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- | Journal: Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. (Pubmed Central) - Jan 20, 2022
On the other hand, BBR decreased the interaction between Gα‑interacting protein‑interacting protein at the C‑terminus (GIPC) and GLUT1, which suggested that the retention of GLUT1 in the cytoplasm may be achieved by inhibiting the interaction between GLUT1 and GIPC, thereby suppressing the glucose transporter function of GLUT1. The results of the present study provided a theoretical basis for the application of the Traditional Chinese medicine component, BBR, for cancer treatment.
- | Journal: In Silico Study of the Structure and Ligand Preference of Pyruvate Kinases from Cyanobacterium Synechocystis sp. PCC 6803. (Pubmed Central) - Jan 18, 2022
Molecular docking studies suggested that for predicted structures of sll0587 and sll1275, respectively, there are three and two possible active or allosteric sites. Furthermore, molecular interaction analysis of modeled structures proposes that sll0587 is strongly inhibited by ATP and when ATP concentration is low, this isoenzyme is active.
- | sapanisertib (CB-228) / Calithera
Journal: p53 haploinsufficiency and increased mTOR signaling define a subset of aggressive hepatocellular carcinoma. (Pubmed Central) - Jan 15, 2022
Our data advance the current understanding of the activation of the Pten/PI3K/Akt/mTOR axis and its downstream target Abcc4 in hepatocarcinogenesis driven by p53 reduction and Tsc1 loss. Targeting mTOR, an unexpected vulnerability in p53 (haplo)deficiency HCC, can be exploited therapeutically to treat Abcc-4-positive HCC patients.
- || Review, Journal: Complex IV- the regulatory center of mitochondrial oxidative phosphorylation. (Pubmed Central) - Jan 15, 2022
This ,allosteric ATP-inhibition" of phosphorylated and dimeric COX maintains a low and healthy mitochondrial membrane potential (relaxed state), and prevents the formation of ROS (reactive oxygen species) which are known to cause numerous diseases. Excessive work and stress abolish this feedback inhibition of COX by Ca-activated dephosphorylation which leads to monomerization and movement of NDUFA4 from complex I to COX with higher rates of COX activity and ATP synthesis (active state) but increased ROS formation and decreased efficiency.
- | Journal: Antiamoeboid activity of squamins C-F, cyclooctapeptides from Annona globifora. (Pubmed Central) - Jan 7, 2022
All peptides trigger mitochondrial damages, significant inhibition of ATP production compared to the negative control, chromatin condensation and slight damages in membrane that affects its permeability despite it conserves integrity at the IC for 24 h. An increase in reactive oxygen species (ROS) was observed in all cases.
- | dasatinib / Generic mfg.
Journal: Development of 2'-aminospiro [pyrano[3,2-c]quinoline]-3'-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation. (Pubmed Central) - Jan 5, 2022
Several Src kinase inhibitors are available, including the FDA-approved drug (dasatinib)...The potency of 3b, 3c, and 3d to inhibit migration, proliferation, and colony formation of MDA-MB-231 and proliferation of MCF7 cells correlates with their potency to suppress Src kinase activity in the same cell line. Noticeably, the cell growth suppression and apoptosis induction in the tested cell lines can be attributed to the ability of the new derivatives to suppress the ERK and Akt survival pathways downstream of Src.
- || pioglitazone / Generic mfg.
Clinical, Journal: Suppression of Myocardial HIF-1α Compromises Metabolic Adaptation and Impairs Cardiac Function in Patients with Cyanotic Congenital Heart Disease During Puberty. (Pubmed Central) - Jan 4, 2022
HIF-1α was identified as the key regulator of cardiac metabolic adaptation in animals exposed to CH, and pubertal IR could suppress its expression. Pioglitazone administration during puberty might help improve cardiac function in CCHD patients.
- | Journal: MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. (Pubmed Central) - Dec 29, 2021
The M854K mutation inhibits ATP-dependent RNA proofreading via an allosteric mechanism, allowing MDA5 to form signaling complexes on endogenous RNAs. This work provides insights on how MDA5 recognizes dsRNA in health and disease.
- | Journal: Identification of potent inhibitors of ATP synthase subunit c (AtpE) from Mycobacterium tuberculosis using in silico approach. (Pubmed Central) - Dec 24, 2021
The results indicated that the ligands formed relatively stable complexes and had free binding energies, less than the binding energy of the ATP. Therefore, these ligands considered as prospective inhibitors of MTB after successful experimental validation.
- | glibenclamide / Generic mfg.
Journal: Vascular K channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. (Pubmed Central) - Dec 23, 2021
Here, we determined cryogenic electron microscopy structures of vascular K channels bound to inhibitory ATP and glibenclamide, which differ informatively from similarly determined pancreatic K channel isoform (Kir6.2/SUR1)...Molecular dynamics simulations reveal MgADP-dependent dynamic tripartite interactions between this linker, SUR2B, and Kir6.1. The structures captured implicate a progression of intermediate states between MgADP-free inactivated, and MgADP-bound activated conformations wherein the glutamate/aspartate-rich linker participates as mobile autoinhibitory domain, suggesting a conformational pathway toward K channel activation.
- | Journal: Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. (Pubmed Central) - Dec 23, 2021
The auto-inhibitory plus the associated "fail-safe" mechanisms and the modes of attachment of the α-subunits provide targets for development of innovative antitubercular drugs. The structure also provides support for an observation made in the bovine ATP synthase that the transmembrane proton-motive force that provides the energy to drive the rotary mechanism is delivered directly and tangentially to the rotor via a Grotthuss water chain in a polar L-shaped tunnel.
- | Journal: Identification and Characterization of a Novel Soluble Pyridine Nucleotide Transhydrogenase from Streptomyces avermitilis. (Pubmed Central) - Dec 22, 2021
In summary, we characterized a recombinant enzyme exhibiting STH activity from Gram-positive bacteria for the first time. Our findings provide new options for cofactor engineering and industrial biocatalytic processes.
- rasagiline / Generic mfg.
Mao-b inhibition facilitates α-synuclein secretion via an abc transporter-mediated pathway and delays its aggregation (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1993;
These findings suggest that MAO-B inhibition modulates the intracellular clearance of detergent-insoluble α-syn via the ABC transporter-mediated non-classical secretion pathway in vitro, and temporarily delays the formation and transmission of α-syn aggregates in rat models. We propose a new function of MAO-B inhibition that modulates α-syn secretion and aggregation in PD treatment.
- Evidence for an astrocytic role in somatosensory adaptation (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1691;
The effects of astrocyte syncytium dialysis with BAPTA and perfusion with low K + aCSF demonstrate that astrocytes play a significant role in somatosensory adaptation. Pharmacological manipulation suggests that astrocytes may use ATP through P2Y1 receptors to recruit interneuron-mediated inhibition and that endocannabinoids from neurons and/or astrocytes also play a role.; Grant Support: NSERC RGPIN-2020-03971
- Two mechanisms of synaptic vesicle clustering by synapsins: roles of liquid-liquid phase separation and oligomerization (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1419;
In summary, both LLPS and oligomerization contribute to synapsin-dependent trafficking of SV. Remarkably, the relative roles of these two processes differ at excitatory and inhibitory synapses.; Grant Support: MOH- 000225
- gemcitabine / Generic mfg.
TARGETING CELLULAR ENERGETICS IN PANCREATIC DUCTAL ADENOCARCINOMA ([VIRTUAL]) - Dec 17, 2021 - Abstract #APCM2021APCM_77;
JAC-B2 is a mitochondrial inhibitor which is orally bioavailable and able to substantially inhibit cancer xenograft growth in in-vivo mouse models. This is most likely mediated through inhibition of mitochondrial gene expression.
- | Journal: Insights into the modulatory effect of magnesium on efflux mechanisms of Candida albicans reveal inhibition of ATP binding cassette multidrug transporters and dysfunctional mitochondria. (Pubmed Central) - Dec 16, 2021
Lastly, we observed that Mg deprivation impairs mitochondrial potential which could be the causal reason for abrogated efflux activity. With growing appreciation of manipulating metal homeostasis to combat MDR, inhibition of efflux activity under Mg deprivation warrants further studies to be utilized as an effective antifungal strategy.
- | Journal: High-mobility group box protein-1 induces acute pancreatitis through activation of neutrophil extracellular trap and subsequent production of IL-1β. (Pubmed Central) - Dec 16, 2021
HMGB1 thus leads to pancreatic injury through the activation of NET and subsequently induces IL-1β processing from neutrophils to pancreatic tissues. These findings demonstrate that HMGB1 and NET are new therapeutic targets for inflammation suppression in severe AP.
- | glibenclamide / Generic mfg., rasagiline / Generic mfg.
Preclinical, Journal: Monoamine oxidase-B inhibition facilitates α-synuclein secretion in vitro and delays its aggregation in rAAV-based rat models of Parkinson's disease. (Pubmed Central) - Dec 16, 2021
MAO-B inhibition preferentially facilitated the secretion of detergent-insoluble α-syn protein and decreased its intracellular accumulation under chloroquine-induced lysosomal dysfunction...Additionally, MAO-B inhibition by selegiline protected A53T α-synuclein-induced nigrostriatal dopaminergic neuronal loss and suppressed the formation and cell-to-cell transmission of α-synuclein aggregates in rat models. We therefore propose a new function of MAO-B inhibition that modulates α-synuclein secretion and aggregation.
- | Leukothera (leukotoxin) / Actinobac Biomed
Journal: Leukotoxin (LtxA/Leukothera) induces ATP expulsion via pannexin-1 channels and subsequent cell death in malignant lymphocytes. (Pubmed Central) - Dec 16, 2021
We show that LtxA is able to kill malignant lymphocytes through an apoptotic death pathway which is potentially linked to a Panx1/P2XR mediated necrotic form of death. Thus, inhibition of ATP release appears to significantly delay the onset of LtxA induced apoptosis while completely disabling the necrotic death pathway in T-lymphocytes, demonstrating the crucial role of ATP release in LtxA-mediated cell death.
- | Journal: Alleviation of CCCP injury by Augmenter of liver regeneration via the PINK1/Parkin pathway-dependent mitophagy. (Pubmed Central) - Dec 16, 2021
Meanwhile, short form ALR (sfALR) also increased PINK1 expression through FOXO3a with the similar pathway to lfALR. In conclusion, our data suggest a novel mechanism through which both lfALR and sfALR protect mitochondria by promoting PINK1/Parkin-dependent mitophagy through FOXO3a activation.
- | Journal: Compartment-specific C metabolic flux analysis reveals boosted NADPH availability coinciding with increased cell-specific productivity for IgG1 producing CHO cells after MTA treatment. (Pubmed Central) - Dec 14, 2021
Mitochondrial shuttle activity of the α-ketoglurarate/malate antiporter (OGC) reversed, reducing cytosolic malate transport. In summary, NADPH supply in MTA-treated cells improved three fold compared to that in non-MTA-treated cells, which can be regarded as a major factor for explaining the boosted CSPs.
- | Journal: Knockdown of FBI-1 Inhibits the Warburg Effect and Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeted Agents via miR-3692/HIF-1α. (Pubmed Central) - Dec 7, 2021
Mechanistically, the miR-30c repressed the expression of HIF-1α by binding to the 3'-untranslated region (3'-UTR) of HIF-1α in a sequence-specific manner, and FBI-1 enhanced the expression of HIF-1α and HIF-1α pathway's activation by repressing the expression of miR. By modulating the miR-30c/HIF-1α, FBI-1 promoted the Warburg effect or the epithelial-mesenchymal transition of HCC cells and promoted the resistance of HCC cells to molecular targeted agents.
- | clopidogrel / Generic mfg.
Journal: Nucleotides modulate synoviocyte proliferation and osteoclast differentiation in macrophages with potential implications for rheumatoid arthritis. (Pubmed Central) - Nov 30, 2021
The ADP-induced TRAP could be inhibited by clopidogrel a P2Y inhibitor...Nucleotide receptors might be potential therapeutic targets in RA. The online version contains supplementary material available at 10.1007/s13205-021-03052-8.
- | Germanin (suramin) / Optimum Therap
Journal: Ectonucleotidases from trypomastigotes from different sources and various genetic backgrounds of Trypanosoma cruzi potentiate their infectivity and host inflammation. (Pubmed Central) - Nov 29, 2021
In vivo studies showed a reduction of inflammatory infiltrate in the cardiac tissues of animals infected with cell culture-derived trypomastigote forms from suramin pre-treated Colombiana strain. In conclusion, TcNTPDase-1 activity in trypomastigotes forms drives part of the biological characteristics observed in distinct DTUs and may induce cardiac pathogenesis during T. cruzi infection.
- | Journal: Role of cyanobacterial phosphoketolase in energy regulation and glucose secretion under dark anaerobic and osmotic stress conditions. (Pubmed Central) - Nov 29, 2021
Interestingly, under this condition, xpk deletion causes glucose secretion in response to osmotic shock such as NaHCO, KHCO and NaCl as part of incomplete glycogen degradation. These findings unveiled the role of this widespread enzyme and open the possibility for enhanced glucose secretion from cyanobacteria.
- | glibenclamide / Generic mfg.
Journal: Naloxone Protects against Lipopolysaccharide-Induced Neuroinflammation and Microglial Activation via Inhibiting ATP-Sensitive Potassium Channel. (Pubmed Central) - Nov 29, 2021
Naloxone prevented LPS-induced neuroinflammation and microglial activation partially through the KATP channel. These findings might highlight the potential of naloxone in neuroinflammation therapy.
- | Journal: Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction. (Pubmed Central) - Nov 29, 2021
Through a two-stage fermentation process, the squalene titer reached 21.1 g/L with a specific squalene titer of 437.1 mg/g dcw, which was the highest at present. This provides new insight into the production of squalene and other terpenes in yeasts based on the advantages of mitochondrial engineering.
- || Review, Journal: Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy. (Pubmed Central) - Nov 29, 2021
Glycyrrhizin (GL), an active compound of licorice, has been reported to both reduce the MDR effect by inhibiting ATP-dependent pumps and function as a regulator of NO production in the TME. In this review, we describe the potential role of GL as an NO regulator and MDR inhibitor that efficiently reduces the MDR effect in cancer chemotherapy.
- FIRST-IN-CLASS CDC45-MCM-GINS HELICASE INHIBITORS OFFER THERAPEUTIC POTENTIAL FOR OSTEOSARCOMA TREATMENT ([VIRTUAL]) - Nov 26, 2021 - Abstract #CTOS2021CTOS_247;
In this review, we describe the potential role of GL as an NO regulator and MDR inhibitor that efficiently reduces the MDR effect in cancer chemotherapy. The discovery of these aminocoumarins as first-in-class, effective CMGi provides an architecture for the development of targeted therapeutics against the hCMG that can be used clinically as innovative interventions in OS management.
- | Journal: Mitochondrial fusion mediated by mitofusin 1 regulates macrophage mycobactericidal activity by enhancing autophagy. (Pubmed Central) - Nov 24, 2021
In summary, our study revealed MFN1-mediated mitochondrial fusion is essential for macrophages mycobactericidal activity through the regulation of ATP dependent autophagy. MFN1-mediated metabolism pathway might be targets for development of host direct therapy (HDT) strategy against TB.
- || Review, Journal: Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase. (Pubmed Central) - Nov 17, 2021
Most regulatory properties of COX are related to "supernumerary" subunits, which are largely absent in bacterial COX. The "allosteric ATP inhibition of COX" was also recently described in intact isolated rat heart mitochondria.
- | Journal: The role of the phosphate groups of trinitrophenyl adenosine 5'-triphosphate (TNP-ATP) in allosteric activation of pyruvate carboxylase and the inhibition of acetyl CoA-dependent activation. (Pubmed Central) - Nov 17, 2021
These findings indicate that mechanisms of PC activation and inhibition of acetyl-CoA activation by TNP-ATP and its derivatives are different. This study provides the basis for possible drug development for treatment of metabolic diseases and cancers with aberrant expression of PC.
- || Nexletol (bempedoic acid) / Esperion Therap, Otsuka
PK/PD data, Journal: Bempedoic acid. Mechanism of action and pharmacokinetic and pharmacodynamic properties. (Pubmed Central) - Nov 16, 2021
It has recently been approved as a lipid-lowering drug in combination with diet, with statins, or with other lipid-lowering drugs in patients with hypercholesterolaemia, mixed dyslipidaemia, statin intolerance, or when these are contraindicated. The marketing of bempedoic acid implies, in clinical practice, having a new family of lipid-lowering drugs.
- | Journal: A cyclic nano-reactor achieving enhanced photodynamic tumor therapy by reversing multiple resistances. (Pubmed Central) - Nov 10, 2021
The marketing of bempedoic acid implies, in clinical practice, having a new family of lipid-lowering drugs. This nano-reactor offers a multifunctional nanoplatform to sensitize TME-limited tumor treatment means via reversing multiple resistances.
- | eplerenone / Generic mfg.
Journal: A scaffolded approach to unearth potential antibacterial components from epicarp of Malaysian Nephelium lappaceum L. (Pubmed Central) - Nov 6, 2021
We report compounds like catechin, eplerenone and oritin-4-beta-ol to be computationally inhibiting the ATP-binding domain of the chaperone, DnaK of P. aeruginosa and MRSA. Thus, our work follows the objective to propose new antimicrobials capable of perforating the barrier of resistance posed by both the gram positives and the negatives.
- || NB003 / Ningbo Tai Kang
PK/PD data, Preclinical, Journal: The pharmacokinetic-pharmacodynamic (PKPD) relationships of AZD3229, a novel and selective inhibitor of cKIT, in a range of mouse xenograft models of GIST. (Pubmed Central) - Nov 4, 2021
Thus, our work follows the objective to propose new antimicrobials capable of perforating the barrier of resistance posed by both the gram positives and the negatives. We demonstrate that AZD3229 warrants clinical investigation as a new treatment for GIST patients based on its ability to inhibit both ATP-binding and A-loop mutations of KIT at clinically relevant exposures.
- | verapamil / Generic mfg.
Journal: Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation. (Pubmed Central) - Nov 4, 2021
This study demonstrated that the ASM/Cer/TXNIP signaling pathway is involved in NLRP3 inflammasome activation. The results documented that the CD36-dependent NF-κB-TXNIP signaling pathway plays an essential role in the Cer-induced activation of NLRP3 inflammasomes in macrophages.
- | Journal: Tanshinones induce tumor cell apoptosis via directly targeting FHIT. (Pubmed Central) - Nov 4, 2021
Finally, we demonstrated that depletion of FHIT significantly blocked TSA's pro-apoptotic function in colorectal cancer HCT116 cells. Taken together, our study sheds new light on the molecular basis of the anti-cancer effects of the tanshinone compounds.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Mitochondria-targeted vitamin E succinate delivery for reversal of multidrug resistance. (Pubmed Central) - Oct 30, 2021
Reported here a versatile mitochondrial-damaging molecule, vitamin E succinate (VES), is creatively utilized to assist MDR reversal of doxorubicin hydrochloride (DOX·HCl) via a nanovesicle platform self-assembled from amphiphilic polyphosphazenes containing pH-sensitive 1H-benzo-[d]imidazol-2-yl) methanamine (BIMA) groups...Further in vivo antitumor investigation on nude mice bearing xenograft drug-resistant human chronic myelogenous leukemia K562/ADR tumors verifies the extremely enhanced anti-tumor efficacy of the dual drug-loaded nanovesicle with the tumor inhibition rate (TIR) of 82.38%. Collectively, this study provides a s safe, facile and promising strategy for both precise drug delivery and MDR eradication to improve cancer therapy.
- | Sirturo (bedaquiline) / J&J, Pharmstandard
Journal: Neuroprotective Effect of a Novel ATP-Synthase Inhibitor Bedaquiline in Cerebral Ischemia-Reperfusion Injury. (Pubmed Central) - Oct 30, 2021
Mitochondrial calcium retention capacity was unaffected by BDQ preconditioning. We concluded that BDQ has neuroprotective properties associated with its action on mitochondrial respiration and ATPase activity.
- | Journal, Epigenetic controller: Inhibition of ACLY leads to suppression of osteoclast differentiation and function via regulation of histone acetylation. (Pubmed Central) - Oct 28, 2021
With the help of RNA-sequencing, we discovered Rac1 as a downstream regulator of ACLY, which was involved in shACLY-mediated suppression of osteoclast differentiation, cytoskeleton organization and signal transduction and was transcriptionally regulated by ACLY via histone H3 acetylation. To summarize, our results proved that inhibition of ATP-citrate lyase led to suppression of osteoclast differentiation and function via regulation of histone acetylation, Rac1 could be a downstream regulator of ACLY.
- | Journal: Cholate Disrupts Regulatory Functions of Cytochrome c Oxidase. (Pubmed Central) - Oct 28, 2021
Consequently, it turns off the "allosteric ATP-inhibition of CytOx", which is reversibly switched on under relaxed conditions via cAMP-dependent phosphorylation and keeps the membrane potential and ROS formation in mitochondria at low levels. This cholate effect gives an insight into the structural-functional relationship of the enzyme with respect to ATP inhibition and its role in mitochondrial respiration and energy production.
- | Journal: Recruitment and remodeling of peridroplet mitochondria in human adipose tissue. (Pubmed Central) - Oct 27, 2021
We found similar changes in a mouse model of re-browning where PDM content in whitened brown adipose tissue was increased upon re-browning induced by decreased housing temperature. Taken together, this study demonstrates the existence of PDM as a separate functional entity in humans and that browning in both mice and humans is associated with a robust expansion of peri-droplet mitochondria characterized by increased ATP synthesis linked respiration.
- | Journal: Inhibition of ATP-sensitive potassium channels exacerbates anoxic coma in Locusta migratoria. (Pubmed Central) - Oct 22, 2021
These results were not the same as the effects of 10 M ouabain on N-induced SD. We conclude that glybenclamide affects the CNS response to anoxia via inhibition of K channels and not an effect on the Na/K-ATPase.
- | febuxostat / Generic mfg., allopurinol / Generic mfg., rosuvastatin / Generic mfg.
Journal: Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin. (Pubmed Central) - Oct 20, 2021
Febuxostat may, therefore, serve as a useful index inhibitor of BCRP in drug-drug interaction studies in humans. Moreover, concomitant use of febuxostat may increase the exposure to BCRP substrate drugs and, thus, the risk of dose-dependent adverse effects.
- | Preclinical, Journal: Phosphate has dual roles in cross-bridge kinetics in rabbit psoas single myofibrils. (Pubmed Central) - Oct 20, 2021
Finally, we found that the sinusoidal waveform of tension is mostly distorted by second harmonics and that this distortion is closely correlated with production of oscillatory work, indicating that the mechanism of generating force is intrinsically nonlinear. A nonlinear force generation mechanism suggests that the length-dependent intrinsic rate constant is asymmetric upon stretch and release and that there may be a ratchet mechanism involved in the CB cycle.
- | Nexletol (bempedoic acid) / Esperion Therap, Otsuka
Journal: Bempedoic acid: mechanism of action (Pubmed Central) - Oct 20, 2021
In a Mendelian randomization study, combined exposure to variants in the ACLY, HMGCR and Niemann-Pick C1-Like 1 genes produced an additive decrease in low-density lipoprotein cholesterol levels and additive reduction in the risk of cardiovascular events. The aim of this review is to describe bempedoic acid mechanism of action, and its pharmacokinetic and pharmacodynamic characteristics.
- | Journal: Altering mammalian transcription networking with ADAADi: An inhibitor of ATP-dependent chromatin remodeling. (Pubmed Central) - Oct 20, 2021
This was accompanied by increased apoptosis leading us to hypothesize that the ADAADi treatment promotes apoptotic-type of cell death by upregulating the transcription of pro-apoptotic genes. ADAADi also inhibited migration of cells as well as their colony forming ability leading us to conclude that the compound has effective anti-tumor properties.
- Nexletol (bempedoic acid) / Esperion Therap, Otsuka
[VIRTUAL] Beneficial Effects of Bempedoic Acid Treatment in ADPKD Mice () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_1862;
BA significantly reduced kidney injury markers and mTOR and ERK signaling. BA may be a promising new ADPKD therapy, having beneficial effects on disease severity when used alone and with tolvaptan in mice.