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- | Journal: Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts. (Pubmed Central) - Jun 28, 2019
In-vitro activation of placental explants and trophoblasts confirmed NLRP3 inflammasome pathway functionality by complement-primed crystal-induced release of IL-1β. This study confirms crystal-induced NLRP3 inflammasome activation located at the syncytiotrophoblast layer as a mechanism of placental inflammation and suggests contribution of enhanced NLRP3 activation to the harmful placental inflammation in pre-eclampsia.
- | Preclinical, Journal: Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation. (Pubmed Central) - Jun 28, 2019
Procyanidin B2 significantly suppressed the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model. This finding revealed a novel mechanism by which procyanidin B2 exerts anti-inflammatory effects and their clinical benefits in health.
- | Preclinical, Journal: Sophocarpine attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation. (Pubmed Central) - Jun 28, 2019
Sophocarpine could ameliorate experimental LN in MRL/lpr. These effects might be through suppressing NLRP3 inflammasome and NF-κB pathway.
- | Preclinical, Journal: Kinome analyses of inflammatory responses to swine barn dust extract in human bronchial epithelial and monocyte cell lines. (Pubmed Central) - Jun 28, 2019
In the THP-1 cell line, in addition to the aforementioned peptides, peptides corresponding to RIG-I-like receptors (RIG-I, MDA5) were found. This is the first report to demonstrate the application of a kinome array to delineate key inflammatory signaling pathways activated upon SBDE exposure in vitro.
- | Preclinical, Journal: Prostaglandin E/EP receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes. (Pubmed Central) - Jun 28, 2019
This is the first report to demonstrate the application of a kinome array to delineate key inflammatory signaling pathways activated upon SBDE exposure in vitro. The PGE/EPR signalling pathway is involved in STZ-induced diabetic retinopathy and could be considered as a potential target for diabetic retinopathy prevention and treatment.
- | Journal: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. (Pubmed Central) - Jun 28, 2019
We identified dampened transcriptional priming, a novel splice variant and an altered leucine-rich repeat domain of bat NLRP3 as the cause. Our results elucidate an important mechanism through which bats dampen inflammation with implications for longevity and unique viral reservoir status.
- | Journal: Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis. (Pubmed Central) - Jun 27, 2019
The NLRP3 inhibitor-MCC950 protects against fasting-induced hepatic steatosis. The novel and critical role of NLRP3 in lipogenesis may explain its importance in regulating the adaptive responses of the liver upon starvation stress and may provide therapeutic value.
- | Preclinical, Journal: Fibronectin type III domain containing 5 attenuates inflammasome activation and phenotypic transformation of adventitial fibroblasts in hypertension. (Pubmed Central) - Jun 26, 2019
FNDC5 reduces NOX2-derived ROS production, NLRP3 inflammasome activation and phenotypic transformation in adventitial fibroblasts of SHR. FNDC5 plays a beneficial role in attenuating vascular inflammation, vascular remodeling and hypertension in SHR.
- | Kolchin (colchicine) / Incepta
Preclinical, Journal: Cardioprotective Role of Colchicine Against Inflammatory Injury in a Rat Model of Acute Myocardial Infarction. (Pubmed Central) - Jun 26, 2019
FNDC5 plays a beneficial role in attenuating vascular inflammation, vascular remodeling and hypertension in SHR. The cardioprotection induced by a short colchicine pretreatment was associated with an anti-inflammatory effect in the early reperfusion phase in our rat MI model.
- | Journal: Research progress on the role of NLRP3 inflammasome in ocular diseases (Pubmed Central) - Jun 26, 2019
In recent years, the research on the role of NLRP3 inflammasome in the pathogenesis and development of ocular surface and fundus diseases has made considerable progress. This review summarizes current understanding in the structure, ocular expression, and mechanisms of activation of NLRP3 inflammasome, as well as the contribution of this protein complex to eye diseases, thereby revealing the theoretical possibility that NLRP3 inflammasome might serve as a novel therapeutic target for the related ocular diseases.(Chin J Ophthalmol, 2018, 54: 396-400).
- | Journal: Heparinoid suppresses Der p-induced IL-1β production by inhibiting ERK and p38 MAPK pathways in keratinocytes. (Pubmed Central) - Jun 26, 2019
mRNA expression was also confirmed with living skin equivalents. Our results demonstrated that heparinoid suppresses the initiation of keratinocyte-mediated skin inflammation.
- | simvastatin / generics
Journal: Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol Crystals. (Pubmed Central) - Jun 26, 2019
Both in vitro and in vivo treatments with simvastatin led to a significant reduction in the levels of expression of IL-1β in response to stimulation with CC. Simvastatin inhibits the expression and activation of IL-1β induced by CC in PBMCs, which may contribute to its protective role in patients with cardiovascular disease.
- | Preclinical, Journal: Procyanidin B2 prevents lupus nephritis development in mice by inhibiting NLRP3 inflammasome activation. (Pubmed Central) - Jun 26, 2019
PCB2 significantly suppressed LN in MRL-lpr mice by inhibiting the activation of NLRP3 inflammasome and subsequent IL-1β and IL-18 production. This finding explores a novel mechanism by which procyanidin exerts inflammatory suppression effects and its clinical benefits in LN prevention.
- | Preclinical, Journal: Protective effects of ethyl acetate extracts of Rimulus Cinnamon on systemic inflammation and lung injury in endotoxin-poisoned mice. (Pubmed Central) - Jun 26, 2019
These results demonstrated the promising anti-inflammatory effects of EAE in endotoxin-poisoned mice. Furthermore, EAE could alleviate the lung injury of endotoxin-poisoned mice by antagonizing the activation of the NLRP3 inflammasome.
- | Journal: Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D. (Pubmed Central) - Jun 26, 2019
Activated caspase-4 and -1 cleaved GSDMD liberating the N-terminal p30 pore-forming fragment that caused the secretion of IL-1β. These findings reveal a novel role for caspase-4 as a sensor molecule to amplify pro-inflammatory responses when macrophage encounters Eh.
- | Preclinical, Journal: An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet-Induced Cardiac Dysfunction in the Mouse. (Pubmed Central) - Jun 26, 2019
These findings reveal a novel role for caspase-4 as a sensor molecule to amplify pro-inflammatory responses when macrophage encounters Eh. An orally available NLRP3 inhibitor prevented WD-induced cardiac dysfunction in the obese mouse.
- | Journal: Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1. (Pubmed Central) - Jun 26, 2019
The administration of miR-126-expressing MSC-Exos significantly reduced high glucose-induced HMGB1 expression and the activity of the NLRP3 inflammasome in HRECs. miR-126 expression in MSC-Exos reduces hyperglycemia-induced retinal inflammation by downregulating the HMGB1 signaling pathway.
- | Journal: NLRP3 inflammasome inactivation driven by miR‑223‑3p reduces tumor growth and increases anticancer immunity in breast cancer. (Pubmed Central) - Jun 26, 2019
In vivo experiments demonstrated the suppressive effect of miR‑233‑3p in tumor growth and immunosuppression. Collectively these findings suggested that the inactivation of the NLRP3 inflammasome driven by miR‑223‑3p reduced the growth and immunosuppression of breast cancer in vitro and in vivo, and may represent a novel therapeutic strategy in treating breast cancer.
- | Clinical, Journal: DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma. (Pubmed Central) - Jun 26, 2019
Inflammatory pathways including glucocorticoid/PPAR signaling (p = 0.0023), MAPK signaling (p = 0.013), NF-κB signaling (p = 0.031), and PI3K/AKT signaling (p = 0.031) were enriched for the effect modification of BMI, while NLRP3-IL1B-IL17 axis was enriched for the effect modification of BMI change over 10 years (p = 0.046). DNA methylation measured in peripheral blood is consistent with inflammation as a link between BMI and adult-onset asthma and with the NLRP3-IL1B-IL17 axis as a link between BMI change over 10 years and adult-onset asthma in non-atopic participants.
- | Review, Journal: Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. (Pubmed Central) - Jun 26, 2019
A perhaps crucial action may be the promotion of macrophage or microglia polarization in favor of the anti-inflammatory phenotype M2. In addition, many factors of the pro- and anti-inflammatory networks are subject to regulation by microRNAs that either target mRNAs of the respective factors or upregulate them by targeting mRNAs of their inhibitor proteins.
- | Januvia (sitagliptin) / Merck (MSD)
Preclinical, Journal, IO Biomarker: Sitagliptin ameliorates thioacetamide-induced acute liver injury via modulating TLR4/NF-KB signaling pathway in mice. (Pubmed Central) - Jun 25, 2019
In addition, many factors of the pro- and anti-inflammatory networks are subject to regulation by microRNAs that either target mRNAs of the respective factors or upregulate them by targeting mRNAs of their inhibitor proteins. Our results suggest that the hepatoprophylactic impact of sitagliptin might be arbitrated via modulating TLR4 and NK-KB signaling cascade followed by depression of inflammation besides apoptosis.
- | Journal: SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes. (Pubmed Central) - Jun 25, 2019
ORF8b triggers cell death consistent with pyroptotic cell death in macrophages. While in those cells lacking NLRP3 accumulating ORF8b cytosolic aggregates cause ER stress, mitochondrial dysfunction, and caspase-independent cell death.
- | Journal: Parkin Impairs Antiviral Immunity by Suppressing the Mitochondrial Reactive Oxygen Species-Nlrp3 Axis and Antiviral Inflammation. (Pubmed Central) - Jun 24, 2019
Collectively, our results suggest that Parkin plays an important role in antiviral immunity by controlling mtROS-NLRP3 axis-mediated inflammation. These findings provide physiological insight of the importance of mitophagy in regulating host antiviral response.
- | Journal: Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma. (Pubmed Central) - Jun 24, 2019
This correlated with blunted induction of NF-κB, the NLRP3 inflammasome, and eosinophilia in transgenic mice. These findings demonstrate a pivotal role for mitochondrial CaMKII in airway epithelium in mitochondrial ROS generation, eosinophilic inflammation, and AHR, providing insights into how mitochondrial ROS mediate features of allergic asthma.
- | Journal: Urolithin A, a Gut Metabolite, Induces Metabolic Reprogramming of Adipose Tissue by Promoting M2 Macrophage Polarization and Mitochondrial Function (OR12-02-19). (Pubmed Central) - Jun 23, 2019
Intake of UroA-producing foods may be a promising intervention strategy to mitigate obesity-mediated chronic inflammation and metabolic dysfunction. United States Department of Agriculture National Institute for Food and Agriculture.
- | Journal, IO Biomarker: Polyphenolic Compounds Ameliorate Stress-induced Depression by Preventing NLRP3 Inflammasome Priming (P19-011-19). (Pubmed Central) - Jun 23, 2019
Taken all together, the results provide evidence of the role of polyphenols in preventing persistent microglial activation, which has been shown to result in reduced long term vulnerability to depressive-like behaviors following expose to chronic stress. This study was supported by a P50 CARBON Center grant from the NCCIH and ODS.
- | Journal: Design of a Novel Synbiotic Formulation to Optimize Gut-derived Phenolic Acid Mediated Gut-brain Axis Signals for the Treatment of Stress-induced Depression and Anxiety (OR23-03-19). (Pubmed Central) - Jun 23, 2019
Collectively, these results support the potential role of a synbiotic in the potentiation of attenuation of psychological impairment in a model of depression through mechanisms that involved innate immune NLRP3 inflammation mediation in microglia. This project was funding a P50 CARBON Center grant from the NCCIH/ODS (Pasinetti, PD/PI).
- | Journal: Benzyl Isothiocyanate Reduces High-Fat/High-Cholesterol/Cholic Acid Diet-Induced Non-Alcoholic Steatohepatitis by Inhibiting the Activation of NLRP3 Inflammasome (P06-084-19). (Pubmed Central) - Jun 23, 2019
These findings suggest that BITC possesses potent anti-steatohepatitis activity, and this protection is likely to be associated with the inhibition of NLRP3 inflammasome activation. This study was supported by the Minister of Science and Technology, Taiwan.
- | Journal: Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation (P06-072-19). (Pubmed Central) - Jun 23, 2019
Our findings identified G-ELNs as a new potent agent that blocks NLRP3 inflammasome assembly and activation. This work was supported by the National Institutes of Health (NIH) 1P20GM104320 Nebraska Center Prevention of Obesity Diseases (NPOD) Seed Grant and Project Leader Grant, and the United States Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) Hatch Project 1015948.
- | Journal: Anti-inflammatory Effect of AMPK Activators from Natural Products in RAW 264.7 Cell Model (P06-095-19). (Pubmed Central) - Jun 23, 2019
This result implicates anti-inflammatory effect of BS and ST, which may be induced by activation of AMPK and then regulated via NLRP3 pathway and caspase-1 expression. This study is supported by the research funding from Shanghai Anti-Aging Research Center, Nu Skin Enterprises, Shanghai, China.
- | Journal: The Canonical Inflammasome: A Macromolecular Complex Driving Inflammation. (Pubmed Central) - Jun 22, 2019
The inflammasome complex functions as a platform for the proximity induced activation of effector caspases, such as caspase-1 and caspase-8. This ultimately leads to the processing of the inflammatory cytokines pro-IL1β and pro-IL18 into their active forms, along with the cleavage of Gasdermin D, a key activator of cell death via pyroptosis.
- | Journal: S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking. (Pubmed Central) - Jun 22, 2019
Mitochondrial engagement activates caspase-1, a process dependent on complex II of the electron transport chain, near the phagosome, promoting its acidification. These data demonstrate a mechanism utilized by S. aureus to sequester itself from antimicrobial processes within the cell.
- | Journal: Structural insights of benzene sulfonamide analogs as NLRP3 inflammasome inhibitors: Design, synthesis, and biological characterization. (Pubmed Central) - Jun 22, 2019
Further characterization confirmed their selectivity and in vivo target engagement. Collectively, the results strongly encourage further development of more potent analogs based on this chemical scaffold.
- | Journal: Polysaccharides from chayote enhance lipid efflux and regulate NLRP3 inflammasome priming in macrophage-like THP-1 cells exposed to cholesterol crystals. (Pubmed Central) - Jun 22, 2019
WSP also reduced active caspase-1 protein levels, and downregulated NLRP3 and IL-1β gene expression in CC-pretreated cells, suggesting that this polysaccharide fraction regulates the priming signals required for NLRP3 inflammasome activation. Thus, WSP regulate lipid efflux and suppress inflammasome priming in macrophages, suggesting that the health benefits of this dietary fiber could go beyond its physical properties on the gastrointestinal tract.
- | Biomarker, Preclinical, Journal, IO Biomarker: Harmine mitigates LPS-induced acute kidney injury through inhibition of the TLR4-NF-κB/NLRP3 inflammasome signalling pathway in mice. (Pubmed Central) - Jun 22, 2019
The involved underlying mechanisms of harmine in LPS-induced acute kidney injury might be related to inhibition of the TLR4-NF-κB pathway and NLRP3 inflammasome pathway. Based on the above conclusion, it is possible for harmine to be used to clinically treat acute kidney injury.
- | Journal: Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation. (Pubmed Central) - Jun 21, 2019
We further demonstrate that differential cleavage of gasdermin D (GSDMD) by apoptotic caspases regulates inflammatory cell lysis. Here, we discuss our findings and perspectives for future studies.
- | Clinical, Journal: The NLRP3 rs10754558 polymorphism is a risk factor for preeclampsia in a Chinese Han population. (Pubmed Central) - Jun 20, 2019
Our results reveal that NLRP3 may be involved in the development of PE in a Chinese Han population. However, further validation of the associations of other NLRP3 SNPs with PE in other populations is required.
- | ATI-450 / Aclaris
Journal: Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals. (Pubmed Central) - Jun 20, 2019
CDD-450 also accelerated TNF-α and IL-6 mRNA decay, inhibited inflammation in mice with cryopyrinopathy, and was as efficacious as global p38α inhibitors in attenuating arthritis in rats and cytokine expression by cells from patients with cryopyrinopathy and rheumatoid arthritis. These findings have clinical translation implications as CDD-450 offers the potential to avoid tachyphylaxis associated with global p38α inhibitors that may result from their inhibition of non-MK2 substrates involved in antiinflammatory and housekeeping responses.
- | Preclinical, Journal: Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice. (Pubmed Central) - Jun 19, 2019
Remarkably, all NOMID-associated inflammatory symptoms are prevented upon ablation of GSDMD. Thus, GSDMD-dependent actions are required for the pathogenesis of NOMID in mice.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Preclinical, Journal: Protective Effect of Naringin on DSS-Induced Ulcerative Colitis in Mice. (Pubmed Central) - Jun 19, 2019
...In the present study, our objective was to explore the potential effect of naringin on dextran sulfate sodium (DSS) induced UC in mice and its involved potential mechanism...Tight junction (TJ) architecture in naringin groups was also maintained by regulating zonula occludens-1 (ZO-1) expression. These results suggested that naringin may be a potential natural agent for protecting mice from DSS-induced UC.
- | Journal: Inhibition of P2x7R-NLRP3 inflammasome activation by Pleurotus citrinopileatus: a possible protective role in alcoholic hepatosteatosis. (Pubmed Central) - Jun 19, 2019
P. citrinopileatus ameliorated alcoholic hepatic steatosis and accompanied inflammatory response via regulating SIRT1-AMPK and P2x7R-NLRP3 inflammasome activation, highlighting a promising strategy and utility of P. citrinopileatus for alcoholic steatohepatitis as dietary health supplements.
- | Journal: Amygdalin attenuates acute liver injury induced by D-galactosamine and lipopolysaccharide by regulating the NLRP3, NF-κB and Nrf2/NQO1 signalling pathways. (Pubmed Central) - Jun 19, 2019
Furthermore, AGD treatment substantially increased nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation and enhanced NAD (P) H: quinoneoxidoreductase 1 protein expression, which was reversed by a Nrf2 inhibitor, in HepG2 cells. In summary, our investigations suggested that the ability of AGD to ameliorate LPS/GalN-induced ALI may involve the inhibition of the NLRP3 inflammasome and NF-κB signalling pathways and the upregulation of the Nrf2/NQO1 signalling pathway.
- | Kolchin (colchicine) / Incepta
Journal: Jia-Wei-Si-Miao-Wan alleviates acute gouty arthritis by targeting NLRP3 inflammasome. (Pubmed Central) - Jun 19, 2019
In vivo data showed that the therapeutic effect of Jia-Wei-Si-Miao-Wan could be comparable with colchicine but had lower hepatic and renal toxicity. In conclusion, Targeting NLRP3 inflammasome and TLR/NF-κB signaling by Jia-Wei-Si-Miao-Wan could be effective in treating AGA.
- ||| It is one thing to discuss phytochemicals as 'novel therapeutic agents' targeting the NLRP3 Inflammasome for treating MS, but there is a mountain to climb to get these into a trial never mind the MS clinic. #ResearchSpeak https://t.co/J6SkMIgMJI (Twitter) - Jun 17, 2019
- | Journal: TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. (Pubmed Central) - Jun 17, 2019
Moreover, the spontaneous inflammation resulting from TAK1-deficient macrophages drives myeloid proliferation in mice, and was rescued by RIPK1 deficiency. Overall, these studies identify a critical role for TAK1 in maintaining NLRP3 inflammasome quiescence and preserving cellular homeostasis and survival.
- | Actemra IV (tocilizumab) / Roche, JW Pharma
Review, Journal: Atherosclerosis: perspectives of anti-inflammatory therapy. (Pubmed Central) - Jun 17, 2019
Convincing evidence for the role of inflammation in development of atherosclerosis in General and good prospects of anti-inflammatory therapy in particular obtained in a randomized placebo-controlled study called CANTOS (Canakinumab Anti-inflammatory Thrombosis Otcomes Study), which studied the effectiveness of treatment with monoclonal antibodies to IL-1β canakinumab (Novartis International AG) in patients with severe atherosclerotic vascular lesions as a new approach to secondary prevention of cardiovascular complications. The results of CАNTOS research, as well as the experience gained in rheumatology in regard to cardiovascular effects of innovative anti-inflammatory drugs, have great importance for the improvement of secondary prevention of atherosclerosis-related cardiovascular complications.
- | Preclinical, Journal: Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice. (Pubmed Central) - Jun 17, 2019
In summary, SEC was able to alleviate depressive-like behavior in a CUMS-induced mice model, accompanied by inhibitory roles in the hyperactivity of the HPA axis and pro-inflammatory cytokine expression. Modulating the NF-κB/NLRP3 and BDNF/CREB/ERK pathways contributed to SEC-mediated antidepressant-like effects.
- | Journal: Effects of n-acetyl-cysteine supplementation in late gestational diet on maternal-placental redox status, placental NLRP3 inflammasome and fecal microbiota in sows. (Pubmed Central) - Jun 17, 2019
Furthermore, NAC increased the relative abundances of fecal Prevotella,Clostridium cluster XIVa and Roseburial/Eubacterium rectale (P < 0.05), which were negatively correlated with placental NLRP3 and positively with solute carrier family 7, member 8 (Slc7a8) (P < 0.05). In conclusion, NAC supplementation during late gestation alleviated maternal-placental oxidative stress and inflammatory response, improved placental function, and altered fecal microbial communities.
- | allopurinol / generics
Preclinical, Journal, IO Biomarker: Effects of Polygonum cuspidatum on AMPK-FOXO3α signaling pathway in a rat model of uric acid-induced renal damage. (Pubmed Central) - Jun 15, 2019
In conclusion, NAC supplementation during late gestation alleviated maternal-placental oxidative stress and inflammatory response, improved placental function, and altered fecal microbial communities. PC up-regulated the expression of AMPK and its downstream molecule FOXO3α and inhibited the biological activity of TLR4, NLRP3, and MCP-1, key signal molecules in the immunoinflammatory network pathway, which may be the molecular mechanism of PC to improve hyperuricemia-mediated immunoinflflammatory metabolic renal damage.
- | Journal: TAK1ng control: TAK1 restrains NLRP3 activation. (Pubmed Central) - Jun 15, 2019
(https://doi.org/10.1084/jem.20171922) demonstrate that macrophage-specific loss of TAK1 causes spontaneous NLRP3 inflammasome activation, driven by unregulated TNF secretion and signaling. This has implications for therapeutically targeting TAK1, enhancing its potential function as an anticancer drug treatment.