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- | Journal: Hydroxysafflor yellow a confers neuroprotection against acute traumatic brain injury by modulating neuronal autophagy to inhibit NLRP3 inflammasomes. (Pubmed Central) - Mar 14, 2023
HSYA enhanced neuronal autophagy by triggering the AMPK/mTOR signalling pathway, leading to inhibition of the NLRP3 inflammasome to improve neurological recovery after TBI.
- Bioinformatic characterization of dendritic and T cell subpopulations in the tumor microenvironment across different cancer types by single-cell RNA-Seq analysis (Section 30; Poster Board #14) - Mar 14, 2023 - Abstract #AACR2023AACR_8076;
Further analysis is being performed to identify Th17 subsets and their potential interactions with the cDC2 subclusters. A robust identification and characterization of these immune cell subsets will build towards our understanding of the interactions between these subpopulations triggered by inflammasome activation within the TME and the mechanisms behind ICB response.
- | Journal: A20 affects macrophage polarization through the NLRP3 inflammasome signaling pathway and promotes breast cancer progression. (Pubmed Central) - Mar 14, 2023
The NLRP3 inhibitor MCC950 alleviated the effect of interference with A20 to promote macrophage proliferation and recruitment, as well as M2-like polarization. In conclusion, interference with A20 inhibited macrophage proliferation and M2-like polarization through the NLRP3 inflammasome signaling pathway to inhibit breast cancer progression.
- selnoflast (RG6418) / Roche
Phase Ib Study Design Evaluating The Safety, Pharmacokinetics And Pharmacodynamics Of Selnoflast, A Novel NLRP3 Inflammasome Inhibitor In Early-Stage PD (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1470;
Results The study design will be described, including inclusion/exclusion criteria, safety, pharmacokinetics and pharmacodynamic parameters (CSF and positron emission tomography imaging) selected for this Phase Ib study. Conclusions To characterise a novel compound acting on the inflammasome, an innovative Phase Ib study design is needed to investigate safety, pharmacokinetics and pharmacodynamics.
- | Journal: SIRT1 Inhibits High Glucose-Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation. (Pubmed Central) - Mar 12, 2023
The TXNIP/NLRP3 inflammasome pathway promotes HG-induced inflammation and HLEC pyroptosis, which is negatively regulated by SIRT1. This suggests viable strategies for treating diabetic cataract.
- | Journal: Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway. (Pubmed Central) - Mar 11, 2023
Moreover, network pharmacology analysis showed that Sip may function via the PI3K/AKT signaling pathway and animal experiment validate the results, which revealed that Sip inhibited NLRP3 inflammasome-mediated pyroptosis by suppressing the phosphorylation of PI3K and AKT. Our findings demonstrated that Sip inhibited NLRP3-mediated cell pyroptosis through activation of the PI3K/AKT pathway in PM2.5-induced lung toxicity, which has a promising application value and development prospect against lung injury in the future.
- | Journal: Putative Therapeutic Impact of Inflammasome Inhibitors against COVID-19-Induced ARDS. (Pubmed Central) - Mar 11, 2023
In this regard, inflammasomes possess a distinct priority for cytokine storm occurrence and subsequently ARDS progression in ill patients with SARS-CoV-2 infection. In this mini-review, the characteristics of known inflammasome inhibitors and designed research in this field were concretely deciphered.
- | Preclinical, Journal: Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1? signaling pathway. (Pubmed Central) - Mar 11, 2023
Additionally, the effect of baicalin magnesium was remarkably superior to that of equimolar baicalin and magnesium sulfate in regard to ameliorating NASH symptoms. In conclusion, the findings suggested that baicalin magnesium may represent a potential drug for the treatment of NASH.
- | Preclinical, Journal: Sustained activation of NLRP3 inflammasome contributes to delayed wound healing in aged mice. (Pubmed Central) - Mar 9, 2023
MCC950 inhibits sustained inflammation and reduces pyroptotic cell death in fibroblasts by blocking the abnormal activation of the NLRP3 inflammasome. Our findings illuminate that the NLRP3 inflammasome is a previously unrecognized regulator of aged wound healing and may be a potential target for the therapeutic strategy of delayed wound healing with aging.
- | Journal: Carnosic acid inhibits NLRP3 inflammasome activation by targeting both priming and assembly steps. (Pubmed Central) - Mar 9, 2023
Furthermore, in mouse models, CA alleviates lipopolysaccharide-induced acute systemic inflammation and MSU-induced peritonitis via NLRP3. Taken together, our data demonstrated the inhibitory effect of CA on NLRP3 inflammasome and pointed out the potential application of CA in the treatment of NLRP3-driven diseases.
- | Journal: pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway. (Pubmed Central) - Mar 9, 2023
Inhibition of autophagy and enhancement of apoptosis induced by LPS were also alleviated by pNaktide, which restored LPS-induced injury to newborn neurons in the hippocampus region. In summary, pNaktide attenuates neuroinflammation, reduces the level of oxidative stress, has neuroprotective effects, and may be used for the treatment of neuroinflammation-related diseases.
- || Review, Journal: Effectiveness of targeting the NLRP3 inflammasome by using natural polyphenols: A systematic review of implications on health effects. (Pubmed Central) - Mar 9, 2023
Recent advances in other beneficial effects, clinical trials, and nano-delivery systems for targeting NLRP3 inflammasome are also reviewed. NLRP3 inflammasome is targeted by natural polyphenols to exert multiple health effects, which broadens the understanding of polyphenol mechanisms and provides valuable guidance to new researchers in this field.
- | Preclinical, Journal: Thiolutin attenuates ischemic stroke injury via inhibition of NLRP3 inflammasome: an in vitro and in vivo study. (Pubmed Central) - Mar 7, 2023
Besides, intraperitoneal injection of THL could prominently reduce the cerebral infarct volume and neuromotor deficit scores in MCAO mice. The present study confirmed that THL attenuated neuronal and cerebral inflammatory injury caused by OGD and MCAO models in mice through restraining NLRP3 inflammasome activation in vitro and in vivo.
- | Journal: Synthesis and Evaluation of [C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis. (Pubmed Central) - Mar 7, 2023
The present study confirmed that THL attenuated neuronal and cerebral inflammatory injury caused by OGD and MCAO models in mice through restraining NLRP3 inflammasome activation in vitro and in vivo. Treatment of ApoE mice with nonradioactive MCC950 (5 mg/kg, iv) 10 min prior to radiotracer administration increased uptake in the intestine (5.3
- | Preclinical, Journal: Expression of histone H1 in rats with traumatic brain injury and the effect of the NLRP3 inflammasome pathway. (Pubmed Central) - Mar 7, 2023
Inhibiting the NLRP3 inflammasome pathway may reduce the expression of histone H1. The expression of histone H1 was affected by the microglia-related central nervous system inflammatory response.
- | Panzem (2-methoxyestradiol) / CASI
Journal: Polydatin ameliorates TBI induced secondary brain injury by inhibiting NLRP3-induced neuroinflammation associated with SOD2 acetylation. (Pubmed Central) - Mar 7, 2023
NLRP3 chemical inhibitor MCC950, SOD2 inhibitor 2-methoxyestradiol, and PD were administered immediately after TBI...PD also inhibited mtROS accumulation and MMP collapse following SI. These results indicated that PD inhibited SOD2 acetylation to alleviate NLRP3 inflammasome activation, thus acting a protective role against TBI neuroinflammation.
- | Journal: Neutrophil Extracellular Traps Induce Alveolar Macrophage Pyroptosis by Regulating NLRP3 Deubiquitination, Aggravating the Development of Septic Lung Injury. (Pubmed Central) - Mar 7, 2023
Removal of ROS could promote the binding of NLRP3 and ubiquitin, inhibit NLRP3 binding to apoptosis-associated spotted proteins (ASC) and further alleviate the inflammatory changes in the lungs. In summary, these findings indicate that NETs prime ROS generation, which promotes NLRP3 inflammasome activation at the post-translational level to mediate AM pyroptosis and sustain lung injury in septic mice.
- | Journal: CoQ10 alleviates hepatic ischemia reperfusion injury via inhibiting NLRP3 activity and promoting Tregs infiltration. (Pubmed Central) - Mar 6, 2023
Furthermore, NLRP3 inflammasome activator treatment in vivo resulted in higher expression of caspase-1 and NLRP3 and reduction of Tregs in liver, which reversed the protection of CoQ10 in the liver injury. Taken together, our study discovered that CoQ10 can suppress NLRP3 activity in KCs and improves Foxp3 Tregs differentiation depending on M2 macrophage polarization of KCs to ameliorate hepatic IRI.
- | Preclinical, Journal: Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption. (Pubmed Central) - Mar 6, 2023
Taken together, our study discovered that CoQ10 can suppress NLRP3 activity in KCs and improves Foxp3 Tregs differentiation depending on M2 macrophage polarization of KCs to ameliorate hepatic IRI. The anti-depressants effects of berberine were accompanied by reduced the neuroinflammatory response via inhibiting the activation of NLRP3 inflammasome and rescued the neuronal deterioration via suppression of impairments in synaptic plasticity and neurogenesis.
- | nitroprusside / Generic mfg.
Journal: ?-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3?/AMPK-Nrf2 signal axis. (Pubmed Central) - Mar 4, 2023
The anti-depressants effects of berberine were accompanied by reduced the neuroinflammatory response via inhibiting the activation of NLRP3 inflammasome and rescued the neuronal deterioration via suppression of impairments in synaptic plasticity and neurogenesis. The results of this study shows that ?-HB can reduce inflammation and oxidative stress, the increased production of ?-HB in serum might be the crucial factor for Suhuang to exert its effect in the treatment of CVA.
- Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis () - Mar 4, 2023 - Abstract #ISID2023ISID_1353;
and IL-18 secretion as well as pyroptotic cell death in lipopolysaccharide (LPS)-primed THP-1 macrophages...Furthermore, PX-12 ameliorated IMQ-induced psoriasis-like skin symptoms in mice. In summary, our results demonstrated that PX-12 acts as an inhibitor of NLRP3 inflammasome and has the potential to treat psoriasis.
- VTX-2735 / Ventyx Biosci
Pharmacokinetics, Safety and Pharmacodynamics of VTX2735, A Potent and Selective NLRP3 Inhibitor, In Healthy Adult Volunteers () - Mar 4, 2023 - Abstract #AAD2023AAD_2905;
VTX2735 also reduced high sensitivity CRP levels 50% from baseline. These data support further development of VTX2735.
- | Preclinical, Journal: Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway. (Pubmed Central) - Mar 3, 2023
In vivo data also showed that Curcumin alleviated TJ impairment in murine testes, improved D-gal-triggered spermatogenesis ability, and inactivated the NLRP3 inflammasome by virtue of the AMPK/SIRT3/mtROS/SOD2 signal transduction pathway. Given the above findings, a novel mechanism where Curcumin modulates BTB function to improve spermatogenesis ability in age-related male reproductive disorder is characterized.
- | Journal: Alcohol-induced extracellular asc specks perpetuate liver inflammation and damage in alcoholic hepatitis even after alcohol cessation. (Pubmed Central) - Mar 3, 2023
Our study demonstrates the central role of NLRP3 and ASC in alcohol-induced liver inflammation and unravels the critical role of ex-ASC specks in the propagation of systemic and liver inflammation in AH. Our data also identify NLRP3 as a potential therapeutic target in AH.
- | Journal: Ononin alleviates DSS-induced colitis through inhibiting NLRP3 inflammasome via triggering mitophagy. (Pubmed Central) - Mar 2, 2023
Our data also identify NLRP3 as a potential therapeutic target in AH. Ononin alleviates DSS-induced
- | cetirizine oral / Generic mfg.
Journal: Human placental extract regulates polarization of macrophages via IRGM/NLRP3 in allergic rhinitis. (Pubmed Central) - Mar 2, 2023
Ovalbumin (OVA)-induced AR rat model was set up and treated by HPE or cetirizine...HPE regulates macrophage polarization through IRGM/NLRP3. We demonstrated that HPE had protection for AR and the protection is achieved partly through suppressing M1 while promoting M2, the process which is mediated by IRGM via inhibiting NLRP3 inflammasome in AR.
- | Journal: Deletion of African Swine Fever Virus (ASFV) H240R Gene Attenuates the Virulence of ASFV by Enhancing NLRP3-Mediated Inflammatory Responses. (Pubmed Central) - Mar 2, 2023
Therefore, investigations are urgently needed to identify virulence factors that are responsible for escaping the host antiviral innate immune responses and provide a new target for development of ASFV live-attenuated vaccine. In this study, we determined that the H240R gene is an essential virulence factor, and its depletion affects the pathogenicity of ASFV by enhancing NLRP3-mediated inflammatory responses, which provides theoretical support for the development of an ASFV attenuated live vaccine.
- | Journal: Genetic deletion or pharmacologic inhibition of the Nlrp3 Inflammasome did not ameliorate experimental NASH. (Pubmed Central) - Mar 2, 2023
We found that genetic deletion or pharmacologic inhibition of the NLRP3 inflammasome did not ameliorate any of the histological components of fibrosing NASH in HFHC-fed mice. Collectively, these results do not support NLRP3 inhibition as a potential target for human NASH.
- || glibenclamide / Generic mfg.
Review, Journal: Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal. (Pubmed Central) - Mar 2, 2023
Glibenclamide reduces neuroinflammation and associated BBB injury by inhibiting the nod-like receptor pyrin 3 (NLRP3) inflammasome, oxidative stress, and microglial activation. Therefore, glibenclamide through inhibition of NLRP3 inflammasome, microglial activation, and oxidative stress may attenuate SARS-CoV-2-mediated neuroinflammation.
- | Journal: P2RY12 increased neuroinflammation to accelerate depression-like behaviors by the NLPR3 inflammasome. (Pubmed Central) - Mar 2, 2023
Therefore, glibenclamide through inhibition of NLRP3 inflammasome, microglial activation, and oxidative stress may attenuate SARS-CoV-2-mediated neuroinflammation. We conclude that P2RY12 increased neuroinflammation to accelerate depression-like behaviors by NLPR3 inflammasome, providing novel information for the treatment of depressionlike behaviors.
- | glibenclamide / Generic mfg.
Journal: Convergence of Fructose-Induced NLRP3 Activation with Oxidative Stress and ER Stress Leading to Hepatic Steatosis. (Pubmed Central) - Mar 2, 2023
Both glyburide or quercetin treatment significantly attenuated hepatic steatosis, associated with mitigated expression of the lipogenic markers in liver. Our findings verified the association of NLRP3 inflammasome with oxidative and ER stress in fructose-induced lipogenic response and indicate that in addition to be a target of oxidative/ER stress, NLRP3 can act as a trigger for oxidative/ER stress to activate a vicious cycle where these cues act in a complex manner to propagate inflammatory response, leading to hepatic steatosis.
- | Journal: USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent autophagy. (Pubmed Central) - Mar 2, 2023
USP22 stabilizes ATG5 via decreasing K27- and K48-linked ubiquitination of ATG5 at the Lys118 site. Taken together, these findings reveal the role USP22 plays in the regulation of NLRP3 inflammasome activation and suggest a potential therapeutic target to treat NLRP3 inflammasome-related diseases.
- | Preclinical, Journal: NLRP3 inflammasome activation increases brain oxidative stress after transient global cerebral ischemia in rats. (Pubmed Central) - Mar 2, 2023
CAT activity decreased in the prefrontal cortex, hippocampus, and cerebellum after I/R and MCC950 reestablished these levels in the prefrontal cortex. Our data provide novel demonstration that inhibiting NLRP3 activation with MCC950 reduces brain oxidative damage after cerebral I/R in rats.
- | Journal: PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration. (Pubmed Central) - Feb 28, 2023
Of note, PARP1 inhibition could rescue rotenone-induced dopaminergic neurons loss. Overall, our study revealed that PARP1 blocks autophagy through poly (ADP-ribosyl)ating TFEB and inhibited NLRP3 degradation, which suggests that intervention of PARP1-TFEB-NLRP3 signaling can be a new treatment strategy for rotenone-induced neurodegeneration.
- | Preclinical, Journal: Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation. (Pubmed Central) - Feb 27, 2023
Overall, our study revealed that PARP1 blocks autophagy through poly (ADP-ribosyl)ating TFEB and inhibited NLRP3 degradation, which suggests that intervention of PARP1-TFEB-NLRP3 signaling can be a new treatment strategy for rotenone-induced neurodegeneration. Mac1 was involved in cognitive dysfunction in a mouse PD model through NOX-NLRP3 inflammasome axis-dependent microglial activation, providing a novel mechanistic basis of cognitive decline in PD.
- | Preclinical, Journal: Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing. (Pubmed Central) - Feb 27, 2023
In conclusion, Exosomes overexpressing H19 promoted HaCaT proliferation, migration and suppressed pyroptosis both in vitro and in vivo. Therefore, HFMSC-derived exosomes that overexpress H19 may be included in strategies for healing diabetic skin wounds.
- | Journal: Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor. (Pubmed Central) - Feb 27, 2023
Mechanistic studies revealed that these Tanshinone I derivatives could inhibit the degradation of the protein NLRP3 and block the oligomerization of NLRP3-induced apoptosis-associated speck-like proteins, thus inhibiting NLRP3 inflammasome activation. In addition, the water solubility, in vitro metabolic stability, and oral bioavailability of these compounds were also greatly improved compared to Tanshinone I. Therefore, this protocol provides a new structural evolution of Tanshinone I and a new class of potent NLRP3 inflammasome inhibitors.
- | Preclinical, Journal: Patchouli alcohol ameliorates depression-like behaviors through inhibiting NLRP3-mediated neuroinflammation in male stress-exposed mice. (Pubmed Central) - Feb 27, 2023
Our results suggest that PA inhibits the NLRP3 inflammasome and ameliorates microglia-mediated neurogenesis impairment, contributing to antidepressant effects. Thus, PA may be a novel treatment for inflammation-driven mental disorders.
- | Journal: Severe COVID-19 patients show a dysregulation of the NLRP3 inflammasome in circulating neutrophils. (Pubmed Central) - Feb 27, 2023
Collectively, our results demonstrate that the NLRP3 inflammasome is hyperactivated in severe COVID-19 neutrophils and its exhaustion may be responsible for the increased susceptibility to subsequent (and possibly lethal) infections. Our findings thus include a novel piece in the complex puzzle of COVID-19 pathogenesis.
- | Preclinical, Journal: In-vitro inhibition of NLRP3 inflammasome by 3,6-dihydroxyflavone (3,6-DHF): a therapeutic strategy for the treatment of chronic inflammatory and autoimmune diseases. (Pubmed Central) - Feb 27, 2023
and TLR-4 was observed along with the marked inhibition of NLRP3, IL-18, NF-?B and pNF-?B at translational level. 3,6-DHF was non-toxic on normal human fibroblast (BJ) and THP-1 cells and, could be a potential therapeutic agent in NLRP3 inflammasome driven diseases.
- | Journal: Effect of Low-Carbohydrate Diet on Beta-Hydroxybutyrate Ketogenesis Metabolic Stimulation and Regulation of NLRP3 Ubiquitination in Obese Saudi Women. (Pubmed Central) - Feb 25, 2023
The results show that the KD effectively encouraged weight loss and NLRP3 inflammasome inhibition. Based on the questionnaire results, it was found that a variety of physical symptoms, including overall energy, physical activity, mood, sleep, focus, skin conditions, and menstruation, had significantly improved.
- | Preclinical, Journal: Hemin attenuated LPS-induced acute lung injury in mice via protecting pulmonary epithelial barrier and regulating HO-1/NLRP3 mediated pyroptosis. (Pubmed Central) - Feb 23, 2023
In contrast, protoporphyrin IX zinc (II) (ZnPP, an HO-1 inhibitor) treatment had no protective effect on LPS inhalation-induced ALI in mice. In summary, HO-1 induction serves a critical role in maintaining airway epithelium homeostasis through the inhibition of NLRP3/ASC/caspase-1-mediated pyroptosis and inflammation in the occurrence of ALI.
- | Journal: MCC950 Regulates Stem Cells Destiny Through Modulating SIRT3-NLRP3 Inflammasome Dynamics During Oxygen Glucose Deprivation. (Pubmed Central) - Feb 22, 2023
To conclude, according to our findings, inhibiting NLRP3 activation while enhancing SIRT3 levels with MCC950 reduces oxidative and inflammatory stress in stem cells under OGD-induced stress. These findings shed light on the causes of hDPSC and hMSC demise following transplantation and point to strategies to lessen therapeutic cell loss under ischemic-reperfusion stress.
- | Preclinical, Journal: Artesunate Alleviates Hyperoxia-Induced Lung Injury in Neonatal Mice by Inhibiting NLRP3 Inflammasome Activation. (Pubmed Central) - Feb 14, 2023
Moreover, artesunate inhibited the mRNA expression and protein levels of NLRP3, ASC, and caspase-1, as well as the phosphorylation of the NF-?B and I?B?. Our findings suggest that artesunate treatment can attenuate hyperoxia-induced lung injury in BPD neonatal mice by inhibiting the activation of NLRP3 inflammasome and the phosphorylation of the NF-?B pathway.
- | Journal: Hepatitis B virus X protein promotes podocyte pyroptosis in hepatitis B virus-associated glomerulonephritis by down-regulating microRNA -223 targeting NLRP3 inflammasome (Pubmed Central) - Feb 14, 2023
The addition of miRNA-223 mimic and NLRP3 siRNA decreased the expression of NLRP3 inflammasome and cytokines, and reduced the number of pyroptosis cells induced by HBx overexpression (all P < 0.05); The addition of miRNA-223 inhibitor and NLRP3 overexpression plasmid significantly increased the expression of NLRP3 inflammasome and cytokines, caspase-1 activity, and the number of pyroptosis cells (all P < 0.05). HBx may promote podocyte pyroptosis of HBV-GN via downregulating miRNA-223 targeting NLRP3 inflammasome, suggesting that miRNA-223 is expected to be a potential target for the treatment of HBV-GN.
- | Preclinical, Journal: RAGE contributes to allergen driven severe neutrophilic airway inflammation via NLRP3 inflammasome activation in mice. (Pubmed Central) - Feb 14, 2023
Neutrophil extracellular traps were elevated in the BALF of wild-type but not RAGE mice and an atypical population of SiglecF+ neutrophils were identified in the BALF. Lastly, time-course studies found that RAGE expression promoted sustained neutrophil accumulation in the BALF of mice in response to AA.
- | Journal: NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs. (Pubmed Central) - Feb 14, 2023
At last, UCHL5 inhibition enhanced osteoblast differentiation by promoting NLRP3 ubiquitination and degradation. Thus, our results provided the proof that NLRP3 acted as a negative modulator in mandibular healing and extended the current knowledge regarding posttranslational modification of NLRP3 by UCHL5.
- | Preclinical, Journal: RBM3 is associated with acute lung injury in septic mice and patients via the NF-?B/NLRP3 pathway. (Pubmed Central) - Feb 13, 2023
In conclusion, RBM3 was overexpressed in sepsis patients and LPS-induced mice. RBM3 gene deficiency aggravated sepsis-associated ALI through the NF-?B/NLRP3 pathway.
- | Journal, Immune cell: Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation. (Pubmed Central) - Feb 12, 2023
Conditional ablation of HMGCL in neutrophils and macrophages had modest effects on body weight and glucose tolerance in aging, but worsened glucose homeostasis in myeloid cell-specific Hmgcl-deficient mice fed a high-fat diet. Our results suggest that during aging, liver-derived circulating ketone bodies might be more important for deactivating the NLRP3 inflammasome and controlling organismal metabolism.
- | Journal: RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome. (Pubmed Central) - Feb 12, 2023
Furthermore, we speculated that c-Jun may participate in ADAR1's inhibition of NLRP3 inflammasome. Our results suggested that ADAR1 is a potential treatment target for NAFLD via regulating the activation of NLRP3 inflammasome.