 |
7 Companies | 6 Products |
|
|
6 Products | |
29 Diseases | |
11 Trials |  |
763 News |  |
| «12...1112131415161718192021...134135» |
- Identification of ZYIL1, a novel NLR family pyrin domain containing 3 protein inhibitor: a potential disease modifier in Parkinson () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1498;
These findings indicate that ZYIL1 appears to have the potential for development as a therapeutic option for PD.
- | Journal: Necrotic Cell Death and Inflammasome NLRP3 Activity in Mycobacterium bovis-Infected Bovine Macrophages. (Pubmed Central) - Aug 30, 2023
Finally, the induction of cell death (apoptosis and pyroptosis) decreased the intracellular bacteria count in the infected bovine macrophages, suggesting that cell death helps to control the intracellular growth of the mycobacteria. Our results indicate that M. bovis induces pyroptosis-like cell death that is partially related to the NLRP3 inflammasome activation and that the cell death process could control bacterial growth.
- | dapansutrile (OLT1177) / Olatec Therap
Journal: Shikonin, an inhibitor of inflammasomes, inhibits Epstein-Barr virus reactivation. (Pubmed Central) - Aug 29, 2023
Similar results were obtained with apigenin and OLT 1177, two other NLRP3 inflammasome inhibitors. It is shown herein that shikonin repressed the transcription of reactivation-induced NLRP3 thereby inhibiting inflammasome activation and EBV lytic phase induction.
- | Preclinical, Journal: Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats. (Pubmed Central) - Aug 28, 2023
In conclusion, microglia are key mediators of the inflammatory response and exhibit continuous phenotypic polarization 7-21 days after HI-induced WMD. This finding can potentially lead to a new treatment regimen targeting the phenotypic polarization of microglia early after HI-induced brain injury.
- | Journal: IL-30 protects against sepsis-induced myocardial dysfunction by inhibiting pro-inflammatory macrophage polarization and pyroptosis. (Pubmed Central) - Aug 28, 2023
This finding can potentially lead to a new treatment regimen targeting the phenotypic polarization of microglia early after HI-induced brain injury. Recombinant IL-30 inhibited pro-inflammatory macrophage polarization and pyroptosis in
- | Journal: Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization. (Pubmed Central) - Aug 27, 2023
Recombinant IL-30 inhibited pro-inflammatory macrophage polarization and pyroptosis in Our findings suggest that the inflammatory states in the brain and peripheral nervous system following repeated mTBIs are coincidental with the development of nociceptive sensitization, and that these events can be significantly reduced by inhibition of NLRP3 inflammasome activation.
- | Journal: Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA. (Pubmed Central) - Aug 26, 2023
Finally, pathological testing of tissue sections and blood biochemical tests showed no significant toxic effects of CLP/siNLRP3. We introduced a prospective approach for the efficient delivery of siRNA in vitro and in vivo with high safety and stability, which was found to have great potential in treating NLRP3-driven diseases in an RNA-silencing manner.
- | Journal: Protective Role of Vitamin K3 on SARS-CoV-2 Structural Protein-Induced Inflammation and Cell Death. (Pubmed Central) - Aug 26, 2023
These findings suggested that vitamin K3 potently suppressed the inflammatory response to prevent endothelial activation and monocyte pyroptosis induced by SARS-CoV-2 proteins. This may provide a new strategy for the treatment of COVID-19.
- || colchicine / Generic mfg.
Review, Journal: Novel Anti-Inflammatory Therapies in Coronary Artery Disease and Acute Coronary Syndromes. (Pubmed Central) - Aug 26, 2023
inhibitors and IL-1 receptor antagonists...Such approaches, although intriguing and promising, ought to be tested in clinical settings before safe conclusions can be drawn. Although the link between inflammation and atherosclerosis is significant, further studies are needed in order to elucidate this association and improve outcomes in patients with CAD.
- | Preclinical, Journal: Hydrogen Sulfide Prevents LPS-Induced Depression-like Behavior through the Suppression of NLRP3 Inflammasome and Pyroptosis and the Improvement of Mitochondrial Function in the Hippocampus of Mice. (Pubmed Central) - Aug 26, 2023
NaHS pretreatment improved impaired mitochondrial morphology and increased membrane potential and ATP production and reduced ROS production in the hippocampus of LPS-treated mice. Our data indicate that HS prevents LPS-induced depression-like behaviors by inhibiting NLRP3 inflammasome activation and pyroptosis and improving mitochondrial function in the hippocampus.
- | Journal: NLRP3 inflammasome-mediated pyroptosis involvement in cadmium exposure-induced cognitive deficits via the Sirt3-mtROS axis. (Pubmed Central) - Aug 26, 2023
In addition, Cd failed to further suppress SOD activity and activate NLRP3 inflammasome-dependent neuronal pyroptosis in Sirt3 shRNA-treated SH-SY5Y cells. Collectively, our findings indicate that Cd exposure induces neuronal injury and cognitive deficits by activating NLRP3 inflammasome-dependent neuronal pyroptosis and that activation of the NLRP3 inflammasome is partially mediated by the Sirt3-mtROS axis.
- | Preclinical, Journal: Transcription Factor Forkhead Box P (Foxp) 1 Reduces Brain Damage During Cerebral Ischemia-Reperfusion Injury in Mice Through FUNDC1. (Pubmed Central) - Aug 26, 2023
Furthermore, the knockdown of FUNDC1 reversed the increased activation of mitophagy and suppressed NLRP3 inflammasome activation induced by Foxp1 overexpression. Collectively, our findings suggest that Foxp1 inhibits NLRP3 inflammasome activation through FUNDC1 to reduce cerebral I/R injury.
- | Journal: Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis. (Pubmed Central) - Aug 25, 2023
Knockdown of MALAT1 repressed NLRP3 inflammasome activation and mitigated Th1/Th2 imbalance in Th2-conditioned CD4T cells, whereas both MALAT1 overexpression and miR-124-3p inhibition ablated the inhibitory effects of icariin on Th2 immune responses. The findings further improve our understanding of the mechanism by which icariin affects AD progression, and highlights the potential of icariin in the treatment of AD.
- | Journal: Obesity enables NLRP3 activation and induces myocardial fibrosis via hyperacetylation of HADHa. (Pubmed Central) - Aug 25, 2023
and IL-18, supporting the connection of NLRP3 inflammation to obesity-induced myocardial fibrosis. In conclusion, our study demonstrates that the heart is susceptible to fibrosis under obesity through hyperacetylated HADHa mediated activation of the NLRP3 inflammasome.
- | allopurinol / Generic mfg.
Journal: Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome. (Pubmed Central) - Aug 24, 2023
In conclusion, our study demonstrates that the heart is susceptible to fibrosis under obesity through hyperacetylated HADHa mediated activation of the NLRP3 inflammasome. SZF inhibits UA-induced renal tubular epithelial cell pyroptosis via by targeting NLRP3 to inhibit tubular inflammatory and prevent the progression of HUA-induced renal injury effectively.
- | Journal: Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways. (Pubmed Central) - Aug 23, 2023
SZF inhibits UA-induced renal tubular epithelial cell pyroptosis via by targeting NLRP3 to inhibit tubular inflammatory and prevent the progression of HUA-induced renal injury effectively. Allicin protects cardiomyocytes against LPS?induced injury through activation of Nrf2/HO-1 and inhibition of NLRP3 signaling pathways.
- || Review, Journal: Inflammasome activation by viral infection: mechanisms of activation and regulation. (Pubmed Central) - Aug 23, 2023
Therefore, in this review, we describe the biological properties of the inflammasome associated with viral infection, discuss the potential mechanisms that activate and/or inhibit NLRP1, NLRP3, and AIM2 inflammasomes by different viruses, and summarize the reciprocal regulatory effects of viral infection on the NLRP3 inflammasome in order to explore the relationship between viral infection and inflammasomes. This review will pave the way for future studies on the activation mechanisms of inflammasomes and provide novel insights for the development of antiviral therapies.
- || Review, Journal: Small molecule inhibitors of NLRP3 inflammasome and GSK-3? in the management of traumatic brain injury: A review. (Pubmed Central) - Aug 22, 2023
In this review, we discuss the identification & development of several structurally diverse and pharmacologically interesting small molecule inhibitors for targeting the NLRP3 inflammasome and GSK-3? in the management of TBI.
- | Journal: NLRP3 Activation Contributes to Memory Impairment in an Experimental Model of Pneumococcal Meningitis. (Pubmed Central) - Aug 21, 2023
in the management of TBI. The animals in the meningitis group at 24
- | Journal: Hederagenin inhibits high glucose-induced fibrosis in human renal cells by suppression of NLRP3 inflammasome activation through reducing cathepsin B expression. (Pubmed Central) - Aug 20, 2023
Hederagenin decreased CTSB level, and CTSB overexpression reversed the suppressive effect of hederagenin on HG-induced NLRP3 inflammasome activation and fibrosis in HRMCs and HRPTEpiCs. In conclusion, hederagenin attenuates HG-induced fibrosis of renal cells by inhibiting NLRP3 inflammasome activation via reducing CTSB expression, indicating a therapeutic potential of hederagenin in diabetic nephropathy.
- | Journal: Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS. (Pubmed Central) - Aug 18, 2023
Through deep immune phenotyping by single-cell mass cytometry we demonstrate that acute NLRP3 inhibition does not ameliorate spinal cord inflammation in this model. Taken together, our data suggests that NLRP3 inhibition alone may not be sufficient to address dynamic and complex neuroinflammatory pathobiological mechanisms including dysregulation of multiple inflammasome pathways in neurodegenerative disease such as ALS.
- | Journal: Assessing the ATP Binding Ability of NLRP3 from Cell Lysates by a Pull-down Assay. (Pubmed Central) - Aug 18, 2023
Efficiency of binding is followed after elution from the beads and detection with Western blot and immunolabelling. The method can be used to evaluate the functionality of NLRP3 variants or to check whether compounds or NLRP3 binding partners interfere with binding of ATP.
- | Journal: Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223/NLRP3/pyroptosis axis: Toward a precision therapy. (Pubmed Central) - Aug 18, 2023
The dual-engineered EVs showed a maximal effect on inhibiting the NLRP3 inflammasome activation and chondrocyte pyroptosis, and offered excellent results for the treatment of OA. This study provides a novel theoretical basis and a promising therapeutic strategy for the application of engineered extracellular vesicles in OA treatment.
- | Journal: Phloretin ameliorates heart function after myocardial infarction via NLRP3/Caspase-1/IL-1? signaling. (Pubmed Central) - Aug 17, 2023
Our results suggest that Phloretin could suppress the NLRP3/Caspase-1/IL-1? pathway to reverse structural and electrical remodeling after MI to prevent the occurrence of VAs and HF.
- | Preclinical, Journal: Daphnetin ameliorates PM2.5-induced airway inflammation by inhibiting NLRP3 inflammasome-mediated pyroptosis in CS-exposed mice. (Pubmed Central) - Aug 17, 2023
Third, Daph significantly protected against CS-induced COPD and PM2.5-CS-induced AECOPD by inhibiting the NLRP3 inflammasome and pyroptosis in mice. Our findings identified the NLRP3 inflammasome as a critical contributor to PM2.5-CS-induced airway inflammation, and Daph as a negative regulator of NLRP3-mediated pyroptosis, which has implications for the pathophysiology of AECOPD.
- | Journal: Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway. (Pubmed Central) - Aug 16, 2023
However, NLRP3 inhibitor MCC950 pretreatment or Mito-ROS scavenging by MitoTEMPO attenuated apoptosis in FFA-induced MAC-T cells by inhibiting the NLRP3 inflammasome pathway. These findings reveal that the Mito-ROS-NLRP3 pathway activation is a potent mechanism underlying mammary epithelial cell apoptosis in response to metabolic stress in ketotic dairy cows, which further contributes to reduced milk yield.
- | Journal: Pyridazine Derivatives as NLRP3 Inhibitors for Treating Asthma, COPD, Parkinson's Disease, and Alzheimer's Disease. (Pubmed Central) - Aug 16, 2023
These findings reveal that the Mito-ROS-NLRP3 pathway activation is a potent mechanism underlying mammary epithelial cell apoptosis in response to metabolic stress in ketotic dairy cows, which further contributes to reduced milk yield. Provided herein are novel pyridazine derivatives as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating asthma, COPD, Parkinson's disease, and Alzheimer's disease, and processes for preparing such compounds.
- | Journal: Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis. (Pubmed Central) - Aug 16, 2023
MCC950 inhibited NLRP3 inflammasome in the in vitro models of AR. MCC950 inhibited ILC2 responses in AR and mice models, suggesting that blocking NLRP3 inflammasome may be a promising target for AR clinical treatment.
- | selisistat (SEN-196) / AOP Orphan Pharma
Journal: Salvianolic acid B ameliorates neuroinflammation and neuronal injury via blocking NLRP3 inflammasome and promoting SIRT1 in experimental subarachnoid hemorrhage. (Pubmed Central) - Aug 15, 2023
Administration of EX527, an inhibitor of SIRT1, abrogated the anti-inflammatory effects of SalB against SAH and further induced NLRP3 inflammasome activation...These results indicated that SalB effectively repressed neuroinflammatory responses and neuronal damage after SAH. The action of SalB appeared to be mediated by blocking NLRP3 inflammasome and promoting SIRT1 signaling.
- | Journal: Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation. (Pubmed Central) - Aug 15, 2023
Neutralizing IL-1? antibodies may be beneficial for the prevention of CKD-induced AF.
- | Journal: A novel stroke rehabilitation strategy and underlying stress granule regulations through inhibition of NLRP3 inflammasome activation. (Pubmed Central) - Aug 15, 2023
antibodies may be beneficial for the prevention of CKD-induced AF. RIC followed by exercise induced a better rehabilitation in ischemic rats, while early RIC alleviated ischemia-reperfusion injury via stress-granule-mediated inhibition of NLRP3 inflammasome.
- || ZYIL1 / Zydus Lifesci
PK/PD data, Journal: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZY-IL1 in Three Patients with Cryopyrin-Associated Periodic Syndromes. (Pubmed Central) - Aug 14, 2023
RIC followed by exercise induced a better rehabilitation in ischemic rats, while early RIC alleviated ischemia-reperfusion injury via stress-granule-mediated inhibition of NLRP3 inflammasome. Three adult subjects with a confirmed diagnosis of CAPS were enrolled and administered 50
- | Preclinical, Journal: Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways. (Pubmed Central) - Aug 14, 2023
The synergistic effects were related to NJ?+?levodopa (1.24?g/kg + 25?mg/kg) increasing the neurotransmitter levels by 38.80%-88.67% in PD rats, and inhibiting oxidative stress and NLRP3 pathway by activating Nrf2 pathway. NJ combined with levodopa is a promising therapeutic candidate for PD, which provides a scientific basis for the subsequent clinical combination therapy of levodopa to enhance the anti-PD effect.
- | Journal: Lactobacillus Plantarum NC8 and its metabolite acetate alleviate type 1 diabetes via inhibiting NLRP3. (Pubmed Central) - Aug 14, 2023
In addition, the number of macrophages in the pancreas were significantly reduced by the treatment with Lactobacillus Plantarum NC8 or acetate. In summary, this study indicated that the regulatory mechanism of Lactobacillus Plantarum NC8 and its metabolite acetate to T1D maybe via inhibiting NLRP3 and provides a novel insights into the mechanism of the alleviated role of probiotics to T1D.
- | budesonide / Generic mfg.
Journal, Combination therapy: Combination therapy with budesonide and acetylcysteine alleviates LPS-induced acute lung injury via the miR-381/NLRP3 molecular axis. (Pubmed Central) - Aug 13, 2023
In summary, this study indicated that the regulatory mechanism of Lactobacillus Plantarum NC8 and its metabolite acetate to T1D maybe via inhibiting NLRP3 and provides a novel insights into the mechanism of the alleviated role of probiotics to T1D. Combined Bud and NAC nebulization therapy alleviates LPS-induced ALI by modulating the miR-381/NLRP3 molecular axis.
- Rizaben (tranilast) / Kissei, Nuon Therapeutics
The Effect of Different NLRP3 Inflammasome Inhibitors on High-Sensitivity C-reactive Protein in Patients After Percutaneous Coronary Intervention (Zone 1, Science and Technology Hall, Level 2) - Aug 12, 2023 - Abstract #AHA2023AHA_5841;
Colchicine could reduce hsCRP in patients after PCI, which is likely to act on neutrophils. Colchicine may still be the important choice for anti-inflammatory treatment of CAD.
- The Role of Female Sex Hormones in Dimorphism of the Immune System in Group 1 Pulmonary Hypertension (Zone 4, Science and Technology Hall, Level 2) - Aug 12, 2023 - Abstract #AHA2023AHA_4913;
RV inflammation is most severe in males, and female sex hormones are cardioprotective. Inhibition of the NLRP3 is beneficial in MCT males and trend to benefit OVX.
- NLRP3 Activation and Calcium-Dependent Contractile Function in Rat Right Ventricle Cardiomyocytes (RVCMs) Are Sexually Dimorphic and Controlled by 17 (103C) - Aug 12, 2023 - Abstract #AHA2023AHA_3077;
E2 prevents RVCM NLRP3 activation and contractile dysfunction in an ERa-dependent manner, likely mediated by ERa binding to the NLRP3 promoter. NLRP3 activation may be therapeutically targetable in PH patients of either sex.
- || Review, Journal: Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities. (Pubmed Central) - Aug 11, 2023
By understanding the regulation of NLRP3 inflammasome activation, specific inhibitors can be rationally designed for the treatment and prevention of various immune- or metabolic-based diseases. Lastly, we review current NLRP3 inflammasome inhibitors and their mechanism of action.
- | Journal, Cytokine storm: Polyphosphazene nanodrugs for targeting delivery and inflammation responsive release of curcumin to treat acute lung injury by effectively inhibiting cytokine storms. (Pubmed Central) - Aug 11, 2023
The administrated mice experiments confirmed that PHCH accumulation was enhanced in lung tissue and showed the efficient scavenging ability of reactive oxygen species (ROS), effectively blocking the cytokine storm and alleviating inflammatory damage in ALI. This smart polyphosphazene nano-drug with targeting delivery property and inflammation-responsive release of curcumin has excellent potential for the clinical treatment of various inflammatory diseases, including ALI.
- | Journal: Inhibition of the NLRP3 Inflammasome Activation/Assembly through the Activation of the PI3K Pathway by Naloxone Protects Neural Stem Cells from Ischemic Condition. (Pubmed Central) - Aug 11, 2023
These neuroprotective and anti-inflammatory effects of naloxone were eliminated when cells were treated with PI3K inhibitors. Our results suggest that NLRP3 inflammasome is a potential therapeutic target and that naloxone reduces ischemic injury in NSCs by inhibiting NLRP3 inflammasome activation/assembly mediated by the activation of the PI3K signaling pathway.
- | Journal: Effects of repetitive transcranial magnetic stimulation combined with acupuncture on NLRP3 inflammasome and protease levels in patients with neuropathic pain. (Pubmed Central) - Aug 10, 2023
Our results suggest that NLRP3 inflammasome is a potential therapeutic target and that naloxone reduces ischemic injury in NSCs by inhibiting NLRP3 inflammasome activation/assembly mediated by the activation of the PI3K signaling pathway. rTMS plus acupuncture can reduce the inflammatory immune response and ease the pain in patients by inhibiting NLRP3 inflammasome and its resulting inflammatory factors, Caspase-1 and IL-1?.
- | doxorubicin hydrochloride / Generic mfg.
Journal: 1,25(OH)D ameliorates doxorubicin?induced cardiomyopathy by inhibiting the NLRP3 inflammasome and oxidative stress. (Pubmed Central) - Aug 10, 2023
In conclusion, the present study demonstrated that 1,25(OH)D regulated histone modification in the NLRP3 and Nrf2 promoters, which in turn inhibits the activation of NLRP3 inflammasome and oxidative stress in cardiomyocytes, alleviating DOX-induced cardiomyopathy. Therefore, 1,25(OH)D may be a potential drug candidate for the treatment of DOX-induced cardiomyopathy.
- | colchicine / Generic mfg.
Journal: Effects of evodiamine on ROS/TXNIP/NLRP3 pathway against gouty arthritis. (Pubmed Central) - Aug 9, 2023
Therefore, 1,25(OH)D may be a potential drug candidate for the treatment of DOX-induced cardiomyopathy. Seventy-two male Sprague-Dawley (SD) rats were randomly assigned into the control, model, high, medium, and low dose of EVO groups and colchicine group...Moreover, evodiamine downregulated the protein expression levels of TXNIP, NLRP3, pro-caspase-1, cleaved
- | Journal: Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Kb Pathway. (Pubmed Central) - Aug 8, 2023
Catalpol acts as anti-depressant and anti-inflammatory molecule indepression induced by CUMS. Combination of catalpol with NF-?B inhibitor might play a role in the treatment of depression through regulating the neuroinflammation.
- | Journal: MSC therapy ameliorates experimental gouty arthritis hinting an early COX-2 induction. (Pubmed Central) - Aug 7, 2023
Ad-MSCs suppressed NF-kB activity, NLRP3 inflammasome, and promoted the presence of M2 alternative macrophages in the synovium. Therefore, this therapeutic approach could be considered as a pharmacological alternative in patients with comorbidities that preclude conventional treatment.
- | selisistat (SEN-196) / AOP Orphan Pharma, Tudcabil (tauroursodeoxycholic acid) / Bruschettini
Journal: Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis. (Pubmed Central) - Aug 7, 2023
The activation of SIRT1 and the subsequent FXR deacetylation restored the BA profiles, especially CDCA, TUDCA, and TCDCA contents, which was the main contributor to NLRP3 inhibition and the hepaprotective effect of GE. Overall, our work provides novel insights that GE as well as Gardeniae Fructus might be the potential attractive candidate for ameliorating BDL-induced liver fibrosis.
- | Journal: Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span. (Pubmed Central) - Aug 7, 2023
Finally, NLRP3 also impacted liver aging. Together, these results suggest a critical role for the NLRP3 inflammasome in podocyte and liver aging.
- | Preclinical, Journal: Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response. (Pubmed Central) - Aug 6, 2023
Mechanically, ANGPTL4 suppression inhibited NLRP3 inflammasome expression in renal tissues of mice. ANGPTL4 silencing inhibits the NLRP3 inflammasome-mediated inflammatory response, thereby ameliorating LN in MRL/lpr mice.
- | Journal: Artesunate ameliorates ligature-induced periodontitis by attenuating NLRP3 inflammasome-mediated osteoclastogenesis and enhancing osteogenic differentiation. (Pubmed Central) - Aug 2, 2023
In addition to regulating osteoclastogenesis, ART significantly enhanced osteogenic differentiation by alleviating the expression of cytokines in inflammatory conditions. Our data shed light on the probably potential mechanism of ART treatment for the intervention of periodontitis.