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- | Review, Journal: NLRP3 inflammasome couples purinergic signaling with activation of the complement cascade for the optimal release of cells from bone marrow. (Pubmed Central) - Aug 10, 2019
In this review, we will highlight the novel role of the innate immunity cell-expressed NLRP3 inflammasome, which, during the initiation phase of HSPC mobilization, couples purinergic signaling with the MBL-dependent pathway of the ComC and, in parallel, the CoaC for optimal release of HSPCs. These data are important to optimize the pharmacological mobilization of HSPCs.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Journal: Systematic understanding of the mechanism and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1. (Pubmed Central) - Aug 10, 2019
SIRT1 inhibitor also decreases the effects of Arctigenin on inflammation in DSS-induced acute colitis. Taken together our results demonstrated that Arctigenin attenuates inflammation in DSS-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1.
- | Journal: LKB1/AMPK-Mediated Regulation by Gentiopicroside Ameliorates P2x7R-Dependent Alcoholic Hepatosteatosis. (Pubmed Central) - Aug 9, 2019
Taken together our results demonstrated that Arctigenin attenuates inflammation in DSS-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1. Activation of LKB1/AMPK signaling by GPS might be mediated by the P2x7R-NLRP3 inflammasome, suggesting a therapeutic utility of P2x7R blockade in alcoholic hepatosteatosis treatment.
- | Review, Journal: An update on the NLRP3 inflammasome and influenza: the road to redemption or perdition? (Pubmed Central) - Aug 9, 2019
This short review will examine recent work on the regulation and targeting of the NLRP3 inflammasome as a means of intrinsic and extrinsic modulation of inflammasome-mediated inflammation. It is encouraging that recent studies suggest 'starving' the inflammasome of substrate, or directly inhibiting activity, may be the means to reducing host inflammatory responses to IAV infection and to directing a positive disease outcome.
- | Clinical, Journal: Inflammasome Genes' Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment. (Pubmed Central) - Aug 9, 2019
In conclusion, this study reports, for the first time, the association of genetic variations in NLRP3 with hepatitis C susceptibility and response to treatment in Egyptian patients. However, further large-scale studies are recommended to confirm our findings.
- | Journal, IO Biomarker: miR-16 inhibits NLRP3 inflammasome activation by directly targeting TLR4 in acute lung injury. (Pubmed Central) - Aug 9, 2019
Overall, our experiments showed that miR-16 protects against acute lung injury in mice by regulating the TLR4/ NF-κB pathway and attenuating inflammatory response. This work suggests a potential novel therapeutic approach to combat ALI.
- | Preclinical, Journal: Pyroptosis is involved in cryopreservation and auto-transplantation of mouse ovarian tissues and pyroptosis inhibition improves ovarian graft function. (Pubmed Central) - Aug 9, 2019
The concentration of estradiol and follicular densities of grafts in pyroptosis inhibition group were significantly higher than that in cryopreserved graft group. Pyroptosis is involved in cryopreservation and auto-transplantation of mouse ovarian tissues, and pyroptosis inhibition can improve the ovarian graft function.
- | Kolchin (colchicine) / Incepta
Preclinical, Journal: Effect of ethanolic extract of Polygonum cuspidatum on acute gouty arthritis in mice through NLRP3/ASC/caspase-1 axis (Pubmed Central) - Aug 9, 2019
...The model mice which injected with ankle joint injection of sodium urate crystals(MSU) were orally administrated with three different concentration of PCE, with colchicine as positive control...The swelling degree of ankle joint significantly relief; expression of IL-1β, IL-6 and TNF-α in joint synovium significantly decrease; mRNA and protein expression of NLRP3, ASC and caspase-1 were significantly decrease in PCE treatment group compared with model group. Our research implied that alcohol extract from P. cuspidatum had positive effect on acute gouty arthritis in mice, and the regulation of NLRP3/ASC/caspase-1 axis may be its mechanism.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Preclinical, Journal: Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development. (Pubmed Central) - Aug 8, 2019
The data suggest that estradiol inhibits the initiation of CRC by regulating Nrf2-related pathways. Moreover, these imply the dual role of Nrf2 and NLRP3 inflammasome, including promotion of tumor progression upon tumor initiation.
- | Legalon (silibinin) / Mylan
Clinical, Journal: Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia. (Pubmed Central) - Aug 8, 2019
THP-1 cells exhibited a similar immunological response profile to monocytes from preeclamptic women when cultured with or without MSU or SB. These results suggest uric acid participates in the systemic inflammatory response characteristic of preeclampsia and that in vitro SB treatment can modulate the sterile inflammation established in monocytes from preeclamptic women.
- | Preclinical, Journal: Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model. (Pubmed Central) - Aug 8, 2019
Furthermore, the presence of ZY-132 was sufficient to hinder the adverse reaction seen with C. sakazakii in a C. sakazakii-induced NEC model. Taking the results together, our study demonstrated the utility of ZY-312 as a promising probiotic agent for the prevention of NEC.
- | Journal: Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior. (Pubmed Central) - Aug 8, 2019
Furthermore, M. vaccae prevented stress-induced increases in anxiety-like behavior. The present findings suggest that M. vaccae enhances immunomodulation in the CNS and mitigates the neuroinflammatory and behavioral effects of stress, which may underpin its capacity to impart a stress resilient phenotype.
- | Solodyn (minocycline) / Bausch Health
Preclinical, Journal: The Involvement of NLRP3 on the Effects of Minocycline in an AD-Like Pathology Induced by β-Amyloid Oligomers Administered to Mice. (Pubmed Central) - Aug 8, 2019
Thus, the anti-inflammatory effect of minocycline involves TLR2 receptors and NLRP3, besides being beneficial by ameliorating memory impairments. Graphical Abstract ᅟ.
- | Journal: Atypical gasdermin D and mixed lineage kinase domain-like protein leakage aggravates tetrachlorobenzoquinone-induced Nod-like receptor protein 3 inflammasome activation. (Pubmed Central) - Aug 8, 2019
The formation of membrane pores not only promotes the extracellular secretion of interleukin 1 beta (IL-1β), but also affects cellular ion homeostasis, in particular promotes K+ outflow, which further activates NLRP3 inflammasome and aggravates cellular inflammation. These results indicated that GSDMD and MLKL play important roles in TCBQ-induced endothelial pro-inflammatory responses, which may point to potential therapeutic approaches for TCBQ-mediated toxicity.
- | Preclinical, Journal: Baicalin tetrazole acts as anti-pneumocystis carinii pneumonia candidate in immunosuppressed rat model. (Pubmed Central) - Aug 8, 2019
The results from present study demonstrate that compound 4c protects pneumocystis carinii induced pneumonia through suppression of inflammatory cytokines and NLRP3 activation. Therefore, compound 4c can be of therapeutic importance for the treatment of pneumocystis carinii induced pneumonia.
- | dexamethasone / generics, aspirin / generics
Journal: Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury. (Pubmed Central) - Aug 7, 2019
We also found that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of the endothelial tight junction protein zonula occludens-1/2 (ZO1/2). We assume that aspirin can ameliorate the endothelial layer dysfunction by suppressing the activation of NLRP3 inflammasome.
- | Journal: Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome. (Pubmed Central) - Aug 7, 2019
Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1β production induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases.
- | Avandia (rosiglitazone) / GSK
Journal: PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN-Dependent Mechanism. (Pubmed Central) - Aug 7, 2019
Loss of PPARγ also resulted in diminished expression of genes involved in sterol biosynthesis, a pathway known to influence IFN production. Together, these findings demonstrate a cross-talk pathway that influences the interplay between metabolism and inflammation in macrophages.
- | Journal: Effect of the Selective NLRP3 Inflammasome Inhibitor mcc950 on Transplantation Outcome in a Pig Liver Transplantation Model with Organs from Donors after Cardiac Death Preserved by Hypothermic Machine Perfusion. (Pubmed Central) - Aug 7, 2019
Together, these findings demonstrate a cross-talk pathway that influences the interplay between metabolism and inflammation in macrophages. The outcome of DCD organs can be improved by the addition of mcc950 to the perfusate of the HMP system and intravenous injection of mcc950 after transplantation.
- | Journal: Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow. (Pubmed Central) - Aug 7, 2019
Conclusions- Elimination of ACAT1 in bone marrow-derived cells aggravates cutaneous xanthoma and atherosclerosis. The development of cutaneous xanthoma is induced mainly via the NLRP3 inflammasome activation.
- | Journal: NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. (Pubmed Central) - Aug 7, 2019
Analysis of bladder innervation established an NLRP3-dependent decrease in overall nerve density and Aδ-fibers in the bladder wall along with an increase in C-fiber populations in the urothelia, which potentially explains the decreased sense of bladder fullness reported by patients and overactivity detected early in DBD. Together, the results demonstrate the role of NLRP3 in the genesis of DBD and suggest specific NLRP3-mediated neuronal changes can produce specific DBD symptoms.
- | Journal: Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures. (Pubmed Central) - Aug 7, 2019
Together, the results demonstrate the role of NLRP3 in the genesis of DBD and suggest specific NLRP3-mediated neuronal changes can produce specific DBD symptoms. Our results indicate that IL-10 is potentially effective in the treatment of inflammation encephalopathy, and suggest the potential usefulness of IL-10 for treating autoimmune or inflammatory ailments.
- | Clinical, Journal: Exploring the Involvement of NLRP3 and IL-1β in Osteoarthritis of the Hand: Results from a Pilot Study. (Pubmed Central) - Aug 7, 2019
Taken together, our results, showing poorly detectable IL-1β concentrations and minimal inflammasome activity in the PBMCs of HOA patients, suggest a low grade of systemic inflammation in HOA. This evidence does not preclude a possible involvement of these factors at the local level.
- | Preclinical, Journal: Improved effects of saponins from Panax japonicus on decline of cognitive function in natural aging rats via NLRP3 inflammasome pathway (Pubmed Central) - Aug 7, 2019
Western blot was used to detect the protein levels of NLRP3,ASC,caspase-1 and the changes of Glu A1,Glu A2,CAMKⅡ,CREB and phosphorylation of CAMKⅡ,CREB in each group.The results showed that SPJ could improve the decline of cognitive function in aging rats,reduce the damage of LTP in the hippocampal CA1 region of aged rats,and decrease the expression of NLRP3,ASC,caspase-1 in aging rats. At the same time,SPJ could enhance the membrane expression of AMPA receptor( Glu A1 and Glu A2),and increase the expression of p-CAMKⅡand p-CREB in aging rats.SPJ could improve cognitive decline of natural aging rats,and its mechanism may be related to regulating NLRP3 inflammasome,thus regulating the membrane expression of AMPA receptor,and enhancing the expression phosphorylation of CAMKⅡ and CREB.
- | Preclinical, Journal: Acupoint catgut embedding improves dysmenorrhea by suppressing activation of NLRP3 inflammasomes in uterine tissues in primary dysmenorrhea rats (Pubmed Central) - Aug 6, 2019
At the same time,SPJ could enhance the membrane expression of AMPA receptor( Glu A1 and Glu A2),and increase the expression of p-CAMKⅡand p-CREB in aging rats.SPJ could improve cognitive decline of natural aging rats,and its mechanism may be related to regulating NLRP3 inflammasome,thus regulating the membrane expression of AMPA receptor,and enhancing the expression phosphorylation of CAMKⅡ and CREB. The acupoint catgut embedding can significantly alleviate the symptoms and pathological damage in PD rats, which may be related to its effect in inhibiting the activation of NLRP3 inflammasome in the uterine tissue.
- | Journal: Screening the Best Compatibility of Selaginella moellendorffii Prescription on Hyperuricemia and Gouty Arthritis and Its Mechanism. (Pubmed Central) - Aug 6, 2019
Furthermore, 6-C-β-D-xylopyranosyl-8-C-β-D-glucopyranosyl, apigenin, and astilbin were identified from SMP-3 extract. In summary, SMP-3 may be a potential therapeutic agent for the prevention of hyperuricemic and gout.
- | doxorubicin hydrochloride / generics
Preclinical, Journal: Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice. (Pubmed Central) - Aug 3, 2019
...We previously reported that thymoquinone (TQ) protected against hyperlipidemia and doxorubicin-induced cardiac damage...The phosphatidylinositide 3-kinase level was significantly decreased in the TQ + CLP group versus the CLP group. These results suggest that TQ effectively modulates autophagy, pyroptosis, and pro-inflammatory, making it important in the treatment of sepsis-induced cardiac damage.
- | Biomarker, Journal: 1,25-Dihydroxy Vitamin D Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM via the p38/NF-κB/NLRP3 Pathway. (Pubmed Central) - Aug 3, 2019
Furthermore, 1,25-(OH)D also reduced transcriptional activation of NF-κB induced by PM as indicated by a significant decrease in luciferase activity in HBE cells stably transfected with the NF-κB response element (RE)-driven luciferase reporter. Taken together, our findings provided novel experimental evidences supporting that vitamin D could reduce the predominantly oxidative stress-mediated inflammation induced by PM via the p38/NF-κB/NLRP3 signaling pathway.
- | metformin / generics
Journal: The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress. (Pubmed Central) - Aug 3, 2019
...C57BL/KsJ-db/db (db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group)...Furthermore, the serum level of homocysteine was also markedly decreased following FA treatments. These findings suggest that through potential suppressions on angiogenesis, inflammation, and oxidative stress, FA may serve as a potential therapeutic agent against DR.
- | Journal, IO Biomarker: NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells. (Pubmed Central) - Aug 3, 2019
The hydrophobic moieties of arginine-based liposomes are crucial in stimulating innate immune cells. A3C14 liposomes were non-immunogenic but strongly activated innate immune cells and promoted antigen presentation, and therefore can be applied as immune adjuvants.
- | Preclinical, Journal: Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats. (Pubmed Central) - Aug 3, 2019
GS Rg1 treatment significantly increased the expression of AMPK, Nrf2 and HO-1 in cardiac tissues. GS Rg1 exhibited protective effect against STZ-induced cardiac dysfunction, which is potentially associated with AMPK/Nrf2/HO-1 signal pathway.
- | Journal: Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. (Pubmed Central) - Aug 3, 2019
Further experiments revealed that the nicotine-NLRP3-ASC-pyroptosis pathway was activated by reactive oxygen species (ROS), since ROS scavenger (N-acetyl-cysteine, NAC) prevented endothelial cell pyroptosis. We conclude that pyroptosis is likely a cellular mechanism for the pro-atherosclerotic property of nicotine and stimulation of ROS to activate NLRP3 inflammasome is a signaling mechanism for nicotine-induced pyroptosis.
- | Review, Journal: Principles of Inflammasome Priming and Inhibition: Implications for Psychiatric Disorders. (Pubmed Central) - Aug 3, 2019
Over the course of an individual's lifetime, persistent neuroinflammation can subsequently lead to the pathophysiological signatures that define psychological disorders. Therefore, targeting the NLRP3 inflammasome complex may represent an innovative and consequential approach to limit neuroinflammatory states in psychiatric disorders, such as major depressive disorder.
- | Preclinical, Journal: Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release. (Pubmed Central) - Aug 3, 2019
NLRP3 inflammasome expression was substantially increased, and mtDNA-NLRP3 inflammasome complexes formed upon PA stimulation. Our data suggest that mtDNA released from mitochondria during PA stimulation causes NLRP3 inflammasome activation, providing a missing link between NLRP3 inflammasome activation and NASH development, via binding of cytosolic mtDNA to the NLRP3 inflammasome.
- | Ilaris (canakinumab) / Novartis
Journal: Role of NLRP3 Inflammasome in Cardiac Inflammation and Remodeling after Myocardial Infarction. (Pubmed Central) - Aug 2, 2019
Furthermore, a recent Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) trial revealed the efficacy of IL-1β inhibition in preventing recurrent cardiovascular events in patients with MI. This review focuses on the role of NLRP3 inflammasome in the process of cardiac inflammation and remodeling after MI, and discusses its potential as a therapeutic target for the prevention and treatment of MI.
- | Preclinical, Journal: IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice. (Pubmed Central) - Aug 2, 2019
In contrast, the IL-1β gene was not detected in either TAC-operated or sham-operated IL-1β mouse atria. These results suggest that an IL-1β activation pathway, different from NLRP3 inflammasomes, plays an important role in pressure overload-induced sustained AF.
- | Preclinical, Journal: MicroRNA-135b alleviates MPP-mediated Parkinson's disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis. (Pubmed Central) - Aug 2, 2019
In summary, miR-135b played a protective role in Parkinson's disease via inhibiting pyroptosis by targeting FoxO1. MiR-135b might serve as a potential therapeutic target in the treatment of Parkinson's disease.
- | Journal: TET-2 up-regulation is associated with the anti-inflammatory action of Vicenin-2. (Pubmed Central) - Aug 1, 2019
This study demonstrates that the anti-inflammatory actions of V-2 are associated not only with increased IL-10 and IL-1Ra expression, but also with TET-2 up-regulation. Further work is required to establish if the effects of V-2 can be definitively linked to TET-2 activity and that these actions are mirrored in a range of relevant cell types.
- | Biomarker, Journal: Rehydration with fructose worsens dehydration-induced renal damage. (Pubmed Central) - Aug 1, 2019
Further work is required to establish if the effects of V-2 can be definitively linked to TET-2 activity and that these actions are mirrored in a range of relevant cell types. These studies suggest that heat stress may activate intrarenal inflammasomes leading to inflammation and renal injury, and provide evidence that rehydration with fructose may accelerate the renal injury and inflammatory response.
- | Review, Journal: Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys. (Pubmed Central) - Aug 1, 2019
Furthermore, we review the potential anti-inflammatory effects of antidiabetic drugs used in routine clinical practice, such as insulin, biguanides, Sodium-glucose co-transporter-2 (SGLT2) inhibitors, sulfonylureas, thiazolidinediones, and dipeptidyl peptidase-4 (DPP-4) inhibitors. In addition, we discuss whether these drugs can also modulate NLRP3 inflammasome activity in renal tissues.
- | Journal: Crocin, a natual product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway. (Pubmed Central) - Aug 1, 2019
In conclusion, these results suggested that crocin as a potential therapeutic candidate for neuro-inflammation and depressive-like behaviors induced by LPS. The inhibition of NLRP3 inflammasome and NF-κB promotes M1 to M2 phenotypic conversion of microglia.
- | Preclinical, Journal: Identification of β-Sitosterol as in Vitro Anti-Inflammatory Constituent in Moringa oleifera. (Pubmed Central) - Aug 1, 2019
There was partial inhibition of NF-κB in macrophages. This is the first study to report an increase in the solubility of nearly water-insoluble phytosterols via the formation of nanoparticles and to delineate the formulation's capacity to inhibit the signal transduction pathways of inflammation in macrophages.
- | Journal: Impact of Morphology on Iron Oxide Nanoparticles-Induced Inflammasome Activation in Macrophages. (Pubmed Central) - Aug 1, 2019
Furthermore, we demonstrate that the release of IL-1β induced by IONPs was only partly mediated by NLRP3, suggesting that inflammasomes other than NLRP3 are also involved in IONPs-induced inflammasome activation. Our results may have implications for designing safer nanoparticles for in vivo applications.
- | pentylenetetrazole (BTD-001) / Balance Therap
Journal: NLRP3 Inflammasome Activation Leads to Epileptic Neuronal Apoptosis. (Pubmed Central) - Aug 1, 2019
The study presented herein demonstrates the interaction between NLRP3 inflammasome and epilepsy progression. In addition, MCC950 might represent an important therapeutic drug for the treatment of NLRP3 inflammasome driven epileptogenic activity.
- | Journal: Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders. (Pubmed Central) - Aug 1, 2019
Finally, we discuss existing problems and potential directions with this issue. The information compiled here summarizes recent progress, thus potentially aiding in the understanding of the NLRP3 inflammasome in cardiovascular disorders, designing experimental and clinical research about the NLRP3 inflammasome, and promoting therapeutics for cardiovascular disorders.
- | Journal, IO Biomarker: Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. (Pubmed Central) - Aug 1, 2019
Thus, HIV ssRNA mediated activation of microglial cells can contribute to neurotoxicity and neurodegeneration via secretion of inflammatory and neurotoxic cytokines. These findings provide a potential mechanism that explains the frequent minor cognitive deficits and chronic inflammation that persist in HIV-infected persons despite treatment with suppressive ART.
- | Preclinical, Journal: Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy. (Pubmed Central) - Aug 1, 2019
These results suggest that inhibiting GSK-3β downregulates NLRP3 inflammasome expression by increasing autophagic activity in cerebral ischemia reperfusion injury. GSK-3β might be an attractive specific target and that it functions by regulating the NLRP3 inflammasome.
- | Preclinical, Journal: NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats. (Pubmed Central) - Aug 1, 2019
Downregulated SIRT3 and upregulated expression of the NLRP3 inflammasome are involved in the degradation of aging bladders. Inflamm‑aging is a novel mechanism underlying bladder dysfunction.
- | Journal: Ammonia exposure induced abnormal expression of cytokines and heat shock proteins via glucose metabolism disorders in chicken neutrophils. (Pubmed Central) - Aug 1, 2019
In addition, the sensitivity of neutrophils to exogenous stimuli was diminished. This information can not only be used to evaluate the damage of NH-spiked neutrophils to chickens, but also provide clues for human health pathophysiology caused by excess NH, providing valuable information for NH risk management.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Preclinical, Journal: Pingwei San ameliorates dextran sulfate sodium-induced chronic colitis in mice. (Pubmed Central) - Aug 1, 2019
This information can not only be used to evaluate the damage of NH-spiked neutrophils to chickens, but also provide clues for human health pathophysiology caused by excess NH, providing valuable information for NH risk management. PWS treatment alleviated the degree of colitis caused by DSS, suggesting that PWS might be a novel agent for the treatment of chronic colitis.