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- | tris DBA palladium (Tris DBA) / Emory University School of Medicine
Journal: Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1- and SIRT3-mediated autophagy induction. (Pubmed Central) - May 15, 2021
In conclusion, Tris DBA effectively ameliorated the mouse IgAN model and targeted signalling pathways downstream of ICs-mediated interaction, which is a novel immunomodulatory strategy. Further development of Tris DBA as a therapeutic candidate for IgAN is warranted.
- | Journal: MiR-223-3p inhibits rTp17-induced inflammasome activation and pyroptosis by targeting NLRP3. (Pubmed Central) - May 15, 2021
Most importantly, a notable negative correlation was observed between miR-223-3p and NLRP3, caspase-1, and IL-1β, respectively, in the serum of syphilis patients and healthy controls. Taken together, our results reveal that miR-223-3p targets NLRP3 to suppress inflammasome activation and pyroptosis in T pallidum-infected endothelial cells, implying that miR-223-3p could be a potential target for syphilis patients.
- || Ilaris (canakinumab) / Novartis
Clinical, Journal: Case of cryopyrin-associated periodic syndrome who recovered from growth delay by treatment with canakinumab. (Pubmed Central) - May 15, 2021
Taken together, our results reveal that miR-223-3p targets NLRP3 to suppress inflammasome activation and pyroptosis in T pallidum-infected endothelial cells, implying that miR-223-3p could be a potential target for syphilis patients. No abstract available
- | Journal: 3-MCPD and glycidol coexposure induces systemic toxicity and synergistic nephrotoxicity via NLRP3 inflammasome activation, necroptosis, and autophagic cell death. (Pubmed Central) - May 15, 2021
Moreover, the NGS results revealed the genes changes associated with nephrotoxicity, inflammation and with the broad toxicity effects induced by 3-MCPD or glycidol alone or in combination, which were consistent with the results of in vitro and in vivo models. In summary, we report for the first time of the comprehensive toxicity effects and the mechanisms caused by 3-MCPD and glycidol coexposure.
- | Journal: Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas. (Pubmed Central) - May 15, 2021
Moreover, NLRP3 inflammasome seemed "exhausted" in TB patients compared to CNT, indicating a more efficient activation of inflammasome in resistant individuals. These findings suggest that inflammasome genetics as well as virulence-dependent level of inflammasome activation contribute to the onset of a susceptible/resistant profile among Mtb-exposed individuals.
- | Journal: Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet. (Pubmed Central) - May 15, 2021
Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.
- | Journal: Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis. (Pubmed Central) - May 15, 2021
DHM improves CCl-induced CLI and regulates the pyroptosis pathway in hepatocytes. DHM may be a potential therapeutic agent for CLI.
- | Journal: Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation. (Pubmed Central) - May 15, 2021
Mutation of pro-IL-1α residues predicted to be involved in CL binding resulted in reduced pro-IL-1α-CL interaction, a reduction in NLRP3 inflammasome activity, and increased mitophagy. These data identify a function for pro-IL-1α in regulating mitophagy and the potency of NLRP3 inflammasome activation.
- | Journal: Regulation of Autophagy Orchestrates Pyroptotic Cell Death in Molybdenum Disulfide Quantum Dot-Induced Microglial Toxicity. (Pubmed Central) - May 15, 2021
However, ROS scavengers could diminish the MoS QD-mediated NLRP3 inflammasome activation and pyroptotic cell death in microglia. Overall, our findings identified pyroptosis as a cellular response to MoS QD exposure in microglial cells, affording novel insights into the neurotoxicity of MoS QDs and facilitating the rational design and application of functional MoS QDs in neuroscience.
- | Preclinical, Journal, IO biomarker: Lychee (Litchi chinensis Sonn.) Pulp Phenolics Activate the Short-Chain Fatty Acid-Free Fatty Acid Receptor Anti-inflammatory Pathway by Regulating Microbiota and Mitigate Intestinal Barrier Damage in Dextran Sulfate Sodium-Induced Colitis in Mice. (Pubmed Central) - May 15, 2021
Consistently, the abundances of probiotic taxa and microbiota (Akkermansia, Lactobacillus, Coprococcus, and Bacteroides uniformis) associated with SCFA synthesis were elevated, whereas harmful bacteria (Enterococcus and Aggregatibacter) were suppressed. These data indicate that LPP ameliorates gut barrier damage, activates the microbiota-SCFA-FFAR signaling cascade, and suppresses the TLR4/NLRP3-NF-κB pathway, and therefore, LPP supplementation could be a promising way to protect the intestinal tract.
- | pioglitazone / Generic mfg.
Preclinical, Journal: Scutellarin protects against diabetic cardiomyopathy via inhibiting oxidative stress and inflammatory response in mice. (Pubmed Central) - May 15, 2021
These data indicate that LPP ameliorates gut barrier damage, activates the microbiota-SCFA-FFAR signaling cascade, and suppresses the TLR4/NLRP3-NF-κB pathway, and therefore, LPP supplementation could be a promising way to protect the intestinal tract. Scu protects against DCM in STZ-induced diabetic mice by inhibiting oxidative stress and inflammatory responses and might be a potential therapeutic agent to treat DCM.
- || Biomarker, Review, Journal: NLRP3 Inflammasome and Its Critical Role in Gynecological Disorders and Obstetrical Complications. (Pubmed Central) - May 15, 2021
The well-established, classic role of NLRP3 inflammasome has been implicated in many disorders. In this review, we discuss the current understanding of NLRP3 inflammasome and its critical role in gynecological disorders and obstetrical complications.
- | Journal: A comparative analysis of NLRP3-related inflammatory mediators in synovial fluid in temporomandibular joint osteoarthritis and internal derangement. (Pubmed Central) - May 15, 2021
The NLRP3 inflammasome signaling pathway may be involved in condylar degeneration. HA could reduce some inflammatory molecules to alleviate inflammation.
- | Journal: GLP-1 alleviates NLRP3 inflammasome-dependent inflammation in perivascular adipose tissue by inhibiting the NF-κB signalling pathway. (Pubmed Central) - May 15, 2021
HA could reduce some inflammatory molecules to alleviate inflammation. GLP-1 may alleviate NLRP3 inflammasome-dependent inflammation in PVAT by inhibiting NF-κB signalling.
- | Journal: ClyA enhances LPS-induced IL-1β secretion in human macrophages through TLR4 and NLRP3 signaling. (Pubmed Central) - May 15, 2021
In conclusion, this study indicated that ClyA enhances the production of IL-1β induced by LPS in human macrophages. The proliferation of CT26 cells was inhibited and the apoptosis was increased when being treated with the macrophage-conditioned media, which provides a feasible treatment for colon tumor.
- | Journal: Cerebrospinal fluid cells immune landscape in multiple sclerosis. (Pubmed Central) - May 15, 2021
Our study identified the change in the CNS immune microenvironment of MS cases by analysis of the in silico data using CIBERSORT. Our data may assist in providing directions for further research as to the molecular mechanisms of MS and provide future potential therapeutic targets in treatment.
- | Journal: Implication of the NLRP3 Inflammasome in Bovine Age-Related Sarcopenia. (Pubmed Central) - May 15, 2021
Moreover, we found a statistically significant age-related increase of pro-inflammatory cytokines such as interleukin-1β and interleukin-18 suggesting the activation of NLRP3 inflammasome. Taken together, our data suggest that NLRP3 inflammasome components may be normally expressed in skeletal muscle, but its priming and activation during aging may contribute to enhance a pro-inflammatory environment altering normal muscular anabolism and metabolism.
- | Journal: Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells. (Pubmed Central) - May 15, 2021
Nrf2-siRNA or HO-1-siRNA could block the autophagy activation enhanced by lycopene in KCs, resulting in the activation of the NLRP3 inflammasome and aggravated hepatic IR injury. Our findings demonstrated that lycopene promoted Nrf2/HO-1 pathway activation and further suppressed the NLRP3 inflammasome via enhancing KC autophagy, which alleviated hepatic IR injury.
- | Preclinical, Journal: A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation. (Pubmed Central) - May 14, 2021
The dysregulation of CYPs/COX-2 metabolized ARA contributes to the uncontrolled inflammatory response in ALI. The dual COX-2 and sEH inhibitor PTUPB exerts anti-inflammatory effects in treating ALI by inhibiting the NLRP3 inflammasome activation.
- | Journal: Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome. (Pubmed Central) - May 14, 2021
In addition, the tlr6 knockdown rats suffering from hyperuricemia showed the lower level of IL-1β and an ameliorative cardiac function. These findings suggest that sUA activates NLRP3 inflammasome in cardiomyocytes and they may provide one therapeutic strategy for myocardial damage induced by sUA.
- | Journal: Acrylamide induces NLRP3 inflammasome activation via oxidative stress- and endoplasmic reticulum stress-mediated MAPK pathway in HepG2 cells. (Pubmed Central) - May 14, 2021
HepG2 cells pretreated with MAPK selective inhibitors led to the inhibition on the activation of NLRP3 inflammasome. Overall, we consider that AA induces the activation of NLRP3 inflammasome through the OS- and ERS-mediated MAPK signaling pathway in HepG2 cells.
- || Review, Journal: NLRP3 inflammasome in endothelial dysfunction. (Pubmed Central) - May 14, 2021
Furthermore, we highlighted the contribution of noncoding RNAs to NLRP3 inflammasome activation-associated endothelial dysfunction, and outlined potential clinical drugs targeting NLRP3 inflammasome involved in endothelial dysfunction. Collectively, this summary provides recent developments and perspectives on how NLRP3 inflammasome interferes with endothelial dysfunction and the potential research value of NLRP3 inflammasome as a potential mediator of endothelial dysfunction.
- | Preclinical, Journal: The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging. (Pubmed Central) - May 14, 2021
Fibrotic, lipid, and oxidative reduction in liver tissues of mice was more pronounced in those old KO NLRP3 mice than in the younger ones, despite their greater liver damage. These results suggest that absence of the NLRP3 inflammasome attenuates age-related liver fibrotic pathology in mice, suggesting that pharmacological targeting may be beneficial.
- | Journal: NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer's disease. (Pubmed Central) - May 14, 2021
Our results identified microglial training as an important modifier of neuropathology in SAD and demonstrated that activation of NLRP3 inflammasome contributed to the pathologies and microglial training in SAD. Therefore, NLRP3 could be a potential therapeutic target for SAD treatment.
- | Journal: Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome. (Pubmed Central) - May 14, 2021
In vitro, the results of reactive oxygen species (ROS) detection, JC‑1 staining, western blotting and TUNEL assays showed that Sal B treatment significantly inhibited intracellular ROS production, increased the mitochondrial membrane potential, regulated the expression of mitophagy‑related proteins, inhibited the activation of the NLRP3 inflammasome and inhibited apoptosis in H9C2 cells. In conclusion, these findings indicated that Sal B exerted protective effects against myocardial ischemic injury by promoting mitophagy and maintaining mitochondrial function.
- | chloroquine phosphate / Generic mfg., hydroxychloroquine / Generic mfg.
Journal: Chloroquine/hydroxychloroquine: an inflammasome inhibitor in severe COVID-19? (Pubmed Central) - May 14, 2021
We surveyed the potential inhibitory effect of chloroquine and hydroxychloroquine on inflammasome. Studies indicate that one of the possible anti-inflammatory mechanisms of chloroquine and hydroxychloroquine is inhibition of the activity of NLRP3 inflammasome.
- | doxycycline / Generic mfg.
Journal: Reticulocalbin 3 deficiency in alveolar epithelium attenuated LPS-induced ALI via NFκB signaling. (Pubmed Central) - May 14, 2021
We examined the role of Rcn3 in the alveolar inflammatory response by using mice with a selective deletion of Rcn3 in alveolar epithelial cells upon doxycycline administration...The studies conducted in MLE12 cells consistently showed that Rcn3 knockdown blunted the activations of NFκB signaling and NLRP3-dependent inflammasome upon LPS exposure. Collectively, these findings suggest a novel role for Rcn3 in regulating the alveolar inflammatory response to pulmonary infection via the NFκB/NLRP3/inflammasome axis and shed additional light on the mechanism of ARDS/ALI.
- || Clinical, Review, Journal: Inflammasome Activation-Induced Hypercoagulopathy: Impact on Cardiovascular Dysfunction Triggered in COVID-19 Patients. (Pubmed Central) - May 14, 2021
The interplay between inflammasome activation and hypercoagulopathy in COVID-19 patients is an emerging area to be further addressed. Targeted therapeutics to suppress inflammasome activation may have a positive effect on the reduction of hyperinflammation-induced hypercoagulopathy and cardiovascular disorders occurring as COVID-19 complications.
- | Journal: Inhibition of Long Non-Coding RNA KCNQ1OT1 Attenuates Neuroinflammation and Neuronal Apoptosis Through Regulating NLRP3 Expression via Sponging miR-30e-3p. (Pubmed Central) - May 14, 2021
Furthermore, KCNQ1OT1 could positively regulate the expression of NLRP3 via repressing miR-30e-3p. Inhibition of KCNQ1OT1 could reduce neuroinflammation and neuronal apoptosis induced by LPS in HMC3 cells by regulating miR-30e-3p/NLRP3 pathway, suggesting that KCNQ1OT1 and miR-30e-3p could serve as promising therapeutic targets for treating neurological diseases.
- | Journal: Lycopus lucidus Turcz Exerts Neuroprotective Effects Against HO-Induced Neuroinflammation by Inhibiting NLRP3 Inflammasome Activation in Cortical Neurons. (Pubmed Central) - May 14, 2021
We demonstrated that LLT enhances axonal elongation and synaptic connectivity upon HO-induced neuronal injury in rat primary cortical neurons. It was first demonstrated in vitro that LLT suppresses NLRP3 inflammasome activation, attenuates inflammation and apoptosis, and consequently promotes neuroprotection and the stimulation of neuron repair, suggesting that it is a promising therapeutic for neurological diseases.
- | Zanosar (streptozocin) / Teva
Journal: Bletilla striata Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome. (Pubmed Central) - May 14, 2021
DM mouse models were induced by high fat-diet feeding combined with low-dose streptozocin injection...Furthermore, treatment with IL-1β almost completely suppressed the beneficial effects of BSP on the NLRP3 inflammasome, IL-1β secretion, and insulin sensitivity in HG-treated BMDMs-CMECs. BSP promotes DFU healing through inhibition of the HG-activated NLRP3 inflammasome.
- [VIRTUAL] αA-Crystallin modulates neuroinflammation in retina via stress specific inflammatory pathways () - May 13, 2021 - Abstract #ARVO2021ARVO_3881;
The data gathered in this study demonstrate the central regulatory role of αA-crystallin and its modulation by phosphorylation on T148 in retinal MGC. This study demonstrates that αA-crystallin can dampen sustained expression of pro-inflammatory cytokines through modulation of multiple key inflammatory pathways, therefore, suggesting its potential as therapeutic target for modulation of chronic neuroinflammation.
- [VIRTUAL] Arginase Isoforms and Diabetic Retinopathy in the db/db Mouse () - May 13, 2021 - Abstract #ARVO2021ARVO_2924;
These results are consistent with our hypothesis that A1 and A2 are linked to the pathophysiology of DR in the db/db mouse, as elevated A1 and A2 correlate with increased markers of hypoxia, inflammation, neurodegeneration in db/db mouse retina compare to controls. Further investigation is needed to elucidate the mechanistic effects of A1/A2 on the pathogenesis of db/db DR.
- [VIRTUAL] RIP3-Mediated Necroptosis Triggers the Activation of NLRP3 Inflammasome in Dry Eye () - May 13, 2021 - Abstract #ARVO2021ARVO_2564;
Further investigation is needed to elucidate the mechanistic effects of A1/A2 on the pathogenesis of db/db DR. RIP3-mediated necroptosis in corneal epithelium activates the NLRP3 inflammatory pathway and promotes the development of DED.
- [VIRTUAL] Activation of NFkB and NLRP3 Inflammasome in the corneal epithelium following short-term desiccating stress () - May 13, 2021 - Abstract #ARVO2021ARVO_2550;
These findings indicate that two key innate inflammatory pathways (NFkB and NLRP3 inflammasome) are activated following short term desiccating stress. Cytokines stimulated by these pathways, IL-12 and IL-18, are required for full expression of the dry eye associated cytokine IFN-γ by T and natural killer cells.
- [VIRTUAL] Tranilast protects against endoplasmic reticulum stress-induced cell death in retinal pigment epithelial cells: Implications for age-related retinal diseases () - May 13, 2021 - Abstract #ARVO2021ARVO_1796;
Our results show that ER-stress causes mitochondrial damage and RPE barrier dysregulation. The beneficial effects of tranilast on RPE function and cell viability under stress may represent a new interventional therapy to ameliorate early pathological pathways that occur in age-related retinal diseases and vision loss.
- [VIRTUAL] Airborne particulate matter topical exposure triggers ocular hypertension () - May 13, 2021 - Abstract #ARVO2021ARVO_1510;
This study provides novel evidence that PM2.5 has a direct toxic effect on intraocular tissues and may contribute to the initiation and development of ocular hypertension. This occurs as a result of increased oxidative stress and the subsequent induction of the NLRP3 inflammasome mediated pyroptosis signaling pathway in trabecular meshwork cells.
- [VIRTUAL] Resveratrol Attenuates Priming of the NLRP3 Inflammasome by Hydrogen Peroxide () - May 13, 2021 - Abstract #ARVO2021ARVO_357;
These effects were blocked by resveratrol. Further studies are needed to determine if other oxidants prime the RPE cell inflammasome, and the mechanism by which resveratrol exerts its inhibitory effect.
- || Review, Journal: IMMUNOREGULATION OF THE DECIDUALIZATION PROGRAM: FOCUS ON THE ENDOPLASMIC RETICULUM STRESS. (Pubmed Central) - May 13, 2021
However, the sterile inflammatory response should be later controlled in favour of a tolerogenic microenvironment to sustain pregnancy. In accordance, alterations of the ER stress and UPR processes can be reflected in recurrent implantation failures (RIF), recurrent pregnancy loss (RPL) or complications associated with deficient placentation, such as preeclampsia (PE).
- | Journal: Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [C]MCC950 in healthy animals. (Pubmed Central) - May 13, 2021
Despite preclinical efficacy in neurodegeneration studies, preclinical positron emission tomography (PET) imaging studies in mouse, rat and rhesus monkey revealed poor brain uptake of low molar activity [C]MCC950 and rapid washout. In silico prediction tools suggest efflux transporter liabilities for MCC950 at microdoses, and this information should be taken into account when developing next generation NLRP3 inhibitors and/or PET radiotracers.
- | Journal: Soy isoflavones ameliorate experimental colitis by targeting ERα/NLRP3 inflammasome pathways. (Pubmed Central) - May 13, 2021
Furthermore, ERα blockade ameliorated DSS-induced inflammatory responses in the intestine, and SIFs markedly suppressed the expression of ERα in a dose-dependent manner. Our study demonstrated that the protective therapeutic action of SIFs on DSS-induced colitis depended on inhibition of ERα and subsequent NLRP3 inflammasome activation, and SIFs are promising therapeutic agents for the treatment of colitis.
- | Journal: Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation. (Pubmed Central) - May 13, 2021
Significance. Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation.
- | sirolimus / Generic mfg.
Preclinical, Journal: Calhex231 ameliorates myocardial fibrosis post myocardial infarction in rats through the autophagy-NLRP3 inflammasome pathway in macrophages. (Pubmed Central) - May 13, 2021
Calhex231 and 3-Methyladenine (a specific inhibitor of autophagy) attenuated both autophagy and NLRP3 inflammasome activation; however, the caspase-1 inhibitor Z-YVAD-FMK did not. Our study indicated that Calhex231 improved cardiac function and ameliorated myocardial fibrosis post MI, likely via the inhibition of autophagy-mediated NLRP3 inflammasome activation; this provides a new therapeutic target for ventricular remodelling-related cardiovascular diseases.
- | Journal: Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis. (Pubmed Central) - May 13, 2021
Analogous defensive properties of propofol were detected in vitro in rat alveolar macrophages incubated with serum from the rI/R rat model. These findings indicate that propofol attenuates rI/R-induced ALI by suppressing pyroptosis, possibly by upregulating SIRT1 in the lungs.
- | Journal: Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation. (Pubmed Central) - May 13, 2021
Mechanically, Tan IIA inhibited NF-κB activation to downregulate pro-interleukin (IL) -1β and NLRP3 expression, and decreased oxLDL-induced expression of lectin-like oxidized LDL receptor-1 (LOX-1) and cluster of differentiation 36 (CD36), thereby attenuating oxLDL cellular uptake and subsequent induction of mitochondrial and lysosomal damage - events that promote the NLRP3 inflammasome assembly. Through regulating both the inflammasome 'priming' and 'activation' steps, Tan IIA potently inhibited oxLDL-induced NLRP3 inflammasome activation, thereby ameliorating atherogenesis.
- | Preclinical, Journal, IO biomarker: Ozone Exposure Promotes Pyroptosis in Rat Lungs via the TLR2/4-NF-κB-NLRP3 Signaling Pathway. (Pubmed Central) - May 13, 2021
When injured, the levels of HMGB1 and HA in BALF increased, which interact with TLR 2/4 to activate the downstream NF-κB signaling pathway. Further activating the NLRP3 inflammasome complex and regulating the ozone-induced pyroptosis.
- | Preclinical, Journal: Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice. (Pubmed Central) - May 13, 2021
Furthermore, inhibition of the Pak-NLRP3 axis decreases the bacterial clearance of CNF1-expressing UTI89 E. coli during bacteraemia in mice. Taken together, our results establish that Pak1 and Pak2 are critical regulators of the NLRP3 inflammasome and reveal the role of the Pak-NLRP3 signalling axis in vivo during bacteraemia in mice.
- | Journal: NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine. (Pubmed Central) - May 13, 2021
Besides, we found eight hub genes (IKK, IKB-α, NLRP3, TRAF6, NF-κB, AMPK, TNFα and PGC-1α), mainly related to the interaction between the NF-κB pathway and NLRP3 inflammasome. Overall, these results demonstrated that Cd could promote the IL-1β/IkB-α-NF-κB-NLRP3 inflammasome activation positive feedback loop to result in neuroinflammation in swine, which provided new insights in understanding Cd-induced toxicity.
- || Review, Journal: Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease. (Pubmed Central) - May 13, 2021
Thus, an appropriate regulation of inflammasomes might be a promising therapeutic strategy for IBD intervention. This review aims at summarizing the main findings in these studies and provide an outline for further studies that might contribute to our understanding of the role of inflammasomes in the pathogenesis and therapeutic treatment of IBD.
- || Review, Journal: Impact of Stress on Epilepsy: Focus on Neuroinflammation-A Mini Review. (Pubmed Central) - May 13, 2021
Here, we summarize studies investigating acute and chronic stress as a seizure trigger and an important factor that worsens epilepsy outcomes and psychiatric comorbidities. Mechanistic insight into the impact of stress on epilepsy may create a window of opportunity for future interventions targeting neuroinflammation-related disorders.