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7 Companies | 6 Products |
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6 Products | |
29 Diseases | |
11 Trials |  |
763 News |  |
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- | Preclinical, Journal: Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. (Pubmed Central) - Feb 15, 2020
These results indicate that caspase-1 could amplify the plural inflammatory responses in the ICH. Administration of Ac-YVAD-cmk has the potential to be a novel therapeutic strategy for ICH.
- | TriptoSar (triptolide) / Pierre Fabre
Journal: The role of inflammasome activation in Triptolide-induced acute liver toxicity. (Pubmed Central) - Feb 15, 2020
Taken together, our results revealed that activation of inflammasome aggravated the acute liver toxicity induced by TP. Inhibition of inflammasome could serve as a novel therapeutic target for the amelioration of TP-induced hepatotoxicity.
- | Journal: Apocynin alleviates lung injury by suppressing NLRP3 inflammasome activation and NF-κB signaling in acute pancreatitis. (Pubmed Central) - Feb 15, 2020
Our findings suggest that beyond anti-oxidative effects, apocynin may also have anti-inflammatory effects by suppressing NLRP3 inflammasome activation and NF-κB signaling in acute pancreatitis. Therefore, apocynin may have therapeutic potential in the treatment of SAP and SAP-induced lung injury.
- | Journal: NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-inflammatory Response Syndromes in Mice With Acute Pancreatitis. (Pubmed Central) - Feb 15, 2020
Infiltrating macrophages promote inflammation and simultaneously induce a Th2 cell-mediated response via IL18. Inhibition of NLRP3 reduces SIRS and CARS, and might be used to treat patients with severe pancreatitis.
- | Journal: NLRP3 inflammasome mediate palmitate-induced endothelial dysfunction. (Pubmed Central) - Feb 15, 2020
Inhibition of NLRP3 reduces SIRS and CARS, and might be used to treat patients with severe pancreatitis. NLRP3 inflammasome activation via AMPKα inactivation mediated palmitate-induced endothelial dysfunction through involves IL-1β-induced insulin signal pathway.
- | Journal: Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome. (Pubmed Central) - Feb 15, 2020
NLRP3 inflammasome activation via AMPKα inactivation mediated palmitate-induced endothelial dysfunction through involves IL-1β-induced insulin signal pathway. These results proven that CpG-ODN protects against allergic airway inflammation via suppressing the activation of NLRP3 inflammasome, and such effect may be resulted from the restored-production of melatonin.
- | Preclinical, Journal: Lespedeza bicolor Extract Ameliorated Renal Inflammation by Regulation of NLRP3 Inflammasome-Associated Hyperinflammation in Type 2 Diabetic Mice. (Pubmed Central) - Feb 15, 2020
Meanwhile, a low dose of LBE supplementation up-regulated energy metabolism demonstrated by phosphorylation of adenosine monophosphate kinase (AMPK) and Sirtuin (SIRT)-1 in T2DM mice. In conclusion, the current study suggested that LBE, in particular, at a high dose could be used as a beneficial therapeutic for hyperglycemia-induced renal damage in T2DM.
- || Review, Journal: The rOX-stars of inflammation: links between the inflammasome and mitochondrial meltdown. (Pubmed Central) - Feb 15, 2020
Here, we review the features of mitochondria that drive inflammatory signalling, with a particular focus on mitochondrial activation of the NLRP3 inflammasome. Given that mitochondrial network dynamics, metabolic activity and redox state are all intricately linked to each other and to NLRP3 inflammasome activity, we highlight the importance of a holistic approach to investigations of NLRP3 activation by dysfunctional mitochondria.
- | OvaSave (ovalbumin) / Sangamo Therapeutics
Journal: Cell-Penetrating Nanoparticles Activate Inflammasome by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation and Enhance Antibody Production. (Pubmed Central) - Feb 15, 2020
Finally, we show that Au4.5 nanoparticles could function as vaccine adjuvants to markedly enhance ovalbumin (OVA)-specific antibody production in an NLRP3-dependent pattern. Our findings have provided molecular insights into size-dependent innate immune signaling activation by cell-penetrating nanoparticles, and identified LC3 as a potential regulatory target for efficient immunotherapy.
- | Decadron (dexamethasone) / Merck (MSD)
Journal: Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. (Pubmed Central) - Feb 14, 2020
Collectively, these results indicated that Suhuang contributed to impairing NLRP3 inflammasome activation via inhibition of ER stress, which was responsible for the protection of pulmonary homeostasis. These findings may provide a pharmacological groundwork and important new experimental data regarding the clinical treatment of Suhuang in CVA patients.
- | allopurinol / Generic mfg.
Preclinical, Journal: Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice. (Pubmed Central) - Feb 14, 2020
Administration with CUR (20 or 40 mg/kg) or allopurinol (ALL, 5 mg/kg) was given to mice orally one hour later after the injection of potassium oxonate (PO) (300 mg/kg, i.p.) for 14 days...Further studies showed that CUR decreased inflammatory cytokines productions (IL-1β, IL-18) in serum, as well as inhibited PO-induced the activation of NLRP3 inflammasome signaling in the kidney. In conclusion, the study revealed that CUR exhibited anti-hyperuricemic and anti-inflammatory effects through suppressing NLRP3 inflammasome activation in kidney and provided the evidence for treating hyperuricemia and associated renal inflammation.
- | Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Byetta (exenatide) / AstraZeneca
Journal: DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome. (Pubmed Central) - Feb 14, 2020
Lina and EX had similar effects on IS and post-infarction function, but Lina attenuated the activation of the inflammasome and the upregulation of collagen-1 and collagen-3 more than direct GLP-1 receptor activation. This effect depends on p38 activation with downstream upregulation of miR-146b levels that suppresses TLR4 expression.
- | Journal: The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis. (Pubmed Central) - Feb 14, 2020
This effect depends on p38 activation with downstream upregulation of miR-146b levels that suppresses TLR4 expression. Together, these data suggest XIAP-mediated inhibition of inflammasome activity in RPE may provide insights into the biological consequences of inflammasome activation in RPE and reveals the caspase-1/XIAP/IL-1β/IL-18 axis as a target for broader applications in AMD biology and treatment design.
- | Journal: Association of NLRP3 and CARD8 inflammasome polymorphisms with aseptic loosening after primary total hip arthroplasty. (Pubmed Central) - Feb 14, 2020
After adjustment for gender, age and follow-up, patients with combined wild type of both NLRP3 and CARD8 had significantly smaller odds for early implant loosening (odds ratio 0.33, p = 0.02). Investigated polymorphisms may influence several inflammatory pathways and contribute to the loosening of artificial implants with potential clinical significance for proper selection of patients and endoprostheses when planning elective total hip arthroplasty.
- | Preclinical, Journal: Blockade of the Adenosine A Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats. (Pubmed Central) - Feb 14, 2020
The effects of the A3 receptor antagonist resulted in the attenuation of kidney injury, as evidenced by decreased levels of the pro-fibrotic marker α-SMA at histological levels and the restoration of proteinuria in diabetic rats. We conclude that ADORA3 antagonism represents a potential therapeutic target that mechanistically works through the selective blockade of the NLRP3 inflammasome.
- | Clinical, Journal: Let-7f-5p ameliorates inflammation by targeting NLRP3 in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. (Pubmed Central) - Feb 14, 2020
Besides, let-7f-5p upregulation ameliorated inflammation through modulating NLRP3 in vivo. In conclusion, our study suggested that high level of let-7f-5p alleviated inflammation in SLE-BMSCs at least partly through targeting NLRP3, highlighting let-7f-5p as a novel promising therapeutic strategy for SLE treatment.
- | Kolchin (colchicine) / Incepta
Journal: Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways. (Pubmed Central) - Feb 14, 2020
In conclusion, our study suggested that high level of let-7f-5p alleviated inflammation in SLE-BMSCs at least partly through targeting NLRP3, highlighting let-7f-5p as a novel promising therapeutic strategy for SLE treatment. This study suggests that chicory extract and chicoric acid may be used as promising therapeutic agents against gout by inhibiting the NF-κB and NLRP3 signaling pathways.
- | Radicava (edaravone) / Mitsubishi Tanabe, edaravone (MT-1186) / Mitsubishi Tanabe
Preclinical, Journal: Edaravone Administration Confers Neuroprotection after Experimental Intracerebral Hemorrhage in Rats via NLRP3 Suppression. (Pubmed Central) - Feb 14, 2020
This study suggests that chicory extract and chicoric acid may be used as promising therapeutic agents against gout by inhibiting the NF-κB and NLRP3 signaling pathways. The present study demonstrated that edaravone conducted neuroprotection after ICH partially via suppressing NF-κB-dependent NLRP3 in microglia, which contributed a novel evidence for clinic usage of edaravone after ICH.
- | Journal: Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway. (Pubmed Central) - Feb 14, 2020
The present study demonstrated that edaravone conducted neuroprotection after ICH partially via suppressing NF-κB-dependent NLRP3 in microglia, which contributed a novel evidence for clinic usage of edaravone after ICH. The present study is the first evidence demonstrating that BCA attenuated Ml/R injury through suppressing TLR4/NF-kB/NLRP3 signaling pathway-mediated anti-inflammation pathway.
- | Journal: Dexmedetomidine attenuates P2X4 and NLRP3 expression in the spine of rats with diabetic neuropathic pain. (Pubmed Central) - Feb 14, 2020
The present study is the first evidence demonstrating that BCA attenuated Ml/R injury through suppressing TLR4/NF-kB/NLRP3 signaling pathway-mediated anti-inflammation pathway. The P2X4/NLRP3 signaling pathway is implicated in the development and presence of DNP in vivo, and Dex protects from this disorder.
- | Preclinical, Journal: Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats. (Pubmed Central) - Feb 13, 2020
Hydrogen inhalation can ameliorate oxidative stress related endothelial cells injury in the brain and improve neurobehavioral outcomes in rats following SAH. Mechanistically, the above beneficial effects might be related to, at least in part, the inhibition of activation of ROS/NLRP3 axis.
- || Review, Journal: Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis. (Pubmed Central) - Feb 13, 2020
Based on this, the present review summarizes recent findings in regard to NLRP3 inflammasome functions during various kidney diseases, and these findings indicate that the NLRP3 inflammasome not only mediates the inflammatory response but is also associated with pyroptosis, mitochondrial regulation, and myofibroblast differentiation during renal fibrosis. These novel findings provide us with a more in-depth understanding of the pathogenesis of renal fibrosis and will aid in the identification of new targets that can be used for the prevention and treatment of this disease.
- || Clinical, Journal, IO Biomarker: Differential expression of genes associated with T lymphocytes function in septic patients with hypoxemia challenge. (Pubmed Central) - Feb 13, 2020
Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O in an arterial blood (PaO) and fraction of inspiration O (FiO) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo. Higher illness severity and incidence of lymphopenia was observed following hypoxemia in sepsis and T cell-related gene signatures were associated with hypoxemia during sepsis.
- | Preclinical, Journal: The protective effect of Lonicera japonica polysaccharide on mice with depression by inhibiting NLRP3 inflammasome. (Pubmed Central) - Feb 13, 2020
LJP exhibited a strong protective effect on mice with depression by inhibiting NLRP3 inflammasome. The results will help to understand the potential use of Lonicera japonica Thun polysaccharide in pharmaceutical and food applications better.
- A Bioisosteric Approach to Novel NLRP3 Inflammasome Inhibitors (Exhibit Hall D, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_4015;
This bioisosteric investigation led to the discovery of a new class of small molecule NLRP3 inhibitors with improved potency and attractive lead-like characteristics. These are highly differentiated from other known NLRP3 inhibitors and offer scope for further optimisation.
- Novel ester-based NLRP3 inflammasome inhibitors (204B, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_1229;
The best compounds from this series are up to 20-fold more potent than CP-456,773 in the human whole blood assay, the most relevant for predicting human efficacy. These esters are highly differentiated from other literature NLRP3 inhibitors and have the potential for further optimisation.
- | Preclinical, Journal: Rhein Suppresses Lung Inflammatory Injury Induced by Human Respiratory Syncytial Virus Through Inhibiting NLRP3 Inflammasome Activation via NF-κB Pathway in Mice. (Pubmed Central) - Feb 13, 2020
Additionally, it was revealed that Rhein inhibited the immune inflammatory response of RSV-infected mice, which was likely to be associated with the inhibition the NLRP3 inflammasome activation via NF-κB pathway. To sum up, our results indicated that Rhein may inhibit RSV-induced pulmonary inflammatory response effectively; meanwhile, it is emphasized that Rhein therapy is likely to be a promising treatment on the RSV-infected lung inflammation and avoidance of lung tissue damage.
- || Review, Journal: RNA Sensing of Mycobacterium tuberculosis and Its Impact on TB Vaccination Strategies. (Pubmed Central) - Feb 10, 2020
The novel findings described here may change our current understanding of the host response to MTB and potentially impact clinical research, as well as future vaccination design. In this review, the current state of the art is summarized, and an outlook is given on how progress can be made.
- | mycophenolate sodium / Generic mfg.
Journal: Mycophenolic acid enhanced lipopolysaccharide-induced interleukin-18 release in THP-1 cells via activation of the NLRP3 inflammasome. (Pubmed Central) - Feb 8, 2020
Ac-YVAD-cmk or increasing extracellular K blocked the activation of caspase-1 and attenuated the release of IL-18. Taken together, MPA synergized with LPS to induce the release of IL-18 via activating the NLRP3 inflammasome and increasing the degradation of pro-IL-18, rather than by enhancing the production of pro-IL-18.
- | Tamoxis (tamoxifen) / Bioprofarma, eplerenone / Generic mfg.
Journal: Role of Angiogenesis and Chronic Inflammation in Fat Hypertrophy in NASH Pathology (Pubmed Central) - Feb 8, 2020
The selective mineralocorticoid receptor (MR) inhibitor eplerenone (Ep) suppresses chronic inflammation in fat and the liver, improves glucose and lipid metabolism, and inhibits body weight and fat mass gain in mice fed a high-fat diet...Thus, we propose novel therapeutic approaches to NASH. Inhibition of PDGF receptor-β signaling prevents AT hypertrophy by regulating AT angiogenesis, and MR inhibitors directly suppress chronic inflammation in the AT and liver.
- | Journal: The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus. (Pubmed Central) - Feb 8, 2020
In vivo infections performed in inflammasome-deficient mice indicate that NLRP3 is involved with footpad swelling, inflammation and pain, establishing a role of the NLRP3 inflammasome in the MAYV pathogenesis. Accordingly, we detected higher levels of caspase1-p20, IL-1β and IL-18 in the serum of MAYV-infected patients as compared to healthy individuals, supporting the participation of the NLRP3-inflammasome during MAYV infection in humans.
- | Biomarker, Journal: AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway. (Pubmed Central) - Feb 8, 2020
In vitro, pyroptosis, characterized by activated caspase-1 and IL-1β, was observed in hepatocytes under heat stress, which was enhanced by Ang II and attenuated by antioxidants, NOX4 siRNA, and AVE 0991. In summary, AVE 0991 attenuates pyroptosis and liver damage induced by heat stress by inhibiting the ROS-NLRP3 inflammatory signalling pathway.
- | Preclinical, Journal, IO Biomarker: Kaempferol alleviates LPS-ATP mediated inflammatory injury in splenic lymphocytes via regulation of the pyroptosis pathway in mice. (Pubmed Central) - Feb 8, 2020
Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD). Our data suggest that kaempferol exhibits anti-pyroptosis activities, which warrants further detailed investigation.
- | Reasanz (serelaxin) / Novartis
Journal: Relaxin inhibits macrophage inflammation by repressing NLRP3. (Pubmed Central) - Feb 8, 2020
Our data suggest that kaempferol exhibits anti-pyroptosis activities, which warrants further detailed investigation. No abstract available
- | Reasanz (serelaxin) / Novartis
Journal: Response to letter on "Relaxin inhibits macrophage inflammation by repressing NLRP3" by Zhou et al. (Pubmed Central) - Feb 8, 2020
No abstract available No abstract available
- || Clinical, Journal: Targeting fat browning in hypermetabolic conditions: a clinical perspective. (Pubmed Central) - Feb 8, 2020
No abstract available No abstract available
- | Journal: Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264.7 macrophages. (Pubmed Central) - Feb 7, 2020
In summary, our study demonstrates that the A. baumannii pathogen pattern recognition receptor Omp34 activates NLRP3 inflammasome via mitochondria-derived ROS in RAW264.7 cells. Accordingly, down-regulating the mitochondria-derived ROS prevents the severe infection consequences caused by A. baumannii-induced NLRP3 inflammasome hyper-activation.
- | Journal: Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. (Pubmed Central) - Feb 7, 2020
Mutations to this interface abolish the ability of NEK7 or NLRP3 to rescue NLRP3 activation in NEK7-knockout or NLRP3-knockout cells. These data suggest that NEK7 bridges adjacent NLRP3 subunits with bipartite interactions to mediate the activation of the NLRP3 inflammasome.
- | methotrexate / Generic mfg.
Journal, IO Biomarker: Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis. (Pubmed Central) - Feb 7, 2020
In conclusion, activation of NLRP3 inflammasome may represent a new mechanism for MTX nephrotoxicity. FA up-regulated PPARγ and Nrf2 signaling, prevented overproduction of ROS, and suppressed NF-κB/NLRP3 inflammasome axis and apoptosis in the kidney of MTX-induced rats.
- | Journal: Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 inflammasome inactivation in sepsis. (Pubmed Central) - Feb 7, 2020
However, the inhibitor of autophagy and the inducer of NLRP3 reversed the protective effect of H2 against organ damage, the inflammatory response and mitochondrial dysfunction in vivo and in vitro. Collectively, the results demonstrated that H2 alleviated mitochondrial dysfunction and cytokine release via autophagy‑mediated NLRP3 inflammasome inactivation.
- | Journal: Inflammasome activity in leucocytes decreases with abdominal aortic aneurysm progression. (Pubmed Central) - Feb 7, 2020
Overall, the aortic wall of AAA contained lymphocytes and macrophages with different states of activity. The present data suggested that therapeutic inhibition of specific inflammasome components might counteract AAA development and progression.
- | Journal: Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway. (Pubmed Central) - Feb 7, 2020
Finally, the apoptotic rate was found to be the highest in the CLP group and the lowest in the sham group. Taken together, in evaluating the therapeutic effect of MT on sepsis‑induced renal injury, the results of the present study showed that MT alleviated sepsis‑induced renal injury by regulating the expression of PINK1, Parkin1, NLRP3, ASC and cleaved caspase‑1 in rats.
- | bleomycin / Generic mfg., BMS
Journal: HIF‑1α promotes NLRP3 inflammasome activation in bleomycin‑induced acute lung injury. (Pubmed Central) - Feb 7, 2020
Therefore, the present study indicated that HIF‑1α could modulate the activation of the NLRP3 inflammasome and the secretion of IL‑1β through NF‑κB signaling in BLM‑induced ALI. The current results improve understanding of the mechanism of ALI and may provide new ideas for identifying therapeutic targets of ALI.
- | Decadron (dexamethasone) / Merck (MSD)
Preclinical, Journal: Comparison of the TLR4/NFκB and NLRP3 signalling pathways in major organs of the mouse after intravenous injection of lipopolysaccharide. (Pubmed Central) - Feb 7, 2020
Dexamethasone (DXM) has an anti-immunoinflammatory effect...The inflammatory damage in small and large intestines, liver and kidney was more severe than other organs. TLR4-NFκB signalling was the major response to LPS stress.
- | Pletal (cilostazol) / Otsuka
Journal: Cilostazol ameliorates high free fatty acid (FFA)-induced activation of NLRP3 inflammasome in human vascular endothelial cells. (Pubmed Central) - Feb 7, 2020
Cilostazol has potential as an already-available, well-tolerated preventive medication that may alleviate some of the adverse vascular effects of living with diabetes. The findings of the present study lay the groundwork for further research on the potential of cilostazol as a safe and effective treatment against diabetic endothelial dysfunction and vacular disease.
- | Preclinical, Journal: XingNaoJing injections protect against cerebral ischemia/reperfusion injury and alleviate blood-brain barrier disruption in rats, through an underlying mechanism of NLRP3 inflammasomes suppression. (Pubmed Central) - Feb 7, 2020
The expression of NLRP3 was inhibited after exposure of XNJ, which was associated with inhibition of the inflammatory response. In summary, XNJ could suppress NLRP3 inflammasomes and improve BBB disruption and brain damage in rats after cerebral I/R injury, which provided a beneficial insight to further explore XNJ.
- | Journal: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition. (Pubmed Central) - Feb 7, 2020
These results identify wild-type NLRP3 as the molecular target of MCC950/CRID3 and show that CAPS-related NLRP3 mutants escape efficient MCC950/CRID3 inhibition. Collectively, this work suggests that MCC950/CRID3-based therapies may effectively treat inflammation driven by wild-type NLRP3 but not CAPS-associated mutants.
- Inhibition of NLRP3 inflammasome derived interleukin 1β during normothermic machine perfusion of human kidneys (Studio) - Feb 7, 2020 - Abstract #BTSCongress2020BTS_71;
- metformin / Generic mfg.
Metformin Ameliorate Nutrient Excess-Induced Cytosolic Escape of Mitochondrial Double Stranded RNA in a Cellular Model of Type 2 Diabetes (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_3049;
We infer that genetic predisposition to T2DM may be involved in altered mitochondrial restrictive mechanism. Mitochondria are the main subcellular targets of metformin.
- azathioprine orodispersible / Generic mfg.
Whole Exome Sequencing Identifies Several Variants Associated with Immune Deficiency, Inflammasomopathy and Non-Ischemic Dilated Cardiomyopathy in a Complex Case of Acquired Generalized Lipodystrophy (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_1623;
As we are yet beginning to understand the molecular mechanisms behind the so-called "acquired fat loss" and its relation to inflammatory and complex immune system diseases, further efforts are critical to better recognize different AGL phenotypes and phenotype-genotype correlations. Additional efforts should be placed on WES for AGL patients and functional validation of identified VUSs.