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7 Companies | 6 Products |
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29 Diseases | |
11 Trials |  |
763 News |  |
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- | Journal: Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise. (Pubmed Central) - Mar 24, 2020
In addition, aerobic exercise downregulated the overexpression of proinflammatory cytokines and NLRP3 inflammasome components and balanced the mitochondrial biogenesis and autophagy-lysosomal system. Thus, we observed that aerobic exercise may ameliorate CKD-induced muscle wasting by improving mitochondrial dysfunction, inflammation, and autophagy-lysosomal system in uremic cachexia.
- | Journal: Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice. (Pubmed Central) - Mar 24, 2020
Thus, we observed that aerobic exercise may ameliorate CKD-induced muscle wasting by improving mitochondrial dysfunction, inflammation, and autophagy-lysosomal system in uremic cachexia. This study demonstrated that AS-IV treatment has an effective therapeutic function of GDM in mice model through the inhibition of NLRP3 inflammasome in the pancreas.
- | ONL1204 / ONL Therap
Preclinical, Journal, IO Biomarker: A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma. (Pubmed Central) - Mar 24, 2020
These results serve as proof-of-principal that the small peptide inhibitor of the Fas receptor, ONL1204, can provide robust neuroprotection in an inducible mouse model of glaucoma, even when administered after IOP elevation. Moreover, Fas signaling contributes to the pathogenesis of glaucoma through activation of both apoptotic and inflammatory pathways.
- | Preclinical, Journal: Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes. (Pubmed Central) - Mar 24, 2020
In summary, these results uncovered that loganin inhibits NF-κB signaling and attenuates cartilage matrix catabolism and pyroptosis of chondrocytes in articular cartilage. Loganin may serve as a potential therapeutic agent for OA treatment.
- | Journal: Inhibition of Synovial Macrophage Pyroptosis Alleviates Synovitis and Fibrosis in Knee Osteoarthritis. (Pubmed Central) - Mar 24, 2020
In addition, the level of fibrotic markers in synovial fibroblasts were significantly decreased after coculture with siRNA GSDMD-transfected macrophages. To conclude, synovial macrophage pyroptosis may occur in the pathological processes of KOA and inhibition of synovial macrophage pyroptosis alleviates synovitis and fibrosis in KOA model rats.
- | Journal: Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny. (Pubmed Central) - Mar 24, 2020
Furthermore, splenocytes stimulated with LPS in vitro exhibited exacerbated inflammatory cytokine responses, which were even more prominent in F2 than F1; this effect could be ascribed to NLRP3 inflammasome hyperactivity in F1 but not F2. Current data illustrates that parental chronic inflammation may mediate the inflammatory profile in offspring, potentially propagating a maladapted proinflammatory phenotype in subsequent generations.
- | Journal: Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism. (Pubmed Central) - Mar 24, 2020
CONCLUSIONS Our findings revealed that uric acid induces inflammation through NLRP3-inflammasome-mediated VSMC proliferation. NLRP3 may be a new therapeutic target for hypertension.
- | methamphetamine / Generic mfg.
Journal: Methamphetamine Induces Intestinal Inflammatory Injury via Nod-Like Receptor 3 Protein (NLRP3) Inflammasome Overexpression In Vitro and In Vivo. (Pubmed Central) - Mar 24, 2020
CONCLUSIONS METH, in addition to being a confirmed neurotoxic drug, can also cause severe intestinal inflammatory injury via NLRP3 inflammasome overexpression. NF-kappaB may be an activator of the NLRP3 inflammasome in METH intestinal inflammatory injury.
- | Journal: Zinc promotes functional recovery after spinal cord injury by activating Nrf2/HO-1 defense pathway and inhibiting inflammation of NLRP3 in nerve cells. (Pubmed Central) - Mar 24, 2020
Potential mechanisms may include activation of the Nrf 2/Ho-1 pathway to inhibit nlrp3 inflammation following spinal cord injury. Zinc has the potential to treat SCI.
- | Journal: Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation. (Pubmed Central) - Mar 24, 2020
Moreover, AMPK may play a role in Nrf2/HO-1 signalling by resveratrol. These results expand our understanding of the myocardial protective mechanism of resveratrol during CIH and suggest that resveratrol treatment may be useful to counteract OSA-associated cardiac injury.
- | Journal: Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage. (Pubmed Central) - Mar 24, 2020
These results expand our understanding of the myocardial protective mechanism of resveratrol during CIH and suggest that resveratrol treatment may be useful to counteract OSA-associated cardiac injury. These in vitro and in vivo studies indicate that T-Exo attenuates inflammatory damage caused by ALF and promotes liver tissue repair by inhibiting the activation of the NLRP3 pathway.
- | Journal: Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human Monocytes. (Pubmed Central) - Mar 22, 2020
These in vitro and in vivo studies indicate that T-Exo attenuates inflammatory damage caused by ALF and promotes liver tissue repair by inhibiting the activation of the NLRP3 pathway. Measures of NLRP3 activation increased when blood β-OHB was elevated using ketone supplements, suggesting that increasing β-OHB exogenously may have unintended effects that augment inflammatory activation.
- | Journal: Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis. (Pubmed Central) - Mar 21, 2020
This study demonstrates that BBR's inhibitory effect on NLRP3 inflammasome activation and pyroptosis may be mediated by ROS/TXNIP axis in vitro for the first time. Our findings suggest BBR is a potential candidate for the treatment of NASH.
- || Review, Journal: Genetic Hearing Loss Associated With Autoinflammation. (Pubmed Central) - Mar 21, 2020
The macrophage/monocyte-like cells in the cochlea were also found to be associated with hearing loss in a Slc26a4-insufficient mouse model of human deafness. This review addresses our understanding of genetic hearing loss mediated by autoinflammation and macrophage/monocyte-like cells in the cochlea.
- || Review, Journal: NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis. (Pubmed Central) - Mar 21, 2020
The differences and similarities between these molecular complexes that monitor cellular health, inflammation, and skin carcinogenesis are also highlighted. Despite numerous scientific data, more studies are still required to better understand the biology of inflammasomes in skin cancer development and to explore their therapeutic potential.
- | Journal: Estrogen deficiency aggravates apical periodontitis by regulating NLRP3/caspase-1/IL-1β axis. (Pubmed Central) - Mar 21, 2020
Thus, taken all these data together, our results demonstrated that the NLRP3/Caspase-1/IL-1β signaling pathway is involved in the estrogen-mediated apical periodontitis and the consequent bone loss in both human being and animal model. This study may provide a potential target for female apical periodontitis therapy.
- | metformin / Generic mfg.
Journal: Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis. (Pubmed Central) - Mar 21, 2020
These results indicate that metformin administration prevented psoriasis development in vivo. Collectively, our findings suggest that metformin-mediated anti-psoriatic effects on the skin have the potential for treating psoriasis in T2DM patients.
- | Journal, BRCA Biomarker: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. (Pubmed Central) - Mar 21, 2020
It is further shown that inflammasome inhibition can prevent tumor recurrence and metastasis. This study uncovers an important role of BRCA1 in regulating mitophagy and suggests a therapeutic approach for fighting this deadly disease.
- | Preclinical, Journal: MCC950, a Selective Inhibitor of NLRP3 Inflammasome, Reduces the Inflammatory Response and Improves Neurological Outcomes in Mice Model of Spinal Cord Injury. (Pubmed Central) - Mar 21, 2020
In conclusion, our findings indicate that MCC950 alleviates inflammatory response and improves functional recovery in the acute mice model of SCI by blocking NLRP3 inflammasome assembly and alleviating downstream neuroinflammation. Therefore, these findings could prove useful in the development of effective therapeutic strategies for the treatment and prognosis of SCI.
- | arecoline / Cogent
Journal: Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation. (Pubmed Central) - Mar 20, 2020
Ang-(1-7) shifted the balance of RAS toward the ACE2/Ang-(1-7)/Mas axis, inhibited arecoline-induced ROS and NLRP3 inflammasome activation, leading to attenuation of migration or collagen synthesis. In summary, Ang-(1-7) attenuates arecoline-induced migration and collagen synthesis via inhibiting NLRP3 inflammasome in human oral myofibroblasts.
- | Preclinical, Journal: Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model. (Pubmed Central) - Mar 20, 2020
Altogether, these data provide a novel link between gluconic metabolism reprogramming and uncontrolled inflammatory response in ALI. This study suggests glycolytic inhibition as an effective anti-inflammatory strategy in treating ALI.
- | Journal: Proteomic profiling of LPS-induced macrophage derived exosomes indicates their involvement in acute liver injury. (Pubmed Central) - Mar 20, 2020
Therefore, the iTRAQ proteomic strategy brought new insights into macrophages derived exosomes. It may improve our understanding of macrophages-exosomes' functions and their possible use as therapeutic targets for sepsis.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Journal: Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling. (Pubmed Central) - Mar 19, 2020
In addition, TSN maintained intestinal barrier by regulating zonula occludens-1 (ZO-1) and occludin expression. In conclusion, our findings demonstrated that, TSN alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis.
- | Preclinical, Journal: Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice. (Pubmed Central) - Mar 19, 2020
In conclusion, α-Cyperone showed the protective effect on LPS-induced ALI in mice by suppressing the NF-κB and NLRP3 signaling pathways, mainly via up-regulating SIRT1. This provides a potential drug for the treatment of LPS-induced ALI.
- | Preclinical, Journal: Vibrio vulnificus cytolysin induces inflammatory responses in RAW264.7 macrophages through calcium signaling and causes inflammation in vivo. (Pubmed Central) - Mar 19, 2020
Histology data also showed that VVC caused inflammatory responses in the skin of mice. Collectively, our findings indicated that VVC induced inflammatory responses in RAW264.7 macrophages and in vivo and suggested the possibility of targeting VVC as a strategy for the clinical management of V. vulnificus-induced inflammatory responses.
- | Legalon (silibinin) / Mylan
Journal: Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion. (Pubmed Central) - Mar 19, 2020
Repression of ROS contributes to the inhibition of the expression of NLRP3, caspase-1 and IL-β proteins as well as of cell migration. Taken together, our study provides evidence that silibinin impairs mitochondrial dynamics and biogenesis, resulting in reduced migration and invasion of the MDA-MB-231 breast cancer cells.
- | Review, Journal: The modulatory role of dopamine receptors in brain neuroinflammation. (Pubmed Central) - Mar 19, 2020
This review briefly outlined the functions and signaling pathways of DA receptor subtypes as well as its role in inflammation-related glial cells, and subsequently summarized the mechanisms of DA receptors affecting neuroinflammation. Meaningfully, this article provided a theoretical basis for drug development targeting DA receptors in inflammation-related brain diseases.
- | methamphetamine / Generic mfg.
Journal: Postmortem Study of Molecular and Histological Changes in the CA1 Hippocampal Region of Chronic Methamphetamine User. (Pubmed Central) - Mar 19, 2020
The prominent role of TLR4, IL1B, CASP1, and NLRP3 in the molecular mechanism of Meth was highlighted via PPI network analysis. Chronic Meth use can induce GFAP and Iba-1 upregulation and neuronal apoptosis in the CA1 region of the postmortem hippocampus.
- || Older people have a higher inflammatory state, perhaps driven by the NLRP3 inflammasome. Bats suppress the NLRP3 inflammasome, tolerate the virus, and live longer. (Twitter) - Mar 18, 2020
- | Journal: Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome. (Pubmed Central) - Mar 18, 2020
As a proof of principle, in this study, we purified a known compound, propolin G, from TGP and identified this compound as a potential inhibitor of the NLRP3 inflammasome. Our results indicated that TGP might be useful for ameliorating gouty inflammation via inhibition of the NLRP3 inflammasome.
- | Istodax (romidepsin) / Astellas, BMS
Journal: Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression. (Pubmed Central) - Mar 18, 2020
Inhibiting the proteasome therefore reversed the cytokine-suppressive effects of romidepsin. HDAC1/2 dual inhibition could therefore be a highly potent new treatment option for acute gout, although safety has to be determined in vivo.
- | atorvastatin / Generic mfg.
Journal: Statins Promote IL-1β-Dependent Adipocyte Insulin Resistance via Lower Prenylation not Cholesterol. (Pubmed Central) - Mar 18, 2020
Atorvastatin (Lipitor) impaired insulin signaling in adipose tissue from wild-type and IL-18 mice, but not IL-1β mice...Our results show that statin lowering of prenylation isoprenoids activate caspase-1/IL-1β inflammasome responses that impair endocrine control of adipocyte lipogenesis. This may allow targeting of cholesterol-independent statin side-effects on adipose lipid handling without compromising the blood lipid/cholesterol lowering effects of statins.
- | Journal: Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation. (Pubmed Central) - Mar 18, 2020
Together, the data suggested G-ELNs as new potent agents that block NLRP3 inflammasome assembly and activation. The unique features of G-ELNs including biomolecule protection and tissue bioavailability should facilitate the development of G-ELN-based therapy to target the NLRP3 inflammasome in the disease settings.
- | metformin / Generic mfg.
Journal: Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. (Pubmed Central) - Mar 18, 2020
Mechanistically, our results demonstrated that metformin can activate AMPK, thus improving autophagy via inhibiting the mTOR pathway and alleviating pyroptosis in DCM. Thus, we provide novel information for the treatment of DCM.
- | Trulicity (dulaglutide) / Eli Lilly
Journal: Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation. (Pubmed Central) - Mar 18, 2020
Mechanistically, our findings indicate that SIRT1 was involved in this process by showing that knockdown of SIRT1 by transfection with SIRT1 siRNA abolished the inhibitory effects of dulaglutide on IL-1β and IL-18 secretion via suppression of NLRP3, ASC, and p10. These data suggest that dulaglutide might serve as a potential drug for the treatment of cardiovascular complications in T2DM patients.
- | Review, Journal, IO Biomarker: The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms. (Pubmed Central) - Mar 18, 2020
Finally, we focus on the consequences of inflammatory responses, in particular, the effect of TNF-α, IL-1β and IL-6 on insulin resistance. Due to the high importance of macrophages and the production of proinflammatory cytokines by them, this work mainly focuses on these cells.
- | Preclinical, Journal: Transplantation of Lymphocytes Co-Cultured with Human Cord Blood-Derived Multipotent Stem Cells Attenuates Inflammasome Activity in Ischemic Stroke. (Pubmed Central) - Mar 17, 2020
The co-cultured cells significantly decreased the number of tMCAO-induced cell apoptosis. Lymphocytes co-cultured with HCB-SCs exhibit a neuroprotective effect after ischemic stroke by promoting Tregs differentiation and suppressing NLRP3 inflammasome activation and neuron apoptosis, and might be a promising therapeutic strategy for ischemic stroke.
- | Journal: Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome. (Pubmed Central) - Mar 17, 2020
The second step was independent of the inflammasome; however, its mechanism remains unknown. This study sets the foundation for better understanding the immunological consequences of inflammasome activation by a new leukocidin class of toxins, which may be shared between marine bacteria and give rise to new pathogenic isolates.
- || Review, Journal: The role of NLRP3 inflammasome in infection-related, immune-mediated and autoimmune skin diseases. (Pubmed Central) - Mar 17, 2020
With the in-depth research, targeting NLRP3 inflammasome and its downstream signaling will provide new insights into the development of future therapeutic strategies. In this review, we summarize the molecular mechanism of NLRP3 inflammasome activation as well as the current knowledge on the contribution of the NLRP3 inflammasome in infection-related, immune-mediated and autoimmune skin diseases.
- || Review, Journal: Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical Pathways. (Pubmed Central) - Mar 17, 2020
Several studies have showed that inflammasomes are closely related to kidney diseases, especially the NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome, which play a role in regulating kidney inflammation and fibrosis. In this review, we focus on the relationship between inflammasomes and kidney diseases, especially the role of the NLRP3 inflammasome in different kinds of kidney disease via both canonical and non-canonical signal pathways.
- TREK-1 Activation Is Required for Inflammasome Activity Through Augmentation of Macrophage Membrane Polarization (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_10114;
In this review, we focus on the relationship between inflammasomes and kidney diseases, especially the role of the NLRP3 inflammasome in different kinds of kidney disease via both canonical and non-canonical signal pathways. Our results suggest that TREK-1 is important in regulating macrophage membrane potential, and may be important in regulating potassium-efflux associated with inflammasome activity.
- IL-1β Suppresses Prevents Type 2 Inflammation, ILC2 Expansion and Asthma Phenotype Development Following Early Life Rhinovirus Infection by Suppressing Epithelial Cell Innate Cytokine Expression (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_9077;
RV infection induces inflammasome priming and activation in subepithelial and luminal macrophages. IL1RA amplifies RV-induced ILC2 expansion and mucous metaplasia, and IL-1β suppresses it, at least in part by decreasing epithelial cell innate cytokine expression.
- Heightened ER Stress in Aged Lung Contributes to Dysregulated NLRP3 Inflammasome Activation During Influenza (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_9064;
IL1RA amplifies RV-induced ILC2 expansion and mucous metaplasia, and IL-1β suppresses it, at least in part by decreasing epithelial cell innate cytokine expression. Data from this study provide new evidence as to why older persons are more susceptible to influenza and provide a possible therapeutic target to decrease morbidity and mortality in this population.
- Innate Immunity of SP-A Was Involved in the Regulation of Both Acute Lung and Kidney Injuries in Pneumonia-Induced Sepsis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area K) - Mar 15, 2020 - Abstract #ATS2020ATS_9056;
SP-A is involved in the regulation of both ALI and AKI in the sepsis through modulating renal apoptosis,pyrotosis and inflammation activation. Supported by NIH R01HL136706
- Evidence for Metabolic Reprogramming of Circulating Neutrophils in Gram-Negative Bacteremic Sepsis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area K) - Mar 15, 2020 - Abstract #ATS2020ATS_9054;
Metabolic intermediates may have a role as biomarkers in GNS. The NLRP3 inflammasome is the dominant processor of IL-1β in human neutrophils, is induced by LPS, and does not require a second signal in these cells.
- Lipopolysaccharide Causes the Metabolic Flux to Glycolysis and Induces NLRP3 Inflammasome Activation and RIPK3-Mediated Necroptosis in the Lung (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area D) - Mar 15, 2020 - Abstract #ATS2020ATS_8607;
The NLRP3 inflammasome is the dominant processor of IL-1β in human neutrophils, is induced by LPS, and does not require a second signal in these cells. Our findings indicate that LPS leads to altered metabolic flux to glycolysis in lung endothelium, which exacerbates lung ECs necroptosis and NLRP3-mediated inflammasome activation to aggravate lung inflammation and pulmonary vascular injury.This abstract is funded by CURE Grant No: 4100083087
- Contrasting Effects of Stored Allogeneic Red Blood Cells and Their Supernatants on Permeability and Inflammatory Responses in Human Pulmonary Endothelial Cells (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area D) - Mar 15, 2020 - Abstract #ATS2020ATS_8593;
RBC supernatants augmented LPS- and TNFα-induced EC inflammation reflected by increased production of IL-6, IL-8 and soluble ICAM1. CONCLUSIONS These findings demonstrate the deleterious effects of RBC supernatants on EC function which may have a major impact in pathological consequences associated with RBC transfusion.
- Trim20/Pyrin Regulates Microparticulate Active GasderminD Mediated Cell Injury in Septic Patients (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area D) - Mar 15, 2020 - Abstract #ATS2020ATS_8578;
Our current work provides evidence that activation of RhoA leads to PKN-mediated phosphorylation - dependent pyrin inhibition. Furthermore, this work is the first documentation of pyrin phosphorylation and its inactivation in pro-inflammatory outcomes and microparticulate inflammasome activation in a physiological disease setting.
- Exosomes Containing GBP2 in Macrophage Induced by Lipopolysaccharide Activate NLRP3 Inflammasome to Mediate the Pyroptosis of Alveolar Type II Cell: A New Mechanism of ALI (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area D) - Mar 15, 2020 - Abstract #ATS2020ATS_8574;
At the same time, GBP2 directly interacted with NLRP3 inflammasome through in immunoprecipitation.3.Ang(1-7) could down-regulate the level of GBP2 in exosomes from LPS-induced RAW264.7 and the activation of NLRP3 inflammasome and GSDMD in MLE-12 and mice. Conclusions LPS-induced and GBP2 enriched exosomes from RAW264.7 triggers pyroptosis via activating NLRP3 inflammasome involved in ALI, Ang(1-7) could supressed the above mentioned changes by decreasing the levels of GBP2 in exosomes.
- Melatonin Alleviates Radiation-Induced Lung Injury Via Regulation of Microrna-30e/NLRP3 Axis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area D) - Mar 15, 2020 - Abstract #ATS2020ATS_8563;
Meanwhile, melatonin exerted its protective effect through negatively regulating the NLRP3 inflammasome in macrophages. The melatonin-mediated miR-30e/NLRP3 signaling may provide novel therapeutic targets for radiation-induced injury.