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7 Companies | 6 Products |
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29 Diseases | |
11 Trials |  |
763 News |  |
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- | Zanosar (streptozocin) / Teva
Journal: Irisin alleviates the pyroptosis of ? cells in T2DM by inhibiting NLRP3 inflammasome through regulating miR-19b-3p/SOCS3/STAT3 axis mediated autophagy. (Pubmed Central) - Aug 15, 2024
In conclusion, irisin alleviated the pyroptosis of ? cells in T2DM by inhibiting NLRP3 signaling through miR-19b-3p/SOCS3/STAT3 axis mediated autophagy.
- | Journal: Novel Compounds as NLRP3 Inhibitors for Treating Cardiovascular Diseases. (Pubmed Central) - Aug 14, 2024
cells in T2DM by inhibiting NLRP3 signaling through miR-19b-3p/SOCS3/STAT3 axis mediated autophagy. Provided herein are novel compounds as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating cardiovascular diseases, and processes for preparing such compounds.
- | Journal: Novel Compounds as NLRP3 Inhibitors for Treating Alzheimer's Disease and Parkinson's Disease. (Pubmed Central) - Aug 14, 2024
Provided herein are novel compounds as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating cardiovascular diseases, and processes for preparing such compounds. Provided herein are novel compounds as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating Alzheimer's disease and Parkinson's disease, and processes for preparing such compounds.
- | Journal: Gasdermin D could be lost in the brain parenchyma infarct core and a pyroptosis-autophagy inhibition effect of Jie-Du-Huo-Xue decoction after stroke. (Pubmed Central) - Aug 14, 2024
JDHXD suppressed pyroptosis and autophagy by inhibiting NLRP3, thereby alleviating CI. In addition, we present a different observation from previous studies that the expression of GSDMD in the infarct core was lower than that in the peri-infarct and contralateral non-ischemic hemispheres on day 3 of CI.
- | Journal: Rutin Ameliorates Inflammation and Oxidative Stress in Ulcerative Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway. (Pubmed Central) - Aug 14, 2024
Conversely, NLRP3 overexpression reversed the restraining role of Rutin in OS. Rutin ameliorates UC by inhibiting inflammation and OS through suppressing NLRP3 inflammasome.
- | Preclinical, Journal: Based on SIRT1/NF-?B/NLRP3 Signal Pathway to Explore the Effect of Yiqi Huatan Huoxue Recipe on Inflammatory Injury in AIT Mice by Pyroptosis. (Pubmed Central) - Aug 13, 2024
Rutin ameliorates UC by inhibiting inflammation and OS through suppressing NLRP3 inflammasome. Yiqi Huatan Huoxue recipe can alleviate thyroid structural damage in AIT mice, and its mechanism may be related to the upregulation of SIRT1, NF-?B deacetylation, and inhibition of NLRP3-mediated pyroptosis.
- | fluvoxamine / Generic mfg.
Preclinical, Journal: Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology. (Pubmed Central) - Aug 13, 2024
deposits and neuroinflammation. As an already approved drug, FXN holds potential as a candidate for human studies against AD.
- | Journal: Downregulation of ATP5F1D inhibits mtROS/NLRP3/caspase-1/GSDMD axis to suppress pyroptosis-mediated malignant progression of endometrial cancer. (Pubmed Central) - Aug 13, 2024
As an already approved drug, FXN holds potential as a candidate for human studies against AD. Downregulation of ATP5F1D as a new therapeutic strategy that could mediate pyroptosis via suppressing mtROS/NLRP3/caspase-1/GSDMD pathway to inhibit EC progression.
- | Journal: Eudragit S100 coated iron oxide-chitosan nanocomposites for colon targeting of 5-aminosalicylic acid ameliorate ulcerative colitis by improving intestinal barrier function and inhibiting NLRP3 inflammasome. (Pubmed Central) - Aug 13, 2024
Additionally, iron oxide nanoparticles used as nanozymes could alleviate inflammation. In summary, this study indicates that ES-IOCS/5-ASA exert anti-inflammatory effects on DSS-induced colitis by improving intestinal barrier function and inhibiting NLRP3 inflammasome expression, presenting a viable therapeutic choice for the treatment of UC.
- | colchicine / Generic mfg.
Journal: Chinese classical decoction Wuwei Xiaodu Drink alleviates gout arthritis by suppressing NLRP3-Mediated inflammation. (Pubmed Central) - Aug 12, 2024
The results of the present study suggested the anti-inflammatory effects of WWXDD in the treatment of gouty arthritis, partially through inhibiting NLRP3 inflammasome activation. Clinical Trial Registration: ClinicalTrials.gov, identifier ChiCTR2100047807.
- | Journal: New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation. (Pubmed Central) - Aug 12, 2024
The present study demonstrates that PRA alleviated PF induced-liver injury by inhibiting NLRP3 inflammasome activation. The results of this study are expected to inform the prevention and control of PF-induced hepatotoxicity in clinical practice.
- | hyoscine butylbromide oral / Generic mfg.
Journal: The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta. (Pubmed Central) - Aug 11, 2024
The results of this study are expected to inform the prevention and control of PF-induced hepatotoxicity in clinical practice. Our results indicate that CA140 improves neuronal/synaptic/cognitive function and ameliorates A?/tau pathology and neuroinflammation by modulating DRD1 signaling in primary hippocampal neurons, primary astrocytes/microglia, WT mice, and aged 5xFAD mice.
- | Journal: Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis. (Pubmed Central) - Aug 10, 2024
Notably, the NLRP3 inhibitor MCC950 reduced migration and invasion of endometrial cells effectively. Furthermore, in the mouse model of adenomyosis, MCC950 exhibited a therapeutic effect by alleviating the severity of adenomyosis.
- | BMS-986299 / BMS, Visudyne (verteporfin) / Novartis
Journal: TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure. (Pubmed Central) - Aug 9, 2024
Furthermore, in the mouse model of adenomyosis, MCC950 exhibited a therapeutic effect by alleviating the severity of adenomyosis. TAOK1 played a crucial role in regulating IL-17-mediated increase in the pyroptosis and decrease in the proliferation of cardiomyocytes by regulating the activities of the NLRP3 inflammasomes and the YAP/TEAD pathway.
- The Inhibition of Mitochondrial NLRP3 Inflammasome Decreases Dopaminergic Cell Death in a 6-OHDA Mouse Model of Parkinson's Disease. (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1924;
TAOK1 played a crucial role in regulating IL-17-mediated increase in the pyroptosis and decrease in the proliferation of cardiomyocytes by regulating the activities of the NLRP3 inflammasomes and the YAP/TEAD pathway. Inhibition of mitochondrial NLRP3 inflammasome may be neuroprotective to dopaminergic neurons that degenerate during PD, hence, may be used as a novel treatment therapy for patients with early- and/or late-onset PD.
- Melatonin Modulates NLRP3 Inflammasome Activation through TLR2 to Protect Against Parkinson's Disease (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1098;
In BV2 cells and PFF-induced mouse models, MLT attenuates the activation of the NLRP3 inflammasome in microglia by modulating TLR2 expression, thereby mitigating neuroinflammation and protecting dopaminergic neurons. These findings contribute novel insights into the anti-inflammatory therapeutic mechanism of MLT in PD.(Submitted to IAPRD meeting on January 28th) ?-syn modulates NLRP3 Activation via TLR2 MLT inhibits NLRP3 Inflammasome Activation MLT protects against DA neurons degeneration in PD
- nibrozetone (RRx-001) / EpicentRx
Validating the clinical stage NLRP3 inflammasome inhibitor nibrozetone as a disease-modifying therapeutic for Parkinson's disease (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_991;
These findings contribute novel insights into the anti-inflammatory therapeutic mechanism of MLT in PD.(Submitted to IAPRD meeting on January 28th) ?-syn modulates NLRP3 Activation via TLR2 MLT inhibits NLRP3 Inflammasome Activation MLT protects against DA neurons degeneration in PD Given the excellent clinical safety record of RRx-001 in human studies to date, our results suggest that RRx-001 could be an attractive neuroprotective strategy for disease modification of PD, with the potential for rapid clinical translation.
- Loganic Acid Alleviates the Bidirectional Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson's Disease (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_968;
Given the excellent clinical safety record of RRx-001 in human studies to date, our results suggest that RRx-001 could be an attractive neuroprotective strategy for disease modification of PD, with the potential for rapid clinical translation. Loganic acid treatment showed a prominent neuroprotective effect via regulating cellular redox homeostasis, restricting microglial activation, and supporting neuronal survival by targeting the NLRP3 inflammasome pathway in both cellular and animal model and further reducing neuroinflammation and neuronal damage associated with PD.
- | Journal: Eclipta prostrata improves alveolar development of bronchopulmonary dysplasia via suppressing the NLRP3 inflammasome in a DLD-dependent manner. (Pubmed Central) - Aug 8, 2024
Loganic acid treatment showed a prominent neuroprotective effect via regulating cellular redox homeostasis, restricting microglial activation, and supporting neuronal survival by targeting the NLRP3 inflammasome pathway in both cellular and animal model and further reducing neuroinflammation and neuronal damage associated with PD. Our study suggested that EAP could attenuate arrest of alveolar development via inhibiting NLRP3 inflammasome in a DLD-dependent way, and could be a potential therapeutic method for BPD.
- | Journal: Aryl hydrocarbon receptor confers protection against macrophage pyroptosis and intestinal inflammation through regulating polyamine biosynthesis. (Pubmed Central) - Aug 8, 2024
AHR expression was positively correlated with ODC1 in intestinal mucosal biopsies from patients with ulcerative colitis. These findings suggest a functional role for the AhR/ODC1/polyamine axis in maintaining intestinal homeostasis, providing potential targets for treatment of inflammatory bowel disease.
- | Journal: The effects of hyaluronan and proteoglycan link protein 1 (HAPLN1) in ameliorating spinal cord injury mediated by Nrf2. (Pubmed Central) - Aug 7, 2024
These effects were mediated by the Nrf2/ARE pathway, and inhibition of Nrf2 with ML385 abolished the beneficial effects of HAPLN1. Based on these findings, we conclude that HAPLN1 inhibits the NLRP3 inflammasome through the stimulation of the Nrf2/ARE pathway, thereby suppressing neuroinflammation, enhancing motor neuronal survival, and improving the recovery of nerve function after SCI.
- | Journal: Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome. (Pubmed Central) - Aug 6, 2024
Furthermore, in vivo results showed that Ang deficiency led to the downregulation of tsRNAs, ultimately leading to an exacerbation of NLRP3 inflammasome-dependent inflammation, including lipopolysaccharide-induced systemic inflammation and type-2 diabetes-related inflammation. Altogether, our study sheds a new light on the role of Ang-induced 5'-tsRNAs in regulating NLRP3 inflammasome activation via SGs, and highlights tsRNAs as a promising target for the treatment of NLRP3 inflammasome-related diseases.
- | Journal: Knockdown of KCNQ1OT1 Alleviates the Activation of NLRP3 Inflammasome Through miR-17-5p/TXNIP Axis in Retinal M (Pubmed Central) - Aug 6, 2024
In conclusion, it was found in this study that KCNQ1OT1 promoted the activation of NLRP3 inflammasome both in vitro and in vivo, which was mediated by miR-17-5p/TXNIP axis. KCNQ1OT1 might be an effective interference target for the prevention and treatment of DR.
- | Preclinical, Journal: NLRP3 Inflammasome Deficiency Alleviates Inflammation and Oxidative Stress by Promoting PINK1/Parkin-Mediated Mitophagy in Allergic Rhinitis Mice and Nasal Epithelial Cells. (Pubmed Central) - Aug 6, 2024
However, PINK1 knockdown abrogated mitophagy and also reversed the protective effects of MCC950 on inflammation, oxidative stress, and apoptosis in HNEpCs stimulated with IL-13. Inhibition of NLRP3 inflammasome exerts the protective effects on AR by facilitating mitophagy regulated by PINK1/Parkin signaling pathway.
- NLRP3 inhibition reduces pathogenic IL1-family signalling in Hidradenitis Suppurativa skin (Open Stage) - Aug 5, 2024 - Abstract #EADV2024EADV_1827;
- NLRP3 inhibition reduces pathogenic IL1-family signalling in Hidradenitis Suppurativa skin (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1784;
Our findings underscore the significant therapeutic promise of targeting the NLRP3 inflammasome in HS with novel potent small molecule inhibitors and support that IL-1 family cytokines are important disease mediators. Beyond HS, these NLRP3 inhibitors may be efficacious for other skin inflammatory diseases where IL-1 family cytokines and continuous neutrophil infiltration play a key pathogenic role.
- | Journal: Palmitoylation of NLRP3 Modulates Inflammasome Activation and Inflammatory Bowel Disease Development. (Pubmed Central) - Aug 5, 2024
Overall, our study reveals that palmitoylation of NLPR3 modulates inflammasome activation and inflammatory bowel disease development. We propose that drugs targeting NLRP3 palmitoylation could be promising candidates in the treatment of NLRP3-mediated inflammatory diseases.
- | chloroquine phosphate / Generic mfg.
Preclinical, Journal: Palmatine Ameliorates Motor Deficits and Dopaminergic Neuron Loss by Regulating NLRP3 Inflammasome through Mitophagy in Parkinson's Disease Model Mice. (Pubmed Central) - Aug 4, 2024
In addition, chloroquine (CQ, mitophagy inhibitor) attenuated the ameliorative effects of PAL on the motor deficits and dopaminergic neuron damage, as well as the inhibitory effect of PAL on NLRP3 inflammasome. Collectively, these results provide strong evidence that PAL ameliorates motor deficits and dopaminergic neuron death in Parkinson's disease, and the mechanism may be related to its inhibition of NLRP3 inflammasome activation via promoting mitophagy.
- | Journal: An integrated network pharmacology and molecular docking approach to reveal the role of Arctigenin against Cutibacterium acnes-induced skin inflammation by targeting the CYP19A1. (Pubmed Central) - Aug 2, 2024
Taken together, our results confirmed that ATG regulated E2 secretion by targeting CYP19A1, thereby inhibiting the NLRP3 inflammasome signaling pathway and improving inflammation levels in acne mice. This study provides a basis for the feasibility of ATG in treating acne in clinical practice.
- | Journal, PARP Biomarker: Intracerebroventricular Infusion of Secretoneurin Inhibits Neuronal NLRP3-Apoptosis Pathway and Preserves Learning and Memory after Cerebral Ischemia. (Pubmed Central) - Aug 1, 2024
In summary, our data indicate that SN could effectively attenuate NLRP3 inflammasome formation, as well as the activation of caspase-1 and -3, the production of pro-inflammatory cytokines, and ultimately the neuronal apoptotic loss induced by GCI. Potential neuronal pyroptosis, or caspase-1-dependent cell death, could also be involved in ischemic neuronal death, which needs further investigation.
- | Journal: Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis. (Pubmed Central) - Aug 1, 2024
Inhibition of NLRP3-mediated pyroptosis effectively protected HUVECs from PS-MPs-induced damage. Pyroptosis played a vital role in controlling the vascular endothelial injury caused by PS-MPs.
- | hyoscine butylbromide oral / Generic mfg.
Journal: Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer's Disease. (Pubmed Central) - Jul 30, 2024
In ex vivo assessments, 13a notably modulates the levels of superoxide, catalase, and malondialdehyde along with AChE and BChE. These findings revealed that 13a holds promise as a potential candidate for further development in AD management.
- | Journal: Release of IL-1? and IL-18 in human primary bronchial epithelial cells exposed to cigarette smoke is independent of NLRP3. (Pubmed Central) - Jul 29, 2024
N-acetyl cysteine reverted CSE-induced caspase-1 activation. Overall, our findings support that the bronchial epithelium may play a central role in the release of IL-1 family cytokines independently of NLRP3 in the lungs of smokers.
- | Journal: Yiqi Jiedu Huayu decoction inhibits precancerous lesions of chronic atrophic gastritis by inhibiting NLRP3 inflammasome-mediated pyroptosis. (Pubmed Central) - Jul 29, 2024
Overall, our findings support that the bronchial epithelium may play a central role in the release of IL-1 family cytokines independently of NLRP3 in the lungs of smokers. Taken together, YJHD alleviated NLRP3 inflammasome formation and pyroptosis of epithelial cells in CAG, potentially through the inactivation of TLR4/NF-?B and IL-6/STAT3 pathways.
- | PLX5622 / Daiichi Sankyo
Preclinical, Journal: Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy. (Pubmed Central) - Jul 29, 2024
plaques, soluble A?-42 levels, or hippocampal neurogenesis. Thus, short-term CSF1R inhibition during the early stages of neuroinflammation in 5xFAD mice promotes the retention of homeostatic microglia with diminished inflammasome activation and mTOR signaling, alongside increased autophagy.
- | colchicine / Generic mfg.
Journal: Successful Treatment With High-Dose Colchicine of a 101-Year-Old Patient Diagnosed With COVID-19 After an Emergency Cholecystectomy. (Pubmed Central) - Jul 29, 2024
We initiated our high-dose colchicine treatment regimen, resulting in the patient's complete recovery and discharge. We are convinced that the administration of high-dose colchicine to high-risk COVID-19 patients should be mandatory.
- | Journal: GDF15 regulated by HDAC2 exerts suppressive effects on oxygen-glucose deprivation/reoxygenation-induced neuronal cell pyroptosis via the NLRP3 inflammasome. (Pubmed Central) - Jul 29, 2024
HDAC2 is involved in mediating OGD-induced GDF15 down-regulation via H3K27ac modification. GDF15 overexpression and HDAC2 inhibition hold potential as useful therapeutic strategies for neuroprotection.
- | Journal: Role of long Intergenic Nonprotein-Coding RNA 00511 in Nod-Like Receptor Protein Pyrin Domain 3-Induced Chondrocyte Pyroptosis via the MicroRNA-9-5p/FUT1 Axis. (Pubmed Central) - Jul 28, 2024
Additionally, downregulation of miR-9-5p or overexpression of FUT1 neutralized the suppressive effect of LINC00511 knockdown on LPSinduced chondrocyte pyroptosis. Silencing LINC00511 inhibited the NLRP3 inflammasome to quench Caspase-1-dependent chondrocyte pyroptosis in OA by promoting miR-9-5p and downregulating FUT1.
- | Journal: Celastrol exerts antiarrhythmic effects in chronic heart failure via NLRP3/Caspase-1/IL-1? signaling pathway. (Pubmed Central) - Jul 28, 2024
Celastrol could alleviate the adverse effects of VAs after MI partially by promoting autonomic nerve remodeling, ventricular electrical reconstruction and ion channel remodeling, and alleviating ventricular fibrosis and inflammatory responses partly by through inhibiting the NLRP3/Caspase-1/IL-1? pathway.
- | Journal: 1,8-cineole ameliorates experimental diabetic angiopathy by inhibiting NLRP3 inflammasome-mediated pyroptosis in HUVECs via SIRT2. (Pubmed Central) - Jul 28, 2024
1,8-Cineole inhibited the deacetylation of NLRP3 by regulating SIRT2, thereby reducing pyroptosis in HUVECs. In conclusion, our findings suggest that PA-HG-induced pyroptosis in HUVECs plays a crucial role in the development of diabetic angiopathy, which can be mitigated by 1,8-cineole.
- | Journal: Lindenane sesquiterpenoid dimers with NLRP3 inflammasome inhibitory activities from Chloranthus holostegius var. shimianensis. (Pubmed Central) - Jul 28, 2024
Compound 17 exhibited dose-dependent inhibition of nigericin-induced pyroptosis in J774A.1 cells. Molecular docking studies suggested a strong interaction between compound 17 and NLRP3.
- | Journal: Gentiopicroside improves NASH and liver fibrosis by suppressing TLR4 and NLRP3 signaling pathways. (Pubmed Central) - Jul 28, 2024
In vitro, GPS attenuated inflammation induced by BMDMs by inhibiting TLR4 and NLRP3 signaling pathways, and Co-culture studies suggested that GPS reduced hepatocyte pyroptosis and HSC activation, which was also confirmed in liver tissues GPS improves NASH and liver fibrosis by inhibiting the TLR4 and NLRP3 signaling pathways. The specific mechanism may be related to the suppression of macrophage-mediated inflammatory responses, thereby reducing hepatocyte pyroptosis and HSC activation.
- | memantine / Generic mfg.
Journal: Mitigating radiation-induced brain injury via NLRP3/NLRC4/Caspase-1 pyroptosis pathway: Efficacy of memantine and hydrogen-rich water. (Pubmed Central) - Jul 28, 2024
Immunohistochemistry further confirmed these molecular changes, suggesting the effectiveness of these agents. Echoing recent scientific inquiries into the protective roles of specific compounds against radiation-induced damages, our study adds to the growing body of evidence on the potential of memantine and hydrogen-rich water as novel therapeutic strategies for RIBI.
- || colchicine / Generic mfg.
Clinical, Review, Journal: Colchicine-The Divine Medicine against COVID-19. (Pubmed Central) - Jul 27, 2024
In addition, post-COVID-19 symptoms in those treated with colchicine were significantly rarer. As a large number of viruses can overactivate the NLRP3 inflammasome (like seasonal influenza), we are convinced that higher colchicine doses would be useful in these cases as well.
- | Journal: Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NF?B through the AMPK/sirT3/Nrf2 Axis. (Pubmed Central) - Jul 27, 2024
the present study demonstrated that STZ and HG-induced oxidative and nitrosative stress play a crucial role in the pathogenesis of diabetic neuropathy. We find, for the first time, that a CBD and BC combination ameliorates DN by modulating the mitochondrial quality control system.
- | ondansetron / Generic mfg.
Journal: TREM-1 inhibition or ondansetron administration ameliorates NLRP3 inflammasome and pyroptosis in traumatic brain injury-induced acute lung injury. (Pubmed Central) - Jul 26, 2024
Ondansetron alleviated TBI-ALI. In terms of mechanism, TREM-1 promotes TBI-ALI via the NLRP3-related pyroptosis pathway, and the protective effect of ondansetron on TBI-ALI may be related to the inhibition of TREM-1.
- | cisplatin / Generic mfg.
Journal: P2X7 receptor deficiency attenuates cisplatin-induced kidney injury via inhibiting NLRP3 inflammasome activation. (Pubmed Central) - Jul 26, 2024
Furthermore, P2X7R -/- mice also showed reduced renal fibrosis and better long-term renal prognosis. In conclusion, our study identified that P2X7R knockout can improve cisplatin induced acute renal injury and chronic renal fibrosis by inhibiting the activation of NLRP3 inflammasome.
- || cisplatin / Generic mfg., fluvoxamine / Generic mfg., fluoxetine / Generic mfg.
Clinical, Retrospective data, Journal: EXPRESS: Fluoxetine, Fluvoxamine and Hearing Loss or Tinnitus After Cisplatin Treatment: A Retrospective Cohort Study. (Pubmed Central) - Jul 26, 2024
Randomized clinical trials are needed to confirm these findings and establish the efficacy of the medications in ototoxicity prevention. Further research is also warranted to investigate the potential mechanisms underlying this protective effect.
- | Journal: Nuclear receptor Rev-erb? alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. (Pubmed Central) - Jul 24, 2024
Taken together, targeting Rev-erb? may be a potential therapeutic strategy for alleviating IVD degeneration and its related diseases.
- | benfotiamine / Generic mfg.
Preclinical, Journal: Benfotiamine protects MPTP-induced Parkinson's disease mouse model via activating Nrf2 signaling pathway. (Pubmed Central) - Jul 23, 2024
Control of Nrf2 proved crucial for BFT, as it facilitated Nrf2 movement to the nucleus, upregulating antioxidant genes and enzymes while mitigating oxidative damage. This study elucidates BFT's neuroprotective effects in a PD mouse model via Nrf2-mediated antioxidant mechanisms and gene expression modulation, underscoring its potential as a therapeutic agent for PD.