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- || Retrospective data, Review, Journal: The Effects of NLRP3 Inflammasome Inhibition in Experimental Acute Pancreatitis: A Systematic Review and Meta-Analysis. (Pubmed Central) - Mar 23, 2022
In addition, inhibition of NLRP3 inflammasome reduced the levels of circulating inflammatory cytokines, as well as mitigating severity of AP-associated acute lung injury and acute intestinal injury. To conclude, inhibition of NLRP3 inflammasome has protective effects on AP by mitigating organ injury and systemic inflammation in animal studies, indicating that NLRP3 inflammasome holds promise as a target for specific AP therapy.
- | Journal: Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation. (Pubmed Central) - Mar 23, 2022
The inactive NLRP3 oligomer represents the NLRP3 resting state, capable of binding to membranes and is likely disrupted for its activation. Visualization of the inhibitor binding mode will enable optimization of the activity of NLRP3 inflammasome inhibitor drugs.
- | Preclinical, Journal: LuQi Formula Ameliorates Myocardial Fibrosis by Suppressing TLR4/MyD88/NF-κB Pathway and NLRP3 Inflammasome Activation in Mice with Myocardial Infarction. (Pubmed Central) - Mar 23, 2022
Our results suggested that LQF could significantly improve cardiac function and ameliorate myocardial fibrosis. In addition, we found that LQF could downregulate the TLR4/MyD88/NF-κB signaling pathway and then inhibit the activation of NLRP3 inflammasome, suggesting that LQF alleviated cardiac fibrosis by decreasing the TLR4/MyD88/NF-κB signaling pathway and then inhibited NLRP3 inflammasome activation in MI mice, which indicates potential therapeutic effect of LQF on patients with MI.
- TIMP2 ATTENUATES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED ACUTE KIDNEY INJURY ([VIRTUAL]) - Mar 23, 2022 - Abstract #SCCM2022SCCM_2361;
Kidney injury scores of TIMP2 −/− mice were also significantly higher than that of WT mice (p< 0.05). Furthermore, the serum levels of IL-1β of TIMP2 −/− mice were higher than that of WT post CLP and LPS treatment.
- The role of the NLRP3 inflammasome in the pathogenesis of hyperfiltration-induced CKD in type 1 diabetes mellitus (Poster area 2) - Mar 22, 2022 - Abstract #DDG2022DDG_544;
Furthermore, the serum levels of IL-1β of TIMP2 −/− mice were higher than that of WT post CLP and LPS treatment. The present data indicate no involvement of the canonical NLRP3 inflammasome in podocytes in hyperfiltration-induced CKD.
- | Preclinical, Journal: Acupuncture inhibits NLRP3 inflammasome activation in the prefrontal cortex of a chronic stress rat model of depression. (Pubmed Central) - Mar 19, 2022
Acupuncture treatment also reduced the number of TUNEL-positive cells in the PFC. These results suggested that acupuncture has antidepressant-like effects, and its mechanism appears to be involved in the inhibition of NLRP3 inflammasome activation and apoptosis in the PFC.
- | Preclinical, Journal: GDF11 alleviates neointimal hyperplasia in a rat model of artery injury by regulating endothelial NLRP3 inflammasome activation and rapid re-endothelialization. (Pubmed Central) - Mar 19, 2022
We conclude that GDF11 improves re-endothelialization and can attenuate vascular remodeling by reducing endothelial NLRP3 inflammasome activation. These findings shed light on new treatment strategies to promote re-endothelialization based on GDF11 as a future target.
- | Journal: Schisandrin B Attenuates Airway Inflammation and Airway Remodeling in Asthma by Inhibiting NLRP3 Inflammasome Activation and Reducing Pyroptosis. (Pubmed Central) - Mar 18, 2022
In conclusion, SB inhibited NLRP3 inflammasome activation and reduced pyroptosis via the miR-135a-5p/TRPC1/STAT3/NF-κB axis, thus alleviating airway inflammation and airway remodeling in asthma. This study may confer novel insights for the management of asthma.
- | Preclinical, Journal: Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice. (Pubmed Central) - Mar 18, 2022
This study may confer novel insights for the management of asthma. The results showed that the upregulation of TRPC5 improved the memory performance of Cx3cr1IL-10 mice related to inhibiting NLRP3 inflammasome-associated neuroinflammation.
- | Journal: miR-29a-5p Alleviates Traumatic Brain Injury- (TBI-) Induced Permeability Disruption via Regulating NLRP3 Pathway. (Pubmed Central) - Mar 18, 2022
miR-29a-5p mimic alleviated the BBB and cerebral water content and inactivates NLRP3 in the mouse TBI model. miR-29a-5p mimics protect TBI-induced increased endothelial cell permeability and BBB dysfunction via suppressing NLRP3 expression and activation.
- | Journal: Euphzycopias A-I, macrocyclic diterpenes with NLRP3 inflammasome inhibitory activity from Euphorbia helioscopia L. (Pubmed Central) - Mar 18, 2022
A phytochemical investigation was conducted on Euphorbia helioscopia, resulting in the isolation of thirteen compounds, including nine undescribed diterpenoids, Euphzycopias A - I (1-9), of which the skeletons of compounds 1-4 were found in E. helioscopia L. Compounds 1-3 had 5/7/6 cyclic systems, while compound 4 had a 4/11 polycyclic system with a 4,7-cyclic ether between C-4 and C-7. The anti-inflammasome test using the isolated compounds (1-6, 8-13) showed that the diterpenes from E. helioscopia L. had a strong inhibitory effect on NLRP3 inflammasomes with IC values of 3.34-14.92 μM.
- || colchicine / Generic mfg.
Clinical, Review, Journal: Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation. (Pubmed Central) - Mar 18, 2022
This may occur through a selective blockade of different steps preceding NLRP3 inflammasome oligomerization as well as through a reduced release of the main cytokines (IL-1β and IL-18). Since most evidence is based on observational studies, definitive conclusion cannot be drawn and additional studies are needed to confirm preliminary results and further dissect how colchicine and other NLRP3 inhibitors reduce the inflammatory burden and evaluate the timing and duration of treatment.
- | Journal: The ROS/GRK2/HIF-1α/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin. (Pubmed Central) - Mar 18, 2022
Furthermore, MDP reduced FLS pyroptosis through targeted inhibition of GRK2 phosphorylation. According to these findings, hypoxia induces FLS pyroptosis through the ROS/GRK2/HIF-1α/NLRP3 pathway, while MDP regulates this pathway to reduce FLS pyroptosis.
- || Review, Journal: The potential of probiotics in the amelioration of hyperuricemia. (Pubmed Central) - Mar 18, 2022
We propose that future research should focus on superior strain resource isolation and insight into the cause-effect mechanisms of probiotics for hyperuricemia amelioration. The safety and effects of the application of probiotics in clinical use also need verification.
- | Preclinical, Journal: Exosomes Derived From Mouse Adipose-derived Mesenchymal Stem Cells Alleviate BAC-induced Mouse Dry Eye Model Via Inhibiting NLRP3 Inflammasome. (Pubmed Central) - Mar 17, 2022
The safety and effects of the application of probiotics in clinical use also need verification. mADSC-Exos alleviate ocular surface inflammation, suggesting that it is a promising treatment for dry eye.
- | Preclinical, Journal: NLRP3 inflammasome signal pathway involves in Vibrio harveyi-induced inflammatory response in murine peritoneal macrophages in vitro. (Pubmed Central) - Mar 17, 2022
Furthermore, blocking the secretion of mature IL-1β could markedly decrease the release of other proinflammatory cytokines, including IL-6, IL-12, and tumor necrosis factor-α. Overall, these data indicated that NLRP3 inflammasome was activated in response to V. harveyi infection and enhanced inflammatory response by promoting IL-1β secretion in murine PMs.
- | Journal: Liposomal chrysin attenuates hepatic ischaemia-reperfusion injury: possible mechanism via inhibiting NLRP3 inflammasome. (Pubmed Central) - Mar 17, 2022
LC has good biocompatibility, and it could attenuate HIR-induced injury. Its mechanism was associated with NLRP3 inflammasome inhibition, and LC might be an effective drug for treating and preventing HIR-induced injury.
- | Journal: Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. (Pubmed Central) - Mar 17, 2022
Mechanistically, J114 disturbed the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization. Overall, our study identified a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation and has species differences, which is worthy of further research to understand the differential regulation of the NLRP3 and AIM2 inflammasomes in humans and mice.
- | Journal: Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway. (Pubmed Central) - Mar 17, 2022
SenA alleviates OA progression by inhibiting NLRP3 signalling pathways. These findings provide an experimental basis for the clinical application of drugs in the treatment of OA.
- | Preclinical, Journal: BuFeiXiaoJiYin ameliorates the NLRP3 inflammation response and gut microbiota in mice with lung cancer companied with Qi-yin deficiency. (Pubmed Central) - Mar 17, 2022
BuFeiXiaoJiYin ameliorates the NLRP3 inflammation response and gut microbiota in mice with lung cancer companied with Qi-yin deficiency. Our study provides a theoretical basis for the clinical development of therapeutic drugs targeting to treat lung cancer.
- | Journal: Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP). (Pubmed Central) - Mar 16, 2022
Collectively, our data indicated that tRF3-Thr-AGT suppressed ZBP1 expressions to restrain NLRP3-mediated pyroptotic cell death and inflammation in AP models. This study, for the first time, identified the role and potential underlying mechanisms by which tRF3-Thr-AGT regulated AP pathogenesis.
- || TriptoSar (triptolide) / Pierre Fabre
Review, Journal: Phenols and terpenoids: natural products as inhibitors of NLRP3 inflammasome in cardiovascular diseases. (Pubmed Central) - Mar 16, 2022
Thus, 20 natural products from phenols and terpenoids for the treatment of cardiovascular disease based on the inhibition of NLRP3 inflammasome were summarized and screened. Docking results showed salvianolic acid B and ellagic acid in phenols, and oridonin and triptolide in terpenoids had a better binding activity with NLRP3, which can provide theoretical support for finding novel NLRP3 inflammasome inhibitors or lead compounds in the future.
- | Journal: Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis. (Pubmed Central) - Mar 16, 2022
Moreover, PCR analysis indicated that the aforementioned effects of SCFAs regulated by La may be due to the activation of G protein-coupled receptors. These findings provided guidance for the application of L. acidophilus in daily life and provided a new molecular target for interactions among L. acidophilus, its metabolites and host immunity.
- | Journal: Activation of NLRP3-Caspase-1 pathway contributes to age-related impairments in cognitive function and synaptic plasticity. (Pubmed Central) - Mar 15, 2022
Furthermore, NLRP3 inflammasome inhibitor elevated the surface expression of AMPA receptor and the phosphorylated levels of CaMKII, CREB in hippocampus, and finally contributed to the attenuation of hippocampal long-term potentiation (LTP) deficits and the improvement of cognitive decline of natural aging rats. These results revealed an important role for the NLRP3-Caspase-1 pathway in aging-induced cognitive decline and suggested that inhibition of NLRP3 inflammasome represented a novel therapeutic intervention for aging-related cognitive impairment.
- | Journal: Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction. (Pubmed Central) - Mar 15, 2022
Furthermore, LicoB exhibits protective effects in mouse models of NLRP3 inflammasome-mediated diseases, including lipopolysaccharide (LPS)-induced septic shock, MSU-induced peritonitis and non-alcoholic steatohepatitis (NASH). Our findings indicate that LicoB is a specific NLRP3 inhibitor and a promising candidate for treating NLRP3 inflammasome-related diseases.
- | Journal, Checkpoint inhibition, PD(L)-1 Biomarker, IO biomarker: Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway. (Pubmed Central) - Mar 15, 2022
Besides, crocin inhibited the activation of NF-κB pathway, which performed as reducing the phosphorylation of p-NF-kappa-B inhibitor-α (p-IκBα), degradation of IκBα, phosphorylation of p65 and p65 DNA binding activity both in vivo and in vitro. By reversing the pyroptosis in cardiomyocytes, crocin treatment in a mouse model exerted great potential to aid in the prevention of ICIs-related myocarditis from a novel target.
- | Journal: Structure-Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas. (Pubmed Central) - Mar 15, 2022
NLRP3 binding was determined by surface plasmon resonance spectroscopy. Sulfonylurea 2 was identified to be equipotent and similarly stable compared to the prototypical NLRP3 inhibitor MCC950.
- | Bay11-7082 / InvivoGen, Mifeprex (mifepristone) / Danco Laboratories
Journal: NLRP3 inflammasome is involved in uterine activation for labor at term and preterm. (Pubmed Central) - Mar 12, 2022
MCC950 postponed labor onset of the mice with LPS and RU38486 treatment and inhibited NLRP3 inflammasome activation in uterus. Our data provide the evidence that NLRP3 inflammasome is involved in uterine activation for labor onset in term and PTB in humans and mouse model.
- | Journal: Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways. (Pubmed Central) - Mar 12, 2022
Consistent with this finding, an NLRP3 inflammasome inhibitor (MCC950) was employed to treat OP, and modulation of pyroptosis was found to ameliorate osteoclastogenesis and bone loss in ovariectomized (OVX) mice, suggesting that UA suppressed osteoclast formation by regulating the inflammatory signal-dependent pyroptosis pathway. Conceivably, UA administration may be a safe and promising therapeutic strategy for osteoclast-related bone diseases such as OP.
- NLPR3-INFLAMMASOME INHIBITION AMELIORATES SECONDARY INFARCT GROWTH IN SUBACUTE ISCHEMIC STROKE IN MICE (E-POSTER LIBRARY) - Mar 12, 2022 - Abstract #ESOC2022ESOC_1004;
In line with our previous results showing a significant impact of the NLRP3-inhibition on post-stroke outcome after an observation period of 1d, our results underline the role of the NLRP3-inflammasome as master-switch of inflammation during IS. Of note, not only the hyperacute but also the delayed treatment after reperfusion lead to better post-stroke outcomes and smaller infarct sizes that persisted for a whole week.
- | Journal: Identification of NLRP3 Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity. (Pubmed Central) - Mar 12, 2022
Our results demonstrate that these NLRP3 inhibitors interfere with ASC speck formation, inhibit pro-inflammatory cytokine IL1-β release, and decrease pyroptotic cell death. We employed spectroscopic techniques and computational docking analyses with QM380 and QM381 and the PYD domain to confirm the experimental results and predict possible mechanisms underlying the inhibition of NLRP3 homo-interactions.
- | LY294002 / Eli Lilly
Journal: Ephedrine ameliorates cerebral ischemia injury via inhibiting NOD-like receptor pyrin domain 3 inflammasome activation through the Akt/GSK3β/NRF2 pathway. (Pubmed Central) - Mar 11, 2022
Meanwhile, LY294002 attenuated the inhibitory effects of ephedrine on NLRP3 inflammasome activation and TNF-α and IL-1β production...In conclusion, ephedrine ameliorated cerebral ischemia injury via inhibiting NLRP3 inflammasome activation through the Akt/GSK3β/NRF2 pathway. Our results revealed a potential role of ephedrine in ischemic stroke treatment.
- || 5-fluorouracil / Generic mfg.
Clinical, Journal: Galangin Enhances Anticancer Efficacy of 5-Fluorouracil in Esophageal Cancer Cells and Xenografts Through NLR Family Pyrin Domain Containing 3 (NLRP3) Downregulation. (Pubmed Central) - Mar 11, 2022
Using xenograft mouse models, we found that galangin exposure further restrained cancer development after 5-FU treatment and increased sensitivity to chemotherapy by suppressing the NLRP3 inflammasome pathway. CONCLUSIONS Our results indicated that galangin played a synergistic anticancer role through NLRP3 inflammasome inhibition when paired with FU-5.
- | Journal: Low Dose of Deoxynivalenol Aggravates Intestinal Inflammation and Barrier Dysfunction Induced by Enterotoxigenic Escherichia coli Infection through Activating Macroautophagy/NLRP3 Inflammasomes. (Pubmed Central) - Mar 11, 2022
CRISPR-Cas9-mediated knockout of LC3B alleviated intestinal inflammation and barrier dysfunction and also inhibited NLRP3 inflammasome. In conclusion, a low dose of DON aggravates intestinal inflammation and barrier dysfunction induced by the ETEC infection by activating macroautophagy and NLRP3 inflammasome.
- || Review, Journal: AA Amyloidosis complicating cryopyrin-associated periodic syndrome: a study on 86 cases including 23 French patients and systematic review. (Pubmed Central) - Mar 11, 2022
AA amyloidosis can occur in nearly all CAPS subtypes. Interleukin-1 inhibitors are effective, underlining the necessity of an early diagnosis of CAPS in order to start this treatment as soon as possible among AA-CAPS patients.
- | Journal: Emodin Alleviates High-Glucose-Induced Pancreatic β-Cell Pyroptosis by Inhibiting NLRP3/GSDMD Signaling. (Pubmed Central) - Mar 11, 2022
Overexpression of NLRP3 reversed the above changes caused by EMD. Collectively, our findings suggest that EMD attenuates high-glucose-induced β-cell pyroptosis by inhibiting NLRP3/GSDMD signaling.
- | Journal: miR-155 inhibits chondrocyte pyroptosis in knee osteoarthritis by targeting SMAD2 and inhibiting the NLRP3/Caspase-1 pathway. (Pubmed Central) - Mar 9, 2022
Collectively, our findings suggest that EMD attenuates high-glucose-induced β-cell pyroptosis by inhibiting NLRP3/GSDMD signaling. miR-155 knockdown inhibited the NLRP3/Caspase-1 pathway by targeting SMAD2, thus inhibiting mouse KOA chondrocyte pyroptosis.
- | Journal: Activation of the NLRP3 inflammasome and elevation of interleukin-1β secretion in infection by sever fever with thrombocytopenia syndrome virus. (Pubmed Central) - Mar 9, 2022
The findings in this study suggest that the activation of the NLPR3 inflammasome and pyroptosis, leading to IL-1β/IL-18 secretion during the SFTSV infection, could play important roles in viral pathogenesis and host protection. Pyroptosis as part of innate immunity might be essential in proinflammatory responses and pathogenicty in humans infected with this novel phlebovirus.
- NOVEL NLRP3 INHIBITORS AS POTENTIAL THERAPEUTICS FOR ALZHEIMER'S DISEASE (HALL C) - Mar 9, 2022 - Abstract #ADPD2022ADPD_1029;
In conclusion, a novel scaffold was identified with unique binding interactions to the LRR domain of NLRP3, and the flexibility to provde both covalent and noncovalent NLRP3 inhibitors. Medicinal chemistry studies confirmed that the scaffold can be optimized to improve inhibitory potency and binding affinity to the NLRP3 protein, and new lead NLRP3 inhibitors have been identified for further development.
- Deciphering role of NLRP3 inflammasome in acute myeloid leukemia microenvironment (E-Poster Website) - Mar 9, 2022 - Abstract #AACR2022AACR_7130;
Paraffin sections of AML BM are being evaluated for NLRP3 pathway markers by immunohistochemistry. Understanding remodelling of BM-MSC, leukemia target and immune cell dynamics through NLRP3 pathway regulation in stroma microenvironment may provide crucial leads in therapeutic modulation of the immune response within the stem cell niche.
- doxorubicin hydrochloride / Generic mfg.
Phenstatin based indole linked chalcone compound 9a exhibits anti-oral cancer activity through regulating NLRP3 inflammasome innate immune pathway (Section 38) - Mar 9, 2022 - Abstract #AACR2022AACR_6117;
Summarizingly, 9a has been found to be regulating inflammatory immune mechanisms and can be developed further as immunomodulatory anti-cancer agent. Since macrophages are major resource immune cells of NLRP3, further studies are underway to test 9a on macrophages from nlrp3-/- and caspase-/- mice in comparison with normal mice.
- | Journal: SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway. (Pubmed Central) - Mar 8, 2022
Importantly, infection of epithelial cells with SARS-CoV-2 similarly activates the NLRP3 inflammasome. With the NLRP3 inhibitor MCC950 and select FDA-approved oral drugs able to block ORF3a-mediated inflammasome activation, as well as key ORF3a amino acid residues needed for virus release and inflammasome activation conserved in the new variants of SARS-CoV-2 isolates across continents, ORF3a and NLRP3 present prime targets for intervention.
- | Journal: Resveratrol Targets AKT1 to Inhibit Inflammasome Activation in Cardiomyocytes Under Acute Sympathetic Stress. (Pubmed Central) - Mar 8, 2022
In conclusion, resveratrol targets AKT1 to inhibit NLRP3 inflammasome activation in cardiomyocytes and cardiac inflammation following acute sympathetic stress. AKT1 is an important target of resveratrol, which should be considered as a treatment option for cardiovascular patients, especially those at risk of acute sympathetic stress.
- | RRx-001 / EpicentRx
Journal: An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups. (Pubmed Central) - Mar 8, 2022
Furthermore, treatment with 149-01 effectively alleviate the severity of several inflammatory diseases in mice, including lipopolysaccharide (LPS)-induced systemic inflammation, monosodium urate crystals (MSU)-induced peritonitis and experimental autoimmune encephalomyelitis (EAE). Thus, our results indicate that 149-01 is a potential lead for developing therapeutic agent for NLRP3-related inflammatory diseases.
- | Journal: Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. (Pubmed Central) - Mar 8, 2022
Treatment of manoalide relieved the pathogenesis of experimental autoimmune encephalomyelitis (EAE) in mice. Thus, our results identify manoalide as a selective and covalent NLRP3 inhibitor and suggest it has the potential for the treatment of NLRP3-associated diseases.
- Inflammasome inhibitors for the treatment of muscular dystrophies () - Mar 6, 2022 - Abstract #AAN2022AAN_2287;
These data were replicated with success in C2C12 murine myoblasts and in human myotubes. This molecule could thus offer promising therapeutic prospects for managing DMD or other muscle and inflammatory disorders.
- | irbesartan / Generic mfg.
Journal: Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy. (Pubmed Central) - Mar 6, 2022
In summary, we conclude that ICA can increase Sesn2-induced mitophagy to inhibit NLRP3 inflammasome activation by the Keap1-Nrf2/HO-1 axis in diabetic nephropathy rats. This might be the underlying mechanism of ICA's protective effect in diabetic nephropathy.
- | Journal, PARP Biomarker: Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment. (Pubmed Central) - Mar 5, 2022
In summary, NBP rescued dopaminergic neurons by reducing NLRP3 inflammasome activation and ameliorating mitochondrial impairments and increases in p-α-Syn levels. This current study may provide novel neuroprotective mechanisms of NBP as a potential therapeutic agent.
- | Journal: Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2. (Pubmed Central) - Mar 5, 2022
Particularly revealing was that the Nrf2 inhibitor ML385 partly blocked the above effects of AST IV. Taken together, these results demonstrate that AST IV alleviates CIRI through inhibiting NLRP3 inflammasome-mediated pyroptosis via activating Nrf2.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation. (Pubmed Central) - Mar 5, 2022
In vivo, CAL afforded a protective effect against DOX-induced cardiac injury by improving myocardial function, inhibiting brain natriuretic peptide, and improving the changes of the histological morphology of DOX-treated mice. Collectively, our findings confirmed that CAL alleviates DOX-induced cardiotoxicity and pyroptosis by inhibiting NLRP3 inflammasome activation in vivo and in vitro.