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11 Trials |  |
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- | dexmedetomidine / Generic mfg.
Preclinical, Journal: Dexmedetomidine's protective mechanism against hyperoxic injury in neonatal rats. (Pubmed Central) - Jul 23, 2024
Furthermore, the expressions of pyroptosis-related proteins such as NLRP3, ASC, cleaved-caspase-1, and GSDMD were significantly decreased, along with the expressions of inflammatory factors in lung tissues. By inhibiting the NLRP3/caspase-1/GSDMD pyroptosis pathway, dexmedetomidine reduces the activation and release of inflammatory factors and provides a protective effect against hyperoxic lung injury in neonatal mice.
- | prednisone / Generic mfg.
Preclinical, Journal: Dioscin attenuates lupus nephritis in NZB/W F1 mice by decreasing NF-?B activation and NLRP3 inflammasome. (Pubmed Central) - Jul 23, 2024
By inhibiting the NLRP3/caspase-1/GSDMD pyroptosis pathway, dexmedetomidine reduces the activation and release of inflammatory factors and provides a protective effect against hyperoxic lung injury in neonatal mice. Dioscin ameliorates lupus nephritis through inhibition of NLRP3 inflammasome and NF-?B signaling.
- | Journal: Huajuxiaoji Formula Alleviates Phenyl Sulfate-Induced Diabetic Kidney Disease by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis. (Pubmed Central) - Jul 23, 2024
HJXJ suppressed pyroptosis and inflammasome activation by inhibiting NLRP3 expression. Generally, HJXJ has the potential to reduce DKD injury and exerts anti-DKD effects by inhibiting the NLRP3-mediated NLRP3 inflammasome activation and pyroptosis in vitro and in vivo.
- | Preclinical, Journal: Vitamin C inhibits NLRP3 inflammasome activation and delays the development of age-related hearing loss in male C57BL/6 mice. (Pubmed Central) - Jul 22, 2024
According to this study, vitamin C protects auditory function in male C57BL/6 presbycusis mice through reducing mtDNA release, inhibiting the NLRP3 inflammasome activation in the auditory pathway. Our study provides a theoretical basis for applying vitamin C to treat presbycusis.
- | Journal: Lactobacillus rhamnosus GG ameliorates triptolide-induced liver injury through modulation of the bile acid-FXR axis. (Pubmed Central) - Jul 22, 2024
The underlying mechanism was associated with the gut microbiota-BA-FXR axis. Therefore, LGG holds the potential to prevent and treat TP hepatotoxicity in the clinic.
- | Journal: MLKL deficiency alleviates acute alcoholic liver injury via inhibition of NLRP3 inflammasome. (Pubmed Central) - Jul 22, 2024
Mechanistically, inhibiting the nuclear translocation of MLKL reduced the nuclear entry of p65, the principal transcriptional regulator of NLRP3, thereby limiting the transcription of Nlrp3 mRNA and subsequent NLRP3 expression. Overall, this study unveils a novel mechanism of MLKL regulates the activation of NLRP3 inflammasomes in a necroptosis independant way in acute alcoholic liver injury.
- | Preclinical, Journal: Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway. (Pubmed Central) - Jul 21, 2024
Notably, the use of MCC950 in Parkin+/- mice did not ameliorate NLRP3 inflammasome activation, autophagy dysfunction, or ?-synuclein aggregation. Thus, MCC950 can only exert its effects in the presence of Parkin/PINK1, and targeting Parkin-mediated NLRP3 inflammasome activation is expected to be a potential therapeutic strategy for Parkinson's disease.
- | Journal: Saikosaponin d protects pancreatic acinar cells against cerulein-induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS-STING pathway. (Pubmed Central) - Jul 20, 2024
Furthermore, SSd abolished cerulein-elevated oxidative stress in AR42J cells, leading to the mitigation of mitochondrial damage and inhibition of cGAS-STING signaling and pyroptosis. In conclusion, SSd protected PACs against cerulein-induced pyroptosis by alleviating mitochondrial damage and inhibiting the cGAS-STING pathway, and it could be a therapeutic candidate for acute pancreatitis.
- | Journal: Characterization of a small molecule inhibitor of the NLRP3 inflammasome and its potential use for acute lung injury. (Pubmed Central) - Jul 20, 2024
Further studies of MS-II-124 in mouse model of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and NLRP3 knockout mice demonstrated its target engagement, efficacy to suppress inflammatory cytokines and infiltration of immune cells in the lung tissues. In summary, the results support the therapeutic potential of MS-II-124 as a NLRP3 inhibitor and warrant future studies of this compound and its analogs to develop therapeutics for ALI/ARDS.
- | Preclinical, Journal: L.acidophilus HSCC LA042 and HKL suspension ameliorate DSS-induced ulcerative colitis in mice by improving the intestinal barrier inhibiting the NLRP3 inflammasome and pathogenic bacteria. (Pubmed Central) - Jul 19, 2024
Additionally, LH treatment altered the gut microbiota's microecology, characterized by a reduction in pathogenic bacteria abundance like Escherichia-shigella and an increase in beneficial bacteria abundance like Akkermansia and Erysipelatoclostridium. Overall, our findings indicate that LH therapy may be associated with intestinal barrier repair, inflammasome inhibition, and gut microbiota regulation, suggesting its potential as a UC treatment.
- | Journal: Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis. (Pubmed Central) - Jul 18, 2024
Activation of GSDMD is also accompanied by the aggregation of the endosomal sorting complex required for transport (ESCRT) membrane repair proteins on the membrane of colorectal tumor cells, suggesting that active membrane repairment may prevent pyroptosis induced by the formation of GSDMD pore in tumor cells. Our results show that gut microbiota/NLRP3-mediated activation of GSDMD promotes the development of colorectal tumors, and supports the use of NLRP3 inhibitors to treat colon cancer.
- RNA-BINDING PROTEIN AUF1 ACTIVATES THE NLRP3 INFLAMMASOME BY UPREGULATING THE EXPRESSION OF NLRP3 TO PROMOTE THE DEVELOPMENT OF H. PYLORI-ASSOCIATED GASTRITIS (Lehar 2) - Jul 18, 2024 - Abstract #UEGW2024UEGW_2693;
pylori infection promotes the cytoplasmic redistribution of AUF1 through CRM1 and AUF1 promotes NLRP3 inflammasomes activation by upregulating the expression of NLRP3. Our findings identify AUF1 as a novel positive regulator of NLRP3 inflammasomes and suggest that dysregulation of AUF1 expression leads to an increased risk of H. pylori-gastritis.
- Repetitive transcranial magnetic stimulation relieves neuropathic pain by blocking integrin ?v?3 (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_954;
We identify a potential link between amygdala neural activity and integrin ?v?3, unveil a significant interaction between integrin ?v?3 and P2X7R in the amygdala, suggesting their involvement in the response to rTMS treatment. Further investigation into P2X7R downstream signaling pathways reveals the activation of the NLRP3 inflammatory signaling pathway as an intrinsic mechanism underlying rTMS efficacy.
- | Calquence (acalabrutinib) / AstraZeneca, Imbruvica (ibrutinib) / AbbVie, J&J
Preclinical, Journal: Bruton's tyrosine kinase (BTK) inhibitors alter blood glucose and insulin in obese mice but reduce inflammation independent of BTK. (Pubmed Central) - Jul 17, 2024
However, ibrutinib and acalabrutinib reduced NF-?B activity pro-inflammatory gene expression and NLRP3 inflammasome activation in macrophages with and without functional BTK. These data highlight the BTK inhibitors can have divergent effect on metabolism and separate effects on metabolic inflammation that can occur independently of actions on BTK.
- | Journal: 4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders. (Pubmed Central) - Jul 16, 2024
4-OI could effectively inhibit NLRP3 signaling, leading to the inhibition of proinflammatory cytokine production in patients with NMOSD-derived PBMCs and in a human macrophage model. Thus, 4-OI and itaconate could have important therapeutic value for the treatment of NMOSD in the future.
- | Journal: Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway. (Pubmed Central) - Jul 16, 2024
Our results provide valuable insights into the therapeutic role of B. fragilis in NEC. Administering B. fragilis may substantially alleviate intestinal damage in NEC.
- | Journal: Biflavonoid Methylchamaejasmin and Khaya grandifoliola (Pubmed Central) - Jul 16, 2024
phagocytosis showed that M8 and KG pretreatments can restore the phagocytic activity of THP-1 cells, which was impaired following inflammasome activation. Altogether, our findings describe for the first time a promising role of biflavonoids and KG extract in preventing inflammasome activation and protecting against neuroinflammation, a key factor in AD development.
- | Bay11-7082 / Bayer, belnacasan (VX-765) / Vertex
Journal: Enhanced Cardiomyocyte NLRP3 Inflammasome-Mediated Pyroptosis Promotes d-Galactose-Induced Cardiac Aging. (Pubmed Central) - Jul 16, 2024
Altogether, our findings describe for the first time a promising role of biflavonoids and KG extract in preventing inflammasome activation and protecting against neuroinflammation, a key factor in AD development. The reactive oxygen species/nuclear factor ?-light-chain enhancer of activated B cells/NLRP3 signaling pathway loop contributes to d-galactose-treated cardiomyocyte senescence and cardiac aging.
- | Journal: Oridonin ameliorates ocular surface inflammatory responses by inhibiting the NLRP3/caspase-1/GSDMD pyroptosis pathway in dry eye. (Pubmed Central) - Jul 15, 2024
In a mouse model of DED, Ori application inhibited the expression of the NLRP3/caspase-1/GSDMD pyroptosis pathway, improved DED signs and injury, decreased corneal sodium fluorescein staining scores, and increased tear volume. Thus, our study suggests that Ori has potential applications for the treatment of DED, provides potential novel therapeutic approaches to treat DED, and provides a theoretical foundation for treating DED using Ori.
- | Journal: Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis. (Pubmed Central) - Jul 14, 2024
These findings provide compelling evidence that MC-LR combined with nitrite synergistically induces pyroptosis in the kidney by activating the TLR4/NLRP3/GSDMD pathway. Overall, this study significantly enhances our comprehension of how environmental toxins interact and induce harm to the kidneys, offering promising avenues for identifying therapeutic targets to alleviate their toxic effects on renal health.
- | Preclinical, Journal: Octahydroindolizine Alkaloid Homocrepidine A from Dendrobium Crepidatum Attenuate P. acnes-Induced Inflammatory in Vitro and in Vivo. (Pubmed Central) - Jul 13, 2024
Our research highlights the protective effects of D. crepidatum and its bioactive compound HCA against acne inflammation, marking the first exploration of its potential in this context. The discoveries indicate that HCA treatment may represent a promising functional approach for acne therapy.
- NLRP3 Inhibition Restricts the Immune Priming and Abscopal Responses Induced by Radiotherapy Combined with Immunotherapy in Microsatellite Stable Colorectal Cancer (Hall C) - Jul 13, 2024 - Abstract #ASTRO2024ASTRO_1779;
- | disulfiram / Generic mfg.
Journal: P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis. (Pubmed Central) - Jul 12, 2024
Disulfiram could effectively improve EAP by inhibiting GSDMD-NT-mediated prostate epithelial cell pyroptosis. In conclusion, the P2X7R-NEK7-NLRP3 axis could promote GSDMD-NT-mediated prostate epithelial cell pyroptosis and chronic prostatitis development, and disulfiram may be an effective drug to treat chronic prostatitis.
- | Tudcabil (tauroursodeoxycholic acid) / Bruschettini
Journal: Promoting longevity in aged liver through NLRP3 inflammasome inhibition using tauroursodeoxycholic acid (TUDCA) and SCD probiotics. (Pubmed Central) - Jul 11, 2024
These results underscore the therapeutic potential of TUDCA and SCD Probiotics for managing age-associated liver disorders, illustrating their individual and synergistic effects on liver health and pathology. This study provides insights into the complex interactions of these agents, advocating for customized therapeutic approaches to combat liver fibrosis, enhance liver functionality, and decrease inflammation in aging populations.
- | Journal: Oridonin attenuates liver ischemia-reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis. (Pubmed Central) - Jul 11, 2024
This study provides insights into the complex interactions of these agents, advocating for customized therapeutic approaches to combat liver fibrosis, enhance liver functionality, and decrease inflammation in aging populations. Ori exerted protective effects on liver IRI via suppressing PKM2/NLRP3-mediated liver macrophage pyroptosis, which might become a potential therapeutic target in the clinic.
- || Review, Journal: Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease. (Pubmed Central) - Jul 11, 2024
Here, we review the role of the NLRP3 inflammasome and microglial ketone body metabolism in AD pathogenesis. We also highlight NLRP3 inflammasome inhibition by several ketone body therapies as a promising new treatment strategy for AD.
- | Journal: The critical role of NLRP3 inflammasome activation in Streptococcus suis-induced blood-brain barrier disruption. (Pubmed Central) - Jul 10, 2024
In addition, the integrity of the BBB was protected with increased TJ proteins expression and decreased pathological injury after the inhibition of NLRP3 inflammasome, indicating NLRP3 inflammasome plays a destructive role in meningitis induced by S. suis. Our study expands the understanding on the role of NLRP3 inflammasome in bacterial meningitis, which provide the valuable information for the development of anti-infective agents targeting NLRP3 to treat bacterial meningitis.
- | Journal: Lyssavirus matrix protein inhibits NLRP3 inflammasome assembly by binding to NLRP3. (Pubmed Central) - Jul 10, 2024
(IL-1?) production in bone-marrow-derived dendritic cells (BMDCs) to facilitate lyssavirus invasion into the brain thereby elevating pathogenicity in mice. Taken together, this study reveals a common mechanism by which lyssavirus inhibits NLRP3 inflammasome activation to evade host defenses.
- | Journal: Anoectochilus roxburghii polysaccharide reduces D-GalN/LPS-induced acute liver injury by regulating the activation of multiple inflammasomes. (Pubmed Central) - Jul 10, 2024
Taken together, this study reveals a common mechanism by which lyssavirus inhibits NLRP3 inflammasome activation to evade host defenses. The inhibitory effect of ARP on a wide range of inflammasomes, as well as its excellent protection against acute liver injury, suggests that ARP may be a candidate for acute liver injury.
- | Preclinical, Journal: Novel NLRP3 inflammasome inhibitors INF150 and INF195 attenuate isoproterenol-induced hypertrophy in H9c2 rat cardiac myoblast. (Pubmed Central) - Jul 10, 2024
The inhibitory effect of ARP on a wide range of inflammasomes, as well as its excellent protection against acute liver injury, suggests that ARP may be a candidate for acute liver injury. No abstract available
- || Review, Journal: Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome. (Pubmed Central) - Jul 10, 2024
In addition, we focused on MSCs and MSC-extracellular vesicles targeting NLRP3 inflammasomes in bone and joint diseases. Finally, the existing problems and future direction are also discussed.
- | Preclinical, Journal: Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization. (Pubmed Central) - Jul 10, 2024
Altogether, our study reveals the vital role of overactivated NLRP3 signaling pathway in aggravating the inflammatory response and cognitive deficits and the potential protective effect of MCC950 in anti-NMDAR encephalitis. Thus, MCC950 represents a promising strategy for anti-inflammation in anti-NMDAR encephalitis and our study lays a theoretical foundation for it to become a clinically targeted drug.
- | Journal: Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease. (Pubmed Central) - Jul 9, 2024
Thus, MCC950 represents a promising strategy for anti-inflammation in anti-NMDAR encephalitis and our study lays a theoretical foundation for it to become a clinically targeted drug. In vitro we used A?-treated HRECs and MIO-M1 cells, and in vivo we used 3
- | Journal: Blood Brain Barrier-Crossing Delivery of Felodipine Nanodrug Ameliorates Anxiety-Like Behavior and Cognitive Impairment in Alzheimer's Disease. (Pubmed Central) - Jul 9, 2024
In addition, it promoted the degradation of damaged mitochondria via mitophagy, thereby inhibiting the neuronal apoptosis. Therefore, the anxiety-like behavior and cognitive impairment of 5xFAD mice with AD is significantly ameliorated, which manifested the potential of LIPUS - assisted BBB-crossing delivery of felodipine@LND to serve as a paradigm for AD therapy based on the well-recognized clinically available felodipine.
- | niclosamide / Generic mfg.
Journal: Niclosamide modulates phenotypic switch and inflammatory responses in human pulmonary arterial smooth muscle cells. (Pubmed Central) - Jul 9, 2024
(IL-?), and cleaved Caspase-1 proteins expression. Together, these results suggested versatile effects of NCL on controlling of proliferation, migration, and inflammatory responses in PASMCs through modulating different pathways, indicating that repurposing of NCL may emerge as a highly effective drug for PAH treatment.
- | Journal: Mitochondrial GRIM19 Loss Induces Liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-?B Signaling. (Pubmed Central) - Jul 8, 2024
Intraperitoneal administration of the NLRP3 inhibitor MCC950 dramatically alleviated GRIM19 loss-driven HF in vivo. The mitochondrial GRIM19 loss facilitates liver fibrosis through NLRP3/IL33 activation via ROS/NF-?B signaling, providing potential therapeutic approaches for earlier HF prevention.
- | dapansutrile (OLT1177) / Olatec Therap
Journal: Dapansutrile OLT1177 suppresses foreign body response inflammation while preserving vascularisation of implanted materials. (Pubmed Central) - Jul 8, 2024
Mechanistic studies revealed that this occurred through activation of early pro-angiogenic markers while suppressing late-stage anti-angiogenic markers. These findings establish OLT1177 as a promising therapeutic approach for mitigating implant fibrosis while supporting vascularisation, suggesting a highly promising selective immunosuppressive strategy for the FBR warranting further research to explore its optimal integration into medical materials and devices.
- | fluoxetine / Generic mfg.
Preclinical, Journal: The antidepressant effect of Shexiang Baoxin Pills on myocardial infarction rats with depression may be achieved through the inhibition of the NLRP3 inflammasome pathway. (Pubmed Central) - Jul 6, 2024
We have observed a significant amelioration in depression-like behavior upon SBP administration during the treatment of AMI, suggesting that this effect may be attributed to the inhibition of NLRP3-mediated pyroptosis. (The main findings are summarized in the graphical abstract in the supplementary file.).
- | Journal: Role of acupuncture in improving the outcome of sepsis-induced lung injury. (Pubmed Central) - Jul 4, 2024
Inhibition of P2X7 led to mitochondrial function recovery of lung tissue by inhibiting NLRP3 and NF-?B. At the same time, acu-exo could improve ALI by decreasing NLRP3 and NF-?B activation.
- | Journal: Mechanism of Vaginal Epithelial Cell Pyroptosis Induced by the NLRP3 Inflammasome in Vulvovaginal Candidiasis. (Pubmed Central) - Jul 3, 2024
albicans activated the NLRP3 inflammasome to induce vaginal epithelial cell pyroptosis. MCC950 inhibited the NLRP3 inflammasome, reduced vaginal epithelial cell pyroptosis, and decreased the release of inflammatory cytokines.
- || Review, Journal: The NLRP3 inflammasome in burns: a novel potential therapeutic target. (Pubmed Central) - Jul 3, 2024
A better understanding of the pathophysiological mechanism underlying the healing of burn wounds may help find optimal therapeutic targets to promote the healing of burn wounds, reduce complications/sequelae following burn, and maximize the restoration of structure and function of burn skin. This review aimed to summarize current understanding of the roles and regulatory mechanisms of the NLRP3 inflammasome in burn wound healing, as well as the preclinical studies of the involvement of NLRP3 inhibitors in burn treatment, highlighting the potential application of NLRP3-targeted therapy in burn wounds.
- | glibenclamide / Generic mfg.
Journal: Can Urinary Bladder Innervation Be Restored After Outlet Obstruction and Denervation? (Pubmed Central) - Jul 3, 2024
It is unclear whether Cox-2 is involved in the decreased nerve density following obstruction, but Cox-2 mRNA increases 5-fold in obstructed bladder. Future therapy against bladder underactivity remaining following relief of obstruction includes either systemic treatment, perhaps by anti-inflammatory drugs, or local treatment by injection of stem cells, mature ganglion cells, and/or neurotrophins or neurotrimin into the bladder wall.
- | OMT-28 / OMEICOS
Journal: Cardioprotective properties of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids. (Pubmed Central) - Jul 2, 2024
Furthermore, OMT-28 (1 ?M) limited IR-induced NLRP3 inflammasome activation similarly like a direct NLRP3 inhibitor (MCC950). Overall, this study demonstrates that OMT-28 possesses potent cardio-protective and anti-inflammatory properties supporting the hypothesis that extending the bioavailability of omega-3 epoxyeicosanoids may improve their prospects as therapeutic agents.
- | Journal: Three Undescribed Protoilludane-type Sesquiterpene Aryl Esters from (Pubmed Central) - Jul 1, 2024
Based on electronic circular dichroism (ECD) calculations, the absolute configurations of three new compounds (1-3) were determined. The anti-inflammatory activity of compounds 1-10 was screened and compound 3 could dose-dependently decrease the level of lactate dehydrogenase, showing IC50 value of 4.525 ?M.
- | Journal: ZBP1 promotes hepatocyte pyroptosis in acute liver injury by regulating the PGAM5/ROS pathway. (Pubmed Central) - Jun 29, 2024
The anti-inflammatory activity of compounds 1-10 was screened and compound 3 could dose-dependently decrease the level of lactate dehydrogenase, showing IC50 value of 4.525 ?M. ZBP1 promotes hepatocellular pyroptosis by modulating mitochondrial damage, which facilitates the extracellular release of ROS.
- | Journal: Artemisinin Alleviates Myocardial Remodeling through TGF-?1/Smad2/3 Pathway and NLRP3 Inflammasome. (Pubmed Central) - Jun 27, 2024
ZBP1 promotes hepatocellular pyroptosis by modulating mitochondrial damage, which facilitates the extracellular release of ROS. Artemisinin relieves myocardial remodeling through TGF-?1/Smad2/3 pathway and NLRP3 inflammasome.
- | Preclinical, Journal: Cinnamaldehyde, A Bioactive Compound from the Leaves of Cinnamomum osmophloeum Kaneh, Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Inhibiting the NLRP3 Inflammasome. (Pubmed Central) - Jun 25, 2024
In the mechanism study, we observed that CA inhibited the NLRP3 inflammasome in macrophages, at least partially, by enhancing the autophagic response, without reducing mitochondrial damage. These findings collectively suggest that CA holds significant potential as a therapeutic agent for enhancing the management of IBD, offering a promising avenue for further research and development.
- | Preclinical, Journal: Roundup (Pubmed Central) - Jun 24, 2024
In summary, our findings indicated that the premature senescence of granulosa cells caused by mitochondrial ROS-triggered NLRP3 inflammasome activation might contribute to the ovarian toxicity of Roundup, in addition to its known effects on steroidogenesis and apoptosis. The online version contains supplementary material available at 10.1007/s43188-024-00229-0.
- | Journal: A novel mechanism of resveratrol alleviates Toxoplasma gondii infection-induced pulmonary inflammation via inhibiting inflammasome activation. (Pubmed Central) - Jun 23, 2024
Considering insights from previous research alongside the outcomes of the current investigation, it appears that the TLR4/NF-?B/NLRP3 signaling pathway emerges as a promising target for immunomodulation to alleviate lung injury from T. gondii infection. The evidence gathered in this study lays the groundwork for the continued exploration and potential future clinical deployment of RSV as a therapeutic agent with anti-Toxoplasma properties and the capability to modulate the inflammatory response.
- | Journal: Tryptanthrin suppresses multiple inflammasome activation to regulate NASH progression by targeting ASC protein. (Pubmed Central) - Jun 23, 2024
The evidence gathered in this study lays the groundwork for the continued exploration and potential future clinical deployment of RSV as a therapeutic agent with anti-Toxoplasma properties and the capability to modulate the inflammatory response. In general, the requirement for ASC in multiple inflammasome complexes makes TPR, as a novel broad-spectrum inflammasome inhibitor, potentially useful for treating a wide range of multifactorial inflammasome-related diseases.