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- | Journal: GATA6 promotes fibrotic repair of tracheal injury through NLRP3 inflammasome-mediated epithelial pyroptosis. (Pubmed Central) - Aug 2, 2023
Finally, the downregulation of GATA6 alleviated NLRP3 inflammasome-mediated pyroptosis induced by tracheal injury in rats, thereby reducing tracheal stenosis, inflammation, and fibrosis. GATA6 promotes fibrotic repair in tracheal injury through NLRP3 inflammasome-mediated epithelial pyroptosis, making it a potential biological therapeutic target for tracheal injury.
- | belnacasan (VX-765) / Vertex, Tudcabil (tauroursodeoxycholic acid) / Bruschettini
Journal: Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Gu (Pubmed Central) - Aug 2, 2023
Compared with specific Caspase-1 inhibitor VX-765, pan-Caspase inhibitor Z-VAD-FMK showed a more significant inhibitory effect on BCG infection-induced pyroptosis of THP-1 macrophages. Taken together, this study demonstrates that ERS mediated NLRP3 inflammasome activation and pyroptosis after BCG infection of THP-1 macrophages, and that BCG infection of THP-1 macrophages induces pyroptosis through canonical and noncanonical pathways.
- | Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Preclinical, Journal: Evidence on the therapeutic role of thiolutin in imiquimod-induced psoriasis-like skin inflammation in mice. (Pubmed Central) - Aug 1, 2023
Taken together, this study demonstrates that ERS mediated NLRP3 inflammasome activation and pyroptosis after BCG infection of THP-1 macrophages, and that BCG infection of THP-1 macrophages induces pyroptosis through canonical and noncanonical pathways. THL may alleviate IMQ-induced psoriasis-like manifestations in mice by inhibiting NLRP3 inflammasome.
- | Herceptin (trastuzumab) / Roche
Preclinical, Journal: Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. (Pubmed Central) - Aug 1, 2023
Our data revealed that the co-activation of NLRP3 inflammasome by Tra promoted the inflammation, oxidative stress and cardiomyocytes apoptosis in Dox combined Tra-induced cardiotoxicity model both in vivo and in vitro. Our results suggest that NLRP3 inhibition is a promising cardioprotective strategy in Dox/Tra combination therapy.
- | Journal: Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF-?B pathway and ameliorates atherosclerosis. (Pubmed Central) - Aug 1, 2023
Apigenin may alleviate atherosclerosis at least partially by inhibiting macrophage pyroptosis. These findings suggest apigenin to be a promising therapeutic agent for inflammatory diseases.
- | Journal: Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3?mediated pyroptosis. (Pubmed Central) - Jul 31, 2023
Immunohistochemistry staining of the knee joint tissue sections from the DMM mice confirmed that GCK attenuated the NLRP3 and GSDMD-NT expression that was induced by DMM surgery. In conclusion, the present study revealed that GCK can reduce cartilage degradation in an osteoarthritis model by inhibiting the NLRP3-inflammasome activation and subsequent pyroptosis.
- | Preclinical, Journal: Perfluorodecanoic acid promotes high-fat diet-triggered adiposity and hepatic lipid accumulation by modulating the NLRP3/caspase-1 pathway in male C57BL/6J mice. (Pubmed Central) - Jul 31, 2023
Thus, PFDA may enhance HFD-induced adiposity and hepatic lipid accumulation through the NLRP3/caspase-1 pathway. This contaminant may be a key risk factor for obesity development in individuals consuming high-fat foods, particularly Western diet.
- | Journal: Atranorin inhibits NLRP3 inflammasome activation by targeting ASC and protects NLRP3 inflammasome-driven diseases. (Pubmed Central) - Jul 31, 2023
Moreover, Atranorin ameliorates intestinal inflammation and epithelial barrier dysfunction in DSS induced mice ulcerative colitis and inhibits NLRP3 inflammasome activation in colon. Altogether, our study identifies Atranorin as a novel NLRP3 inhibitor that targets ASC protein and highlights the potential therapeutic effects of Atranorin in NLRP3 inflammasome-driven diseases including acute inflammation, gouty arthritis and ulcerative colitis.
- || Review, Journal: Inhibitors of NLRP3 Inflammasome in Ischemic Heart Disease: Focus on Functional and Redox Aspects. (Pubmed Central) - Jul 29, 2023
In this review, we analyze the interrelation between ROS and NLRP3 in ischemic heart disease and the effects of some NLRP3 inhibitors as possible therapeutic agents in this disease condition. All compounds considered in this review need larger studies to confirm their appropriate use in clinical scenarios as anti-ischemic drugs.
- | Preclinical, Journal: Quantum Molecular Resonance Inhibits NLRP3 Inflammasome/Nitrosative Stress and Promotes M1 to M2 Macrophage Polarization: Potential Therapeutic Effect in Osteoarthritis Model In Vitro. (Pubmed Central) - Jul 29, 2023
protein expression and secretion. Finally, our findings indicate that QMR treatment induces a switch in macrophage polarization from the M1 phenotype to the M2 phenotype.
- | Journal: TWEAK promotes inflammatory response in liver fibrosis. (Pubmed Central) - Jul 28, 2023
According to our results, TWEAK promoted M1 polarization of liver KCs and J774A.1 cells, and silencing CD266 expression or treatment with the NLRP3 inhibitor suppressed the effect of TWEAK. In the mouse experiment, it was discovered that after knocking down NLRP3 expression or using NLRP3 inhibitor to antagonize the effect of TWEAK, the mouse liver function and M1 cell level in liver tissues were improved.
- | Journal: Discovery of a selective NLRP3-targeting compound with therapeutic activity in MSU-induced peritonitis and DSS-induced acute intestinal inflammation. (Pubmed Central) - Jul 27, 2023
Importantly, treatment with SB-222200 demonstrates alleviation of NLRP3-dependent inflammatory diseases in mouse models, such as monosodium urate crystal-induced peritonitis and dextran sulfate sodium-induced acute intestinal inflammation. Therefore, SB-222200 holds promise as a lead compound for the development of NLRP3 inhibitors to combat NLRP3-driven disease and serves as a versatile tool for pharmacologically investigating NLRP3 biology.
- | Journal: circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-?B in vascular smooth muscle cells. (Pubmed Central) - Jul 27, 2023
Importantly, employing a decoy oligonucleotide to compete with circACTA2 for binding to p50 could attenuate the expression of NLRP3, ASC, and caspase-1. These findings provide a novel insight into the functional roles of circACTA2 in VSMCs, and targeting the circACTA2-NF-?B-NLRP3 axis represents a promising therapeutic strategy for vascular remodeling.
- | Journal: Loganin alleviates myocardial ischemia-reperfusion injury through GLP-1R/NLRP3-mediated pyroptosis pathway. (Pubmed Central) - Jul 27, 2023
GLP-1R/NLRP3 activation by GLP-1R inhibition or NLRP3 overexpression reversed the suppressive effects of loganin on OGD/R-induced cardiomyocyte pyroptosis. These data indicated that loganin prevented OGD/R-induced proliferation inhibition, apoptosis and pyroptosis in OGD/R-treated cardiomyocytes by inhibiting GLP-1R/NLRP3 activity, indicating the therapeutic potential of loganin in myocardial I/R injury.
- | Journal: Sirt3 regulates NLRP3 and participates in the effects of plantainoside D on acute lung injury sepsis. (Pubmed Central) - Jul 26, 2023
PD could protect sepsis ALI via Sirt3/NLRP3 signal pathway. The findings provide a new treatment target for sepsis ALI and a potential treatment measure.
- | Preclinical, Journal: Zishen Yutai Pill improves sperm quality and reduces testicular inflammation in experimental varicocele rats. (Pubmed Central) - Jul 24, 2023
The findings provide a new treatment target for sepsis ALI and a potential treatment measure. Compared to the VC model, expressions of NLRP3, ASC, and caspase-1 in rats treated with ZYP were significantly down-regulated, as validated by both qRT-PCR and WB analysis (P
- | Journal: NLRP3 inflammasome inhibition of OP9 cells enhance therapy for inflammatory bowel disease. (Pubmed Central) - Jul 24, 2023
Thus, OP9 cell line is similar to MSCs in characteristic and function, and is an ideal substitute for MSCs research. The preliminary exploration of the inflammasome system in OP9 cells lays a theoretical and methodological foundation for further study of MSCs.
- | trimetazidine / Generic mfg.
Journal: Gentiopicroside enhances the protective effect of trimetazidine against myocardial ischemia-reperfusion injury via the AMPK/NLRP3 inflammasome signaling. (Pubmed Central) - Jul 21, 2023
Furthermore, GPS intensified TMZ-mediated inhibition of oxidative injury, inflammation, and the AMPK/NLRP3 signaling in MI/R rats. Collectively, GPS enhances the protective efficacy of TMZ against MI/R injury through AMPK activation-mediated inhibition of NLRP3 inflammasome signaling, implying a promising therapeutic agent for the treatment of MI/R.
- | glibenclamide / Generic mfg., dimethyl fumarate / Generic mfg.
Preclinical, Journal: Dimethyl fumarate-mediated Nrf2/ARE pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation. (Pubmed Central) - Jul 21, 2023
(IL-1?), nuclear factor-?B (NF-?B), Nrf2, superoxide dismutase 1, catalase, IGF 1, heme oxygenase 1, receptor for the advanced glycation end product (RAGE), and collagen-1 in diabetic rats. Further, a mechanistic molecular study employing other specific NLRP3 inhibitors and Nrf2 activators will significantly contribute to the development of novel therapy for fatty liver diseases.
- | Journal: Anthocyanin attenuates high salt-induced hypertension via inhibiting the hyperactivity of the sympathetic nervous system. (Pubmed Central) - Jul 20, 2023
Excessive salt intake activates NLRP3-dependent inflammation and oxidative stress and increased ATR expression and function in the PVN. Bilateral PVN infusion of anthocyanin lowers peripheral sympathetic nerve activity and blood pressure in rats with salt-induced hypertension by improvement of expression and function of ATR in the PVN through inhibiting NLRP3 related inflammatory and oxidative stress.
- Anti-allodynic Effect Of Intrathecal Gastrodin With Involvement Of Nlrp3 Inflammasome Inhibition At Spinal Level In Neuropathic Pain Of Rat (Exhibit Hall) - Jul 20, 2023 - Abstract #ASA2023ASA_1738;
NLRP3 inflammasome was expressed mainly in the neurons at spinal level and greatly increased in SNL. Intrathecal gastrodin has analgesic effect for SNL-induced mechanical allodynia possibly by suppressing the expression of NLRP3 inflammasome components and IL-1?.
- || Review, Journal: A Patent Review of NLRP3 Inhibitors to Treat Autoimmune Diseases. (Pubmed Central) - Jul 20, 2023
Due to the complex nature of the NLRP3 inflammasome, novel screening assays along with target engagement methods could benefit the drug discovery and clinical translation. In addition, clinical trials on NLRP3 inhibitors are still in their early stages, and continuous investigations are needed to fully assess their safety and effectiveness.
- | Journal: PM2.5 exposure aggravates acute liver injury by creating an inflammatory microenvironment through Kupffer cell. (Pubmed Central) - Jul 19, 2023
As suggested by our results, long-term exposure to PM2.5 can create an inflammatory microenvironment to aggravate mouse acute liver injury. The effect is related to NLRP3-mediated M1 polarization in Kupffer cells.
- | Journal: Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD. (Pubmed Central) - Jul 19, 2023
The effect is related to NLRP3-mediated M1 polarization in Kupffer cells. Provided herein are novel fused bicyclic heteroaryl compounds as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating asthma or COPD and processes for preparing such compounds.
- || Legalon (silibinin) / Viatris
Review, Journal: Beneficial effects of flavonoids on cardiovascular diseases by influencing NLRP3 inflammasome. (Pubmed Central) - Jul 19, 2023
In brief, the PDB format of NLRP3 was selected as a protein file, and 34 flavonoids in SDF format were selected as the ligand file, and then input to CB-Dock for molecular docking. The docking results showed that epigallocatechin-3-gallate (EGCG), amentoflavone, baicalin, scutellarin, vitexin, silibinin, and puerarin had good binding affinities to NLRP3, which could be used as NLRP3 inhibitors, and aid in the discovery of lead compounds for the design and development of CVDs.
- | Bay11-7082 / Bayer
Journal: Inhibition of the NF-?B Signaling Pathway Alleviates Pyroptosis in Bladder Epithelial Cells and Neurogenic Bladder Fibrosis. (Pubmed Central) - Jul 18, 2023
Moreover, using the NLRP3 inhibitor MCC950 rescued TGF-?1-induced fibrosis, and the NF-?B signaling pathway inhibitor BAY 11-7082 effectively rescued TGF-?1-induced pyroptosis and the deposition of extracellular matrix by SV-HUC-1 cells. In summary, our research demonstrated for the first time that the NF-?B signaling pathway inhibition rescued bladder epithelial cells pyroptosis and fibrosis in neurogenic bladders.
- | Preclinical, Journal: Sodium aescinate improve behavioral performance by inhibiting dorsal raphe nucleus NLRP3 inflammasome in Post-traumatic stress disorder Rat Model. (Pubmed Central) - Jul 18, 2023
In addition, NLRP3 inflammasome activation in DRN of PTSD rats impaired mitochondria function by inhibiting ATP synthesis and increasing ROS production, whereas SA can effectively reverse the pathological progression of mitochondria. We recommend SA as a new candidate for the pharmacological treatment of PTSD.
- | Journal: Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome-mediated endothelial cell pyroptosis. (Pubmed Central) - Jul 17, 2023
Its effectiveness was lowered by CLIC4 overexpression but not by knockdown. Overall The beneficial effect of SDSS against CIRI in this study can be ascribed to blocking endothelial pyroptosis by binding to CLIC4 and then inhibiting chloride efflux-dependent NLRP3 inflammasome activation.
- | Preclinical, Journal: Muscone attenuates susceptibility to ventricular arrhythmia by inhibiting NLRP3 inflammasome activation in rats after myocardial infarction. (Pubmed Central) - Jul 17, 2023
Furthermore, Cx43 expression in the BZ was increased by muscone treatment, and this change was coupled by inhibition of the NLRP3/IL-1?/p38 MAPK pathway. Taken together, our results demonstrated that muscone reduces susceptibility to VA, mainly by decreasing ventricular inflammation and fibrosis, and attenuates abnormal Cx43 expression by inhibiting NLRP3 inflammasome activation after myocardial infarction in rats.
- | Journal: Pterostilbene Attenuates High-Intensity Swimming Exercise-Induced Glucose Absorption Dysfunction Associated with the Inhibition of NLRP3 Inflammasome-Induced IECs Pyroptosis. (Pubmed Central) - Jul 15, 2023
Additionally, knockdown of SIRT3, a major regulator of mitochondria function, by siRNA or inhibiting its activity by 3-TYP abolished the effects of PTE on pyroptosis, mitochondrial homeostasis, and ROS generation of IEC in vitro. Our results revealed that PTE could alleviate HISE-induced intestinal glucose absorption dysfunction associated with the inhibition of NLRP3 inflammasome-induced IECs pyroptosis.
- | Preclinical, Journal: HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPAR?/NLRP3/GSDMD to improve neurological function after intraventricular hemorrhage in mice. (Pubmed Central) - Jul 14, 2023
Therefore, we concluded that BRD reduced pyroptosis and neuroinflammation and improve nerve function in part by activating the PPAR?/NLRP3/GSDMD signaling pathway. Our findings suggest a potential preventive role for BRD in IVH.
- | Victoza (liraglutide) / Novo Nordisk
Journal: GLP-1R knockdown abrogates the protective effects of liraglutide on ischaemic stroke via inhibition of M2 polarisation and activation of NLRP3 inflammasome by reducing Nrf2 activation. (Pubmed Central) - Jul 14, 2023
Further, Nrf2 knockdown counteracted the protection of liraglutide on MCAO rats, whereas sulforaphane (agonist of Nrf2) counteracted the effect of Nrf2 knockdown on liraglutide-treated MCAO rats. Collectively, GLP-1R knockdown abrogated the protection of liraglutide on MCAO rats by activating NLRP3 via inactivating Nrf2.
- | Journal: FoxO1/NLRP3 Inflammasome Promotes Age-Related Alveolar Bone Resorption. (Pubmed Central) - Jul 14, 2023
Concordant with our study, MCC950, a specific inhibitor of NLRP3 inflammasome, greatly rescued osteoblast differentiation under oxidative stress. Our data shed light on the manifestations of FoxO1 depletion in osteoblasts and propose a possible mechanism for the therapy of age-related alveolar bone loss.
- || Review, Journal: NLRP3 inflammasome activation after ischemic stroke. (Pubmed Central) - Jul 12, 2023
In addition, we go over how pyroptosis interacts with other processes for regulated cell death. In addition, specific NLRP3 inflammasome pathway inhibitors are identified, which offer new approaches to preventing ischemic brain injury.
- | Journal: Molecular mechanism of miRNA-23a in sepsis-induced lung injury. (Pubmed Central) - Jul 12, 2023
In addition, specific NLRP3 inflammasome pathway inhibitors are identified, which offer new approaches to preventing ischemic brain injury. miR-23a can significantly alleviate sepsis-induced lung injury in CLP-induced septic mice and LPS-stimulated cell lines by suppressing NLRP3 inflammasome activation and inflammatory response, while promoting the CXCR4/PTEN/PI3K/AKT pathway.
- || Actemra IV (tocilizumab) / Roche, JW Pharma, Kineret (anakinra) / SOBI
Retrospective data, Review, Journal: Efficacy and safety of inhibiting the NLRP3/IL-1?/IL-6 pathway in patients with ST-elevation myocardial infarction: A meta-analysis. (Pubmed Central) - Jul 10, 2023
Preliminary results from the available RCTs suggest colchicine and anakinra may respectively reduce the risks of recurrent MI and new-onset or worsening HF. The available RCTs in this meta-analysis lack power to determine any differences on mortality.
- | Journal, Machine learning: Multinomial classification of NLRP3 inhibitory compounds based on large scale machine learning approaches. (Pubmed Central) - Jul 7, 2023
The top models were then used to predict data from unseen datasets. In summary, these QSAR classification models exhibited robust statistical results and were interpretable, which strongly supported their use for rapid screening of NLRP3 inhibitors.
- | Journal: Encapsulation of MCC950 in Liposomes Decorated with Anti-Frizzled 1 Improves Drug Bioavailability and Effectiveness in Fatty Liver Disease. (Pubmed Central) - Jul 7, 2023
Luminescent carbon dots (CDs) were also co-encapsulated with MCC950 in LPs to obtain optically traceable nanoformulations that have proved the enhanced ability of the targeted LPs to be internalized into THP-1 cells with respect to their nontargeted counterparts. Our results suggest that MCC950 encapsulation into targeted LPs represents a valuable strategy to achieve reformulation of the NLRP3 inhibitor, able to significantly curtail the threshold of MCC950 doses for inhibiting inflammasome activation, thus offering a new therapeutic approach.
- C9orf72 dipeptides trigger neuroinflammation via the NLRP3 inflammasome (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_6215;
Here, we demonstrate that C9orf72 dipeptides could directly contribute to neuroinflammation in FTD/ALS via the NLRP3 inflammasome. Furthermore, we demonstrate that this can be inhibited pharmacologically, highlighting NLRP3 as a potential therapeutic target in FTD/ALS.
- Regulation of pro-inflammatory cytokine release by purinergic signalling in a human monocyte-derived microglial model (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_2471;
Furthermore, we demonstrate that this can be inhibited pharmacologically, highlighting NLRP3 as a potential therapeutic target in FTD/ALS. Modulation of purinergic signalling has the potential to regulate neuroinflammation and the ability of P2X7 receptor antagonists to suppress a pro-inflammatory response by microglia suggests this pharmacological action may offer benefit to patients with AD.
- Development of NLRP3 PET Radiotracers for Alzheimer's disease (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_2018;
Modulation of purinergic signalling has the potential to regulate neuroinflammation and the ability of P2X7 receptor antagonists to suppress a pro-inflammatory response by microglia suggests this pharmacological action may offer benefit to patients with AD. A novel C-11 labeled NRP3 PET radiotracer was developed and demonstrated to serve as a suitable CNS PET tracer to monitor inflammatory responses in the brain.
- NLRP3-inflammasome inhibition by Leishmania-derived factors in the neuropathogenesis of Alzheimer's Disease (AD): assessing the molecular and therapeutic role (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_1691;
L is able to modulate the immune response in vertebrates, suppressing the inflammatory response, and allowing the parasites to survive and replicate in phagocytic cells of our immune system, such as in macrophages. Given this ability, one can imagine exploiting this effect of damping immune response to ameliorate or cure those diseases in which inflammation plays a key role or it is one of the major drivers, such as AD.
- NLRP3 inflammasome inhibition protects against intracranial aneurysm rupture and alters phenotype of infiltrating macrophages () - Jul 6, 2023 - Abstract #CNSMission2023CNS_MISSION_980;
- | Journal: Bufalin reduces myocardial infarction-induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL-1? signalling pathway. (Pubmed Central) - Jul 4, 2023
Hence, the present study findings suggest that bufalin can alleviate fibrosis and improve cardiac function in a mouse model by suppressing NLRP3/IL-1? signalling post-MI.
- | Journal: Unified Total Synthesis of the Limonoid Alkaloids: Strategies for the De Novo Synthesis of Highly Substituted Pyridine Scaffolds. (Pubmed Central) - Jul 3, 2023
In addition, NMR calculations suggested structural misassignment of several limonoid alkaloids, and predicted their C3-epimers as the correct structures, which was further validated unequivocally through chemical synthesis. The materials produced in this study were evaluated for cytotoxicity, anti-oxidant effects, anti-inflammatory action, PTP1B and Nlrp3 inflammasome inhibition, which led to compelling anti-inflammatory activity and anti-oxidant effects being discovered.
- | Journal: MARCH9 Mediates NOX2 Ubiquitination to Alleviate NLRP3 Inflammasome-Dependent Pancreatic Cell Pyroptosis in Acute Pancreatitis. (Pubmed Central) - Jul 2, 2023
The materials produced in this study were evaluated for cytotoxicity, anti-oxidant effects, anti-inflammatory action, PTP1B and Nlrp3 inflammasome inhibition, which led to compelling anti-inflammatory activity and anti-oxidant effects being discovered. Our results suggested that MARCH9 suppresses NLRP3 inflammasome-mediated pancreatic cell injury through mediating the ubiquitination and degradation of NADPH oxidase-2, which compromises ROS generation and NLRP3 inflammasomal activation.
- | Journal: The landscape of mitophagy in sepsis reveals PHB1 as an NLRP3 inflammasome inhibitor. (Pubmed Central) - Jun 30, 2023
In addition, mitophagy inhibitor treatment abolished PHB1 knockdown-mediated activation of NLRP3 inflammasomes, suggesting that PHB1 inhibited the activation of inflammasomes through mitophagy. In conclusion, this study reveals that a high degree of mitophagy may predict a good outcome of sepsis, and PHB1 is a key NLRP3 inflammasome regulator via mitophagy in inflammatory diseases such as sepsis.
- | Journal: Trehalose Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting NLRP3-Mediated Pyroptosis. (Pubmed Central) - Jun 28, 2023
Furthermore, TRE intervention suppressed the expression of pyroptosis-related proteins following I/R. TRE attenuates myocardial I/R injury in mice by inhibiting NLRP3-mediated caspase-1-dependent pyroptosis in cardiomyocytes.
- | Journal: Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury. (Pubmed Central) - Jun 28, 2023
TRE attenuates myocardial I/R injury in mice by inhibiting NLRP3-mediated caspase-1-dependent pyroptosis in cardiomyocytes. LCN2/24p3R mediates astrocyte pyroptosis via NLRP3 inflammasome activation following cerebral ischemia/reperfusion injury.
- | Journal: Targeting Spike Glycoprotein S1 Mediated by NLRP3 Inflammasome Machinery and the Cytokine Releases in A549 Lung Epithelial Cells by Nanocurcumin. (Pubmed Central) - Jun 28, 2023
Overall, the nanoparticle formulation of curcumin improved its solubility and bioavailability, demonstrating anti-inflammatory effects in a CoV2-SP-induced scenario by inhibiting inflammatory mediators and the NLRP3 inflammasome machinery. Nanocurcumin shows promise as an anti-inflammatory product for preventing COVID-19-related airway inflammation.