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- | hydroxychloroquine / Generic mfg., hydroxychloroquine / VG Lifesciences
Journal: Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. (Pubmed Central) - Dec 21, 2019
Notably, we found that HCQ attenuated renal injury through downregulation of CTSB and CTSL-mediated NLRP3 inflammasome activation. This study provides new insights into the anti-inflammatory effect of HCQ in the treatment of AKI.
- | Journal: Intracellular organelles in health and kidney disease. (Pubmed Central) - Dec 21, 2019
Proteinuria and hyperglycemia in diabetic nephropathy may induce endoplasmic reticulum stress in tubular cells of the kidney. Due to the accumulation in the proximal tubule lysosomes, impaired function of these organelles may be an important mechanism leading to proximal tubular toxicity.
- | Journal: Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3 inflammasome activation in smooth muscle cells. (Pubmed Central) - Dec 21, 2019
RA also led to diminished nicotine-induced activation of NLRP3 inflammasome and elevation in the CRP level in the aortic tissue of the model rats. The results of this study suggested a protective role of RA in nicotine-induced atherosclerosis by inhibiting the ROS-NLRP3 inflammasome-CRP axial, and RA therefore represented a potential effective therapeutic approach to atherosclerosis, in particular for those who smoke.
- | Preclinical, Journal: TREM-1 Attenuates RIPK3 Mediated Necroptosis in Hyperoxia Induced Lung Injury in Neonatal Mice. (Pubmed Central) - Dec 21, 2019
Mechanistically, we show that TREM-1 activation alleviates lung inflammation and improves alveolarization through down-regulating RIPK3 mediated necroptosis and nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3)-inflammasome activation in hyperoxia-exposed neonatal mice. These data show that activating TREM-1, enhancing angiopoietin 1 signaling or blocking RIPK3-mediated necroptosis pathway may act as new therapeutic interventions to control adverse effects of hyperoxia on the development of BPD.
- | Journal: Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension. (Pubmed Central) - Dec 21, 2019
This beneficial effect of βOHB was likely independent of gut-microbiotal and Th17-mediated effects of salt and instead facilitated by βOHB inhibiting the renal Nlrp3 inflammasome. The juxtaposed effects of dietary salt and exercise on salt-sensitive hypertension, which decrease and increase βOHB respectively, indicate that nutritional supplementation of a precursor of βOHB provides a similar benefit to salt-sensitive hypertension as exercise.
- | Journal: Regulatory elements in vectors containing the ctEF-1α first intron and double enhancers for an efficient recombinant protein expression system. (Pubmed Central) - Dec 21, 2019
We found that cell viability was more than 70% 11 days after cells were transfected with the pHH-GM1 vector. The pHH-GM1 vector with the ctEF-1α first intron and double enhancers, Simian virus 40 and Cytomegalovirus (SV40 and CMV) is an efficient CMV promoter-based gene expression system that can potentially be applied to study genes of interest and improve protein production.
- | Journal, IO Biomarker: Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways. (Pubmed Central) - Dec 21, 2019
The exaggerated sensitivity to activation correlates with high basal ROS levels in CAPS monocytes. In conclusion, the vesicular pathway limits IL-1β release upon low pathogen load while stronger stimulation or concomitant cell stress induce instead uncontrolled secretion via GSDMD leading to detrimental inflammatory manifestations.
- | Journal: Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation. (Pubmed Central) - Dec 21, 2019
In vivo, inhibition of Cbl with an analgesic drug, hydrocotarnine, increases inflammasome-mediated IL-18 secretion in the colon, and protects mice from dextran sulphate sodium-induced colitis. Together, our novel findings provide new insights into the role of the SFK-Cbl axis in suppressing NLRP3 inflammasome activation and identify a novel clinical utility of hydrocortanine for disease treatment.
- | Journal: Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. (Pubmed Central) - Dec 21, 2019
The NLRP3 inflammasome plays a significant role in amplifying Stx2/LPS-induced GSDMD cleavage and pyroptosis, with significant reduction of these responses in NLRP3-deficient THP-1 cells. Together, these data show that Stx2/LPS complex activates the non-canonical inflammasome and mitochondrial ROS upstream of the NLRP3 inflammasome to promote cytokine maturation and pyroptosis.
- | Journal: Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome. (Pubmed Central) - Dec 21, 2019
HU308 showed the same effects as JWH-133. Taken together, we demonstrated for the first time the cardioprotective effect of CB2R agonist and its NLRP3 inflammasome-related mechanism in MI.
- | Journal: TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation. (Pubmed Central) - Dec 21, 2019
The data reported here suggest that TSPO-VDAC complex upregulation in BD patients, the simultaneous downregulation of mitophagic proteins and NLRP3 inflammasome activation could lead to an accumulation of dysfunctional mitochondria, resulting in inflammation and apoptosis. In summary, the findings of this study provide novel evidence that mitochondrial dysfunction measured in peripheral blood is associated with BD.
- | Journal: Trans-Golgi network breaks away to activate NLRP3. (Pubmed Central) - Dec 21, 2019
In summary, the findings of this study provide novel evidence that mitochondrial dysfunction measured in peripheral blood is associated with BD. No abstract available
- | venlafaxine / Generic mfg., fluoxetine / Generic mfg.
Journal: Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway. (Pubmed Central) - Dec 21, 2019
Next, we observed that in the hippocampus, tianeptine and fluoxetine suppressed upregulation of TLR4...Our results provide new evidence that chronic administration of antidepressants exerts anti-inflammatory effects more pronounced in the hippocampus, through suppression of the NLRP3 inflammasome activation. These effects are accompanied by an improvement in the behavioral dysfunctions evoked by prenatal stress.
- | Journal: NLRP3 Activation Induced by Neutrophil Extracellular Traps Sustains Inflammatory Response in the Diabetic Wound. (Pubmed Central) - Dec 21, 2019
In addition, NET digestion by DNase I alleviated the activation of NLRP3 inflammasome, regulated the immune cell infiltration, and accelerated wound healing in diabetic rat model. These findings illustrate a new mechanism by which NETs contribute to the activation of NLRP3 inflammasome and sustained inflammatory response in the diabetic wound.
- | Preclinical, Journal: Electroacupuncture Pretreatment Attenuates Inflammatory Lung Injury After Cardiopulmonary Bypass by Suppressing NLRP3 Inflammasome Activation in Rats. (Pubmed Central) - Dec 21, 2019
The EA pretreatment suppressed NLRP3 inflammasome activation, reduced lung edema, and inhibited IL-1β release into the serum and BALF after CPB. Our findings suggest that EA pretreatment attenuates inflammatory lung injury after CPB by suppressing NLRP3 inflammasome activation.
- Molecular Mechanisms, Temporal and Spatial Dynamics of Inflammasome Activation in Ischemic Stroke (Hall H) - Dec 21, 2019 - Abstract #ISC2020ISC_1304;
The impact of inflammasome activation is detrimental to ischemic stroke. Inhibiting Caspase-1/11 signalings is a promising therapeutic strategy for stroke.
- Mesenchymal Stromal Cell Administration Attenuates Post-Stroke Susceptibility to Spontaneous Infection Through Prevention of Caspase-1-Dependent Splenic Marginal Zone B Cell Death (Hall H) - Dec 21, 2019 - Abstract #ISC2020ISC_733;
In terms of mechanism, we demonstrate that MSCs attenuate caspase-1-dependent MZB cells death partially through direct mitochondrial transfer and subsequent inhibition of NLRP3 activation. Taken together, this study suggests MSCs administration alleviates post-stroke immunodepression and spontaneous infections via MZB cells protection.
- Inhibition of Thioredoxin Interacting Protein Attenuates Tissue Plasminogen Activator Induced Brain Damage Under Acute Hyperglycemia in Murine Stroke Model (Hall H) - Dec 21, 2019 - Abstract #ISC2020ISC_673;
Taken together, this study suggests MSCs administration alleviates post-stroke immunodepression and spontaneous infections via MZB cells protection. Taken together, these data indicate that inhibition of TXNIP with verapamil may have therapeutic implications on ischemic stroke in the acute hyperglycemic condition.
- FBXO3-FBXL2 AXIS MODULATORS AS A NOVEL CLASS OF ORAL SMALL MOLECULE COMPOUNDS FOR THE TREATMENT OF CROHN’S DISEASE (Exhibit Hall 1 - Austin Convention Center) - Dec 21, 2019 - Abstract #CCCongress2020CCCONGRESS_374;
BC1261, a Fbxo3 inhibitor, was efficacious in both acute and chronic preclinical models of colitis. Taken together, these results suggest the potential utility of selective Fbxo3-Fbxl2 modulation in the treatment of CD.
- OXPHOS INDUCTION IN HEALING: A CRITICAL MISSING STEP IN INFLAMMATORY BOWEL DISEASE? (Exhibit Hall 1 - Austin Convention Center) - Dec 21, 2019 - Abstract #CCCongress2020CCCONGRESS_362;
As expected, samples from colitis patients exhibited significant upregulation of inflammatory markers (iNOS, NLRP3, CCL2, RANTES, TGF-b1, CCL20 and CXCL10) compared to 'biopsy of the biopsy' sites in normal patients undergoing healing. Intriguingly, epithelial marker E-cadherin was noted to be decreased in samples obtained from colitis patients with concomitant increase in mesenchymal markers (Vimentin, Snail, Twist-1 and Zeb-1) compared to previously biopsied normal controls.
- EFFECT OF LYSOSOMAL SHORT CHAIN FATTY ACID DELIVERY ON IMMUNE RESPONSE (Exhibit Hall 1 - Austin Convention Center) - Dec 21, 2019 - Abstract #CCCongress2020CCCONGRESS_353;
Furthermore, that concentrative uptake to the phagolysosome leads to enhanced stimulation of these receptors leading to responses at lower ambient concentrations or doses. We are assessing this substance class as potential IBD therapeutics.
- | Journal: Osteopontin in the host response to Leishmania amazonensis. (Pubmed Central) - Dec 20, 2019
amazonensis infection induces opn gene expression and protein, which in turn participates in shaping the host response to the parasites, seemingly by decreasing the activation of inflammation. OPN, further evaluated as a target for Leishmaniasis control represents an additional interest in improving vaccination strategies against the parasites.
- | Journal: Necrotic cell debris induces a NF-κB-driven inflammasome response in vascular smooth muscle cells derived from abdominal aortic aneurysms (AAA-SMC). (Pubmed Central) - Dec 20, 2019
Analysis of the SMC supernatants by ELISA revealed CD-induced release of the senescence-associated cytokines IL-6 and MCP-1 in native and IFN-γ-primed SMC, whereas no secretion of Interleukin-(IL) 1α and IL-1β secretion were observed. Our results implicate a role of necrotic cell debris derived from dead neighboring cells in SMC dysfunction and in inflammatory response of AAA tissue.
- | Journal: Estrogen receptors participate in carcinogenesis signaling pathways by directly regulating NOD-like receptors. (Pubmed Central) - Dec 20, 2019
In short, the research demonstrates that ERs participate in the NLR-associated signaling pathway in cancer by directly regulating NLRs. Our results provide novel insight into ERs as therapeutic targets in NLR-related inflammation and cancer.
- || Clinical, Journal: Aberrant expression of NLRP3, NLRC4 and NLRP6 inflammasomes in patients with primary immune thrombocytopenia. (Pubmed Central) - Dec 20, 2019
Our results provide novel insight into ERs as therapeutic targets in NLR-related inflammation and cancer. No abstract available
- | glibenclamide / Generic mfg.
Journal: Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome. (Pubmed Central) - Dec 20, 2019
Glibenclamide maintained BBB integrity in experimental ICH by inhibiting the activation of the NLRP3 inflammasome in microvessel endothelial cells. Our findings will contribute to elucidating the pharmacological mechanism of action of glibenclamide and to developing a novel therapy for clinical ICH.
- || Clinical, Journal: Inflammatory status and severity of disease in dengue patients are associated with lipoprotein alterations. (Pubmed Central) - Dec 20, 2019
Our findings will contribute to elucidating the pharmacological mechanism of action of glibenclamide and to developing a novel therapy for clinical ICH. The results suggest that there is a relationship between the alteration of LDL and HDL with the imbalance in the inflammatory response, which could be associated with the severity of dengue.
- | low molecular weight dextran sulfate (ILB) / TikoMed, bile acid cholic acid (INT-777) / Intercept
Journal: Genistein protects against DSS-induced colitis by inhibiting NLRP3 inflammasome via TGR5-cAMP signaling. (Pubmed Central) - Dec 20, 2019
The effects of Genistein in dextran sulfate sodium (DSS)-induced murine colitis via targeting NLRP3 inflammasome was investigated in this study...Moreover, Genistein treatment down-regulated production of caspase-1 and IL-1β and increased intracellular cAMP level, which were similar to the treatment for INT-777, a semi-synthetic TGR5 agonist, in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells and U937 cells...In conclusion, our study unveils that Genistein was able to inhibit NLRP3 inflammasome via TGR5-cAMP signaling in macrophages. It therefore might be a potential effective drug for inflammatory bowel diseases.
- | Journal: Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy. (Pubmed Central) - Dec 20, 2019
It therefore might be a potential effective drug for inflammatory bowel diseases. ASC deficiency is neuroprotective in neonatal HI brain damage in mice, while NLRP3 deficiency increases brain damage.
- | Journal: The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes. (Pubmed Central) - Dec 20, 2019
These results reveal that in addition to their role as danger signals released from dead cells, IL-1 family cytokines can be secreted in the absence of cell death. We propose that models used in the study of IL-1 release should be considered context dependently.
- | Journal: The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages. (Pubmed Central) - Dec 20, 2019
We also observed that elevation of PKR expression due to the C5a-C5aR2 interaction depends on the mitogen-activated protein (MAP) kinase kinase (MEK)/extracellular signal-regulated kinases (ERK) pathway and type I interferon (IFN) signaling. In conclusion, these findings reveal that C5aR2 contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages.
- | Ilaris (canakinumab) / Novartis
Journal: Potential therapeutic value of interleukin 1β-targeted strategies in atherosclerotic cardiovascular disease. (Pubmed Central) - Dec 20, 2019
Here, we review our current knowledge of the biology of interleukin-1β, a key regulator of inflammation in atherosclerotic plaque and the target of the first clinical trial to demonstrate that an anti-inflammatory drug can effectively reduce cardiovascular risk. We discuss the challenges faced by interleukin-1β inhibitors and other anti-inflammatory compounds in their translation to the clinical scenario, and identify other potential targets within this signaling pathway that hold promise in the cardiovascular setting.
- | Journal: CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy. (Pubmed Central) - Dec 20, 2019
However, after blocking NLRP3 with MCC950, although podocyte injury was alleviated and release of IL-1β was decreased, there was no change in the expression of CD36, ADRP, and intracellular lipid droplets. Taken together, our study suggests that CD36-mediated lipid accumulation and activation of NLRP3 inflammasome may be one of the potential pathogeneses of ORG podocyte injury.
- | Decadron (dexamethasone) / Merck (MSD)
Preclinical, Journal: Pulegone inhibits inflammation via suppression of NLRP3 inflammasome and reducing cytokine production in mice. (Pubmed Central) - Dec 20, 2019
Materials and The C57BL/6J mice were randomly divided into five groups: Normal, Lipopolysaccharides (LPS), Dexamethasone (DEX, 5 mg/kg), Pulegone (0.095 and 0.190 g/kg) groups...Immunohistochemical study showed a decreased positive cell numbers of P2X7R in Pulegone (0.095 and 0.190 g/kg) groups. Pulegone exerts anti-inflammatory effects on LPS-induced sepsis mice via inhibition of the NLRP3 expression.
- | Biomarker, Preclinical, Journal, PARP Biomarker: Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis rats. (Pubmed Central) - Dec 20, 2019
Additionally, MF decreased the levels of fumarate, cAMP, xanthurenic acid and d-glucurone-6,3-lactone, and increased the levels of hippuric acid and phenylacetylglycine, and then adjusted the changes of phenylalanine metabolism, TCA cycle and ascorbate and aldarate metabolic pathways. The above results suggested that MF can effectively prevent AH by modulating specific AH-associated genes, potential biomarkers and metabolic pathways in AH rats, etc.
- | Journal: Hydrogen Sulfide Attenuates High Glucose-Induced Human Retinal Pigment Epithelial Cell Inflammation by Inhibiting ROS Formation and NLRP3 Inflammasome Activation. (Pubmed Central) - Dec 20, 2019
Taken together, the findings of the present study have demonstrated that HS protects cultured RPE cells from high glucose-induced damage through inhibiting ROS formation and NLRP3 inflammasome activation. It might suggest that HS represents a potential therapeutic target for the treatment of diabetic retinopathy.
- || Shingrix (zoster vaccine recombinant adjuvanted) / GSK, Japan Vaccine, Mosquirix (RTS,S) / GSK
Clinical, Journal: Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review. (Pubmed Central) - Dec 20, 2019
It might suggest that HS represents a potential therapeutic target for the treatment of diabetic retinopathy. The most advanced phase III clinical applications led to the development of two vaccines containing QS-21 as part of the AS, the Herpes Zoster vaccine (HZ/su) (Shingrix™) which received a license in 2017 from the FDA and a marketing authorization in the EU in 2018 and the RTS,S/AS01 vaccine (Mosquirix™) against malaria, which was approved by the EMA in 2015 for further implementation in Sub-Saharan countries for routine use.
- | Journal, IO Biomarker: Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal Ischemia/Reperfusion. (Pubmed Central) - Dec 20, 2019
Dexmedetomidine-mediated protective effects on liver injury and NLRP3 inflammasome activation during intestinal I/R were partially abrogated via irisin-neutralizing antibody treatment. The results suggest that irisin might contribute to the hepatoprotection of dexmedetomidine during intestinal ischemia/reperfusion.
- | Journal: Galangin Suppresses Renal Inflammation via the Inhibition of NF-κB, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells. (Pubmed Central) - Dec 20, 2019
Moreover, western blotting showed that galangin treatment effectively inhibited nuclear factor-kappa B (NF-κB), phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) and nucleotide-binding domain- (NOD-) like receptor protein 3 (NLRP3) signaling pathway activation. Taken together, these findings suggested that galangin plays a pivotal role in renal inflammation by suppressing inflammatory responses, which might be closely associated with the inhibition of NLRP3 inflammasome, NF-κB and PI3K/AKT signaling pathway activation.
- | Review, Journal: The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. (Pubmed Central) - Dec 19, 2019
How NLRP3 responds to those signaling events and initiates the assembly of the NLRP3 inflammasome is not fully understood. In this review, we summarize our current understanding of the mechanisms of NLRP3 inflammasome activation by multiple signaling events, and its regulation by post-translational modifications and interacting partners of NLRP3.
- | Preclinical, Journal: Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome. (Pubmed Central) - Dec 19, 2019
These results suggest that matrine plays an important role in PAMs co-stimulated with PRRSV 5'UTR RNA and LPS via its effect on NF-κB and the NLRP3 inflammasome. These findings lay the foundation for the exploration of the clinical application of matrine in PRRSV disease.
- | Journal, PARP Biomarker: Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal. (Pubmed Central) - Dec 19, 2019
Damage to mitochondria, lysosomes, and endoplasmic reticulum in atRAL-exposed ARPE-19 cells was partially alleviated by treatment with MCC950, a selective NLRP3 inflammasome inhibitor. Aberrant build-up of atRAL promotes the death of RPE cells via NLRP3 inflammasome activation.
- | Journal: NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis. (Pubmed Central) - Dec 19, 2019
Our results showed that melatonin attenuates pristane-induced LN through restoring of morphology and attenuation of oxidative stress and inflammation through a pathway that inhibited activation of NLRP3 inflammasome signaling. Our data clearly demonstrate that melatonin has protective activity on lupus nephritis in these mice that is highly associated with its effect on enhancing the Nrf2 antioxidant signaling pathway and decreasing renal NLRP3 inflammasome activation.
- | Preclinical, Journal: NLRP3 inflammasome activation is associated with PM -induced cardiac functional and pathological injury in mice. (Pubmed Central) - Dec 19, 2019
And, NLRP3 activation-associated proteins of NLRP3, IL-1β, IL-18, Cleaved caspase-1 p10, and Cleaved IL-1β were upregulated in heart tissue of PM -induced mice. In summary, PM exposure could induce cardiac functional and pathological injury, which may be associated with the activation of NLRP3 inflammasome.
- | Journal: Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease. (Pubmed Central) - Dec 19, 2019
Knockdown of Gal3 suppressed inflammation, reduced mHTT aggregation, restored neuronal DARPP32 levels, ameliorated motor dysfunction, and increased survival in HD mice. Thus, suppression of Gal3 ameliorates microglia-mediated pathogenesis, which suggests that Gal3 is a novel druggable target for HD.
- | Clinical, Journal: Serum levels of NLRP3 and HMGB-1 are associated with the prognosis of patients with severe blunt abdominal trauma. (Pubmed Central) - Dec 19, 2019
Thus, suppression of Gal3 ameliorates microglia-mediated pathogenesis, which suggests that Gal3 is a novel druggable target for HD. The serum levels of NLRP3 and HMGB-1 were significantly elevated in severe blunt abdominal trauma patients, and the serum levels of both NLRP3 and HMGB-1 were correlated with 6-month mortality in severe blunt abdominal trauma patients.
- | Journal: Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell. (Pubmed Central) - Dec 19, 2019
The serum levels of NLRP3 and HMGB-1 were significantly elevated in severe blunt abdominal trauma patients, and the serum levels of both NLRP3 and HMGB-1 were correlated with 6-month mortality in severe blunt abdominal trauma patients. Our results confirmed that BBR can effectively affect both tumor outgrowth and spontaneous metastasis in TNBC, and that we identified a new mechanism associated with inhibition the NLRP3 inflammasome pathway, suggesting its potential therapeutic relevance in clinical use.
- | Journal: Role reversal: adaptive immunity instructs inflammasome activation for anti-viral defence. (Pubmed Central) - Dec 19, 2019
In this issue of The EMBO Journal, Labzin et al reveal that the adaptive immune system can instruct the innate response to adenovirus infection. In human macrophages, antibody-coated adenovirus triggers a novel TRIM21-dependent pathway that activates the NLRP3 inflammasome and the secretion of IL-1β.
- | Journal: Electroacupuncture ameliorates cardiopulmonary bypass induced apoptosis in lung via ROS /Nrf2/NLRP3 inflammasome pathway. (Pubmed Central) - Dec 19, 2019
These findings indicate that EAc had a critical anti-apoptotic role by suppression of ROS/Nrf2/NLRP3 inflammasome pathway. EAc might be a possible therapeutic treatment for CPB-induced acute lung injury.
- Thrombin receptor PAR4 drives inflammatory signaling in the heart (Borgward) - Dec 17, 2019 - Abstract #GTH2020GTH_78;
We provide a mechanistic explanation for the chronic low-grade thromboinflammation that characterizes diabetic cardiomyopathy and for the cardioprotective effects of thrombin inhibition in this setting. The strong bleeding side-effects of the direct thrombin inhibitors might limit their use to patients with a clear indication for anticoagulation, but the emerging PAR4-selective antagonists may provide a feasible alternative approach to blunt cardiac inflammation in patients with diabetes.