NLRP3 inhib 
Welcome,         Profile    Billing    Logout  
 7 Companies  6 Products   6 Products   29 Diseases   11 Trials   763 News 


«12...5253545556575859606162...134135»
  • ||||||||||  Review, Journal:  Inflammasome as an Effective Platform for Fibrosis Therapy. (Pubmed Central) -  Apr 29, 2021   
    Recently, researches on the function of inflammasome have attracted extensive attention, and data derived from these researches have increased our understanding of the effects and regulation of inflammasome during fibrosis. In this review, we emphasize the growing evidence for both indirect and direct effects of inflammasomes in triggering fibrosis as well as potential novel targets for antifibrotic therapies.
  • ||||||||||  allopurinol / Generic mfg.
    Review, Journal:  Beyond urate lowering: Analgesic and anti-inflammatory properties of allopurinol. (Pubmed Central) -  Apr 28, 2021   
    Also, allopurinol blocks the stimulating effects of thioredoxin-interacting protein and interacts directly with the redox-active domain of thioredoxin as a negative regulator, decreasing NLRP3 activation. The importance of allopurinol's analgesic and anti-inflammatory properties requires further study and the implications to patient care better understood.
  • ||||||||||  Journal:  EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells. (Pubmed Central) -  Apr 28, 2021   
    Mechanistically, EphA2 binds to NLRP3 and induces its phosphorylation at Tyr132, thereby interfering with ASC speck formation and blocking the activation of the NLRP3-inflammasome. These data demonstrate that reovirus employs EphA2 to suppress inflammasome activation in AECs and that EphA2 deficiency causes a pathological exacerbation of asthma in an ova-induced asthma model.
  • ||||||||||  Clinical, Journal:  Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. (Pubmed Central) -  Apr 28, 2021   
    These data suggest that palmitate may be a critical nutritional signal from the HFD that is directly involved in hippocampal and amygdalar inflammation. Interestingly, microglial activation markers were increased in response to HFD or palmitate in an age-independent manner, suggesting that HFD sensitivity of microglia, under these experimental conditions, is not the sole mediator of the exaggerated inflammatory response observed in whole tissue extracts from aged HFD-fed rats.
  • ||||||||||  metformin / Generic mfg.
    Journal:  Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway. (Pubmed Central) -  Apr 28, 2021   
    Finally, in vitro studies revealed that the NLRP3 activator nigericin abolished the anti-inflammatory effects of metformin in NRVMs, but it had little effect on AMPK phosphorylation. Collectively, our study confirmed that metformin exerts cardioprotective effects by regulating myocardial I/R injury-induced inflammatory response, which was largely dependent on the enhancement of the AMPK pathway, thereby suppressing NLRP3 inflammasome activation.
  • ||||||||||  Preclinical, Journal:  Protective effect and immune mechanism of berberine on cerebral ischemia/reperfusion injury in rats (Pubmed Central) -  Apr 28, 2021   
    Compared with the model group, the degree of neurological deficit and the rate of cerebral infarction were increased in the BBR-H, BBR-M and BBR-L groups (P＜0.05), and the levels of serum NO, TNF-α, IFN-β, IL-6, NF-κB p65, NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1 in brain tissue were increased (P＜0.05), while the activities of SOD, GSH-Px and the levels of CD4, CD8 and CD4/CD8 in serum were decreased (P＜0.05). Berberine may reduce oxidative stress, inhibit inflammation, enhance immune function, and reduce cerebral ischemia/reperfusion injury in rats, which may be related to the inhibition of NF-κB-NLRP3 signaling.
  • ||||||||||  Preclinical, Journal:  Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet. (Pubmed Central) -  Apr 27, 2021   
    In conclusion, these data demonstrate that KD decreased the reactive astrocytes and activated the microglia in the corpus callosum, and that KD inhibited the HADC3 and NLRP3 inflammasome signaling pathway in CPZ-treated mice. This suggests that the inhibition of the HADC3 and NLRP3 signaling pathway may be a novel mechanism by which KD exerts its protective actions for the treatment of demyelinating diseases.
  • ||||||||||  Journal:  Vascular Protection by Exercise in Obesity: Inflammasome-associated Mechanisms. (Pubmed Central) -  Apr 27, 2021   
    Our findings suggest that voluntary running ameriolates mechanisms associated with vascular dysfunction by suppressing NLRP3 inflammasome, improving NO production, and reducing oxidative stress. Such benefits of physical activity may be, at least in part, associated with APN-AdipoR1 signaling and tight junction protein expression.
  • ||||||||||  dexmedetomidine / Generic mfg.
    Journal:  Dexmedetomidine alleviates LPS‑induced acute lung injury via regulation of the p38/HO‑1 pathway. (Pubmed Central) -  Apr 27, 2021   
    In addition, pharmacological inhibition of p38 using the inhibitor SB20380 further enhanced the effect of Dex. Collectively, these preliminarily results identified the effects of Dex intervention on the pathogenesis of ALI via the regulation of p38/HO‑1 signaling pathways, which impacted the inflammatory effects, thus providing a theoretical basis and novel evidence for the development of new targets for clinical treatment of ALI.
  • ||||||||||  Review, Journal:  NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword. (Pubmed Central) -  Apr 27, 2021   
    Conversely, other reports have indicated a protective role in certain cancers. In this review, we summarize these contradictory roles of NLRP3 inflammasome in cancer, shed the light on oncogenic signaling leading to NLRP3 activation and IL-1β production and outline the current knowledge on therapeutic approaches.
  • ||||||||||  Journal:  Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF‑1α and apoptosis. (Pubmed Central) -  Apr 27, 2021   
    The expression levels of hypoxia‑inducible factor 1‑α and NLRP3 increased after oxygen and glucose deprivation (OGD), and reduced after treatment with OGD and TMP (all P<0.05). It was concluded that TMP can reduce renal injury and improve renal function in RIRI rats, and its mechanism may be related to the reduction of NLRP3 expression in renal tissues.
  • ||||||||||  Clinical, Journal:  Impact of contact lens wear on NLRP3 gene expression: Implications for ocular frailty in middle-aged adults. (Pubmed Central) -  Apr 27, 2021   
    These data suggest that long-term contact lens wear could trigger an inflammatory response in middle age orchestrated by NLRP3 inflammasome and modulated by CD73 and MUC16 proteins. Further studies are needed to confirm our gene expression findings at the protein level as well as to investigate the potential role of long-term CL wear in the onset of ocular frailty.
  • ||||||||||  Review, Journal:  Flavonoids against the SARS-CoV-2 induced inflammatory storm. (Pubmed Central) -  Apr 27, 2021   
    The identification of agents, including naturally occurring substances such as flavonoids, represents great approach potentially utilizable in the management of COVID-19. Although not clinically investigated yet, the applicability of flavonoids against COVID-19 could be a promising strategy due to a broad spectrum of their biological activities.
  • ||||||||||  metformin / Generic mfg.
    Clinical, Journal:  Metformin upregulates mitophagy in patients with T2DM: A randomized placebo-controlled study. (Pubmed Central) -  Apr 24, 2021   
    Our observations underscore that metformin upregulates mitophagy and subsequently ameliorates the altered mitochondrial morphology and function, independent of its glucose-lowering effect. Further, restoration of normal mitochondrial phenotype may improve cellular function, including β-cells, which may prevent further worsening of hyperglycaemia in patients with T2DM.
  • ||||||||||  Journal:  BAFF-driven NLRP3 inflammasome activation in B cells. (Pubmed Central) -  Apr 24, 2021   
    B-cell receptor (BCR) stimulation on the Lyn signaling pathway inhibited BAFF-induced Src activities and attenuated BAFF-induced NLRP3 inflammasome activation. These findings reveal an additional function of BAFF in B-cell homeostasis that is associated with BCR activities.
  • ||||||||||  Journal:  Eva1a inhibits NLRP3 activation to reduce liver ischemia-reperfusion injury via inducing autophagy in kupffer cells. (Pubmed Central) -  Apr 24, 2021   
    We also found that the addition of siATG7, siATG5 and siATG12 would reverse the IR autophagy of liver induced by overexpression of Eva1a, but inhibition of the Beclin1-Vps34 pathway did not significantly reverse the effect of overexpression of Eva1a.These prove that Eva1a and ATG16L1 may work together in the liver IR model to actively induce the formation of autophagosomes and be independent from the beclin1-vps34-induced autophagy pathway to limit the excessive activation of IR inflammation. Our study provides brand new insights into the mechanism of liver macrophages in the progression of inflammation in the context of liver ischemia-reperfusion injury.
  • ||||||||||  Clinical, Review, Journal:  P2X Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches. (Pubmed Central) -  Apr 24, 2021   
    Finding potent and selective P2X receptor inhibitors which are also CNS penetrable and display acceptable pharmacokinetics (PK) has presented challenges for both academic researchers and pharmaceutical companies. In this review, we discuss the role of P2X receptor function in neurodegenerative diseases, the pharmacological inhibition of the receptor, and PET radiopharmaceuticals which permit non-invasive monitoring of the P2X receptor contribution to neuroinflammation associated with neurodegeneration.
  • ||||||||||  Review, Journal:  Lymphomagenesis predictors and related pathogenesis. (Pubmed Central) -  Apr 24, 2021   
    The knowledge of the pathophysiology allows the discrimination of markers that participate in the initial stages. Considering that the lymphoproliferation process includes the progression of lymphoma towards more aggressive subtypes, it is essential to recognise biomarkers associated with a worse prognosis.
  • ||||||||||  [VIRTUAL] Novel Compound Heterozygous variants in IKBKB associated with Autoimmunity and Autoinflammation () -  Apr 23, 2021 - Abstract #CIS2021CIS_214;    
    Though the specific consequences of these individual IKBKB variants remains unknown, the phenotype could suggest dysfunctional signaling of the canonical NF-κB pathway affecting its interaction with NLRP3, TNFα, and IL-1β. These findings suggest that a IKBKB mutations should be considered in the setting of disease manifesting with features of autoinflammation or autoimmune dysregulation.
  • ||||||||||  [VIRTUAL] A pediatric case of trisomy 8 mosaicism with periodic fevers () -  Apr 23, 2021 - Abstract #CIS2021CIS_122;    
    While our patient has not shown clinical signs of BD or MDS, prior Japanese reports of T8S were exclusively in adults. Periodic fevers could be the initial insult, prior to developing clinical signs of T8S.
  • ||||||||||  glibenclamide / Generic mfg.
    Journal:  Alterations in Plasma Membrane Ion Channel Structures Stimulate NLRP3 Inflammasomes Activation in APOL1 Risk Milieu. (Pubmed Central) -  Apr 23, 2021   
    Since glyburide (a specific inhibitor of K efflux channels) inhibited the transcription of NLRP3, IL-1β, and IL-18, the role of K efflux in the activation of inflammasomes in APOL1 risk milieu was implicated...Analysis of multiple membrane (lipid bilayer) models of interaction with the peripheral protein, integral membrane protein, and multimer protein revealed that for an APOL1 multimer model, APOL1G0 is not energetically favorable while the APOL1G1 and APOL1G2 moieties favor the insertion of multiple ion channels into the lipid bilayer. We conclude that altered pore configurations carry the potential to facilitate K ion transport in APOL1 risk milieu.
  • ||||||||||  Biomarker, Journal:  Inflammasome in ALS Skeletal Muscle: NLRP3 as a Potential Biomarker. (Pubmed Central) -  Apr 23, 2021   
    In conclusion, NLRP3 could be involved in skeletal muscle pathogenesis of ALS, either through inflammasome or independently, and may play a dual role during disease progression. NLRP3 gene expression levels could be used as a biomarker to improve diagnosis and prognosis in skeletal muscle from animal models and also to support diagnosis in clinical practice with the blood of ALS patients.
  • ||||||||||  Journal:  BPTES inhibits anthrax lethal toxin-induced inflammatory response. (Pubmed Central) -  Apr 22, 2021   
    Furthermore, BPTES could prevent disease progression in mice challenged with the anthrax lethal toxin. Taken together, our studies indicate that BPTES can be a promising pharmacological inhibitor to treat anthrax lethal toxin-related inflammatory diseases.
  • ||||||||||  Journal:  Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca/NF-κB pathway. (Pubmed Central) -  Apr 22, 2021   
    Thus, we propose that activation of NLRP3 inflammasome in nucleus pulposus cells mediated by Piezo1 through the Ca/NF-κB pathway is a novel pathogenesis for the progress of intervertebral disc degeneration. As per our knowledge this is the first study which has provided evidence linking Piezo1-mediated inflammation in nucleus pulposus cells with the production of NLRP3 inflammasome.