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- || glibenclamide / Generic mfg.
Review, Journal: Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal. (Pubmed Central) - Mar 2, 2023
Glibenclamide reduces neuroinflammation and associated BBB injury by inhibiting the nod-like receptor pyrin 3 (NLRP3) inflammasome, oxidative stress, and microglial activation. Therefore, glibenclamide through inhibition of NLRP3 inflammasome, microglial activation, and oxidative stress may attenuate SARS-CoV-2-mediated neuroinflammation.
- | Journal: 7-desacetoxy-6,7-dehydrogedunin discovered by high-throughput screening system suppresses melanogenesis through ATP-P2X7 signaling inhibition. (Pubmed Central) - Feb 27, 2023
Therefore, glibenclamide through inhibition of NLRP3 inflammasome, microglial activation, and oxidative stress may attenuate SARS-CoV-2-mediated neuroinflammation. 7DG has an anti-melanogenic effect through ATP-P2X7 pathway inhibition and could be a potential skin whitening material.
- | tranexamic acid oral / Generic mfg.
Journal: Upregulation of CD86 and IL-12 by rhododendrol in THP-1 cells cocultured with melanocytes through ROS and ATP. (Pubmed Central) - Feb 27, 2023
RD is a pro-hapten sensitizer dependent on tyrosinase that induces ROS generation and ATP release from melanocytes for CD86 and IL-12 upregulation in DCs, possibly leading to the generation of tyrosinase-specific cytotoxic T lymphocytes. The coculture system h-CLATw/M may be useful for predicting the sensitizing potential to induce leukoderma.
- | Journal: Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion binding site and the ATP binding pocket. (Pubmed Central) - Feb 27, 2023
The N-terminus may mediate the ATP inhibition of AtCLCa by interacting with both ATP and the pore-forming transmembrane helix. Together, our studies provide insights into the nitrate selectivity and ATP regulation of plant CLCs.
- Synthesis And Pharmacological Validation Of Novel Neuroprotective Purinergic Receptor P2X4 Antagonists For The Treatment Of Ischemic Stroke (Learning Studio 2 Hall F) - Feb 16, 2023 - Abstract #ISC2023ISC_1968;
Together, our studies provide insights into the nitrate selectivity and ATP regulation of plant CLCs. This study indicates MRS4719 is a potent P2X4R antagonist and has translational potential for the treating of ischemic stroke across the age.
- Synthesis And Pharmacological Validation Of Novel Neuroprotective Purinergic Receptor P2X4 Antagonists For The Treatment Of Ischemic Stroke (Learning Studio 2 Hall F) - Feb 16, 2023 - Abstract #ISC2023ISC_1967;
This study indicates MRS4719 is a potent P2X4R antagonist and has translational potential for the treating of ischemic stroke across the age. This study indicates MRS4719 is a potent P2X4R antagonist and has translational potential for the treating of ischemic stroke across the age.
- Synthesis And Pharmacological Validation Of Novel Neuroprotective Purinergic Receptor P2X4 Antagonists For The Treatment Of Ischemic Stroke (Learning Studio 1 Hall F) - Feb 16, 2023 - Abstract #ISC2023ISC_1966;
This study indicates MRS4719 is a potent P2X4R antagonist and has translational potential for the treating of ischemic stroke across the age. This study indicates MRS4719 is a potent P2X4R antagonist and has translational potential for the treating of ischemic stroke across the age.
- Production of bioactive water-soluble indirubin derivative using novel plant P450 (Hall F-H (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_8840;
The compounds inhibit the growth of pathogenic strain Salmonella and cause cell cycle arrest of HeLa cells. In summary, we develop an efficient, sustainable, and green system for in vivo synthesis of pharmaceutically applicable indirubin derivatives.
- Sirturo (bedaquiline) / J&J, Pharmstandard
Synthesis of selective inhibitors of Pseudomonas aeruginosa ATP synthase (Room 109 (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_578;
Since the development of the anti-tubercular drug Bedaquiline, ATP synthase has become a target of interest for antibiotic development...The strongest inhibitor showed an IC50 of 10 ?g/mL and decreased activity of PA ATP synthase to 24% relative to the control. Current work is focusing on improve whole cell antibiotic activity of these analogs by improving accumulation.
- | Journal: Piezocatalytic 2D WS2 Nanosheets for Ultrasound-Triggered and Mitochondria-Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism-Targeted Chemotherapy. (Pubmed Central) - Feb 13, 2023
Notably, a single intravenous injection of FX11@TPEG-WS under US irradiation remarkably suppressed the tumor growth of mice without systemic toxicity. This study demonstrates that the combination of US-triggered piezodynamic cancer therapy and energy metabolism-targeted chemotherapy using mitochondria-targeting piezoelectric 2D WS nanosheets is a novel therapeutic strategy for the selective and effective treatment of tumors .
- | chloroquine phosphate / Generic mfg.
Journal: Chloroquine-Based Mitochondrial ATP Inhibitors. (Pubmed Central) - Feb 12, 2023
The most potent mito. ATP inhibitor was found to be N-(4-((2,4-Dinitrophenyl)amino)pentyl)-N-ethylacetamide (17).
- Synthesis And Pharmacological Validation Of Novel Neuroprotective Purinergic Receptor P2X4 Antagonists For The Treatment Of Ischemic Stroke (Room C140 / C142; In Person) - Feb 7, 2023 - Abstract #ISC2023ISC_344;
ATP inhibitor was found to be N-(4-((2,4-Dinitrophenyl)amino)pentyl)-N-ethylacetamide (17). This study indicates MRS4719 is a potent P2X4R antagonist and has translational potential for the treating of ischemic stroke across the age.
- | Germanin (suramin) / Optimum Therap
Preclinical, Journal: Mast Cell-Associated Serotonin in Acupoint Contributes to Acupuncture Analgesia in Arthritis Rats by Mediating ATP Release. (Pubmed Central) - Feb 2, 2023
Our results suggest that MC-associated 5-HT release at acupoints contributes to AP analgesia, and the mediation of ATP secretion through 5-HT1A receptors might be the underlying mechanism at play. ATP could facilitate adenosine production or the propagation of needling signals.
- | Journal: The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis. (Pubmed Central) - Jan 24, 2023
The IF1-OSCP interaction is confirmed by NMR spectroscopy analysis of the recombinant soluble proteins. Overall, our results suggest that the IF1-OSCP interaction protects cancer cells from PTP-dependent apoptosis under normoxic conditions.
- | Journal: Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells. (Pubmed Central) - Jan 21, 2023
This study highlights the use of 1,4-naphthoquinones as promising purinergic P2X7 receptor antagonists with anti-inflammatory activity. Based on the data obtained, studied synthetic 1,4-NQs can be considered as potential scaffolds for the development of new anti-inflammatory and analgesic drugs.
- | Journal: A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling. (Pubmed Central) - Jan 20, 2023
Beyond to inhibit the release of pro-inflammatory cytokines, both doses of Immunity-6™ induced the release of anti-inflammatory cytokine IL-10 (p < 0.001), while only the higher dose (10 ug/mL) of Immunity-6™ induced the release of anti-inflammatory IL-1ra (p < 0.05) and klotho (p < 0.001). Thus, Immunity-6™ may be a promising adjuvant in the treatment of leukemia and further clinical trials are guaranteed.
- | paclitaxel / Generic mfg.
Journal: NIR Activated Multimodal Therapeutics Based on Metal-Phenolic Networks-Functionalized Nanoplatform for Combating against Multidrug Resistance and Metastasis. (Pubmed Central) - Jan 19, 2023
t-P@TFP NPs trigger the phase transition of perfluoropentane (PFP) to release tannic acid (TA)/ferric ion (Fe )-coated paclitaxel (PTX) and cause hyperthermia in the tumor region to efficiently kill cancer cells...Furthermore, hyperthermia-induced immunogenic cell death (ICD) transforms "cold" tumors into "hot" tumors with the assistance of PD-1/PD-L1 blockade to evoke antitumor immunogenicity. This work carefully reveals the mechanisms underlying the abilities of these multifunctional NPs, providing new insights into combating the proliferation and metastasis of multidrug-resistant tumors.
- | Journal: Overcoming multidrug-resistant lung cancer by mitochondrial-associated ATP inhibition using nanodrugs. (Pubmed Central) - Jan 13, 2023
This study identified that H69AR lung cancer cells, an adriamycin (DOX) drug-resistant tumor cell line, did not activate drug resistance function on designed nano-anticancer drugs with a specific nano size. In summary, this study identified that the specific size of the nanodrug in combination with DOX overcame multidrug-resistant tumors by inducing selective accumulation in tumor cells and inhibiting ATP by mitochondrial damage.
- | Nexletol (bempedoic acid) / Esperion Therap, Otsuka, Daiichi Sankyo
Preclinical, Journal: Bempedoic Acid Restores Liver HS Production in a Female Sprague-Dawley Rat Dietary Model of Non-Alcoholic Fatty Liver. (Pubmed Central) - Jan 9, 2023
Our data show that the HFHFr diet reduces the total and enzymatic production of liver HS, mainly by decreasing the expression of CBS and CSE. Furthermore, BemA treatment restored HS production, increasing the expression of CBS and CSE, providing evidence for the involvement of FXR transcriptional activity and the mTORC1 (mammalian target of rapamycin1)/S6K1 (ribosomal protein S6 kinase beta-1)/PGC1α (peroxisome proliferator receptor gamma coactivator1α) pathway.
- | Journal: Adenosine triphosphate can act as a determinant of lysine acetylation of non-native and native substrates. (Pubmed Central) - Dec 30, 2022
However, both ADP and AMP had no evident inhibition on the PatZ-catalyzed acetylation of Acs. Based on these results, we proposed that ATP can act as an inhibitor of acetylation, and it may regulate the function of PatZ by inhibiting its autoacetylation and compensate for the function of deacetylase CobB.
- | paclitaxel / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker: Nanoenabled Tumor Energy Metabolism Disorder via Sonodynamic Therapy for Multidrug Resistance Reversal and Metastasis Inhibition. (Pubmed Central) - Dec 29, 2022
A US-controlled "Nanoenabled Energy Metabolism Jammer" (TL@HPN) is designed using perfluoropentane (PFP) adsorbing oxygen in the core, and a targeting peptide (CGNKRTR) is attached to the liposome as the delivery carrier shell to incorporate hematoporphyrin monomethyl ether (HMME) and paclitaxel (PTX)...Persistently elevated oxidative stress levels inhibited ATP production and downregulated P-gp expression by disrupting the redox balance and electron transfer of the respiratory chain. We varied the effect of TL@HPN combined with PD-1/PD-L1 to activate autoimmunity and inhibit tumor metastasis, providing a practical strategy for expanding the use of SDT-mediated tumor energy metabolism.
- | Journal: Is the vesicular nucleotide transporter a molecular target of eicosapentaenoic acid? (Pubmed Central) - Dec 27, 2022
These results indicate that EPA at sub-μM acts as a proton conductor and increases proton permeability across the membrane, regardless of the presence or absence of VNUT, thereby inhibiting non-specifically the vesicular storage of neurotransmitters. Thus, EPA may affect a broader range of chemical transmission than proposed.
- | Preclinical, Journal: 3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model. (Pubmed Central) - Dec 13, 2022
Importantly, we also observed inhibition in lactic acid production responsible for tumor aggression. These results provide new evidence that 3-BP severely inhibit glucose metabolism in cancer cells by blocking hexokinase II, and disrupting mitochondria by suppressing BCL2L1 in pancreatic cancer.
- | Journal: CaCO-assistant synthesis of pH/near-infrared light-responsive and injectable sodium alginate hydrogels for melanoma synergistic treatment. (Pubmed Central) - Dec 7, 2022
Notably, besides the heat elevation, the near-infrared light (NIR) irradiation would further enhance the release of Ca to promote the Ca-involved cell death. Therefore, a pH/NIR-responsive and injectable SA-based hydrogels were successfully established and showed enhanced treatment efficacy of melanoma through the synergism of photothermal therapy and calcium ions interference therapy.
- | LY294002 / Eli Lilly
Journal: AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer. (Pubmed Central) - Dec 6, 2022
In vivo experiments showed that ATP induced tumor growth, while AR-C118925XX inhibited ATP-induced tumor growth. Our conclusion is that P2RY2 activated the AKT/GSK-3beta/VEGF signal to promote the proliferation and migration of GC, suggesting that P2RY2 may be a new potential target for the treatment of GC.
- | Journal: Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids. (Pubmed Central) - Dec 2, 2022
Proton transport proceeds via self-assembly of the deprotonated aryl-carbamates into membrane permeable dimeric species, formed by intermolecular binding of the carboxylate group to the carbamate moiety. These results highlight the anion transport capacity of the carbamate functional group.
- | Journal: Substrate stiffness enhances human regulatory T cell induction and metabolism. (Pubmed Central) - Dec 2, 2022
Inhibition of ATP synthase significantly reduced the rate of Treg induction and abrogated the difference among gels while activation of AMPK (AMP-activated protein kinase) increased Treg induction on the softer sample but not on the harder sample. Treg induction is thus mechanosensitive and OXPHOS-dependent, providing new strategies for improving the production of these cells for cellular immunotherapy.
- | Journal: Benzo[d]thiazole-2-carboxamides as new antituberculosis chemotypes inhibiting mycobacterial ATP phosphoribosyl transferase. (Pubmed Central) - Nov 30, 2022
Compound 1n exhibited stronger competitive inhibition toward ATP compared with 2a. The inhibition of the growth of Mycobacterium tuberculosis by targeting the L-histidine biosynthesis pathway and molecular modeling studies further supported the inhibition of ATP-PRTase.
- || Preclinical, Review, Journal: ATP-Sensitive Potassium Channel Opener Diazoxide Reduces Myocardial Stunning in a Porcine Regional With Subsequent Global Ischemia Model. (Pubmed Central) - Nov 30, 2022
Conclusions Diazoxide reduces myocardial stunning and facilitates separation from cardiopulmonary bypass in a model that mimics the clinical setting of ongoing myocardial ischemia before revascularization. Diazoxide has the potential to reduce myocardial stunning in the clinical setting.
- | Journal: Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tuberculosis and Nontuberculous Mycobacterial F-ATP Synthase Decipher New Targets for Inhibitors. (Pubmed Central) - Nov 30, 2022
We demonstrate that the unique mycobacterial γ-loop and subunit δ are critical elements required for ATP formation. The data underline that these mycobacterium-specific elements of α, γ, and δ are attractive targets, providing a platform for the discovery of species-specific inhibitors.
- | Journal: TIMM44 is a potential therapeutic target of human glioma. (Pubmed Central) - Nov 29, 2022
Moreover, the intracranial growth of TIMM44 KO glioma cells in the mouse brain was largely inhibited. Together, overexpressed TIMM44 could be a novel and promising therapeutic target of human glioma.
- | Journal: Differences in adsorption, transmembrane transport and degradation of pyrene and benzo[a]pyrene by Bacillus sp. strain M1. (Pubmed Central) - Nov 28, 2022
Key enzymes involved in these processes were identified and their activity differed, with intracellular gentisate 1,2-dioxygenase and extracellular polyphenol oxidase as likely candidates to be involved in BaP degradation, while intracellular catechol-1,2- dioxygenase and salicylate hydroxylase are more likely involved in Pyr degradation. These results provide new insights for sustainable environmental remediation of pyrene and benzo(a)pyrene by these bacteria.
- | apilimod (STA-5326) / Madrigal Pharma
Journal: Rational Design and Synthesis of D-galactosyl Lysophospholipids as Selective Substrates and non-ATP-competitive Inhibitors of Phosphatidylinositol Phosphate Kinases. (Pubmed Central) - Nov 25, 2022
Derivatization of this compound led to the discovery of a human PIKfyve inhibitor with an apparent IC of 6.2 μM, which significantly potentiated the inhibitory effect of Apilimod, an ATP-competitive PIKfyve inhibitor under clinical trials against SARS-CoV-2 infection and amyotrophic lateral sclerosis. Our results provide the proof of concept that D-galactose-based phosphoinositide mimetics can be developed into artificial substrates and new inhibitors of PIPKs.
- || Review, Journal: Propofol-Related Infusion Syndrome: A Clinical Review. (Pubmed Central) - Nov 22, 2022
The other essentials of management of various manifestations of PRIS will be discussed in this article, along with a detailed explanation of the condition, its risk factors, diagnosis, pathophysiology, and presenting features. This article aims to make clinicians more aware of the occurrence of this syndrome so that better ways to manage and treat this condition can be formulated in the future.
- | tamoxifen / Generic mfg.
Journal, IO biomarker: Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase. (Pubmed Central) - Nov 20, 2022
Furthermore, the cholesterol and TG contents were increased in LCC2 than in MCF7. Our data revealed that ACLY plays a key role in TAM resistance and ACLY inhibition by HCA-mediated sensitization of BC-resistant cells to TAM.
- | Biomarker, Journal: Peripheral blood mononuclear cell mitochondrial copy number and adenosine triphosphate inhibition test in NAFLD. (Pubmed Central) - Nov 16, 2022
The mtDNA copy number and mitochondrial ATP inhibition substrate test demonstrated negative correlations with the degree of hepatic steatosis, whereas the ATP concentration showed a positive correlation with the mtDNA copy number. The mitochondrial copy number of peripheral blood mononuclear cells and mitochondrial ATP inhibition substrate can be used as biomarkers for assessing the mitochondrial dysfunction in patients with NAFLD.
- | doxorubicin hydrochloride / Generic mfg., epirubicin / Generic mfg.
Journal: 2,4-Dinitrophenol as an Uncoupler Augments the Anthracyclines Toxicity against Prostate Cancer Cells. (Pubmed Central) - Nov 16, 2022
The synergistic activity may consist of an inhibition of ATP synthesis and the simultaneous production of toxic amounts of ROS, destroying the mitochondria. Additionally, the sensitivity of the LNCaP cell line to the anthracyclines is relatively higher compared to the other two (PC-3, DU-145).
- | Journal: Lymphedema as first clinical presentation of Cantu Syndrome: reversed phenotyping after identification of gain-of-function variant in ABCC9. (Pubmed Central) - Nov 8, 2022
In this case, there were no additional features consistent with CS, and the properties of p.(Ile416Thr) (the corresponding mutation in rat SUR2A)--containing channels were not different from WT. This proof-of-principle study shows that idiopathic lymphedema may actually be a first presentation of otherwise unrecognized Cantu Syndrome, but molecular phenotyping of identified variants is necessary to confirm relevance.
- ziftomenib (KO-539) / Kura Oncology, Xpovio (selinexor) / Karyopharm, Menarini, FORUS Therap
Novel Combination of Clinical Menin Inhibitor Ziftomenib and the Nuclear Export Inhibitor Selinexor Synergistically Inhibit MLL-r AML (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_5773;
These preclinical findings demonstrate that simultaneous inhibition of the menin-KMT2A interaction and nuclear export could be a viable strategy for the treatment of MLL-r AML. Ongoing experiments with CDX and PDX using MLL-r models and functional analysis using total transcriptome sequencing and proteomics will be presented at the ASH meeting.
- Venclexta (venetoclax) / Roche, AbbVie
Electron Transport Chain Complex V Inhibition Enhances the Antileukemic Activity of Low-Dose Venetoclax in Acute Myeloid Leukemia (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_4077;
Targeting complex V and BCL-2 together resulted in the decreased expansion of human AML cell lines, and primary patient samples; and there was a preferential reduction of AML in vivo. These preliminary data represent a potential for ammocidin/VEN therapy in AML.
- Transcriptional and Metabolic Profiling Reveals Alpha-Ketoglutarate As a Novel Mediator of Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms (ENMCC - 275-277) - Nov 4, 2022 - Abstract #ASH2022ASH_3430;
In summary, these studies reveal a previously unrecognized metabolic disorder in platelets from MPN patients and highlight a prominent role for a-KG in aberrant MPN platelet activity and monocyte-driven inflammation. These findings have potential relevance for novel therapeutic approaches for MPN patients.
- | Preclinical, Journal: Pinocembrin Inhibits P2X4 Receptor-Mediated Pyroptosis in Hippocampus to Alleviate the Behaviours of Chronic Pain and Depression Comorbidity in Rats. (Pubmed Central) - Nov 2, 2022
The mechanism of pinocembrin in treating rats with chronic pain and depression comorbidity. GJ stands for gap junction, and Cx43 is mainly expressed in astrocytes.
- | Journal: A Cantú syndrome mutation produces dual effects on KATP channels by disrupting ankyrin B regulation. (Pubmed Central) - Nov 2, 2022
Our results are the first demonstration of a CS mutation whose functional consequences involve the disruption of AnkB effects on KATP channels providing a novel mechanism by which CS mutations can reduce ATP block. Furthermore, they may help explain the mild phenotype associated with this mutation.
- | Journal: Exploring the druggability of the binding site of aurovertin, an exogenous allosteric inhibitor of FF-ATP synthase. (Pubmed Central) - Nov 1, 2022
Finally, an analysis of bacterial sequences was carried out to determine conservation of the aurovertin binding site. Taken together, our results constitute a first step in paving the way for structure-based development of new allosteric drugs targeting FF-ATP synthase sites of exogenous inhibitors.
- | Germanin (suramin) / Optimum Therap
Preclinical, Journal: Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK-Ay mice. (Pubmed Central) - Oct 30, 2022
Taken together, our results constitute a first step in paving the way for structure-based development of new allosteric drugs targeting FF-ATP synthase sites of exogenous inhibitors. These results suggest that the NLRP3 inflammasome is activated in a diabetic kidney and that inhibition of the NLRP3 inflammasome with suramin protects against the progression of early stage DKD.
- | Journal: A Coccidia-Specific Phosphate Transporter Is Essential for the Growth of Toxoplasma gondii Parasites. (Pubmed Central) - Oct 29, 2022
As such, TgPT2 represents a potential target for drug design against toxoplasmosis. In addition, our data indicated that Toxoplasma can take up ATP and AMP from the environment, providing new insights into the energy metabolism of Toxoplasma.
- | dorsomorphin (Compound C) / EMD Serono
Journal: Compound C Inhibits Ovarian Cancer Progression via PI3K-AKT-mTOR-NFκB Pathway. (Pubmed Central) - Oct 28, 2022
Moreover, compound C re-sensitized patient-derived resistant cells to cisplatin. Together, our findings highlight compound C as a potent multi-faceted therapeutic in OvCa.
- || Review, Journal: Tyrosine Kinase Inhibitors for Pediatric Leukemia: History and Current Status. (Pubmed Central) - Oct 25, 2022
In conclusion, we focus on chronic myeloid leukemia and acute lymphoblastic leukemia as the examples of pediatric blood cancer that significantly benefit from TKIs-based target therapy. Further development of TKIs will allow us to better manage pediatric leukemia.
- | deoxyglucose / Generic mfg.
Journal: What does not kill mesangial cells makes it stronger? The response of the endoplasmic reticulum stress and the O-GlcNAc signaling to ATP depletion. (Pubmed Central) - Oct 25, 2022
Immortalized mouse mesangial cells culture was incubated for 30, 45 and 60 min, or not (control group) with a buffer containing antimycin A and 2-deoxy-d-glucose, inhibitors of ATP synthesis...Successive ATP depletion induced lower levels O-GlcNAcylation leading to a 30 % cell death in every H/R process. We concluded that lower levels of O-GlcNAcylation and the GRP78/PERK/p-eIF2α UPR response are the molecular mechanisms involved in H/R mesangial cell survival.
- | Journal: The Flavone Cirsiliol from Salvia x jamensis Binds the F Moiety of ATP Synthase, Modulating Free Radical Production. (Pubmed Central) - Oct 22, 2022
Moreover, cirsiliol was effective in reducing the free radical production by the OS exposed to ambient light. We report a considerable protective effect of cirsiliol on the structural stability of rod OS, suggesting it may be considered a promising compound against oxidative stress.