NLRP3 inhib 
Welcome,         Profile    Billing    Logout  
 7 Companies  6 Products   6 Products   29 Diseases   11 Trials   763 News 


«12...6162636465666768697071...134135»
  • ||||||||||  sirolimus / Generic mfg.
    Preclinical, Journal, IO biomarker:  Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. (Pubmed Central) -  Feb 26, 2021   
    Novel object recognition and the open field test results showed that oral administration of spermidine, spermine and rapamycin increased discrimination index, modified number, inner squares distance and times...In addition, western blot results (Bcl-2, Bax and Caspase-3, NLRP3, IL-18, IL-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including NGF, PSD95and PSD93 and BDNF in neurons of SAMP8 mice. These results indicated that the effect of spermidine and spermine on anti-aging is related with improving autophagy and mitochondrial function.
  • ||||||||||  Review, Journal:  Role of pyroptosis in liver diseases. (Pubmed Central) -  Feb 26, 2021   
    In our review, we have focused on the role of pyroptosis based on the molecular and pathophysiological mechanisms in the development of liver diseases. We have also highlighted targeting of pyroptosis for the therapeutic implications in liver diseases in the near future.
  • ||||||||||  Journal:  10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells. (Pubmed Central) -  Feb 26, 2021   
    p53 may mediate the anti-inflammation effect of 10-HDAA in two ways: first by directly deactivating the NLRP3 inflammatory pathway, second by indirectly promoting autophagy. Taken together, our results reveal a novel function of tumor suppressor p53 in the inhibition of neuroinflammation and provide a theoretical basis for broadening the application range of 10-HDAA and RJ.
  • ||||||||||  Journal:  NLRP3 inflammasome is involved in nerve recovery after sciatic nerve injury. (Pubmed Central) -  Feb 26, 2021   
    Moreover, NLRP3-KO mice exhibited an increased sciatic functional index (SFI), which was determined by footprint analysis, suggesting that NLRP3 deficiency is beneficial to sciatic nerve recovery after injury. Therefore, our results indicate that NLRP3 is involved in the recovery from sciatic nerve injury and mediates the production of inflammatory factors, such as IL-1β, after sciatic nerve injury.
  • ||||||||||  Preclinical, Journal:  Anti-colitic effects of Physalin B on dextran sodium sulfate-induced BALB/c mice by suppressing multiple inflammatory signaling pathways. (Pubmed Central) -  Feb 26, 2021   
    Therefore, our results indicate that NLRP3 is involved in the recovery from sciatic nerve injury and mediates the production of inflammatory factors, such as IL-1β, after sciatic nerve injury. This study preliminary confirmed the therapeutic effect of Physalin B on experimental acute UC mice and provided robust evidence support for the anti-inflammatory effect of Physalin B, suggesting that Physalin B might be a potential agent for the therapeutic efficacy on UC.
  • ||||||||||  Journal:  Juglone Suppresses LPS-induced Inflammatory Responses and NLRP3 Activation in Macrophages. (Pubmed Central) -  Feb 26, 2021   
    Juglone also inhibited the ATPase activities of NLRP3 in LPS/ATP-stimulated J774.1 macrophages. Our results suggested that juglone could inhibit inflammatory cytokine production and NLRP3 inflammasome activation in macrophages, and should be considered as a therapeutic strategy for inflammation-related diseases.
  • ||||||||||  Journal:  Selective inhibition of NLRP3 inflammasome by designed peptide originating from ASC. (Pubmed Central) -  Feb 26, 2021   
    The peptide effectively dampened neutrophil infiltration in the silica-induced peritonitis and when equipped with Antennapedia or Angiopep-2 motifs crossed the blood-brain barrier in a mouse model. Our study demonstrates that peptides represent an important tool for targeting multiprotein inflammatory complexes and can serve as the basis for the development of novel anti-inflammatory strategies for neurodegeneration.
  • ||||||||||  Review, Journal:  The anti-diabetic activity of licorice, a widely used Chinese herb. (Pubmed Central) -  Feb 26, 2021   
    Licorice and its metabolites have a great therapeutic potential for the treatment of diabetes mellitus. However, a better understanding of their pharmacological mechanisms is needed for evaluating its efficacy and safety.
  • ||||||||||  Journal, IO biomarker:  Cell-Penetrable Peptide-Conjugated FADD Induces Apoptosis and Regulates Inflammatory Signaling in Cancer Cells. (Pubmed Central) -  Feb 26, 2021   
    In cancer cells, TAT-FADD suppresses the canonical NLRP3 inflammasome priming and restricts the processing and secretion of proinflammatory IL-1β. Our results demonstrate that TAT-mediated intracellular delivery of FADD protein can potentially recite apoptosis signaling with simultaneous regulation of anti-apoptotic and proinflammatory NF-κB signaling activation in cancer cells.
  • ||||||||||  Journal:  D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway. (Pubmed Central) -  Feb 26, 2021   
    Finally d- carvone can successfully improve the cerebral I/R induced rats neuroinflammation, in the hippocampus and cortical areas of the brain finally reduces cerebral I/R induced injury. These results were hypothesized that d-carvone contributed to cerebral stroke associated with the TLR3, giving an excellent therapeutic approach for cerebral I/R brain injury.
  • ||||||||||  Journal:  Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors. (Pubmed Central) -  Feb 25, 2021   
    In this work, a series of novel chalcone derivatives bearing bispiperazine linker have been synthesized and in vitro anti-inflammatory, cytotoxic activity and anti-inflammatory mechanism have been screened. The results indicated that most bispiperazinochalcone derivatives displayed good inhibition of NO (IC  40 μM), and selectively inhibited the production of IL-1β via inhibiting NLRP3 inflammasome activation, as promising candidate compounds for the treatment of NLRP3 inflammasome-driven diseases.
  • ||||||||||  Kineret (anakinra) / SOBI, Arcalyst (rilonacept) / Regeneron, Kiniksa, Ilaris (canakinumab) / Novartis
    Journal:  Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease. (Pubmed Central) -  Feb 25, 2021   
    In conclusion, there is overwhelming evidence linking the NLRP3 inflammasome and the IL-1 cytokines with the pathogenesis of cardiovascular diseases. The future will likely include targeted inhibitors to block the IL-1 isoforms, and possibly oral NLRP3 inflammasome inhibitors, across a wide spectrum of cardiovascular diseases.
  • ||||||||||  Review, Journal:  The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation. (Pubmed Central) -  Feb 25, 2021   
    Lipid perturbation and cholesterol trafficking to the ER activate the NLRP3 inflammasome. These findings emphasize the importance of the ER in initiation and regulation of the NLRP3 inflammasome.
  • ||||||||||  Review, Journal:  Crosstalk between ER stress, NLRP3 inflammasome, and inflammation. (Pubmed Central) -  Feb 25, 2021   
    • ERS can activate the NLRP3 inflammasome to induce inflammatory responses via oxidative stress, calcium homeostasis, and NF-κB activation. • The interactions between ERS and NLRP3 inflammasome are associated with inflammation, which represent a potential therapeutic opportunity of inflammatory diseases.
  • ||||||||||  Journal:  Mogrol, an aglycone of mogrosides, attenuates ulcerative colitis by promoting AMPK activation. (Pubmed Central) -  Feb 25, 2021   
    In sum, our study indicated that BFG may reduce inflammation, treat co-existing anxiety after myocardial infarction through inhibition of CXCR4/NF-κB/GSDMD signalling. Mogrol exerts protective effects in experimental UC and inhibits production of inflammatory mediators through activation of AMPK-mediated signaling pathways.
  • ||||||||||  Preclinical, Journal:  Palbinone alleviates diabetic retinopathy in STZ-induced rats by inhibiting NLRP3 inflammatory activity. (Pubmed Central) -  Feb 24, 2021   
    PB administration exerted efficient antioxidant activities, Nrf2 pathway activation, and inhibition of NLRP3 inflammasome. This current investigation concluded that PB considerably reduced the retinal inflammation and oxidative stress stimulated via high glucose, and also activated the antioxidative Nrf2 pathway and inhibited the NLRP3 inflammasome formation in rats.
  • ||||||||||  Journal, Adverse events:  Chronic inflammation, Adverse Outcome Pathways, and risk assessment: A diagrammatic exposition. (Pubmed Central) -  Feb 24, 2021   
    Similar considerations hold for other AOPs that are rate-limited by processes with activation thresholds. The risk analysis implications of AOPs with threshold or threshold-like pharmacodynamic responses include the need to consider how cumulative dose per unit time is distributed over time and the possibility that safe, or virtually safe, exposure concentrations can be defined for such processes.
  • ||||||||||  Review, Journal:  Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors? (Pubmed Central) -  Feb 24, 2021   
    A recent progress of microRNA research was described as regulatory circuits of initiation and propagation of inflammaging. Finally, we briefly introduced our preliminary results obtained from the mouse models, in which Foxo1 and Foxo3 genes were conditionally knocked out in the myeloid cell lineage.
  • ||||||||||  Preclinical, Journal:  Oxidative stress activates the TRPM2-Ca-NLRP3 axis to promote PM-induced lung injury of mice. (Pubmed Central) -  Feb 24, 2021   
    In vitro experiments with A549 cells and primary type II alveolar epithelium cells (SD cells) showed that ROS induced by PM exposure could mediate intracellular Ca mobilization via TRPM2, with a subsequent activation of NLRP3. In our present study, we demonstrated the contribution of the ROS-TRPM2-Ca-NLRP3 pathway in PM-induced acute lung injury and offered a potential therapeutical target valid for related pathology.
  • ||||||||||  Preclinical, Journal:  Differential Effect of Extracellular Acidic Environment on IL-1β Released from Human and Mouse Phagocytes. (Pubmed Central) -  Feb 24, 2021   
    We show that IL-1β secretion in mouse macrophages is reversible upon restoration of physiological pH. pH sensitivity of NLRP3, NLRC4 and AIM2 inflammasomes appeared to be conferred by the processes upstream of the apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and most likely contributed by the cell background rather than species-specific amino acid sequences of the sensor proteins.
  • ||||||||||  cisplatin / Generic mfg.
    Journal:  Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin. (Pubmed Central) -  Feb 23, 2021   
    Using DDP-resistant NSCLC cells, mouse xenograft studies verified the oncogenic function of XIST and its ability to inhibit programmed cell death, thereby mediating DDP chemoresistance. These findings suggest that XIST expression may serve as a novel biomarker to predict DDP treatment efficacy, and may help in the design of new therapies to circumvent DDP chemoresistance in NSCLC and other tumor types.
  • ||||||||||  Preclinical, Journal:  Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats. (Pubmed Central) -  Feb 23, 2021   
    The current work for the first time reveals that exogenous HS attenuates hyperglycemia-induced fibrosis of the diaphragm muscle and strengthens diaphragmatic biomechanical properties in diabetes mellitus, and the mechanism may involve the alleviation of collagen deposition by suppression of the nucleotide-binding oligomerization domain-like receptor protein (NLRP) 3 inflammasome-mediated inflammatory reaction. Therefore, HS supplementation could be used as an efficient targeted therapy against the NLRP3 inflammasome in the diabetic diaphragm.
  • ||||||||||  Review, Journal, IO biomarker:  Innate Immune Sensing of Influenza A Virus. (Pubmed Central) -  Feb 23, 2021   
    In this review, we discuss the role of PRRs such as Toll-like receptors (TLRs), Retinoic acid-inducible gene I (RIG-I), NOD-, LRR-, pyrin domain-containing protein 3 (NLRP3), and Z-DNA binding protein 1 (ZBP1) in sensing and restricting influenza viral infection. Further, we also discuss the mechanisms influenza virus utilizes, especially the role of viral non-structure proteins NS1, PB1-F2, and PA-X, to evade the host innate immune responses.
  • ||||||||||  Journal:  TREM-1-targeting LP17 attenuates cerebral ischemia-induced neuronal injury by inhibiting oxidative stress and pyroptosis. (Pubmed Central) -  Feb 23, 2021   
    This was achieved through the inhibition of the levels of NLRP3, caspase-1, ASC (an apoptosis-associated speck-like protein containing a CARD) and gasdermin D. These results confirmed that inhibiting TREM-1 protects against ischemia-induced neuronal damage and alleviates microglial mediated neuro-inflammation by reducing oxidative stress and pyroptosis. Therefore, blocking TREM-1 expression provides an effective intervention for improving ischemic stroke.
  • ||||||||||  Review, Journal:  The Role of Protein Tyrosine Phosphatases in Inflammasome Activation. (Pubmed Central) -  Feb 23, 2021   
    Particularly, the action of specific tyrosine kinases and phosphatases are of critical importance for the regulation of inflammasome assembly and activity. By summarizing the currently available literature on the interaction of tyrosine phosphatases with inflammasome components we here provide an overview how tyrosine phosphatases affect the activation status of inflammasomes.