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7 Companies | 6 Products |
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29 Diseases | |
11 Trials |  |
763 News |  |
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- | Journal: Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages. (Pubmed Central) - May 13, 2019
In particular, the S. mutans-induced NLRP3 inflammasome was mediated by adenosine triphosphate (ATP) release, potassium depletion and lysosomal damage. Our study provides novel insight into the innate immune response against S. mutans infection.
- | Preclinical, Journal, IO Biomarker: NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study. (Pubmed Central) - May 13, 2019
TiO NPs also led to morphological changes in the liver and intestine. TiO NPs could have cytotoxic effects on the intestine and liver structure and function by inducing oxidative stress, inflammation, and apoptosis.
- | Kolchin (colchicine) / Incepta
Journal: Neutrophilic urticarial dermatosis: A review. (Pubmed Central) - May 11, 2019
Treatment of NUD depends on the clinical context. Dapsone and colchicine are often effective.
- | Journal: Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production. (Pubmed Central) - May 11, 2019
Our results demonstrated that rapamycin protects mice against LPS-induced ALI partly by inhibiting the production and secretion of IL-1β and IL-18. mTOR and rapamycin might represent an appropriate therapeutic target and strategy for preventing ALI induced by LPS.
- | Review, Journal: The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease. (Pubmed Central) - May 11, 2019
In this review we focus on the mechanisms of activation of the NLRP3 inflammasome and pyroptosis and their inflammatory effects on the development of PD. In addition, we focus on some inhibitors of NLRP3 inflammatory pathways to alleviate the progression of PD by inhibiting central inflammation and provide new therapeutic strategies for the treatment of PD.
- | Preclinical, Journal: Effect of ursolic acid on cardiomyopathy of mice with diabetes and its mechanism (Pubmed Central) - May 11, 2019
In addition, we focus on some inhibitors of NLRP3 inflammatory pathways to alleviate the progression of PD by inhibiting central inflammation and provide new therapeutic strategies for the treatment of PD. Ursolic acid has a obvious protective effect on myocardial injury in mice with diabetes induced by high-fat diet combined with low dose streptozotocin, and its mechanism may be associated with inhibiting NLRP3 inflammasome activation, reducing IL-1β generation and alleviating myocardial inflammatory injury.
- | metformin / generics
Journal: Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin. (Pubmed Central) - May 10, 2019
Matrine protects against MCD-induced development of NASH which is refractory to metformin treatment. Its anti-NASH effects involve enhancing HSP72 and downregulating mTOR but do not rely on amelioration of hepatosteatosis.
- | Journal: Total flavonoids in Scutellaria barbata prevents NLRP3 inflammasome expression in tumor cells by affecting autologous pathway (Pubmed Central) - May 9, 2019
Serum IL-1β and IL-18 levels in model control group were found higher than those in control group (P<0.001), but they were significantly lowered in positive control group and TF-SB groups (P<0.05, P<0.01 or P<0.001). Taken together, total flavonoids in S. barbata could effectively alter the tumor growth micro-environment by inhibiting the expression of NLRP3 inflammasome, and its anti-tumor effect may be associated with the induction of tumor cell autophagy.
- | Review, Journal: Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders. (Pubmed Central) - May 9, 2019
We present, in the way of reviewing relevant literature, the preclinical data and scientific rationale supporting the role of the P2X7-NLRP3-IL-1β pathway in mood disorders. We also highlight recent advances in drug discovery and development of P2X7 small molecule antagonists and P2X7 PET ligands which provide optimism that clinical tools are availableto address critical proof-of-concept experiments in mood disorders.
- | Victoza (liraglutide) / Novo Nordisk
Preclinical, Journal: Liraglutide protects non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in a mouse model induced by high-fat diet. (Pubmed Central) - May 9, 2019
In vitro studies found that the mitochondrial dysfunction in Kupffer cells induced by palmitic acid was attenuated, and the protein levels of NLRP3, ASC and caspase-1 were also decrease markedly. These results demonstrate that liraglutide was able to alleviate high-fat diet-induced hepatic steatosis via inhibiting NLRP3 inflammasome activation, suggesting that liraglutide is a potent drug that can reverse the pathological hallmarks of NAFLD.
- | Journal: Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep. (Pubmed Central) - May 9, 2019
Four additional significant regions were detected in secondary sex-stratified and combined discovery and replication analyses, including a region overlapping Reelin, a known marker of respiratory complex neurons.These are the first genome-wide significant findings reported for oxyhemoglobin saturation during sleep, a phenotype of high clinical interest. Our replicated associations with HK1 and IL18R1 suggest that variants in inflammatory pathways, such as the biologically-plausible NLRP3 inflammasome, may contribute to nocturnal hypoxemia.
- | Journal, IO Biomarker: Inhibition of Caspase-1-dependent pyroptosis attenuates copper-induced apoptosis in chicken hepatocytes. (Pubmed Central) - May 8, 2019
Furthermore, treatment with Cu and Z-YVAD-FMK could down-regulate the mRNA levels of Caspase-3, Bak1, Bax, and CytC and Caspase-3 protein expression, up-regulate the mRNA expression of Bcl2, increase the MMP and reduce cell apoptosis compared to treatment with Cu in hepatocytes. Collectively, these finding evidenced that excess Cu induced pyroptosis by generating ROS in hepatocytes, and the inhibition of Caspase-1-dependent pyroptosis might attenuate Cu-induced apoptosis.
- | Preclinical, Journal: Fine particulate matter-induced cardiovascular injury is associated with NLRP3 inflammasome activation in Apo E mice. (Pubmed Central) - May 8, 2019
PM exposure was also associated with the activation of NLRP3 inflammasome, which characterized by elevated protein expression of NLRP3, ASC, caspase-1, IL-1β and IL-18 in myocardium. All these results demonstrated PM-related cardiac injury is mediated by macrophages polarization and NLRP3 inflammasome activation.
- | Journal: Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy. (Pubmed Central) - May 7, 2019
All these results demonstrated PM-related cardiac injury is mediated by macrophages polarization and NLRP3 inflammasome activation. The NLRP3 inflammasome plays a key pathogenic role in DMD and muscle inflammation, thereby opening new therapeutic perspectives for these and other related disorders.
- | Journal: Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome. (Pubmed Central) - May 7, 2019
E. faecalis promoted apoptosis and pyroptosis of MG63 cells via the NLRP3 inflammasome. This indicates that E. faecalis infection may result in the delayed reconstruction of periapical lesions, and NLRP3 is the potential target of new intracanal therapeutic agents.
- | Preclinical, Journal: NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice. (Pubmed Central) - May 7, 2019
Furthermore, we also found exposure of IL-1β to HK-2 cells induced ROS generation and expression of TXNIP and Nox4. Taken together, inhibition of NLRP3 inflammasome activation inhibits renal inflammation and fibrosis at least in part via suppression of oxidative stress in diabetic nephropathy.
- | Journal: Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis. (Pubmed Central) - May 7, 2019
Broad inflammasome-inhibition, but not NLRP3-selective inhibition, protected against IL-1β-induced INS-1 cell-toxicity. We suggest that IL-1β causes β-cell toxicity in part by NLRP1 mediated caspase-1-activation and maturation of IL-1β leading to an autocrine potentiation loop.
- | Journal: The Beta-Hydroxybutyrate Suppresses the Migration of Glioma Cells by Inhibition of NLRP3 Inflammasome. (Pubmed Central) - May 7, 2019
Our results suggested that BHB inhibits the activation of NLRP3 inflammasome in C6 glioma cells and consequently suppressed the C6 cell migration. These findings also implicated that by inhibiting NLRP3 inflammasome, BHB reduced the inflammatory microenvironment which provided ancillary therapeutic benefits for the intervention of glioma.
- | Journal: Renal amyloidosis revealing a cryopyrin associated periodic syndrome (Pubmed Central) - May 7, 2019
AA amyloidosis is known to happen in Muckle-Wells syndrome. Other occasional renal impairments are described in this syndrome whereas the IgA nephropathy association remains poorly characterized.
- | Suiny (anagliptin) / Kowa, Sanwa Kagaku Kenkyusho
Journal: Anagliptin ameliorates high glucose- induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1. (Pubmed Central) - May 7, 2019
Silencing of SIRT1 by transfection with SIRT1 siRNA abolished the inhibitory effects of anagliptin in NLRP3 inflammasome activation. These results display that anagliptin may confer protection against high glucose- induced endothelial injury via SIRT1-dependent inhibition of NLRP3 infammasome activation.
- | Kineret (anakinra) / SOBI, Affibody, Ilaris (canakinumab) / Novartis
Clinical, Journal: Severe cryopyrin-associated periodic syndrome first characterized by early childhood-onset sensorineural hearing loss - Case report and literature review. (Pubmed Central) - May 7, 2019
We describe a patient with severe cryopyrin-associated periodic syndrome who presented at age 18 months with macrocephaly and moderate sensorineural hearing loss, later developing systemic sequelae. The pathogenic nature of the de novo NLRP3 gene variant identified was supported by a markedly elevated serum amyloid A level and sustained clinical response to anti-IL-1 therapy.
- | Biomarker, Journal: NEOPTERIN PRECONDITIONING PREVENTS INFLAMMASOME ACTIVATION IN MAMMALIAN ASTROCYTES. (Pubmed Central) - May 7, 2019
Mechanistically, neopterin might induce eletrophilic stress and consequently the nuclear translocation of the transcription factor Nrf-2, and the anti-inflammatory cytokines IL-10 and IL-1ra release, which would induce the inhibition of the inflammasome activation. Altogether, this strongly suggests an essential role of neopterin during inflammatory processes.
- | Journal: The effect of high glucose-based peritoneal dialysis fluids on thioredoxin-interacting protein expression in human peritoneal mesothelial cells. (Pubmed Central) - May 7, 2019
Altogether, this strongly suggests an essential role of neopterin during inflammatory processes. The results of the present study revealed a novel mechanism underlying high glucose-containing PD-mediated peritoneal inflammatory injury, supporting the attenuation of ROS generation as a potential therapeutic strategy to alleviate such pathology.
- | Preclinical, Journal: Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats. (Pubmed Central) - May 7, 2019
Our results show that Celastrol can attenuate the inflammatory response of the spinal cord after SCI, which is associated with inhibition of microglial activation and pyroptosis pathway. Further study to explore the use of Celastrol to treat SCI is warranted.
- | Preclinical, Journal: Fraxin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting the NF-κB and NLRP3 signalling pathways. (Pubmed Central) - May 7, 2019
The expression of proteins involved in the NF-κB and NLRP3 inflammatory corpuscle signalling pathways was consistent between the lung tissues and cell samples. Overall, fraxin played a protective role in LPS-induced lung injury by inhibiting the NF-κB and NLRP3 signalling pathways.
- | Journal: Suppression of miR-21 and miR-155 of macrophage by cinnamaldehyde ameliorates ulcerative colitis. (Pubmed Central) - May 7, 2019
Meanwhile, data revealed that transferred miR-21 or miR-155 inhibitor suppressed levels of IL-1β and IL-6, whereas miR-21 or miR-155 mimics increased expressions of these, and CA suppressed these expressions. Our results indicate that CA could ameliorate DSS-induced colitis through inhibition of NLRP3 inflammasome activation and miR-21 and miR-155 levels in colons and macrophage, suggesting that CA might be a potentially effective drug for UC.
- | Preclinical, Journal: Pseudoginsenoside-F11 attenuates cognitive impairment by ameliorating oxidative stress and neuroinflammation in d‑galactose-treated mice. (Pubmed Central) - May 7, 2019
Finally, d‑gal treatment reduced the level of nuclear factor erythroid-related factor 2 (Nrf2) and glutathione S-transferase (GST) in hippocampus, which could reverse by PF11. Together, our findings indicated that PF11 exerts a protective effect against MCI-like pathological changes.
- | Preclinical, Journal: Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress. (Pubmed Central) - May 7, 2019
The stress-induced activation of indolamine-2, 3-dioxygenase (IDO) and an increased kynurenine/tryptophan ratio were also ameliorated by curcumin supplementation. In conclusion, the study revealed that curcumin relieves a depressive-like state through the inhibition of the NLRP3 inflammasome and kynurenine pathway.
- | praziquantel (MSC2499550A) / Merck (MSD)
Journal: The use of gold nanorods as a new vaccine platform against schistosomiasis. (Pubmed Central) - May 5, 2019
...At present, the main strategy adopted for the control of schistosomiasis is the use of safe chemotherapy, such as praziquantel...Furthermore, AuNRs-NH-rSm29 could activate dendritic cells in vitro, enhancing MHCII and MHCI expression and the production of IL-1β in a NLRP3-, ASC- and Caspase-1-dependent manner. In summary, our findings support the use of nanorods as an immunization strategy in vaccine development against infectious diseases.
- |||| Preclinical: Next, J. Todd Purves details bladder inflammation and obstruction. Preventing denervation and obstruction (in rats) via NLRP3 inhibition prevents late stage dysfunction. #AUA19 (Twitter) - May 5, 2019
- | Journal: NLRP3 inflammasome plays an important role in caspase-1 activation and IL-1β secretion in macrophages infected with Pasteurella multocida. (Pubmed Central) - May 5, 2019
Furthermore, spleen tyrosine kinase (Syk) was indicated to be involved in IL-1β secretion, possibly by regulating the NLRP3 inflammasome. Our results provide new insight into the host proinflammatory immune response against P. multocida and the critical involvement of the NLRP3 inflammasome in this activity.
- | sirolimus / generics
Journal: Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells. (Pubmed Central) - May 2, 2019
...In our study, 3-methyladenine (3-MA), an autophagy inhibitor, aggravated NLRP3 inflammasome activation, pyroptosis and decreased cell migration, rapamycin (Rapa), an autophagy inducer, alleviated aforementioned phenomenon under acrolein stress...In conclusion, it is possible that acrolein induced cell pyroptosis and suppressed cell migration via ROS-dependent autophagy. What's more, NLRP3 inflammasome activation plays a key role in this process.
- | Review, Journal: The role of mitochondria in NLRP3 inflammasome activation. (Pubmed Central) - May 2, 2019
These molecules bind to NLRP3 that is translocated on mitochondria and activate the NLRP3 inflammasome. Here we review recently described mechanisms by which mitochondria regulate NLRP3 inflammasome activation.
- | Journal: A comparative analysis of the capacity of the Candida species to elicit vaginal immunopathology. (Pubmed Central) - May 2, 2019
Collectively, our findings demonstrate that although NAC species are increasingly reported as causative agents of VVC, C. albicans appears to be exceedingly vaginopathogenic, exhibiting robust immunopathology, hypha formation and Candidalysin expression. Thus, this study provides mechanistic insight as to why C. albicans is overwhelmingly the major pathogen reported during VVC.
- | Journal: Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide. (Pubmed Central) - May 2, 2019
And APO attenuated P.g-LPS-induced TXNIP protein expression and mPDLFs injury. In conclusion, our results demonstrate that ROS/TXNIP/Nlrp3 Inflammasome pathway is a key initiating mechanism necessary for P.g-LPS-induced subsequent mPDLFs inflammatory response leading to chronic periodontitis.
- | Preclinical, Journal: LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks. (Pubmed Central) - May 2, 2019
Intercellular cell adhesion molecule-1 (ICAM-1) and NOD-like receptor protein 3 (NLRP3) induction by individual or mixed-field exposures were also significantly blunted by LGM2605. We conclude that LGM2605 is a likely candidate to reduce tissue damage from space-relevant radiation exposure.
- | Journal: Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis. (Pubmed Central) - May 2, 2019
Based on these findings, we engineered a monoclonal antibody against HNP-1 to block the interaction with P2X7 and found that the blocking antibody protected mice carrying high copy number of DEFA1/DEFA3 from lethal sepsis. We thus demonstrate that DEFA1/DEFA3 copy number variation strongly modulates sepsis development in vivo and explore a paradigm for the precision treatment of sepsis tailored by individual genetic information.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Journal: Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production. (Pubmed Central) - May 1, 2019
We thus demonstrate that DEFA1/DEFA3 copy number variation strongly modulates sepsis development in vivo and explore a paradigm for the precision treatment of sepsis tailored by individual genetic information. Curcumin could strongly suppress DSS-induced NLRP3 inflammsome activation and alleviate DSS-induced colitis in mice, thus it may be a promising candidate drug in clinical application for IBD therapy.
- | palmatine / LKT Laboratories, low molecular weight dextran sulfate (ILB) / TikoMed
Journal: Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation. (Pubmed Central) - May 1, 2019
In parallel, CsA significantly attenuated the therapeutic effect of palmatine in DSS mice, illustrating that the anti-colitis effect of palmatine is closely related to mitophagy. Taken together, the current results demonstrated that palmatine protected mice against DSS-induced colitis by facilitating PINK1/Parkin-driven mitophagy and thus inactivating NLRP3 inflammasomes in macrophage.
- | Preclinical, Journal: IL-17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPKα/p38MAPK/ERK1/2 signal pathway in mice. (Pubmed Central) - May 1, 2019
Taken together, the current results demonstrated that palmatine protected mice against DSS-induced colitis by facilitating PINK1/Parkin-driven mitophagy and thus inactivating NLRP3 inflammasomes in macrophage. IL-17A aggravates inflammatory response during AMI by inducing macrophages infiltration and activating NLRP3 inflammasome through AMPKα/p38MAPK/ERK1/2 pathway.
- | Journal: Apolipoprotein A-IV may inhibit inflammation via regulating NLRP3/IL-1 path to anti-atherosclerosis. (Pubmed Central) - May 1, 2019
IL-17A aggravates inflammatory response during AMI by inducing macrophages infiltration and activating NLRP3 inflammasome through AMPKα/p38MAPK/ERK1/2 pathway. No abstract available
- | low molecular weight dextran sulfate (ILB) / TikoMed
Journal: Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1. (Pubmed Central) - May 1, 2019
No abstract available The anti-inflammatory effects of EA on DSS-induced acute colitis may rely on regulating macrophage polarization, NLRP3/IL-1β suppression and Nrf2/HO-1 promotion.
- | Journal: NLRP1 inhibiting pathway to be explored in anti-atherosclerosis treatment approach. (Pubmed Central) - May 1, 2019
The anti-inflammatory effects of EA on DSS-induced acute colitis may rely on regulating macrophage polarization, NLRP3/IL-1β suppression and Nrf2/HO-1 promotion. No abstract available
- | Journal: The effects of cooking oil fumes-derived PM on blood vessel formation through ROS-mediated NLRP3 inflammasome pathway in human umbilical vein endothelial cells. (Pubmed Central) - May 1, 2019
This study proved that COFs-derived PM could significantly reduce HUVECs viability, induce the overproduction of ROS, lead to inflammation and inhibit VEGF expression, thus affect angiogenesis of HUVECs in vitro. It was revealed that the impact caused by COFs-derived PM on blood vessel formation through a ROS-mediated NLRP3 inflammasome pathway.
- | Journal: The role of Nrf2 in NLRP3 inflammasome activation. (Pubmed Central) - May 1, 2019
It was revealed that the impact caused by COFs-derived PM on blood vessel formation through a ROS-mediated NLRP3 inflammasome pathway. No abstract available
- | Clinical, Journal: Induction of systemic inflammation by hyaluronan and hsp70 in women with pre-eclampsia. (Pubmed Central) - Apr 30, 2019
Monocytes cultured with Hsp70 produced elevated levels of IL-1β and TNF-α through a mechanism independent of inflammasomes activation. These results suggest the participation of these DAMPs in the systemic inflammatory response that is characteristic of PE.
- | Clinical, Review, Journal: A Guide to IL-1 family cytokines in adjuvanticity. (Pubmed Central) - Apr 30, 2019
The coordinated release of IL-1 family members in response to adjuvant-induced damage or cell death may be a determining factor in the transition from local inflammation to the induction of an adaptive response. Here, we analyse the effects of IL-1 family cytokines on innate and adaptive immunity with a particular emphasis on activation of antigen presenting cells and induction of T cell-mediated immunity, and we address in detail the contribution of these cytokines to the modes of action of vaccine adjuvants including those currently approved for human use.
- | Journal: Association of Type 2 Diabetes with Submicron Titanium Dioxide Crystals in the Pancreas. (Pubmed Central) - Apr 30, 2019
In this pilot study of 11 pancreatic specimens, 8 of the type 2 diabetic pancreas and 3 of the non-diabetic pancreas, we show that 110±70 nm average diameter TiO2 crystals abound in the type 2 diabetic pancreas, but not in the non-diabetic pancreas. In the type 2 diabetic pancreas, their count is as high as 108 -109 per gram.
- | Journal: NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass. (Pubmed Central) - Apr 30, 2019
Therefore, our data indicated that the Nlrp3/ASC-mediated AM pyroptosis increased HMGB1 secretion in ALI induced by CPB. These findings may provide a therapeutic strategy to reduce lung injury and inflammatory responses during CPB.
- | Journal: Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid β-oxidation, and attenuates NLRP3 inflammasome activation. (Pubmed Central) - Apr 30, 2019
In contrast, supplementation with CoQ10 significantly recovered mitochondrial function and concurrently decreased the generation of reactive oxygen species and lipid peroxides, inhibited the accumulation of lipid droplets and the formation of the NOD-like receptor family pyrin domain-containing three (NLRP3) inflammasome, and reduced interleukin-1β release and cell death. These results clarify the causal role of CoQ10 in coupling the electron transport chain with β-oxidation, which may promote the development of CoQ10-directed therapies for MADD patients.