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- |||| NIBR (@NovartisScience) NLRP3 inflammasome inhibitor functions as an intramolecular glue – locking the protein in an inactive conformation https://t.co/DVkIRBiDj1! (Twitter) - Nov 19, 2021
- | Journal: Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-κB signaling. (Pubmed Central) - Nov 17, 2021
Our study demonstrated that irisin countered LPS-mediated liver injury via inhibiting apoptosis, NLRP3 inflammasome activation and NF-κB signaling. These findings revealed the role of irisin as a promising new anti-pyroptosis/apoptosis agent to reconcile the onset and progression of septic liver injury.
- | Journal: The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome. (Pubmed Central) - Nov 17, 2021
In primary astrocytes, gliquidone selectively affected LPS-mediated proinflammatory cytokine expression and decreased STAT3/NF-κB signaling in an NLRP3-independent manner. These results indicate that gliquidone differentially modulates LPS-induced microglial and astroglial neuroinflammation in BV2 microglial cells, primary astrocytes, and a model of neuroinflammatory disease.
- | dapansutrile (OLT1177) / Olatec Therap
Biomarker, Journal: The NLRP3 inhibitor dapansutrile attenuates folic acid induced nephrotoxicity via inhibiting inflammasome/caspase-1/IL axis and regulating autophagy/proliferation. (Pubmed Central) - Nov 17, 2021
DAPA potentially alleviates FA induced nephrotoxicity through targeting inflammasome/caspase-1/IL axis. Moreover, it shows a regulatory effect on renal regeneration and autophagy.
- | Journal: Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress. (Pubmed Central) - Nov 17, 2021
Meanwhile, supplement resveratrol further inhibited the NLRP3 inflammasome pathway, decreased protein level of NLRP3 and caspase1 p20, reduced the secretion of IL-1β. Taken together, our results indicate that resveratrol against the oxidative damage and inflammation injury in duck jejunum induced by heat stress via active SIRT1 signaling pathways.
- | Journal: Cytotoxin-associated gene A (CagA) promotes aortic endothelial inflammation and accelerates atherosclerosis through the NLRP3/caspase-1/IL-1β axis. (Pubmed Central) - Nov 17, 2021
In vivo, the inhibition of NLRP3 by MCC950 significantly attenuated the promoting effect of CagA on plaque growth of ApoE mice. We also propose NLRP3 as a potential therapeutic target for CagA-positive H. pylori infection-related atherosclerosis and emphasize the importance of inflammation in atherosclerosis pathology.
- | Preclinical, Journal: Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension. (Pubmed Central) - Nov 12, 2021
NLRP3 inflammasome inhibition ameliorated LPS-induced changes in the immune microenvironment in the right heart and right ventricular dysfunction in rats with PAH. Selective inhibition of NLRP3 pathway interfered the interaction between hypertrophic cardiomyocytes and macrophages in the initial stage of inflammation and maintained the immune microenvironment balance, eventually contributing to attenuation of LPS-induced acute heart failure in PAH rats.
- | Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
Journal: Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway. (Pubmed Central) - Nov 11, 2021
In contrast, the silencing of TAK1 inhibited the expression levels of the NLRP3 inflammasome. In summary, LCZ696 reduced the expression levels of the NLRP3 inflammasome, suppressed inflammatory responses, improved the ventricular remodeling and exhibited protective effects in the MI heart by inhibiting the TAK1/JNK signaling pathway.
- | Journal: Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway. (Pubmed Central) - Nov 11, 2021
Moreover, DI induced cellular autophagy, whereas inhibition of autophagy with 3‑methyladenine markedly reversed its inhibitory effect on NLRP3‑dependent pyroptosis. Taken together, the present study suggested that DI participated in the Nrf‑2/HO‑1 pathway and served a key role in microglia inflammation and NLRP3 inflammasome‑mediated pyroptosis via induction of autophagy.
- | Journal: The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. (Pubmed Central) - Nov 10, 2021
Furthermore, 4-OI inhibited NLRP3-dependent IL-1β release from PBMCs isolated from cryopyrin-associated periodic syndrome (CAPS) patients, and reduced inflammation in an in vivo model of urate-induced peritonitis. Our results identify itaconate as an endogenous metabolic regulator of the NLRP3 inflammasome and describe a process that may be exploited therapeutically to alleviate inflammation in NLRP3-driven disorders.
- | Journal: Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. (Pubmed Central) - Nov 10, 2021
Sodium hydrosulfide (NaHS) not only alleviated upregulation of NLRP3 protein expression levels, but also relieved renal injury, release of cytokines and cell apoptosis induced by renal I/R in wild‑type mice, but not in Nrf2‑KO mice. NaHS alleviated NLRP3 inflammasome activation, renal injury, the inflammatory response and cell apoptosis via the Nrf2 signaling pathway in renal I/R model mice.
- | Journal: Treatment With Melatonin After Corneal Graft Attenuates Rejection. (Pubmed Central) - Nov 7, 2021
Our study demonstrates that MT promotes the survival of mouse corneal grafts by inhibiting NLRP3-mediated immune regulation, reducing immune cell activation and cell migration, and inhibiting the production of inflammatory-related cytokines. Treatment with MT might provide a potential clinical therapeutic target for corneal transplantation.
- | Journal: Antituberculosis Drugs (Rifampicin and Isoniazid) Induce Liver Injury by Regulating NLRP3 Inflammasomes. (Pubmed Central) - Nov 6, 2021
The NLRP3 inflammasome was required for INH- and RIF-induced liver injuries that were produced by inflammatory responses, OS, the antioxidant defense system, and drug-metabolizing enzymes. This study indicated that the NLRP3 inflammasome is involved in antituberculosis drug-induced liver injuries (ATLIs) and suggests NLRP3 as a potential target for attenuating the inflammation response in ATLIs.
- | Journal: ROCK1 regulates sepsis-induced acute kidney injury via TLR2-mediated endoplasmic reticulum stress/pyroptosis axis. (Pubmed Central) - Nov 6, 2021
In conclusion, ROCK1 may regulate sepsis-induced AKI via TLR2-mediated ERS/pyroptosis axis. Our data demonstrated the role and underlying mechanism of ROCK1 in septic AKI, providing theoretical basis for sepsis-induced AKI treatment.
- | Preclinical, Journal: Vinpocetine attenuates ischemic stroke through inhibiting NLRP3 inflammasome expression in mice. (Pubmed Central) - Nov 5, 2021
The experimental results indicated that post-treatment with Vinp decreased cerebral infarct size, improved behavior recover, reduced NLRP3 inflammasome expression, suppress the transfer of NF-κB to nucleus and pro-inflammatory cytokines release in MCAO/R mice. In conclusion, the present study demonstrates that Vinp alleviates ischemic stroke by regulating levels of NLRP3 inflammasome, NF-κB and pro-inflammatory cytokines in vivo, offering an alternative medication for ischemic stroke associated with inflammation.
- | Preclinical, Journal: Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis. (Pubmed Central) - Nov 5, 2021
Furthermore, knockdown of caspase-1 also ameliorated OTA-induced renal fibrosis via the inhibition of pyroptosis. Collectively, the chosen doses of OTA-triggered nephrotoxicity through NLRP3 inflammasome activation and caspase-1-dependent pyroptosis both in vitro and in vivo.
- | Journal: A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation. (Pubmed Central) - Nov 5, 2021
Our high-content screening assay yielded robust assay metrics and identified a number of inhibitors of NLRP3-dependent ASC speck formation, including compounds targeting HSP90, JAK and IKK-β. Additional assays to investigate inflammasome priming or activation, NLRP3 downstream effectors such as caspase-1, IL-1β and pyroptosis form the basis of a screening cascade to identify NLRP3 inflammasome inhibitors in drug discovery programs.
- | Preclinical, Journal: Targeting against the activity of the NLRP3 inflammasome is a potential therapy for rat testicular tissue cryopreservation and transplantation. (Pubmed Central) - Nov 5, 2021
Testicular tissue cryopreservation and transplantation exhibited upregulated expression of NLRP3 pathway and NLRP3 inflammasome blockade improves testicular graft function. These finding suggest that NLRP3 inflammasome is a therapeutic target for testicular tissue cryopreservation and transplantation.
- | Preclinical, Journal: Blockage of NLRP3 inflammasome activation ameliorates acute inflammatory injury and long-term cognitive impairment induced by necrotizing enterocolitis in mice. (Pubmed Central) - Nov 4, 2021
These finding suggest that NLRP3 inflammasome is a therapeutic target for testicular tissue cryopreservation and transplantation. Our findings suggest that NLRP3 inflammasome activation participates in NEC-induced intestinal and brain injury, and early intervention with NLRP3 inhibitor may provide beneficial therapeutic effect on NEC infants.
- | Journal: Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies. (Pubmed Central) - Nov 4, 2021
NLRP3 inhibition by the selective inhibitor CRID3 sodium salt and NLRP3 deficiency improved the overall clearance of α-syn oligomers. Together, these data show that distinct α-syn forms exert different microglial NLRP3 inflammasome activation properties, thereby compromising its degradation, which can be prevented by NLRP3 inhibition.
- || Review, Journal: Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome. (Pubmed Central) - Nov 4, 2021
Therefore, the mechanism of NLRP3 inflammasome activation is discussed mainly from the perspective of mitochondria in this review. Moreover, the effect and potential mechanism of exercise on NLRP3 inflammasome are explored, hoping to provide new target for relevant research.
- | Preclinical, Journal: Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo. (Pubmed Central) - Nov 1, 2021
Importantly, DHT possessed a significant therapeutic effect on NLRP3 inflammasome-mediated sepsis in mice. Therefore, our results aimed to clarify DHT as a specific small-molecule inhibitor for the NLRP3 inflammasome and suggested that DHT can be used as a potential drug against NLRP3-mediated diseases.
- | Journal: Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson's disease model. (Pubmed Central) - Oct 31, 2021
All the collected data revealed that ECH ameliorated PD mice neuroethology through promoting DA neuron survival and inhibiting the activated microglia-mediated NLRP3/CASP-1/IL-1β inflammatory signaling. These findings highlight the crucial roles of NLRP3 inflammasome involved in PD neuropathology and ECH exertes neuroprotection for PD as double-targeting neuroinflammation and DA neuronal survival.
- | Journal: S100A9 blockade prevents lipopolysaccharide-induced lung injury via suppressing the NLRP3 pathway. (Pubmed Central) - Oct 31, 2021
The results of the current study suggested that inhibition of S100A9 could protect against LPS-induced lung injury via inhibiting the NLRP3 pathway. Therefore, S100A9 blockade could be considered as a novel therapeutic strategy for lung injury in sepsis.
- || Kineret (anakinra) / SOBI, Ilaris (canakinumab) / Novartis
Review, Journal: Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950. (Pubmed Central) - Oct 30, 2021
Activation of NLRP3 can be inhibited with MCC950, resulting in efficacy in more than 100 nonclinical models of inflammatory diseases. As several next-generation NLRP3 inhibitors are entering proof-of-concept clinical trials in 2020, a review of the pharmacology of MCC950 is timely and significant.
- | Journal: NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. (Pubmed Central) - Oct 30, 2021
Finally, NLRP3 deficiency resulted in a lower density of NETs in thrombi produced by a stenosis-induced mouse model of deep vein thrombosis. Altogether, our results indicate a PAD4-dependent formation of the NLRP3 inflammasome in neutrophils and implicate NLRP3 in NETosis under noninfectious conditions in vitro and in vivo.
- | Journal: Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance. (Pubmed Central) - Oct 30, 2021
Interestingly, MCC950, a specific pharmacological NLRP3 inflammasome inhibitor, promoted GLUT4 translocation in fibers isolated from the FDB muscle of NCD- and HFD-fed mice. In conclusion, we found increased NLRP3 inflammasome components in adult skeletal muscle of obese insulin-resistant animals, which might contribute to the low-grade chronic metabolic inflammation of skeletal muscle and IR development.
- | Preclinical, Journal: NLRP3 Inflammasome Inhibition Prevents α-Synuclein Pathology by Relieving Autophagy Dysfunction in Chronic MPTP-Treated NLRP3 Knockout Mice. (Pubmed Central) - Oct 29, 2021
Most importantly, it relieves autophagy dysfunction in the midbrain of PD mice. Collectively, we demonstrate for the first time that improving autophagy function is involved in the preventive effect of NLRP3 inflammasome inhibition on α-synuclein pathology in PD.
- | telmisartan / Generic mfg.
Journal: Telmisartan Inhibits the NLRP3 Inflammasome by Activating the PI3K Pathway in Neural Stem Cells Injured by Oxygen-Glucose Deprivation. (Pubmed Central) - Oct 29, 2021
These beneficial effects of telmisartan were blocked by a PI3K inhibitor. Together, these results indicate that telmisartan attenuated the activation of the NLRP3 inflammasome by triggering the PI3K pathway, thereby contributing to neuroprotection.
- | Preclinical, Journal: Electroacupuncture Ameliorates Neuroinflammation-Mediated Cognitive Deficits through Inhibition of NLRP3 in Presenilin1/2 Conditional Double Knockout Mice. (Pubmed Central) - Oct 29, 2021
Furthermore, EA treatment is not able to further improve the AD-like phenotypes of PS cDKO mice in combination with the MCC950 administration. Therefore, EA stimulation at GV 20 and GV 24 acupoints may be a potential alternative therapy for deterring cognitive deficits in AD through suppression of NLRP3 inflammasome activation.
- | Journal: Cardamonin Inhibited IL-1β-induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO1 Signaling Pathway in Chondrocyte. (Pubmed Central) - Oct 29, 2021
SiNrf2 reversed the function of cardamonin on IL-1β-induced cell apoptosis and expression of pro-inflammatory cytokines, Nrf2, NQO-1, NLRP3 inflammasome in chondrocytes. Cardamonin inhibited IL-1β-induced injury by inhibition of NLRP3 inflammasome via activating Nrf2/NQO1 signaling pathway in chondrocyte.
- | Journal, IO biomarker: NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation. (Pubmed Central) - Oct 28, 2021
At the same time, no changes in the other cytokines and IκBζ, a well-known transcriptional factor of Lcn2 transcription, were observed. Overall, NLRP3 triggers are a regulator of LCN2 expression suggesting a new linkage of inflammasome activation and LCN2 secretion in the innate immunity.
- | colchicine / Generic mfg.
Biomarker, Journal: Colchicine reduces extracellular vesicle NLRP3 inflammasome protein levels in chronic coronary disease: A LoDoCo2 biomarker substudy. (Pubmed Central) - Oct 28, 2021
Colchicine leads to a reduction of EV NLRP3 protein levels. This indicates that inhibitory effects on the NLRP3 inflammasome might contribute to the atheroprotective effects of colchicine in coronary disease.
- | Preclinical, Journal: Combined Therapy With Polyethylene Glycol-20k and MCC950 Preserves Post-Resuscitated Myocardial Function in a Rat Model of Cardiac Arrest and Cardiopulmonary Resuscitation. (Pubmed Central) - Oct 27, 2021
Conclusions Combined therapy with PEG-20k and MCC950 is superior to either therapy alone for preserving post-resuscitated myocardial function, restituting sublingual microcirculation at restoration of spontaneous circulation at 6 hours. The responsible mechanisms involve upregulated expression of SIRT1/PGC1-α in tandem with inhibition of NLRP3 inflammasomes.
- | selisistat (SEN-196) / AOP Orphan Pharma
Journal: Cerebroprotection by dioscin after experimental subarachnoid hemorrhage via inhibiting NLRP3 inflammasome through SIRT1-dependent pathway. (Pubmed Central) - Oct 27, 2021
Dioscin provides protection against SAH via the suppression of NLRP3 inflammasome activation through SIRT1-dependent pathway. Dioscin may be a new candidate to ameliorate EBI after SAH.
- | Preclinical, Journal: Spinal Tuina Improves Cognitive Impairment in Cerebral Palsy Rats through Inhibiting Pyroptosis Induced by NLRP3 and Caspase-1. (Pubmed Central) - Oct 27, 2021
Moreover, immunohistochemistry and western blot also revealed a reduced expression of NLRP3 inflammasome and corresponding pyroptosis-related molecules induced by NLRP3 in CP rats after Tuina treatment. Therefore, our study indicated that Tuina treatment may improve impaired neurocognitive function of CP rats, which was possibly realised via inhibiting NLRP3-induced pyroptosis.
- || Review, Journal: Mechanisms of Kidney Cell Pyroptosis in Chronic Kidney Disease and the Effects of Traditional Chinese Medicine. (Pubmed Central) - Oct 25, 2021
Traditional Chinese medicine (TCM) and extracts can interfere with the occurrence and development of kidney cell pyroptosis in CKD by inhibiting the NLRP3 signaling pathway and oxidative stress, activating Nrf-2 signaling, protecting mitochondrial integrity, regulating AMPK signaling, and regulating TXNIP/NLRP3 axis, which have become increasingly prominent. It is critical to explore the effects of TCM on kidney cell pyroptosis in CKD and its mechanisms to identify targets and develop new and effective drugs.
- | Journal: CMPK2 accelerates liver ischemia/reperfusion injury via the NLRP3 signaling pathway. (Pubmed Central) - Oct 22, 2021
In conclusion, the results of the present study demonstrate that CMPK2 is indispensable for NLRP3 inflammasome activation, making CMPK2 an effective target to relieve the liver from I/R injury. In addition, the function of CMPK2 is closely associated with NLRP3 inflammasome activation, instead of AIM2.
- | metformin / Generic mfg.
Preclinical, Journal, IO biomarker: Novel complementary coloprotective effects of metformin and MCC950 by modulating HSP90/NLRP3 interaction and inducing autophagy in rats. (Pubmed Central) - Oct 22, 2021
The observed impeding effect on HSP90 along with inducing autophagy (effect of metformin) suggests that NLRP3 is prone to autophagic degradation. In conclusion, we reveal that the combination of metformin with MCC950 has a protective role in DSS-induced colitis and might become a candidate in a promising approach for the future treatment of human UC.
- | Journal: NLRP3 Regulates IL-4 Expression in TOX CD4 T Cells of Cutaneous T Cell Lymphoma to Potentially Promote Disease Progression. (Pubmed Central) - Oct 22, 2021
This mechanism of IL-4 regulation mediated by NLRP3 is amplified in late-stage CTCL associated with disease progression. These results indicate that NLRP3 might be a key regulator of IL-4 expression in TOX CD4 T cells of CTCL patients and that this mechanism might have important implications in the progression of the disease.
- | Journal: miR-223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL-1β Pathway to Meliorate Neuropathic Pain. (Pubmed Central) - Oct 22, 2021
Overexpression of miR-223 reduces the protein levels of NLRP3, ASC, caspase-1, IL-1β, and IL-18 in the spinal cord of CCI mice, increases the proportion of M2-type macrophages, and reduces the proportion of M1-type macrophages. miR-223 may facilitate the development of neuropathic pain in CCI mice by inhibiting NLRP3-mediated neuroinflammation.
- | Preclinical, Journal: Aeromonas sobria Induces Proinflammatory Cytokines Production in Mouse Macrophages via Activating NLRP3 Inflammasome Signaling Pathways. (Pubmed Central) - Oct 22, 2021
Blocking of NLRP3 inflammasome activation through K efflux and cathepsin B or caspase approaches downregulated A. sobria-induced proinflammatory cytokine production. Overall, these data indicated that A. sobria induced proinflammatory cytokine production in PMφs through activating NLRP3 inflammasome signaling pathways.
- | dapansutrile (OLT1177) / Olatec Therap
Journal, Myeloid-derived suppressor cells, PD(L)-1 Biomarker, IO biomarker: Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression. (Pubmed Central) - Oct 22, 2021
In PMN-MDSCs isolated from tumor-bearing mice treated with OLT1177, we observed significant reductions in immunosuppressive genes such as Pdcd1l1, Arg1, Il10 and Tgfb1. In conclusion, the data presented here show that the inhibition of NLRP3 reduces IL-1β induction of pSTAT3(Y705) preventing expression of immunosuppressive genes as well as activity in PMN-MDSCs.
- [VIRTUAL] CHRONIC ALCOHOL BINGE EXACERBATES FIBROSIS IN A HIGH FAT-CHOLESTEROL-SUGAR DIET-INDUCED MODEL OF NASH INVOLVING NEUTROPHIL INFILTRATION, INFLAMMASOME ACTIVATION AND PYROPTOSIS () - Oct 21, 2021 - Abstract #AASLD2021AASLD_1990;
In conclusion, the data presented here show that the inhibition of NLRP3 reduces IL-1β induction of pSTAT3(Y705) preventing expression of immunosuppressive genes as well as activity in PMN-MDSCs. Chronic alcohol binges in NASH model increases neutrophil infiltration, NET formation, inflammasome activation and pyroptosis which accelerate liver fibrosis.
- [VIRTUAL] NLRP3-DEPENDENT ASC SPECKS RELEASED BY PYROPTOTIC HEPATOCYTES AND MACROPHAGES PERPETUATE INFLAMMATION IN ALCOHOLIC HEPATITIS () - Oct 21, 2021 - Abstract #AASLD2021AASLD_1557;
Alcohol binge triggers exASC specks release from both hepatocytes and MØs involving pyroptosis . NLRP3 activation, eliciting exASC specks formation and release, is a major driver of sustained inflammation in AH identifying NLRP3 as a potential therapeutic target in AH .
- | Journal: Silenced SOX2-OT alleviates ventricular arrhythmia associated with heart failure by inhibiting NLRP3 expression via regulating miR-2355-3p. (Pubmed Central) - Oct 20, 2021
NLRP3 activation, eliciting exASC specks formation and release, is a major driver of sustained inflammation in AH identifying NLRP3 as a potential therapeutic target in AH . Silencing SOX2-OT alleviated cardiac dysfunction in rats by reducing the activation of NLRP3 inflammasomes via regulating miR-2355-3p.
- | Ilaris (canakinumab) / Novartis
Journal: Anti-inflammatory therapy in ischaemic heart disease: from canakinumab to colchicine. (Pubmed Central) - Oct 20, 2021
In summary, canakinumab and colchicine have shown efficacy in preventing MACE in ischaemic heart disease patients, but only colchicine has acceptable safety (and cost) for use in secondary cardiovascular prevention. Clinical results are expected with the anti-IL6 ziltivekimab.
- | Preclinical, Journal, IO biomarker: Hepatic protective effects of Shenling Baizhu powder, a herbal compound, against inflammatory damage via TLR4/NLRP3 signalling pathway in rats with nonalcoholic fatty liver disease. (Pubmed Central) - Oct 20, 2021
SLBZP can inhibit NLRP3 inflammasome activation and interleukin-1β release by suppressing LPS-induced TLR4 expression in rats with HFD-induced NAFLD. Thus, SLBZP may be beneficial for the prevention and treatment of inflammatory damage and associated diseases.
- | Bay11-7082 / InvivoGen
Journal: Activated protein C overexpression suppresses the pyroptosis of subarachnoid hemorrhage model cells by regulating the NLRP3 inflammasome pathway. (Pubmed Central) - Oct 20, 2021
Moreover, the NLRP3 inhibitor BAY11-7082 could reverse the upregulation of pyroptosis induced by APC-knockdown. Overall, the present study revealed that APC could ameliorate SAH-induced early brain injury by suppressing pyroptosis via inhibition of the NLRP3 inflammasome, which could provide a novel strategy for the treatment of SAH.
- bardoxolone methyl (RTA 402) / Kyowa Kirin, Reata
[VIRTUAL] Nrf2 Activators Induce Inflammasome Attenuation: Possible Role in Diabetic Nephropathy () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2008;
Mouse bone marrow macrophages were treated with Bardoxolone (1µM), an Nrf2 inducer, and ND-13 (1µM) for 24 hours...Compared to controls and diabetic individuals, patients with diabetic nephropathy presented a trend to increase IL-1β release. Conclusion All these data point out that inflammasome pre-activation could have a role in the pathogenesis of diabetic nephropathy, that Nrf2 pathway stimulation is a promising approach to decrease immune cells inflammasome pre-activation, and ND-13 could be a new approach to protect the renal damage associated to inflammasome over-activation in renal diseases.