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- | Journal: APOPTOSIS SIGNAL REGULATING KINASE-1 PROMOTES INFLAMMASOME PRIMING IN MACROPHAGES. (Pubmed Central) - Jan 1, 2020
Similarly, treatment of MH-S cells with LPS + ATP caused an increase in both cleaved caspase-1 and IL-1β, that was diminished by the ASK-1 inhibitor NQDI1. These results demonstrate, for the first time, that ASK1 promotes inflammasome priming.
- | simvastatin / Generic mfg.
Journal, IO Biomarker: Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression. (Pubmed Central) - Jan 1, 2020
Compared with wild-type and simvastatin treated mice, the specific deletion of pulmonary GGPPS1 attenuated the severity of lung injury by inhibiting apoptosis of AECs...This effect might be attributed to the downregulation of GGPP levels. Our results suggested that inhibition of pulmonary GGPPS1 attenuated LPS-induced ALI, predominantly by suppressing the NLRP3 inflammasome through Rab10-mediated TLR4 replenishment.
- | Journal: ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. (Pubmed Central) - Jan 1, 2020
Furthermore, deficiency of BRCC3, the catalytically active component of BRISC, displays similar phenotypes to ABRO1 knockout mice. Our findings reveal an ABRO1-mediated regulatory signaling system that controls activation of the NLRP3 inflammasome and provide novel potential targets for treating NLRP3-associated inflammatory diseases.
- | Preclinical, Journal: A Traditional Clinic Chinese Medicine Prescription Qu-Zhuo-Tong-Bi (QZTB) Alleviates Gouty Arthritis in Model Rats. (Pubmed Central) - Jan 1, 2020
QZTB (500 mg/kg) and the positive control drug meloxicam were administrated by gavages twice a day for 7 days before, or 3 days after, first MSU injection in different experiments, respectively...In addition, QZTB treatment significantly decreased both mRNA and protein levels of NLRP3, as well as the production of IL-1 and TNF-α in the ankle joint of model rats. Taken together, these results suggest that QZTB may be a promising herbal formula for the prevention and treatment of gouty arthritis in humans.
- | Journal: Hydrogen sulfide modulates high glucose-induced NLRP3 inflammasome activation in 3T3-L1 adipocytes. (Pubmed Central) - Jan 1, 2020
Furthermore, NaHS inhibited the expression of NLRP3, ASC and cleaved caspase-1, and the production of IL-1β and IL-18 in adipocytes treated with HG. In conclusion, HG may increase and exogenous HS may inhibit HG-induced NLRP3 inflammasome activation in adipocytes.
- | Preclinical, Journal: MicroRNA-133b Alleviates Hypoxia Injury by Direct Targeting on NOD-Like Receptor Protein 3 in Rat H9c2 Cardiomyocyte. (Pubmed Central) - Dec 31, 2019
Overexpression of NLRP3 significantly inhibited cell viability, migration, and invasion but induced cell apoptosis in H9c2 treated with hypoxia. Thus, miR-133b protects H9c2 against hypoxia injury via downregulation of NLRP3.
- || RalGAPα2 and NLRP3 Orchestrate Tumor Invasion in Colitis-Associated Cancers https://t.co/vBeYUcuytB (Twitter) - Dec 30, 2019
- | Biomarker, Review, Journal: Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases. (Pubmed Central) - Dec 29, 2019
Other miRNAs like miR-155-5p modulate TLR-, IL-1R-, TNFR-, and IFNAR-mediated signaling pathways upstream of the inflammasomes. In this study, we discuss how a more detailed elucidation of miRNA-driven inflammasome regulation helps in understanding the molecular processes underlying immune-mediated human diseases, holds potential for the identification of biomarkers and may offer novel targets for the development of future therapeutics.
- | Journal: microRNA-520c-3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3. (Pubmed Central) - Dec 29, 2019
In this study, we discuss how a more detailed elucidation of miRNA-driven inflammasome regulation helps in understanding the molecular processes underlying immune-mediated human diseases, holds potential for the identification of biomarkers and may offer novel targets for the development of future therapeutics. Collectively, miR-520c-3p could potentially inhibit NLRP3 inflammasome activation and inflammatory cascade in PE by downregulating NLRP3, highlighting the potential of miR-520c-3p as a therapeutic target for PE treatment.
- | Journal: Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation. (Pubmed Central) - Dec 28, 2019
In addition, high-glucose treatment induced cardiac fibrosis and increased cardiac inflammation in cardiac fibroblast cells, but these effects were ameliorated by CV extract treatment. Therefore, we conclude that the protective effect of CV on DCM is associated with the suppression of TGF-β1/Smad signaling and attenuation of NLRP3 inflammasome activation, suggesting that CV extract may be a potential therapeutic agent for DCM.
- | Journal: Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows. (Pubmed Central) - Dec 27, 2019
More importantly, the mRNA and protein abundance of NLRP3 and caspase-1 (CASP1) along with CASP1 activity were greater in the liver of cows with ketosis. Overall, the data indicate that the onset of ketosis is accompanied by activation of the NF-κB signaling pathway and NLRP3 inflammasome, resulting in a state of inflammation.
- | Journal: Progress in the study of macrophage activation and ulcerative colitis from the Notch/NF-κB/NLRP3 signaling pathway (Pubmed Central) - Dec 27, 2019
Notch, NF-κB and NLRP3 inflammatory bodies constitute the upstream and downstream signal pathways in the existing immune inflammatory diseases. Notch signal pathway can regulate the activation of macrophage via NF-κB/NLRP3 inflammatory body signaling pathway.
- | Journal: Pyroptosis in Antiviral Immunity. (Pubmed Central) - Dec 26, 2019
Viruses have evolved their own mechanisms to modulate inflammasome signaling and pyroptosis. Here, we review the current literature regarding the role of pyroptosis in antiviral immune responses.
- | Review, Journal: NLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy. (Pubmed Central) - Dec 26, 2019
An increasing number of studies indicated NLRP3 inflammasome and their downstream mediators as important targets for statin drugs in inflammatory diseases. In this review, we discussed different aspect of the NLRP3 inflammasome signaling pathways and focused on the effect of statin drugs on NLRP3 inflammasomes in association to atherosclerosis in order to elucidate possible targets for future research and clinical settings.
- | Journal: TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI). (Pubmed Central) - Dec 26, 2019
TRPV1 promotes activation of astrocytes and release of astrocyte-derived IL-1β mainly via JAK2-STAT3 signaling and activation of the NLRP3 inflammasome. Our findings provide mechanistic insights into TRPV1-mediated brain damage and neurobehavioral disorders caused by neonatal HI and potentially identify astrocytic TRPV1 as a novel therapeutic target for treating HIE in the subacute stages (24 h).
- | Preclinical, Journal: Suppressive Effect of Huzhentongfeng on Experimental Gouty Arthritis: An In Vivo and In Vitro Study. (Pubmed Central) - Dec 26, 2019
Moreover, HZTF also showed effects in cell-free and cell-base tests of antioxidant capacity. The results prove that HZTF possessed the potential preventive effect against gout arthritis, and the effect may be attributed to its preventing effect on neutrophil infiltration and proinflammatory cytokines secretion such as IL-1β, IL-6, and TNF-α which were caused by the activation of inflammasome.
- | probenecid / Generic mfg.
Journal: NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP. (Pubmed Central) - Dec 25, 2019
Mice were treated with MPTP/P, i.e., MPTP (25 mg/kg, s.c.) plus probenecid (250 mg/kg, i.p.) every 4 days, for ten times...Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1β (IL-1β), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation. Our results demonstrate that MPTP/P-caused olfactory bulb damage might be related to NLRP3-mediated inflammation.
- | Journal: Pregnane X receptor activation triggers rapid ATP release in primed macrophages that mediates NLRP3 inflammasome activation. (Pubmed Central) - Dec 25, 2019
Our findings identify a mechanism whereby the PXR drives innate immune signaling, providing a potential link between xenobiotic exposure and the induction of innate inflammatory responses. SIGNIFICANCE STATEMENT: n/a (as per email of April 4/19 from Cassandra Wood).
- | Journal: The relationship between inflammasomes and the endoplasmic reticulum stress response in the injured spinal cord. (Pubmed Central) - Dec 25, 2019
Conclusions Inflammasome component protein expression increases after SCI in association with increased ER stress. OPCs had significantly higher levels of inflammasome proteins compared to astrocytes, which may be associated with the high rates of OPC cell death after SCI.
- | Journal: Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction. (Pubmed Central) - Dec 25, 2019
The levels of TXNIP, NLRP3 and cleaved caspase‑1 and production of ROS were suppressed by siTXNIP, accompanied by increases in catalase and MnSOD. TXNIP/NLRP3 serves an important role in the development of sepsis‑induced myocardial damage.
- || rosuvastatin / Generic mfg., AstraZeneca
Clinical, Journal: NLRP3 inflammasome expression in peripheral blood monocytes of coronary heart disease patients and its modulation by rosuvastatin. (Pubmed Central) - Dec 25, 2019
The activation of NLRP3 inflammasome may be involved in the development of CHD, and rosuvastatin could attenuate the inflammatory process of atherosclerosis by downregulating NLRP3 expression and its downstream mediators. These findings indicated a potential role of NLRP3 in the pathogenesis and management of CHD, and also provided new insights into the mechanistic framework of rosuvastatin activity.
- | Journal: Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. (Pubmed Central) - Dec 25, 2019
NLRP3 inflammasome knockout blocked many of the observed microglial changes upon lipopolysaccharide, including alterations in microglial morphology and amyloid pathology. NLRP3 inhibition may thus represent a novel therapeutic target that may protect the brain from toxic peripheral inflammation during systemic infection.
- The complement system drives inflammatory memory via metabolic reprogramming of synovial fibroblasts (Promotion Hall KU Leuven) - Dec 25, 2019 - Abstract #EWRR2020EWRR_79;
Depletion or genetic deficiency of complement component C3 abrogated the inflammatory tissue memory in vivo and normalized the aggressive SF phenotype. Our results suggest that inflammatory memory depends on intracellular complement C3 activation and metabolic reprogramming in SF, thus driving enhanced NLRP3 inflammasome activity.
- || Clinical, Journal: NLRP3 level in cerebrospinal fluid of patients with neuromyelitis optica spectrum disorders: Increased levels and association with disease severity. (Pubmed Central) - Dec 24, 2019
Our findings suggest that CSF levels of the NLRP3 inflammasome may serve as a diagnostic biomarker for distinguishing NMOSD and MS. Pyroptosis mediated by the NLRP3 inflammasome following mitochondrial damage may play an important role in the pathogenesis of these neuroinflammatory disorders, especially NMOSD.
- Resvega alleviates oxidative stress and inflammasome activation in retinal pigment epithelial cells () - Dec 24, 2019 - Abstract #EVER2019EVER_321;
All those were reduced by the pre‐treatment with Resvega, which had no impact on the cell viability. Conclusions Our results suggest that Resvega has potential to alleviate oxidative stress and inflammation in human retinal pigment epithelial cells.
- In Vivo corneal confocal microscopy study of keratoendotheliitis fugax hereditaria caused by a pathogenic variant in the NLRP3 gene () - Dec 24, 2019 - Abstract #EVER2019EVER_141;
With repeated attacks, needle‐shaped hyperreflective extracellular matrix elements emerge and cause a persistent opacity. The disease will be excellent in vivo human model to study the activation of the NLRP3 inflammasome and the tissue specificity in cryopyrin‐associated periodic syndromes.
- Inhibition of adaptor proteins MAVS and TXNIP reduces inflammasome activation in RPE cells () - Dec 24, 2019 - Abstract #EVER2019EVER_109;
Additionally, silencing of TXNIP protected from cell membrane rupturing and reduced the amount of extracellular NLRP3, which indicates attenuated inflammasome activity. In RPE cells, regulatory proteins TXNIP and MAVS are involved in the activation of NLRP3 inflammasome.
- | Soluble Aβ Oligomers and Protofibrils Induce NLRP3 Inflammasome Activation in Microglia by @HenekaMichael https://t.co/gKPuPiXY38 (Twitter) - Dec 24, 2019
- | Journal: The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. (Pubmed Central) - Dec 23, 2019
Conversely, the pyroptotic cell death effectors gasdermin D and gasdermin E are not essential for BAX/BAK-induced IL-1β release. These findings highlight that innate immune cells undergoing BAX/BAK-mediated apoptosis have the capacity to generate pro-inflammatory signals and provide an explanation as to why IL-1β activation is often associated with cellular stress, such as during chemotherapy.
- | Journal: BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages. (Pubmed Central) - Dec 23, 2019
IAP depletion, in turn, operates upstream of ripoptosome complex formation, subsequently resulting in caspase-8-dependent IL-1β maturation. These results establish the ripoptosome/caspase-8 complex as a pro-inflammatory checkpoint that senses the perturbation of mitochondrial integrity.
- | Journal: p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine. (Pubmed Central) - Dec 23, 2019
Collectively, these findings show that p31-43 gliadin has an intrinsic propensity to form oligomers which trigger the NLRP3 inflammasome and that this pathway is required for intestinal inflammation and pathology when p31-43 is administered orally to mice. This innate activation of the inflammasome may have important implications in the initial stages of CD pathogenesis.
- | Journal: NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis. (Pubmed Central) - Dec 23, 2019
Ang II-induced apoptosis was inhibited after administration of the NLRP3 inhibitor MCC950, and TXNIP silencing could reduce the NLRP3 expression and apoptosis, while both effects of Ang II on TXNIP-NLRP3 and its apoptosis-inducing effect were inhibited by angiotensin II type I receptor (AT1R) blocker Telmisartan. Our results demonstrated that the TXNIP-NLRP3 inflammasome pathway mediated Ang II-induced INS-1 cell apoptosis and might hopefully become a novel target for the treatment of diabetes mellitus.
- | Journal, IO Biomarker: Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress. (Pubmed Central) - Dec 23, 2019
Moreover, our research showed that ACD could dramatically increase superoxide dismutase (SOD) and glutathione (GSH) production, and reduce COX-2, inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS) and malondialdehyde (MDA) production through upregulating the expression of the anti-oxidative enzymes heme oxygenase-1 (HO-1) and quinone (NQO1), which were related to the induction of nuclear transcription factor 2 (Nrf2) nuclear translocation. These results indicated that ACD exhibited anti-inflammatory activity, which was associated with the inhibition of inflammatory mediator production via the downregulation of the NLRP3 inflammasome and TLR4-NF-κB/-MAPK signaling pathways, and the antioxidative effects of ACD were connected with GSH and SOD activation through upregulation of the Nrf2-mediated signaling pathways.
- | Review, Journal: The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation. (Pubmed Central) - Dec 23, 2019
With respect to its physiological function in the mucosal environment, MUC1 has been demonstrated to play a dynamic role in protection of the host from infection by a wide variety of pathogens and to regulate inflammatory responses to infection. This review briefly summarizes the current knowledge and new findings regarding the structural features relating to the function of MUC1, its role as a protective barrier against pathogen invasion and mechanisms by which this cs-mucin regulates inflammation.
- | Preclinical, Journal: Puerarin inhibits vascular calcification of uremic rats. (Pubmed Central) - Dec 23, 2019
In addition, we found that puerarin reduced IL-1β possibly through targeting NLRP3/Caspase1/IL-1β and NF-κB signaling pathways and inhibiting the generation of reactive oxygen species. Taken together, we demonstrated that puerarin has the capability of inhibiting vascular calcification in uremic rats by inhibiting inflammation.
- | Preclinical, Journal: Suppression of NLRP3 inflammasome improves alveolar bone defect healing in diabetic rats. (Pubmed Central) - Dec 23, 2019
Our findings suggested that inhibition of NLRP3 inflammasome could improve alveolar bone defect healing in diabetic rats. The beneficial effect may correlate with reduced proinflammatory cytokine production and increased osteogenic gene expression in hyperglycemia.
- | Journal: Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent. (Pubmed Central) - Dec 23, 2019
While the lpxA mutant induced a priming response, measured as increased expression of NLRP3 and IL1B, the LOS-expressing FAM20 further increased this priming. We conclude that although non-LOS components of N. meningitidis contribute to the priming of the inflammasome activity, LOS per se is to be considered as the central component of N. meningitidis virulence, responsible for both priming and licensing of inflammasome activation.
- | Journal: Increased extracellular vesicle miRNA-466 family in the bronchoalveolar lavage fluid as a precipitating factor of ARDS. (Pubmed Central) - Dec 23, 2019
These findings imply that miRNA-466 family molecules are secreted via EVs into the airways in an ARDS model, and this exacerbates inflammation through the NLRP3 inflammasome. Our results suggest that the NLRP3 inflammasome pathway, regulated by extracellular vesicle miRNA, could act as a therapeutic target for ARDS.
- | Journal: Anti-inflammatory Effects of Dopamine in Lipopolysaccharide (LPS)-stimulated RAW264.7 Cells via Inhibiting NLRP3 Inflammasome Activation. (Pubmed Central) - Dec 23, 2019
Improvement of DA correlated with its effect on NLRP3 activation. Thus, DA and agonists of DRD1, as a functional molecule that bridges the neuronal and immune systems, may represent effective strategies for limiting pathological inflammation.
- | Journal: Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation. (Pubmed Central) - Dec 23, 2019
Cardioprotective effects stemming from the inhibition of sEH included preserved activities of both cytosolic thioredoxin (Trx)-1 and mitochondrial Trx-2 antioxidant enzymes. Together, these data demonstrate that inhibiting sEH imparts cardioprotection against IR injury via maintaining post-ischemic mitochondrial function and attenuating a detrimental innate inflammatory response.
- | Journal: Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol. (Pubmed Central) - Dec 23, 2019
Moreover, LNE significantly ameliorated P. acnes-induced inflammation in a mouse model of acne. We suggest for the first time that LNE hold therapeutic value for the improvement of P. acnes-induced skin inflammation.
- | Journal: Atmospheric HS triggers immune damage by activating the TLR-7/MyD88/NF-κB pathway and NLRP3 inflammasome in broiler thymus. (Pubmed Central) - Dec 23, 2019
In conclusion, atmospheric HS actives the TLR-7/MyD88/NF-κB pathway and the NLRP3 inflammasome to promote an inflammatory response, which then causes tissues damage in broiler thymus. These results provide new insights for unveiling the immunotoxic effects of HS.
- | doxycycline / Generic mfg.
Journal: Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. (Pubmed Central) - Dec 23, 2019
LPS, ATP, and doxycycline play critical roles in regulating host immune responses. This evidence provides guidance for the application of tetracycline drugs for the clinical treatment of periodontal disease.
- | Journal: Eicosapentaenoic acid enriched phosphatidylcholine mitigated Aβ1-42 induced neurotoxicity via autophagy-inflammasome pathway. (Pubmed Central) - Dec 22, 2019
Further mechanism studies suggested that EPA-PC could inhibit Aβ-induced neurotoxicity by alleviating NLRP3 inflammasome activation and enhancing autophagy. These findings indicate that EPA could improve cognitive deficiency in Aβ1-42 induced AD rats via autophagic-inflammasomal pathway and the bioactivity differs in its molecular forms.
- Herceptin (trastuzumab) / Roche, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca, doxorubicin hydrochloride / Generic mfg.
[VIRTUAL] THE SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITOR DAPAGLIFLOZIN EXERTS CARDIOPROTECTIVE EFFECTS AGAINST DOXORUBICIN AND TRASTUZUMAB TOXICITY THROUGH TLR4/MYD88/NF-KB SIGNALING AND NLRP3 INFLAMMASOME PATHWAY (eAbstract Virtual Hall) - Dec 22, 2019 - Abstract #ACC2020ACC_6752;
These findings indicate that EPA could improve cognitive deficiency in Aβ1-42 induced AD rats via autophagic-inflammasomal pathway and the bioactivity differs in its molecular forms. The overall picture obtained provides the proof of concept for translational studies designed to investigate the cardioprotective use of Dapagliflozin during anticancer therapies.
- Keytruda (pembrolizumab) / Merck (MSD), Herceptin (trastuzumab) / Roche
[VIRTUAL] THE COMBINATION THERAPY OF ANTI-PD1 ANTIBODY PEMBROLIZUMAB AND ANTI-HER2 ANTIBODY TRASTUZUMAB EXERTS CARDIOTOXIC, PRO-INFLAMMATORY AND PRO-FIBROTIC PROPERTIES IN PRECLINICAL MODELS (eAbstract Virtual Hall) - Dec 22, 2019 - Abstract #ACC2020ACC_6751;
The overall picture obtained provides the proof of concept for translational studies designed to investigate the cardioprotective use of Dapagliflozin during anticancer therapies. Pembrolizumab associated to Trastuzumab leads to strong cardiac pro-inflammatory effects mediated by overexpression of Arachidonate/Leukotrienes and TLR4/MyD88/NF-κB pathways.
- | Journal: lncRNA GAS5/miR-452-5p Reduces Oxidative Stress and Pyroptosis of High-Glucose-Stimulated Renal Tubular Cells. (Pubmed Central) - Dec 22, 2019
miR-452-5p interference could cause the same changes as GAS5 overexpression for HG-induced HK-2 cells, and GAS5 inhibition could reverse the effect of miR-452-5p interference. GAS5 overexpression inhibited the inflammation, oxidative stress and pyroptosis of HG-induced renal tubular cells by downregulating the expression of miR-452-5p.
- | Journal: NLRP3 Inflammasome Mediated Interleukin-1β Production in Cancer-Associated Fibroblast Contributes to ALA-PDT for Cutaneous Squamous Cell Carcinoma. (Pubmed Central) - Dec 22, 2019
Furthermore, NLRP3-inflammasome and p-p65/p65 were elevated after ALA-PDT mediated IL1β production in cancer-associated-fibroblasts. By means of activating NLRP3-inflammasome with IL1β production in CAFs, PDT stimulates local acute-inflammatory-response, which further promotes PDT effect for cSCC.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Journal: The Abilities of Salidroside on Ameliorating Inflammation, Skewing the Imbalanced Nucleotide Oligomerization Domain-Like Receptor Family Pyrin Domain Containing 3/Autophagy, and Maintaining Intestinal Barrier Are Profitable in Colitis. (Pubmed Central) - Dec 22, 2019
Whereas, it is not known whether Sal has other protective mechanisms on dextran sulfate sodium (DSS)-induced colitis in mice...In vitro, Sal showed PPARγ-dependent anti-inflammatory effect in LPS-stimulated RAW264.7 cells. In summary, our results demonstrated that Sal might be an effective factor for UC treatment and its pharmacological value deserved further development.
- | cisplatin / Generic mfg.
Journal: Farrerol Attenuates Cisplatin-Induced Nephrotoxicity by Inhibiting the Reactive Oxygen Species-Mediated Oxidation, Inflammation, and Apoptotic Signaling Pathways. (Pubmed Central) - Dec 22, 2019
Notably, farrerol exerted slight protection in Nrf2-knockout mice compared with wild-type mice. These findings indicate that farrerol can effectively activate Nrf2 and can serve as a therapeutic target in the treatment of acute kidney injury (AKI).