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- | Journal: Inhibition of the NLRP3 inflammasome reduces brain edema and regulates the distribution of aquaporin-4 after cerebral ischaemia-reperfusion. (Pubmed Central) - May 6, 2020
The NLRP3 inflammasome facilitated brain edema and BBB disruption after cerebral ischaemia-reperfusion in mice, and NLRP3 inflammasome inhibition with MCC950 regulated the expression and distribution of AQP4 in the infarct area. Hence, the NLRP3 inflammasome is considered to be an important target for the treatment of brain edema in cerebral ischaemia-reperfusion, and MCC950 has potential value for ischaemic stroke treatment.
- | cordycepin (OVI-123) / OncoVista
Biomarker, Journal: Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK. (Pubmed Central) - May 6, 2020
Mechanistically, CRD was also revealed to activate activated protein kinase (AMPK) and attenuated inflammation both in vivo and in vitro. On the whole, this study indicated that CRD protects mice from pancreatic inflammatory process and damage by suppressed NF-κB and NLRP3 inflammasome activation via AMPK, which probably contributed to the potential therapy for AP.
- | Biomarker, Journal: NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis. (Pubmed Central) - May 6, 2020
On the whole, this study indicated that CRD protects mice from pancreatic inflammatory process and damage by suppressed NF-κB and NLRP3 inflammasome activation via AMPK, which probably contributed to the potential therapy for AP. No abstract available
- | belnacasan (VX-765) / Vertex
Journal: GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition. (Pubmed Central) - May 4, 2020
Moreover, incomplete pyroptosis accompanied by IL-1α release is observed under the pharmacological inhibition of caspase-1 with VX765. These findings suggest that caspase-1 inhibition during NLRP3 inflammasome activation modulates forms of cell death and permits the release of IL-1α from dying cells.
- || SGLT2 inhibitor attenuates NLRP3 inflammasome activation, which might help to explain its cardi- oprotective effects ⚠️DM➡️Inflation➡️CVdisease 📂https://t.co/ynMXvM0vY9 @nature @secardiologia (Twitter) - May 4, 2020
- Decadron (dexamethasone) / Merck (MSD)
RIP3 BLOCKADE DRIVES MYELOID-DERIVED SUPPRESSOR CELLS-MEDIATED IMMUNE TOLERANCE IN AUTOIMMUNE HEPATITIS () - May 4, 2020 - Abstract #DDW2020DDW_7117;
RIP3 inhibition ameliorates liver inflammation and protects immune hepatitis through a mechanism mediated by CD11b+Gr1+ MDSCs with immunoregulatory properties. Targeting RIP3 kinase may hold a new therapeutic potential in treating AIH
- CAUSAL INFERENCE ANALYSIS OF THE TRANSCRIPTOME IDENTIFIED DIFFERENTIAL INNATE IMMUNITY AND INFLAMMATORY PATHWAY BETWEEN CROHN'S DISEASE AND ULCERATIVE COLITIS () - May 4, 2020 - Abstract #DDW2020DDW_6708;
Our results suggested that CD is more active in innate immunity and inflammatory responses than UC. Our findings also identified potential markers to distinguish CD from UC, and may serve as potential therapeutic targets for CD
- THE THERAPEUTIC EFFECT AND RELATED MECHANISM OF LACTIC ACID ON ULVERATIVE COLITIS BY REGULATING PYROPTOSIS () - May 4, 2020 - Abstract #DDW2020DDW_6469;
Furtherly, we found lactic acid transported by MCT1 can regulate cell polarization and non-classical pyroptosis pathways to treat UC. Therefore, lactic acid probiotics might be a potential therapeutic agent for the treatment of UC
- colchicine / Generic mfg.
EFFECT OF COLCHICINE TREATMENT ON SEVERE NSAID-INDUCED SMALL INTESTINAL DAMAGE: A PILOT STUDY () - May 4, 2020 - Abstract #DDW2020DDW_5455;
Colchicine treatment results in a high rate of complete healing of severe NSAID-induced small intestinal lesions. A randomized, placebo-controlled trial to verify the effects of colchicine on NSAID-induced small intestinal damage is warranted.
- GLYCINE PROTECTS FROM TLR4 AND NLRP3 INFLAMMASOME DEPENDENT HEPATITIS () - May 4, 2020 - Abstract #DDW2020DDW_3802;
Glycine suppress TLR4 and NLRP3 mediated pro-inflammatory signaling. This has identified a new area of immune regulation associated by metabolites that may be relevant in a diverse range of conditions, including nonalcoholic steatohepatitis, alcoholic hepatitis and total parenteral nutrition-induced immune suppression
- | Preclinical, Journal, IO Biomarker: In Vitro Anti-Inflammatory Effects of Phenolic Compounds from Moraiolo Virgin Olive Oil (MVOO) in Brain Cells via Regulating the TLR4/NLRP3 Axis. (Pubmed Central) - May 2, 2020
Finally, we showed protective effect of MVOO-PE in a transwell neuron-microglia co-culture system. In conclusion, these results suggest that MVOO-PE could exerts anti-inflammatory activity on brain cells and become a promising candidate for preventing several neuroinflammatory diseases.
- [VIRTUAL] Prostatic enlargement and chronic inflammation in association with downregulation of SQSTM1/p62 in high fat diet induced obesity rat model () - May 2, 2020 - Abstract #EAUI2020EAU-I_1498;
High fat diet obesity model demonstrated not only bladder over activity as evidenced by decreased single voided volume but also downregulation of SQSTM1/p62 in the prostate in association with prostatic enlargement with chronic inflammation as evidenced by upregulation of inflammatory cytokines and histological inflammatory findings. Therefore downregulation of SQSTM1/p62 could be an important factor that could cause chronic prostatic inflammation leading to bladder symptoms in BPH patients.
- [VIRTUAL] Inflammatory gene expression signature in mouse models of obstructive and neurogenic bladder dysfunction () - May 2, 2020 - Abstract #EAUI2020EAU-I_900;
This goes along with specifically upregulated RNAs involved in the inflammatory response. EAE mice with established neuroinflammatory symptoms show signs of inflammation and hypoxia in the bladder.
- || A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti–PD-1 immunotherapy https://t.co/LOYAmu1vfa (Twitter) - May 1, 2020
- | Preclinical, Journal: Schwann cell transplantation exerts neuroprotective roles in rat model of spinal cord injury by combating inflammasome activation and improving motor recovery and remyelination. (Pubmed Central) - May 1, 2020
Motor deficits in the hind limb, neuronal cell death and demyelination were also found in the SCI group, which were counteracted in the treatment group. From our findings we conclude promising role for cell therapy with SCs for targeting axonal demyelination and degeneration possibly through attenuation of the activity for inflammasome complexes and related inflammatory circuit.
- | Journal, IO Biomarker: Implications of EET in renal ischemia/reperfusion by regulating NLRP3 expression and pyroptosis (Pubmed Central) - May 1, 2020
Besides, the co-administration of TAK242 and EET analog could even markedly reduced the expression levels of each proteins than those in I/R group and I/R with EET group (all P<0.001). EET exerts a protective effect on attenuating renal I/R injury possibly through inhibiting TLR4 pathway to regulate the activation of NLRP3-induced pyroptosis.
- | Journal: The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development. (Pubmed Central) - May 1, 2020
Furthermore, deletion of the Zα2 domain of ZBP1 was sufficient to rescue Ripk1 mice from the perinatal lethality which is caused by ZBP1-driven cell death and inflammation. Our findings identify the essential role of the Zα2 domain of ZBP1 in several physiological functions and establish a link between Z-RNA sensing via the Zα2 domain and the promotion of influenza-induced PANoptosis and perinatal lethality.
- || Review, Journal: A review on myricetin as a potential therapeutic candidate for cancer prevention. (Pubmed Central) - May 1, 2020
This comprehensive review represents the effect of myricetin on various hallmarks of cancer with insight into the molecular mechanism employed by myricetin to mitigate cell proliferation, angiogenesis, metastasis, and induce apoptosis. In addition, enhanced bioavailability of myricetin through conjugation and its increased efficacy as an anticancer agent when used in combination are also highlighted.
- | Review, Journal: Omnipresence of inflammasome activities in inflammatory bone diseases. (Pubmed Central) - Apr 30, 2020
Thus, while acute inflammation is important for the maintenance of bone integrity, its chronic state damages this tissue. In this review, we discuss the role of the inflammasomes in inflammation-induced osteolysis.
- | low molecular weight dextran sulfate (ILB) / TikoMed, Tecfidera (dimethyl fumarate) / Biogen
Journal: Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. (Pubmed Central) - Apr 30, 2020
In addition, protein expression of the inflammatory mediator, COX-2, was reduced by DMF administration. Our results suggest that DMF alleviates DSS-induced colonic inflammatory damage, likely via up-regulating GCLC and GPX and down-regulating COX-2 protein expression in colonic tissue.
- | Preclinical, Journal: The role of activated NLRP3 inflammatory body in acute kidney injury in rats caused by sepsis and NLRP3-TXNIP signaling pathway. (Pubmed Central) - Apr 30, 2020
Activation of NLRP3 inflammatory corpuscles could promote AKI induced by sepsis. Simultaneously, renal injury may lead to the production of mitochondrial reactive oxygen species (mROS), which may induce the binding of TXNIP to NLRP3.
- bleomycin / Generic mfg., BMS
[VIRTUAL] The role of HIF-1α in regulating NLRP3 inflammasome activation in bladder cancer. () - Apr 29, 2020 - Abstract #ASCO2020ASCO_4309;
Collectively, these results suggest that targeting NLRP3 inflammasome might offer potential to treat hypoxic malignant tumor in bladder carcinoma. Research Funding: Ministry of Science and Technology, Taiwan
- | Adomet (S-adenosyl-L-methionine) / Abbott
Journal: Purine Release, Metabolism, and Signaling in the Inflammatory Response. (Pubmed Central) - Apr 29, 2020
Expected final online publication date for the Annual Review of Immunology Volume 37 is April 26, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
- | Journal: Dietary modulation of energy homoeostasis and metabolic-inflammation. (Pubmed Central) - Apr 29, 2020
Whilst metabolic-inflammation is a critical biological interaction, there is a paucity of data in relation to the nature and the extent to which nutritional status affects metabolic-inflammation. The complex paradigm will be discussed within the context of if/how dietary components, in particular fatty acids, may modulate obesity, T2D and CVD risk, via inflammatory and metabolic processes.
- | Journal: NLRP3 inflammasome activation in platelets in response to sepsis. (Pubmed Central) - Apr 29, 2020
NLRP3 is activated in platelets in response to CLP and is associated with inflammation, endothelial permeability and multiorgan injury. Our results indicate that activated platelets may play a role to cause multiorgan injury in sepsis and may have therapeutic potential for the treatment of sepsis multiorgan injury.
- Erivedge (vismodegib) / Roche
Hedgehog Signaling Selectively Assembles NLRP3 Inflammasomes in ZFYVE21hi T Peripheral Helper Cells During Ischemia Reperfusion Injury () - Apr 29, 2020 - Abstract #FOCIS2020FOCIS_96;
Sera from DGF patients containing high levels of Hedgehog ligands moreover potentiated ZFYVE21, IL-18, and TPH cell activation, and these effects were reversed with vismodegib, an FDA-approved Hedgehog signal antagonist. Hedgehog ligands released by endothelial cells following IRI expand alloimmune ZFYVE21hi T peripheral helper cells to promote dnDSA and its related vascular pathologies.
- | Journal: Exposure of DBP in gestation induces inflammation of testicular Sertoli cells in progeny by activating NLRP3 inflammasomes. (Pubmed Central) - Apr 28, 2020
Further, we confirmed that the activation of the NLRP3/caspase-1/IL-1β canonical inflammasome pathway induced secretion of inflammatory factors of SCs and immune response, and INF39 (an inhibitor of NLRP3) could inhibit the inflammation in vitro. Collectively, these findings indicated that NLRP3 inflammasomes played key roles in DBP-induced inflammation in testicular SCs.
- | Journal: A promiscuous inflammasome sparks replication of a common tumor virus. (Pubmed Central) - Apr 28, 2020
As a result, only TXNIPKAP1 cells, that is, in a primed/prolytic state, turn expression of the replication/lytic/reactivation switch protein on to enter the replicative phase. Our findings 1) demonstrate that EBV dovetails its escape strategy to a key cellular danger-sensing mechanism, 2) indicate that transcription may be regulated by KAP1 abundance aside from canonical regulation through its posttranslational modification, 3) mechanistically link diabetes, which frequently activates the NLRP3 inflammasome, to deregulation of a tumor virus, and 4) demonstrate that B lymphocytes from NOMID (neonatal onset multisystem inflammatory disease) patients who have NLRP3 mutations and suffer from hyperactive innate responses are defective in controlling a herpesvirus.
- | Journal: Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome. (Pubmed Central) - Apr 28, 2020
NHE mediates killing of cells from multiple lineages and hosts, highlighting a versatile functional repertoire in different host species. These data indicate that NHE and HBL operate synergistically to induce inflammation and show that multiple virulence factors from the same pathogen with conserved function and mechanism of action can be exploited for sensing by a single inflammasome.
- | Journal: Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries. (Pubmed Central) - Apr 28, 2020
Aging markedly increased the expression of genes encoding oxidative stress factors and NLRP3 inflammasome components, but the expression of these genes was significantly reduced by KRGSF treatment. Thus, the reduction in ovarian health with age is associated with greater oxidative stress response and inflammation, but KRGSF treatment may limit these age-related changes.
- | Journal: Low-Dose Radiation Therapy Promotes Radiation Pneumonitis by Activating NLRP3 Inflammasome. (Pubmed Central) - Apr 28, 2020
The inhibition or deletion of NLRP3 can specifically alleviate the mouse lung inflammation caused by radiation and LPS treatment. This study reveals the mechanism of low-dose radiation therapy-induced RP; furthermore, it offers a possible treatment strategy for patients.
- | Journal: Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model. (Pubmed Central) - Apr 28, 2020
A significant (34%; p < 0.01) decrease in epithelial SPHK2 was also noted at mucus obstruction sites. These results support that mucus obstruction may enhance NLRP3 inflammasome activation and dysregulated S1P signaling.
- | Actemra IV (tocilizumab) / Roche, JW Pharma
Journal: Periodic fever: From Still's disease to Muckle-Wells syndrome. (Pubmed Central) - Apr 27, 2020
In this case, the first-line therapy, anti-interleukin 1 (IL-1), failed to control the disease. Nevertheless, the IL-6 inhibitor, tocilizumab, proved effective, achieving the total remission of nephrotic syndrome associated with AA secondary amyloidosis, changing the bleak prognosis of this disease.
- | Preclinical, Journal: Indigo fruits ingredient, aucubin protects against LPS-induced cardiac dysfunction in mice. (Pubmed Central) - Apr 26, 2020
Hence, AUB might be a promising agent for the treatment of LPS-induced cardiac dysfunction. SIGNIFICANCE STATEMENT: Aucubin exerts a protective effect against LPS-induced cardiac dysfunction by regulating NLRP3 inflammasome.
- | metformin / Generic mfg.
Journal: NLRP3 inflammasome inhibitor glyburide expedites diabetic-induced impaired fracture healing. (Pubmed Central) - Apr 26, 2020
An animal model of diabetic-induced fracture was established and the mice were administrated with metformin or glyburide for 3 weeks...Apart from decreasing a percentage of cartilage area and increasing the percentage of bone and fibrotic tissue area, treatment of glyburide increased the maximum torque and yield torque of fractures. These results implied that glyburide might be used as a potential drug candidate for diabetic-induced fracture.
- | Journal: C1q/TNF-related protein-9 attenuates atherosclerosis through AMPK-NLRP3 inflammasome singling pathway. (Pubmed Central) - Apr 26, 2020
These results implied that glyburide might be used as a potential drug candidate for diabetic-induced fracture. Our data here indicated that the CTRP9 showed atheroprotective function via CTRP9-AMPK- NLRP3 inflammasome pathway.
- | Ilaris (canakinumab) / Novartis
Journal: A new strategy for the treatment of atherothrombosis - inhibition of inflammation. (Pubmed Central) - Apr 26, 2020
The efficacy and safety of this treatment, in secondary prevention, were documented in the CANTOS study. Other therapeutic procedures, including suppression of the inflammatory component of atherogenesis, are at the stage of clinical assessment.
- | Journal: Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome. (Pubmed Central) - Apr 26, 2020
In short, our study provided evidence that Sal B could attenuate myocardial ischemic injury via inhibition of TLR4/NF-κB/NLRP3 signaling pathway. And in an upstream level, MD-2 may be the potential target.
- | Preclinical, Journal: The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns. (Pubmed Central) - Apr 25, 2020
PCR and western blot results suggested that the pranoprofen group expressed less NLRP3, IL-1β, and MMP-13 mRNA and protein expression in corneal tissue than the saline group (p < 0.05). Pranoprofen may alleviate inflammatory response by inhibiting the expression levels of NLRP3 and IL-1β at the early stage of corneal alkali injury, lowering the expression of MMP-13 and ultimately reducing corneal epithelial damage.
- || Review, Journal: NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis. (Pubmed Central) - Apr 25, 2020
After recognizing and binding to the damage factors, NLRP3 inflammasome will be assembled to activate IL-1β and caspase-1 pathways, resulting in promoting the inflammation process of AS, reducing the stability of the plaques, and finally increasing the incidence of adverse cardiovascular events. Taken above, the article will review the potential benefits of drugs targeting the NLRP3 inflammasome in the therapy of AS.
- | Preclinical, Journal: trans-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF-κB/NLRP3 Inflammasome Pathway. (Pubmed Central) - Apr 25, 2020
Similar to FLU, TCA reverses the depression-like behaviors in rats, which indicates that TCA has a significant antidepressant-like effect. The mechanism of the antidepressant property of TCA might be that it inhibits the activation of the NF-κB pathway and NLRP3 inflammasome in the prefrontal cortex and hippocampus of CUMS rats.
- | Journal: Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction. (Pubmed Central) - Apr 25, 2020
Moreover, in these conditions, Cathepsin B interacts with NLRP3 at the endoplasmic reticulum (ER) level. To conclude, different NLRP3 activators lead to Cathepsin B interaction with NLRP3 at the ER level and to subsequent caspase-1 activation.
- TREM2/β-catenin attenuates macrophage pyroptosis to promote bacterial eradication of pyogenic bacteria (Board Number: P1082) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_2491;
Notably, in vitro studies suggested that TREM2/β-catenin suppressed NLRP3 and NLRC4 inflammasome activation at priming and/or assembly stage. Collectively, our study provides a novel mechanism of TREM2-mediated anti-pyogenic bacterial immunity and explores the relationship between pyroptosis and bacterial eradication.
- low molecular weight dextran sulfate (ILB) / TikoMed
HY209 alleviates inflammation in colitis mice through NLRP3 inflammasome inhibition (Board Number: P1046) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_2456;
In here, we evaluated the therapy efficacy of HY209 in an acute colitis mice model which induced by using dextran sulfate sodium (DSS)...In vitro, HY209 showed a strong inhibition to LPS and ATP/BzATP activated NLRP3 inflammasome formation in the bone marrow derived macrophages (BMDMs). In summary, our findings demonstrated that HY209 alleviates inflammation in colitis mice through NLRP3 inflammasome inhibition, discovery the potential of HY209 as a therapeutic option for colitis.
- Induction of autophagy or mitophagy improves the cardiovascular lesions of Kawasaki Disease in a murine model of vasculitis (Board Number: P834) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_2344;
This data suggests that induction of autophagy leads to decreased cardiovascular lesions, whereas impaired mitophagy results in exacerbation of LCWE-induced cardiovascular lesions in this murine model of KD vasculitis. These findings enhance our understanding of the pathogenesis of the cardiovascular lesions in KD vasculitis and may provide novel therapeutic targets to prevent or treat these complications.
- PU.1 and IRF8 modulate the activation of NLRP3 inflammasome via regulating the monocyte-specific expression of the NLRP3 and its component genes. (Board Number: P492) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_2143;
Furthermore, we found that the silencing of PU.1 and IRF8 dramatically abrogated the processing of pro-IL-1β. These results indicate that PU.1 and IRF8 are involved in the monocytic lineage-specific NLRP3 expression by binding to the EICE site within the distal promoter.
- Non-haemolytic enterotoxin induces pore-formation and activation of the inflammasome and pyroptosis (Board Number: P444) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_2121;
Moreover, our data suggest that both NHE and HBL operate synergistically to induce inflammation in the host. Overall, our results highlight that multiple virulence factors from the same pathogen exhibiting conserved function and mechanism of action can be exploited for sensing by a single inflammasome, ultimately leading to increased capacity of the host to detect and defend against naturally-occurring genetic variants.
- A multi-component bacterial toxin incites host inflammation via the NLRP3 inflammasome (Board Number: P439) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_2116;
Our unpublished results further show that the transmembrane region of the apical subunit of HBL is dispensable for membrane binding but essential for inflammasome activation. Overall, our results indicate that intracellular sensing of a toxin secreted by an extracellular bacterium is critical for the innate immune recognition of infection.
- NLRP3 inflammasome in immune cells regulates metastatic potential of cancer P463 (Board Number: P463) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_2115;
The results would provide a novel anti-cancer immuntherapy to regulate the activity of NLRP3 inflammasome in tumor microenvironment. [Supported by grants from BK21 PLUS program, NRF-2019R1A2C2085739, and NRF-2017R1A4A1015036].
- The Rab11-family interacting protein 2 is an important regulator of inflammatory cell death in human macrophages (Board Number: P462) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_2114;
Similar results were found when FIP2 silenced THP-1 cells were LPS primed and treated with virulent clinical isolates of uropathogenic Escherichia coli (UPEC). Together these data show that FIP2 is a regulator of NLRP3 inflammasome assembly and activation.