitor MCC950 ameliorates obliterative bronchiolitis by inhibiting Th1/Th17 response and promoting Treg response after orthotopic tracheal transplantation in mice. (Pubmed Central) - Oct 8, 2020
The mechanistic analysis showed that MCC950 regulated the balance of Th1/Th17 and Treg cells and that this process is partially mediated by inhibition of IL-1β and IL-18. Therefore, targeting the Nlrp3 inflammasome is a promising strategy for controlling OB after lung transplantation.