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- || Review, Journal: Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases. (Pubmed Central) - Feb 23, 2021
Understanding the underlying mechanisms behind the sex differences in NLRP3 inflammasome-mediated neurodegenerative diseases will help researchers to develop more targeted therapies and increase our diagnostic and prognostic abilities. In addition, the superiority of the combined use of microglial autophagy inducers with the specific inhibitors of the NLRP3 inflammasome in the inhibition of NLRP3 inflammasome-mediated neuroinflammation requires further preclinical and clinical validations in the future.
- | Journal, IO biomarker: Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway. (Pubmed Central) - Feb 23, 2021
Both animal models and in vitro experiments suggested that ISO may effectively lower uric acid produce. The mechanism might be the inhibition of XOD activity and NLRP3 inflammasome of upregulation.
- || Clinical, Journal: Autoantibodies in NLRP3-associated autoinflammatory disease: a case report. (Pubmed Central) - Feb 23, 2021
The mechanism might be the inhibition of XOD activity and NLRP3 inflammasome of upregulation. No abstract available
- | Journal: MicroRNA-574-5p Attenuates Acute Respiratory Distress Syndrome by Targeting HMGB1. (Pubmed Central) - Feb 23, 2021
This study demonstrated that miR-574-5p provided negative feedback to LPS-induced inflammation and relieved ARDS. It may provide new therapeutic strategies for ARDS.
- [VIRTUAL] Dissecting TLR-mediated immune responses to amyloids in the enteric nervous system () - Feb 23, 2021 - Abstract #BWG2021BWG_122;
We also confirmed that inflammasome activation can be measured (albeit indirectly) in THP-1 cells after dual stimulation. We are now using this model to investigate their sensitivity to amyloids and we are extending our measurements to query the response in neuronal cells, so as to gain a cell-type resolved view on inflammasome signaling in the gut.
- || Review, Journal: Inflammatory Caspases Drive Pyroptosis in Acute Lung Injury. (Pubmed Central) - Feb 23, 2021
Meanwhile, inhibition of inflammasome, the key to initiating pyroptosis is currently the main way to treat acute lung injury. The review summarizes the relationship among inflammatory caspases, pyroptosis and acute lung injury and provides general directions and strategies to conduct further research.
- | Journal: Moxibustion against Cyclophosphamide-Induced Premature Ovarian Failure in Rats through Inhibiting NLRP3-/Caspase-1-/GSDMD-Dependent Pyroptosis. (Pubmed Central) - Feb 23, 2021
On the one hand, Mox directly inhibited TXNIP/NLRP3/caspase-1 signaling-induced pyroptosis, and on the other hand, it indirectly decreased NLRP3, pro-IL-1β, and pro-IL-18 through inhibiting TLR4/MyD88/NF-κB signaling. Our results show that Mox might be a new therapeutic strategy for the treatment of POF.
- | PDC*mel / PDC line Pharma
Journal: Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine. (Pubmed Central) - Feb 23, 2021
MTX can function as a potent adjuvant in DC vaccines by increasing antigen presentation and T cell priming. Our findings provide a new strategy for the application of DC-based anti-tumour immunotherapy.
- | Journal: Identification of anti-inflammatory vesicle-like nanoparticles in honey. (Pubmed Central) - Feb 23, 2021
miR-4057 in H-VLNs was identified in inhibiting NLRP3 inflammasome activation. Together, our studies have identified anti-inflammatory VLNs as a new bioactive agent in honey.
- || Review, Journal: The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders. (Pubmed Central) - Feb 23, 2021
Here, we comprehensively review the roles, mechanisms and interactions of both ER stress and inflammasomes, as well as their interconnected relationships in inflammatory signalling cascades. We also discuss novel therapeutic strategies that are being developed to treat ER stress- and inflammasome-related inflammatory disorders.
- | Journal: Acetate Downregulates the Activation of NLRP3 Inflammasomes and Attenuates Lung Injury in Neonatal Mice With Bronchopulmonary Dysplasia. (Pubmed Central) - Feb 23, 2021
These results indicate that acetate may regulate intestinal flora and reduce inflammatory reactions and lung injury in BPD. Therefore, acetate may be an effective drug to protect against neonatal BPD.
- | Journal: Regulatory T cells induced by B cells suppress NLRP3 inflammasome activation and alleviate monosodium urate-induced gouty inflammation. (Pubmed Central) - Feb 23, 2021
Treg-of-B cells ameliorated gouty inflammation in a mouse air pouch model by reducing neutrophil and leukocyte influx and cytokine and chemokine production. Our results demonstrated that Treg-of-B cells exerted regulatory effects on innate immunity by suppressing NLRP3 inflammasome activation and feasible for future therapeutic applications.
- ||| The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches https://t.co/OrCt8TNnjl (Twitter) - Feb 22, 2021
- [VIRTUAL] “Application of the Eurofever/PRINTO Clinical Classification Criteria for Autoinflammatory Recurrent Fevers in a Canadian Cohort.” () - Feb 21, 2021 - Abstract #CRAAHPA2021CRA-AHPA_274;
This may be due to variation in clinical diagnostic practice, differences in ethnic composition of the populations, or inclusion of non-specific criteria. This study also highlights the importance of not equating classification criteria with diagnostic criteria.
- | Preclinical, Journal: Calreticulin Blockade Attenuates Murine Acute Lung Injury by Inducing Polarization of M2 Subtype Macrophages. (Pubmed Central) - Feb 20, 2021
Siglec F+CD206+M2 subtype macrophages and p38 MAPK/STAT6 signaling pathway played important role in the immune regulation of aCALR. Blocking CALR activity is a promising therapeutic approach in the treatment of ARDS/ALI.
- || Review, Journal: NLRP3 Inflammasome-A Key Player in Antiviral Responses. (Pubmed Central) - Feb 20, 2021
Meanwhile, several viruses have evolved elaborate strategies to evade the immune system by targeting the NLRP3 inflammasome. In this review, we will focus on the crosstalk between the NLRP3 inflammasome and viruses, provide an overview of viral infection-induced NLRP3 inflammasome activation, and the immune escape strategies of viruses through their modulation of the NLRP3 inflammasome activity.
- || Review, Journal: Purinergic Receptors: Elucidating the Role of these Immune Mediators in HIV-1 Fusion. (Pubmed Central) - Feb 20, 2021
They also appear to abrogate activity of downstream mediators that potentiate activation of the NLRP3 inflammasome pathway. Here we review the literature on purinergic receptors, the drugs that inhibit their function, and the evidence implicating these receptors in HIV-1 entry.
- | Preclinical, Journal: Ameliorative effect of selective NLRP3 inflammasome inhibitor MCC950 in an ovalbumin-induced allergic rhinitis murine model. (Pubmed Central) - Feb 20, 2021
In spleen mononuclear cells culture and stimulation experiment, NLRP3, Caspase-1, ASC, IL-1β and IL-18 levels were upregulated by OVA but inhibited by MCC950. In conclusion, MCC950 could effectively exert its ameliorative effect in murine AR by inhibiting NLRP3 and leads to reduction of Caspase-1, ASC, IL-1β and IL-18, resulting in the attenuation of the allergic and inflammatory responses.
- || Review, Journal: The P2X7 Receptor and NLRP3 Axis in Non-Alcoholic Fatty Liver Disease: A Brief Review. (Pubmed Central) - Feb 20, 2021
To this regard, extracellular ATP acts as an internal danger signal coming from damaged cells participating in the activation of the inflammatory process, a signaling pathway common to many different tissues. Here, we briefly review the involvement of the P2X7 receptor/inflammasome NLRP3 axis in the pathophysiological events leading to NAFLD and its inflammatory and fibrotic evolutions, reporting the possible therapeutical strategies targeting the P2X7 receptor/NLRP3 inflammasome.
- | Journal, Combination therapy: HSP70-Mediated NLRP3 Inflammasome Suppression Underlies Reversal of Acute Kidney Injury Following Extracellular Vesicle and Focused Ultrasound Combination Therapy. (Pubmed Central) - Feb 20, 2021
Using a mouse model of cisplatin-induced AKI, we show that combination therapy with pFUS and EVs restores physiological and molecular markers of kidney function, more so than either alone...In vitro knockdown studies suggest that HSP70 is a positive regulator of the NLRP3 inflammasome. Our study therefore demonstrates the ability of pFUS to enhance EV therapy for AKI and provides further mechanistic understanding of their anti-inflammatory and regenerative effects.
- || Review, Journal: Focus on the Role of NLRP3 Inflammasome in Diseases. (Pubmed Central) - Feb 20, 2021
Additionally, increasing data in animal models, supported by human studies, strongly implicate the involvement of the inflammasome in the initiation or progression of disorders with a high impact on public health, such as metabolic pathologies (obesity, type 2 diabetes, atherosclerosis), cardiovascular diseases (ischemic and non-ischemic heart disease), inflammatory issues (liver diseases, inflammatory bowel diseases, gut microbiome, rheumatoid arthritis) and neurologic disorders (Parkinson's disease, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis and other neurological disorders), compared to other molecular platforms. This review will provide a focus on the available knowledge about the NLRP3 inflammasome role in these pathologies and describe the balance between the activation of the harmful and beneficial inflammasome so that new therapies can be created for patients with these diseases.
- | Journal: Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU-470 in RAW 264.7 Cells through the TLR4-NF-κB-NLRP3 Pathway. (Pubmed Central) - Feb 20, 2021
Importantly, PIM-1 siRNA transfection attenuated up-regulation of NLRP3 and pro-IL-1β in LPS-treated RAW 264.7 cells. Taken together, these findings indicate that PIM-1 plays a key role in inflammatory signaling and that KMU-470 is a potential anti-inflammatory agent.
- | Journal: Artemisinin suppresses myocardial ischemia-reperfusion injury via NLRP3 inflammasome mechanism. (Pubmed Central) - Feb 20, 2021
In conclusion, our findings further confirmed that activation of the NLRP3 inflammasome pathway is involved in myocardial I/R injury, whereas artemisinin preconditioning could effectively protect against myocardial I/R injury through suppression of NLRP3 inflammasome activation. Therefore, the NLRP3 inflammasome might serve as a promising therapeutic target providing new mechanisms for understanding the effect of artemisinin during the evolution of myocardial infarction.
- || Review, Journal: NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis. (Pubmed Central) - Feb 20, 2021
Inflammasome-mediated inflammation has become increasingly important in acute pancreatitis, an inflammatory disorder of the pancreas that is one of the fatal diseases of the gastrointestinal tract. This review presents an update on the progress of research into the contribution of the NLRP3 inflammasome to acute pancreatic injury, examining the mechanisms of NLRP3 activation by multiple signaling events, the downstream interleukin 1 family of cytokines involved and the current state of the literature on NLRP3 inflammasome-specific inhibitors.
- | Journal: Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis. (Pubmed Central) - Feb 20, 2021
Our studies revealed that RSV induces lytic cell death in macrophages via both of these mechanisms, specifically through the ASC (Apoptosis-associated speck like protein containing a caspase recruitment domain)-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome activation of both caspase-1 dependent pyroptosis and receptor-interacting serine/threonine-protein kinase 3 (RIPK3), as well as a mixed lineage kinase domain like pseudokinase (MLKL)-dependent necroptosis. In addition, we demonstrated an important role of reactive oxygen species (ROS) during lytic cell death of RSV-infected macrophages.
- | Preclinical, Journal: Protective effects of syringin against oxidative stress and inflammation in diabetic pregnant rats via TLR4/MyD88/NF-κB signaling pathway. (Pubmed Central) - Feb 20, 2021
Intriguingly, the decrease in TLR4 expression and the downstream molecules of MyD88, NF-κB, and NLRP3 were also observed in syringin administered GDM rats that indicate the insulin secretion stimulatory actions of syringin through the suppression of TLR4 signaling. These novel findings of the study provide evidence that syringin could be a probable candidate to be used in the treatment of gestational diabetes in the future.
- | Preclinical, Journal: P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats. (Pubmed Central) - Feb 20, 2021
All these abnormal alterations could be largely reversed after treatment of short hairpin RNA (shRNA) targeting P2Y12. Our results indicate that the silence of P2Y12 by shRNA may effectively correct the anomalous activity of celiac SND and improve the dysfunctional hepatic glucokinase by counteracting hepatocyte inflammation and likely pyroptosis due to activated NLRP3 inflammasome and caspase-1 signaling, thereby attenuating hyperglycemia in T2DM rats.
- | Journal: NLRP3 inflammasome is involved in the mechanism of mitigative effect of selenium on lead-induced inflammatory damage in chicken kidneys. (Pubmed Central) - Feb 20, 2021
NLRP3 inflammasome, caspase-1, and IL-1β may be sensitive indicators in Pb-induced chicken kidney inflammatory damage. In conclusion, NLRP3 inflammasome took part in antagonistic role of Se against Pb-caused inflammation via changing oxidative stress indicators, cytokines, and inflammation-related genes in the chicken kidneys.
- | gentamicin sulfate / Generic mfg.
Journal: Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways. (Pubmed Central) - Feb 20, 2021
Collectively, UMB markedly amended all GNT-induced renal changes. These nephroprotective outcomes could be attributed to its ability to impede TLR-4/NF-κB-p65/NLRP-3 inflammasome and JAK1/STAT-3 pathways activation, as well as to its anti-inflammatory property.
- | Journal: Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome. (Pubmed Central) - Feb 20, 2021
Finally, overexpression of NLRP3 with plasmid transfection could further enhance the activation of NLRP3 inflammasome by IOP. Taken together, these results suggest that IOP suppresses the development of CAC, possibly by activation of the NLRP3 inflammasome, and reveal that IOP may be a therapeutic drug candidate for CAC.
- | Preclinical, Journal: Pomelo peel oil alleviates cerebral NLRP3 inflammasome activation in a cardiopulmonary resuscitation rat model. (Pubmed Central) - Feb 20, 2021
Treatment of the rats with PPO significantly decreased the pathological damage of the brain tissue and reduced the expression of NSE, production of ROS and secretion of NF-κB, NLRP3, IL-1β and GSDMD. In conclusion, these results demonstrate the ability of PPO to protect the brain against I/R injury in rats after CPR by a mechanism involving inhibition of the inflammation and pyroptosis mediated by NLRP3 inflammasome activation.
- | Journal: A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3-NLRP3 Pathway. (Pubmed Central) - Feb 18, 2021
Assessment of cardiac mitochondria demonstrated SA-26 preserved SIRT3 activity and reduced acetylation of manganese superoxide dismutase (MnSOD) suggesting enhanced antioxidant capacity. Together, these data demonstrate that the cardioprotective effects of the EDP analogue SA-26 against IR injury involve preservation of mitochondrial SIRT3 activity, which attenuates a detrimental innate NLRP3 inflammasome response.
- || Review, Journal: Epigenetic Mechanisms of Inflammasome Regulation. (Pubmed Central) - Feb 18, 2021
For example, our team recently explored the role of microRNAs (miRNAs) targeting and modulating the components of the inflammasome as potential biomarkers in bladder cancer and during therapy. This suggests that the epigenetic control of inflammasome-related genes could represent a potential target for further investigations of molecular mechanisms regulating inflammatory pathways.
- | Journal: Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop. (Pubmed Central) - Feb 18, 2021
In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD.
- Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
[VIRTUAL] HYPERGLYCEMIA INCREASED IPILIMUMAB-INDUCED CARDIOTOXICITY, ENHANCED IMMUNE-RESISTANCE IN ERɑ+, PR+, HER2- BREAST CANCER CELLS MODULATING CYTOKINES AND NLRP3/MYD88 EXPRESSION (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_3186;
Moreover, IC50 value of nivolumab against MCF7-cells increased significantly under HG vs LG (P<0.001). Hyperglycemia exacerbates Ipilimumab-induced cardiotoxicity and immunoresistace and set the stage to preclinical and clinical trials aimed to decrease glucose through dietary or lifestyle changes or through new hypoglycemic drugs (gliflozins).
- Opdivo (nivolumab) / Ono Pharma, BMS
[VIRTUAL] CTLA-4 AND PD-1 BLOCKING AGENTS EXERTES CARDIOTOXIC, PRO-FIBROTIC AND PRO-INFLAMMATORY EFFECTS IN CELLULAR AND PRECLINICAL MODELS (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_297;
Nivolumab and Ipilimumab exert cytotoxic effects mediated by NLRP3/IL-1β and MyD88 pathways leading to pro-inflammatory cytokine storm in heart tissue. These results could indicates new strategies to reduce ICIs induced cardiotoxicity through new anti-inflammatory drugs
- Herceptin (trastuzumab) / Roche, Repatha (evolocumab) / Amgen, Astellas
[VIRTUAL] PCSK9 INHIBITOR EVOLOCUMAB REDUCES CARDIOTOXICITY OF DOXORUBICIN AND TRASTUZUMAB SEQUENTIAL TREATMENT THROUGH MYD88/NF-KB/MTORC1 PATHWAYS (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_296;
Evolocumab, a PCSK9 inhibitor, reduced the risk of cardiovascular events in patients with atherosclerotic cardiovascular diseases when added to maximally tolerated statin therapy (± ezetimibe), and recent data from the ODYSSEY OUTCOMES trial indicate that alirocumab added to maximally tolerated statin therapy (± other lipid-lowering drugs) reduces the risk of cardiovascular events in patients with a recent acute coronary syndrome. The PCSK9 inhibitor evolocumab exerts direct effects in cardiomyocytes during doxorubicin and trastuzumab exposure turning on a new light on its possible use in preclinical models
- Opdivo (nivolumab) / Ono Pharma, BMS
[VIRTUAL] OXIDIZED LOW-DENSITY LIPOPROTEIN EXACERBATES NIVOLUMAB-INDUCED CARDIOTOXICITY BY MODULATING TLR4/NF-κB AND NLRP3 PATHWAYS (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_295;
Ox-LDL exacerbates apoptosis and inflammation in cardiomyocytes during exposure to Nivolumab turning the light on their role in ICIs-induced cardiotoxicity. These results place the first step to preclinical studies aimed to reduce ox-LDL during treatment with ICIs.
- | s-nitrosoglutathione (N30-201) / Alpine
Journal, IO biomarker: S-Nitrosylation of Muscle LIM Protein Facilitates Myocardial Hypertrophy Through Toll-Like Receptor 3-Mediated Receptor-Interacting Protein Kinase 3 and NLRP3 Inflammasome Activation. (Pubmed Central) - Feb 17, 2021
Denitrosylation of MLP by the mutation of nitrosylation sites or overexpression of S-nitrosoglutathione reductase was used to analyze the contribution of SNO-MLP in myocardial hypertrophy...This interaction in turn induced NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation, thereby promoting the development of myocardial hypertrophy. Our findings revealed a key role of SNO-MLP in myocardial hypertrophy and demonstrated TLR3-mediated RIP3 and NLRP3 inflammasome activation as the downstream signaling pathway, which may represent a novel therapeutic target for myocardial hypertrophy and heart failure.
- || Clinical, Journal: Elevated plasma galectin-3 levels and their correlation with disease activity in adult-onset Still's disease. (Pubmed Central) - Feb 17, 2021
Our findings revealed a key role of SNO-MLP in myocardial hypertrophy and demonstrated TLR3-mediated RIP3 and NLRP3 inflammasome activation as the downstream signaling pathway, which may represent a novel therapeutic target for myocardial hypertrophy and heart failure. Elevated galectin-3 levels and their positive correlation with disease activity scores, inflammatory parameter, and inflammasome downstream cytokines suggest the involvement of galectin-3 in AOSD pathogenesis.Key Points• We revealed for the first time the association of plasma galectin-3 levels with AOSD activity parameters.• We explored the link between galectin-3 levels and NLRP3-inflammasome downstream cytokines in AOSD disease.
- | Journal: IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death. (Pubmed Central) - Feb 17, 2021
Mechanistically, IRF8-mediated phosphorylation of IRF3 was required for Ifnb transcription, which in turn triggered the caspase-11-dependent NLRP3 inflammasome activation in the infected BMDMs. Overall, our findings suggest that IRF8 promotes NLRP3 inflammasome activation during infection with Gram-negative bacteria.
- | Journal: Calcium-Sensing Receptor on Neutrophil Promotes Myocardial Apoptosis and Fibrosis After Acute Myocardial Infarction via NLRP3 Inflammasome Activation. (Pubmed Central) - Feb 17, 2021
The results suggest that CaSR activates NLRP3 inflammasome in neutrophils, contributing to ventricular remodelling after AMI. CaSR inhibition may be a potential therapeutic target for heart failure in AMI.
- | Journal: NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma. (Pubmed Central) - Feb 17, 2021
Furthermore, we find no role for NLRP3 in NLRC4 function, or for NLRC4 in a model of melanoma. These results clarify our understanding of the mechanism and biological functions of NAIP/NLRC4 activation.
- | Daliresp (roflumilast) / AstraZeneca, Takeda, AbbVie
Journal: Roflumilast, a Phosphodiesterases-4 (PDE4) Inhibitor, Alleviates Sepsis‑induced Acute Kidney Injury. (Pubmed Central) - Feb 17, 2021
Finally, high concentration of roflumilast (3 mg/kg) did not have an adverse effect on liver, heart, lung, or spleen. CONCLUSIONS Our study indicated that roflumilast could ameliorate AKI induced by sepsis through restraining inflammatory response and apoptosis of the kidney, providing a molecular basis for a novel medical treatment of septic AKI.
- || Review, Journal: Does NLRP3 Inflammasome and Aryl Hydrocarbon Receptor Play an Interlinked Role in Bowel Inflammation and Colitis-Associated Colorectal Cancer? (Pubmed Central) - Feb 17, 2021
AhR has been described to play a role in the inhibition of the NLRP3 inflammasome activation pathway. This review will summarise the signalling pathways of both the NLRP3 inflammasome and AhR; as well as new-found links between these two signalling pathways in intestinal immunity and some potential therapeutic agents that have been found to take advantage of this link in the treatment of colitis and CAC.
- | Journal: Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway. (Pubmed Central) - Feb 17, 2021
Low expression of NOX4 inhibits the dissociation of thioredoxin (Trx) and thioredoxin-interacting protein (TXNIP) and the suppression of NLRP3 inflammasome activation. To summarize, our study provided evidence that punicalagin can alleviate diabetic nephropathy, and the effect is associated with downregulating the expression of NOX4, inhibiting TXNIP/NLRP3 pathway-mediated pyroptosis, suggesting its therapeutic implications for complications of diabetes.
- | progesterone / Generic mfg.
Journal: Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury. (Pubmed Central) - Feb 17, 2021
Pre-treatment with an autophagy inhibitor blocked Progesterone's (PROG's) beneficial effects in microglia. Our data suggest that modulation of microglial priming is one of the molecular mechanisms by which PROG ameliorates ischemic brain injury under stressful conditions.
- | Journal: The Role of P2X7 Purinergic Receptors in the Renal Inflammation Associated with Angiotensin II-induced Hypertension. (Pubmed Central) - Feb 17, 2021
Increased IL-2, IL-6, TNFα, IL-1β, IL-18 and overexpression of NLRP3 inflammasome were induced by angiotensin II and suppressed by BBG. These studies suggest that P2X7 receptor-mediated renal vasoconstriction, tubulointerstitial inflammation and activation of NLRP3 inflammasome are associated with angiotensin II-induced hypertension.
- | Journal: Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling. (Pubmed Central) - Feb 17, 2021
The subsequent ALOX15-mediated oxidative stress was decreased by CEP treatment in vivo and in vitro, as evidenced by reduced ROS generation and MDA level, and increased SOD activity. Taken together, we demonstrate that CEP attenuates cerebral I/R injury probably by inhibiting microglia activation and NLRP3 inflammasome-induced inflammation and reducing oxidative stress via suppressing 12/15-LOX signaling.
- || Review, Journal: Targeting the pathways of regulated necrosis: a potential strategy for alleviation of cardio-cerebrovascular injury. (Pubmed Central) - Feb 17, 2021
Further study needs to focus on the crosstalk and interplay among different types of regulated necrosis. Pharmacological intervention of two or more types of regulated necrosis simultaneously may have advantages in clinic to treat injury-relevant diseases.