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- || Review, Journal: From Innate Immunity to Metabolic Disorder: A Review of the NLRP3 Inflammasome in Diabetes Mellitus. (Pubmed Central) - Sep 28, 2023
NLRP3 activation is also instrumental for the presence of numerous complications associated with DM, microvascular and macrovascular. A considerable number of anti-diabetic drugs have demonstrated the ability to inhibit the NLRP3 inflammasome.
- | Journal: Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis. (Pubmed Central) - Sep 27, 2023
Importantly, L38 exhibited positive therapeutic effects in DSS-induced ulcerative colitis mouse model. Taken together, this study presents a promising inhibitor of NLRP3 inflammasome deserving further investigation.
- | Journal: TanshinoneIIA inhibits melanocyte pyroptosis by regulating the ROS/NLRP3 signaling axis. (Pubmed Central) - Sep 27, 2023
Taken together, this study presents a promising inhibitor of NLRP3 inflammasome deserving further investigation. TanshinoneIIA suppressed melanocyte pyroptosis probably through modulating the ROS/NLRP3 signaling axis, which provides the evidence for therapeutic effect in vitiligo.
- | Journal: Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome (Pubmed Central) - Sep 27, 2023
At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it increased by 1.5 times. Thus, NS3 can be considered as one of the factors of NLRP3 inflammasome activation and inflammatory pathogenesis in chronic hepatitis C virus infection.
- | glibenclamide / Generic mfg.
Journal: Repositioning Glibenclamide in cardiac fibrosis by targeting TGF-?1-pSmad2/3-NLRP3 cascade. (Pubmed Central) - Sep 26, 2023
The cascade of TGF-?1-pSmad2/3-NLRP3 was downregulated along with suppression of IL-1?. Our study repositioned anti-diabetic drug Glibenclamide to treat cardiac fibrosis by inhibiting the TGF-?1-pSmad2/3-NLRP3 cascade.
- | indoximod (NLG8189) / Lumos Pharma
Preclinical, Journal, IO biomarker: IDO-Kynurenine pathway mediates NLRP3 inflammasome activation-induced postoperative cognitive impairment in aged mice. (Pubmed Central) - Sep 25, 2023
Hence, this study elucidated whether IDO-Kynurenine pathway mediates NLRP3 inflammasome activation-induced postoperative cognitive impairment in aged mice.POCD model was established in aged C57BL/6J mice by exploratory laparotomy under isoflurane anesthesia...To clarify the role of IDO-Kynurenine pathway in postoperative cognitive impairment, we treated these mice with the IDO inhibitor 1-methyl-Ltryptophan (1-MT) to observe its effect on learning and memory abilities and the tryptophan (TRP), KYN and kynurenic acid (KYNA) levels...Together, these results reveal that IDO-Kynurenine pathway mediates NLRP3 inflammasome activation-induced postoperative cognitive impairment. IDO-Kynurenine pathway may be a novel target for the treatment of cognitive impairment induced by anesthesia and surgery in old patients.
- | MitoQ (mitoquinone) / Antipodean
Preclinical, Journal: Parkin-mediated mitophagy protects against aluminum trichloride-induced hippocampal apoptosis in mice via the mtROS-NLRP3 pathway. (Pubmed Central) - Sep 25, 2023
The results showed that inhibition of mtROS and NLRP3 attenuated hippocampal NLRP3-inflammasome activation, apoptosis, and damage in AlCl-treated Parkin mice. These findings indicate that Parkin-mediated mitophagy protects against AlCl-induced hippocampal apoptosis in mice via the mtROS-NLRP3 pathway.
- | Preclinical, Journal: Bile acids ameliorates lipopolysaccharide-induced endometritis in mice by inhibiting NLRP3 inflammasome activation. (Pubmed Central) - Sep 25, 2023
These findings indicate that Parkin-mediated mitophagy protects against AlCl-induced hippocampal apoptosis in mice via the mtROS-NLRP3 pathway. NLRP3 inflammasome is a promising target for endometritis treatment and BAs exhibit anti-inflammatory properties by repressing NLRP3 inflammasome activation, making them a possible novel therapeutic strategy for endometritis.
- | probenecid / Generic mfg.
Journal: Qiji Shujiang granules alleviates dopaminergic neuronal injury of parkinson's disease by inhibiting NLRP3/Caspase-1 pathway mediated pyroptosis. (Pubmed Central) - Sep 25, 2023
This study provides pharmacological support for the use of QJG in the treatment of PD. Herein, we concluded that QJG induced the alleviation of pyroptosis by inhibiting the NLRP3/caspase-1 pathway to exert a neuroprotective effect.
- | isoflurane / Generic mfg.
Preclinical, Journal: Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. (Pubmed Central) - Sep 25, 2023
After inhibition of autophagy pathway or key protein AMPK in autophagy, neurobehavioral scores and protein expression of NLRP3, IL-1?, and IL-18 were significantly increased (P?<?0.05). Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats.
- | Journal: The effects of nucleotide-binding oligomerization domain-like receptor 3 inflammasome on obstructive sleep apnea and its complications (Pubmed Central) - Sep 24, 2023
Targeting inhibition of NLRP3 inflammasome may serve as a co-therapeutic strategy for OSA-induced related complications. This article reviews NLRP3 inflammasome and its mechanism in OSA-related concurrent diseases, which can provide scientific basis for prevention and intervention of OSA and its related complications.
- Macrophage Extracellular Traps Induced by Monosodium Urate or Calcium Pyrophosphate Crystals Form Independently of NLRP3 Inflammasome Activation (Poster Hall; in person) - Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_2189;
METosis required differentiation of monocytes to M1 or M2 macrophages, was independent of inflammasome activation and did not induce IL-1b secretion in the absence of priming with LPS/IFNg. These results suggest that MET formation may represent an alternative mechanism by which macrophages may trap crystals without provoking pyroptosis and inflammatory flares.
- || Review, Journal: The role of NLRP3 inflammasome in sepsis: A potential therapeutic target. (Pubmed Central) - Sep 23, 2023
Of note, several herbal extracts targeting NLRP3 inflammasome in the treatment of sepsis were emphasized. We hope that this paper could provide a basis for further drug research targeting NLRP3 inflammasome.
- || ulinastatin injection / Generic mfg.
Review, Journal: NLRP3 inflammasome involves in the pathophysiology of sepsis-induced myocardial dysfunction by multiple mechanisms. (Pubmed Central) - Sep 23, 2023
These experimental findings indicated that NLRP3 inflammasome could be a promising therapeutic target for SIMD treatment. However, the clinical translation of NLRP3 inhibitors for treating SIMD still requires robust in vivo and preclinical trials.
- | Journal: Limonoids from the roots of Melia azedarach and their anti-inflammatory activity. (Pubmed Central) - Sep 23, 2023
(1L-1?) secretion in LPS plus nigericin-induced THP-1 macrophages by inhibiting NLRP3 inflammasome activation. The results strongly suggested that limonoids from the roots of M. azedarach might be candidates for treating inflammation-related diseases.
- | Edurant (rilpivirine) / J&J
Journal, Immunomodulating: Anti-inflammatory and immunomodulating effects of rilpivirine: Relevance for the therapeutics of chronic liver disease. (Pubmed Central) - Sep 23, 2023
RPV was also proven anti-inflammatory in PBMC from patients with CLD treated ex vivo. In conclusion, beyond its well-described role in antiretroviral therapy, RPV manifests anti-inflammatory and immunoregulatory effects, a finding that could be of great relevance for the search of novel targets or repositioning strategies for CLD.
- || Review, Journal: Estrogen plays an important role by influencing the NLRP3 inflammasome. (Pubmed Central) - Sep 23, 2023
However, the mechanism of these effects is not summarized. This article reviewed the progress in understanding the effects of estrogen on the NLRP3 inflammasome and its mechanisms in recent years to provide a theoretical basis for an in-depth study.
- | Preclinical, Journal: CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1? signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice. (Pubmed Central) - Sep 22, 2023
Therefore, CXCL5 could exacerbate NASH by promoting lipotoxicity of hepatocytes via upregulating NLRP3/Caspase-1/IL-1? signaling in KCs.
- | escitalopram / Generic mfg.
Preclinical, Journal: SIRT1/PARP-1/NLRP3 cascade as a potential target for niacin neuroprotective effect in lipopolysaccharide-induced depressive-like behavior in mice. (Pubmed Central) - Sep 22, 2023
signaling in KCs. Accordingly, NA is deemed as a prosperous candidate for depression management via targeting SIRT1/PARP-1 pathway.
- || DFV890 / Novartis, dapansutrile (OLT1177) / Olatec Therap
Review, Journal: Research progress of NLRP3 inflammasome and its inhibitors with aging diseases. (Pubmed Central) - Sep 22, 2023
antibodies. This article reviews the relationship between NLRP3 inflammasome and aging diseases: summarizes some of the relevant experimental results reported in recent years, and introduces the biological signals or pathways closely related to the NLRP3 inflammasome in a variety of aging diseases, and also introduces some promising small molecule inhibitors of NLRP3 inflammasome for clinical treatment, such as: ZYIL1, DFV890 and OLT1177, they have excellent pharmacological effects and good pharmacokinetics.
- Age-related Clonal Hematopoiesis Predisposes To Hypertension In Mice Through An Inflammasome Mechanism (Best of AHA Specialty Conferences, Science and Technology Hall, Level 2) - Sep 21, 2023 - Abstract #AHA2023AHA_7296;
This article reviews the relationship between NLRP3 inflammasome and aging diseases: summarizes some of the relevant experimental results reported in recent years, and introduces the biological signals or pathways closely related to the NLRP3 inflammasome in a variety of aging diseases, and also introduces some promising small molecule inhibitors of NLRP3 inflammasome for clinical treatment, such as: ZYIL1, DFV890 and OLT1177, they have excellent pharmacological effects and good pharmacokinetics. Our data show that a sub-pressor dose of Ang II promotes hypertension due to elevated renal immune cell infiltration in a Tet2-CH model, promoting IL1-
- | Legalon (silibinin) / Viatris
Journal: Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation. (Pubmed Central) - Sep 21, 2023
These results suggest that silibinin may alleviate inflammation in DCA-exposed HepG2 cells by mitigating pyroptosis, possibly through its binding affinity and inhibition of the NLRP3 inflammasome. Overall, our study indicates that silibinin holds promise as a therapeutic agent for NASH by modulating pyroptosis and inhibiting NLRP3 inflammasome activation.
- | PX-478 / Seagen
Preclinical, Journal: Resveratrol alleviates MSU-induced gouty arthritis in rats through inhibition of HIF-1?- and NLRP3-derived IL-1? secretion in macrophages. (Pubmed Central) - Sep 20, 2023
modulation and inhibition of NLRP3 inflammasome activation. Our study might offer a novel sight for the treatment of gouty arthritis.
- | Journal: Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells. (Pubmed Central) - Sep 20, 2023
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1?/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.
- | probenecid / Generic mfg.
Preclinical, Journal: Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson's disease by inducing autophagy (Pubmed Central) - Sep 19, 2023
It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA. DHM can improve motor function of PD mice probably by activating autophagy to inhibit pyroptosis and necroptosis and reduce neuroinflammation.
- || Review, Journal: Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases. (Pubmed Central) - Sep 19, 2023
DHM can improve motor function of PD mice probably by activating autophagy to inhibit pyroptosis and necroptosis and reduce neuroinflammation. Understanding these mechanisms will contribute to a deeper understanding of the link between neuronal pyroptosis and neurodegenerative diseases, and hold significant implications for the treatment and prevention of neurodegenerative diseases.
- | Journal, Machine learning: Discovery of NLRP3 inhibitors using machine learning: Identification of a hit compound to treat NLRP3 activation-driven diseases. (Pubmed Central) - Sep 18, 2023
Importantly, CSC-6 has lower cytotoxicity and exhibits better stability in human-derived liver microsomes, which is more favorable for the drug to maintain its efficacy in vivo for longer. The discovery of CSC-6 may contribute to the design and discovery of related NLRP3 inhibitors.
- || Review, Journal: Role of the NLRP3 inflammasome in gynecological disease. (Pubmed Central) - Sep 18, 2023
Therefore, proper control of NLRP3 inflammasome activity is critical. This paper summarizes the structure and function of the NLRP3 inflammasome and highlights the therapeutic potential of targeting it in gynecological diseases, such as endometriosis, polycystic ovary syndrome and breast cancer The application of NLRP3 inflammasome inhibitors is also discussed.
- || Review, Journal: Medicinal chemistry strategies targeting NLRP3 inflammasome pathway: A recent update from 2019 to mid-2023. (Pubmed Central) - Sep 18, 2023
This review updates the recently reported (2019 to mid-2023) molecule inhibitors targeting the NLRP3 inflammasome pathway, summarizes their structure-activity relationships (SARs), and discusses the therapeutic effects on inflammatory diseases. I hope this review will contribute to the development of novel inhibitors targeting NLRP3 inflammasome pathway as potential drugs.
- | fuzheng Huayu / Shanghai Sundise
Journal: Fuzheng Huayu recipe alleviates liver fibrosis via inhibiting NLRP3 inflammasome activation in macrophages. (Pubmed Central) - Sep 18, 2023
Ultimately, these effects may lead to the improvement of liver fibrosis. The ability of FZHY to act on this novel mechanism represents an important aspect of its therapeutic potential for liver fibrosis.
- | Journal: Wuzi Yanzong Pill relieves MPTP-induced motor dysfunction and neuron loss by inhibiting NLRP3 inflammasome-mediated neuroinflammation. (Pubmed Central) - Sep 18, 2023
Simultaneously, WYP intervention inhibited the expression of NLRP3 inflammasome, accompanied by the decrease of the TLR4/MyD88/NF-?B pathway. However, the exact target and interaction of WYP on NLRP3 inflammasome and TLR4/MyD88/NF-?B pathway still needs to be further investigated.
- | fluconazole oral / Generic mfg.
Journal, IO biomarker: Longdan Xiegan decoction ameliorates vulvovaginal candidiasis by inhibiting the NLRP3 inflammasome via the Toll-like receptor /MyD88 pathway. (Pubmed Central) - Sep 18, 2023
The results showed that LXD could eliminate the invasion of vaginal hyphae in mice, reduce the recruitment of neutrophils, and reduce the expression of TLR/MyD88 pathway-related proteins and NLRP3 inflammasome. The above results clearly indicate that LXD may profoundly regulate NLRP3 inflammasome through the TLR/MyD88 pathway and play a therapeutic role in VVC.
- || midazolam hydrochloride / Generic mfg.
P1 data, PK/PD data, Clinical Trial,Phase I, Journal: First-in-human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC-2394, in healthy?volunteers. (Pubmed Central) - Sep 15, 2023
and IL-18, across all tested doses. Despite favorable PK and target engagement PD, the GDC-2394 safety profile precludes its further development.
- || Review, Journal: Molecular Activation of NLRP3 Inflammasome by Particles and Crystals: A Continuing Challenge of Immunology and Toxicology. (Pubmed Central) - Sep 14, 2023
Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 64 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
- | Preclinical, Journal: 5-Methoxytryptophan ameliorates endotoxin-induced acute lung injury in vivo and in vitro by inhibiting NLRP3 inflammasome-mediated pyroptosis through the Nrf2/HO-1 signaling pathway. (Pubmed Central) - Sep 14, 2023
Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. These findings suggested that 5-MTP could effectively ameliorate ALI by inhibiting NLRP3-mediated pyroptosis via the Nrf2/HO-1 signaling pathway.
- | Preclinical, Journal: hMSCs treatment attenuates murine herpesvirus-68 (MHV-68) pneumonia through altering innate immune response via ROS/NLRP3 signaling pathway. (Pubmed Central) - Sep 13, 2023
Moreover, administration of MCC950, a selective NLRP3 inhibitor has been shown to effectively reduce ROS production and subsequently alleviate inflammation induced by MHV-68. Taken together, our work has shown that hMSCs can effectively protect mice from lethal MHV-68 pneumonia, which may throw new light on strategy for combating human EBV-associated pneumonia.
- | Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Journal: Inhibition of NLRP3 Inflammasome Activation by 3H-1,2-Dithiole-3-Thione: A Potential Therapeutic Approach for Psoriasis Treatment. (Pubmed Central) - Sep 13, 2023
In an imiquimod-induced psoriasis mouse model, D3T treatment demonstrated significant reductions in ear thickness, skin redness, and scaling compared to a control group...The mechanical study also revealed that D3T could inhibit NLRP3 inflammasome activation by inhibiting the JNK pathway in HaCaT cells. These results indicate that targeting NLRP3 inflammasome activation is a promising strategy in the treatment of psoriasis.
- | Journal: Puerarin Inhibits NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis via P2X7 Receptor in Cardiomyocytes and Macrophages. (Pubmed Central) - Sep 13, 2023
The molecular docking results indicated key binding activity between the P2X7 receptor and puerarin. These findings indicate that puerarin effectively regulated the pyroptosis signaling pathway during DCM, and this regulation was associated with the P2X7 receptor.
- Tumor-mediated education of bone marrow neutrophil progenitors facilitates the development of checkpoint inhibitor-associated toxicity (Ground Level - Exhibit Hall C - San Diego) - Sep 13, 2023 - Abstract #SITC2023SITC_112;
Conclusions Tumor-mediated re-programming of neutrophil progenitors facilitates the development of inflammatory colitis and pneumonitis in response to anti-PD-1 immunotherapy. The tumor-intrinsic NLRP3-HSP70 signaling axis primes neutrophil populations for enhanced pathologic responses to anti-PD-1 immunotherapy and provides both pharmacologic targets and biomarkers capable of improving the management of irAEs in cancer patients.
- | Journal: CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis. (Pubmed Central) - Sep 11, 2023
Mechanistically, our work demonstrated that CHIP interacted with and ubiquitinated NLRP3 to promote its proteasomal degradation, leading to the inhibition of NLRP3/ACS inflammasome-mediated pyroptosis. In summary, this study revealed that CHIP ubiquitinated NLRP3 to alleviate pyroptosis in septic renal injuries, suggesting that CHIP might be a potential therapeutic target for S-AKI.
- | perindopril arginine / Generic mfg.
Preclinical, Journal, Immunomodulating: Xin-Li formula attenuates heart failure induced by a combination of hyperlipidemia and myocardial infarction in rats via Treg immunomodulation and NLRP3 inflammasome inhibition. (Pubmed Central) - Sep 11, 2023
A rat model of HF induced by hyperlipidemia and MI was established with intragastric administration of XLF and Perindopril...Additionally, XLF inhibited NLRP3 inflammasome activation in LPS/ATP-stimulated THP-1 macrophages. Taken together, this study raises the exciting possibility that Xin-Li Formula may benefit HF patients due to its immunomodulatory and anti-inflammatory effects via Treg activation and NLRP3 inflammasome inhibition.
- | Journal: Genistein upregulates AHR to protect against environmental toxin-induced NASH by inhibiting NLRP3 inflammasome activation and reconstructing antioxidant defense mechanisms. (Pubmed Central) - Sep 7, 2023
More important, the interaction and co-localization between AHR and NLRP3 was first proved, and genistein could promote the levels of AHR that interacted with NLRP3, which thereafter blocked the activation of NLRP3 inflammasome. Conclusively, in this research, we confirmed the AHR-dependent protective role of genistein in environmental toxin-linked NASH, which shed light on the potential precautions for contaminants-induced NASH.
- | glibenclamide / Generic mfg., dimethyl fumarate / Generic mfg.
Preclinical, Journal: Simultaneous intervention against oxidative stress and inflammation by targeting Nrf2/ARE and NLRP3 inflammasome pathway mitigates thioacetamide-induced liver fibrosis in rat. (Pubmed Central) - Sep 7, 2023
Glibenclamide (GLB) is an USFDA-approved drug for type 2 diabetes and is reported to possess anti-inflammatory activity by inhibiting inflammatory cytokines...Treatment with GLB, DMF, and GLB+DMF significantly protected against TAA-mediated oxidative stress and inflammatory conditions by improving hepatic function test, triglycerides, hydroxyproline, and histopathological alterations, by inhibiting the NLRP3 inflammasome signaling and fibrogenic markers, and by activating Nrf2/ARE pathway in Wistar rats. The present results suggest that simultaneous Nrf2/ARE activation and NLRP3 inflammasome inhibition could significantly contribute to developing a novel therapy for patients with liver fibrosis.
- | Journal: TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2. (Pubmed Central) - Sep 7, 2023
Our results demonstrated that TMAO promotes NLRP3 inflammasome activation of microglia aggravating neurological injury in ischemic stroke through FTO/IGF2BP2. These findings explained the molecular mechanism of TMAO aggravating ischemic stroke in detail and provided molecular mechanism for clinical treatment.
- | Journal: Lonicerin alleviates the progression of experimental rheumatoid arthritis by downregulating M1 macrophages through the NF-?B signaling pathway. (Pubmed Central) - Sep 7, 2023
and IL-18 release. These results indicated that LON might exert anti-RA effects by regulating the polarization of M1/M2 macrophage, especially by inhibiting macrophage polarization toward M1.
- | Preclinical, Journal: Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice. (Pubmed Central) - Sep 7, 2023
Furthermore, PU reduced the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) and inhibited NLRP3 inflammasome activation, reducing the levels of inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), interleukin-18 (IL-18), and interleukin-1 beta (IL-1?) in both accelerated aging and naturally senescent mouse models. PU effectively improved neuroinflammation, learning and memory deficits, and redox homeostasis in aging mice, and it could be a potential therapeutic agent for AD.
- | Zolinza (vorinostat) / Merck (MSD), thalidomide / Generic mfg.
Journal: Pharmacological inhibition of HDAC6 suppresses xNLRP3 inflammasome-mediated IL-1? release. (Pubmed Central) - Sep 7, 2023
Collectively, our findings indicate that HDAC6 inhibitors show potent anti-inflammatory activity and suppressing IL-1? release by human macrophages independent of NLRP3 assembly and activation.
- | colchicine / Generic mfg., Kineret (anakinra) / SOBI
Journal: NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis. (Pubmed Central) - Sep 7, 2023
The non-selective NLRP3 inhibitor colchicine reduced hospitalization and death in a subgroup of COVID-19 outpatients but is not approved for the treatment of COVID-19...We herein outline the contribution of immunothrombosis to COVID-19-associated coagulopathy, and review preclinical and clinical evidence suggesting an engagement of the NLRP3 inflammasome pathway in the immunothrombotic pathogenesis of COVID-19. We also summarize current efforts to target the NLRP3 inflammasome pathway in COVID-19, and discuss challenges, unmet gaps and the therapeutic potential that inflammasome-targeted strategies may provide for inflammation-driven thrombotic disorders including COVID-19.
- | Journal: TTC4 inhibits NLRP3 inflammation in rheumatoid arthritis by HSP70. (Pubmed Central) - Sep 7, 2023
In this study, the TTC4 gene reduced oxidative response and inflammation in the rheumatoid arthritis model through the HSP70/NLRP3 pathway. Therefore, it can be concluded that TTC4 can be used as diagnosis and prognosis evaluation of rheumatoid arthritis.
- | Preclinical, Journal: A (Pubmed Central) - Sep 7, 2023
The animals were euthanized after 16 weeks, and tissues from the spinal cord, sciatic nerve, and urine were taken. Our findings showed that daily treatment of A