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- AUR300 / Aurinia Pharma
Therapeutic Peptide Aur300 Targeting Cd206 Inhibits Macrophage-Dependent Inflammation, Fibrosis And Calcinosis In Scleroderma () - Jul 31, 2022 - Abstract #IWSR2022IWSR_128;
These data support the notion that multiple aspects of SSc could be attributable to activated macrophages. By targeting these cells, therapeutic peptide AUR300 effectively inhibits multiple disease-relevant pathways resistant to current standard DMARDs.
- AUR300 / Aurinia Pharma
Novel therapeutic peptides targeting CD206 modulate ATP-induced release of inflammatory and B cell activating factors in lupus macrophages () - Jan 30, 2022 - Abstract #BSR2022BSR_511;
These properties are enhanced by exposure to an ATP-like stimulus. In particular, lupus but not control macrophages had the capacity to synthesis BAFF when exposed to the DAMP stimulus.
- | Journal: TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression. (Pubmed Central) - Jan 29, 2022
These novel data provide evidence for the action of TWEAK/Fn14 on macrophage recruitment and phenotype, and cancer-associated fibroblast proliferation in CCA. Targeting TWEAK/Fn14 and its downstream signals may provide a means to inhibit CCA niche development and tumour growth.
- | Journal: Targeting of adipose tissue macrophages by bee venom phospholipase A2 attenuates high-fat diet-induced obesity. (Pubmed Central) - Jan 29, 2022
Targeting TWEAK/Fn14 and its downstream signals may provide a means to inhibit CCA niche development and tumour growth. bvPLA2 is a potential therapeutic strategy for the management of obesity by regulating adipose tissue macrophage homeostasis.
- | ribitol (BBP-418) / BridgeBio
Journal: Inflammation, fibrosis and skeletal muscle regeneration in LGMDR9 are orchestrated by macrophages. (Pubmed Central) - Jan 29, 2022
Our results show characteristic immune inflammatory features in LGMDR9 and more specifically shed light on the predominant role of macrophages and their function in vascular organization, fibrosis and myogenesis. Understanding disease-specific immune phenomena potentially inform about possibilities for anti-fibrotic and anti-inflammatory therapeutic strategies, which may complement Ribitol replacement and gene therapies for LGMDR9 that may be available in the future.
- | Preclinical, Journal: Protective effects of recombinant 53-kDa protein of Trichinella spiralis on acute lung injury in mice via alleviating lung pyroptosis by promoting M2 macrophage polarization. (Pubmed Central) - Jan 29, 2022
In addition, the polarization of M2 macrophages induced by rTsP53 treatment could alleviate ALI by suppressing lung pyroptosis. RTsP53 was identified as a potential agent for treating LPS-induced ALI via alleviating lung pyroptosis by promoting M2 macrophage polarization.
- | Journal: Flow cytometric analysis of equine bronchoalveolar lavage fluid cells in horses with and without severe equine asthma. (Pubmed Central) - Jan 29, 2022
Increased expression of CD163 and CD206 during exacerbation of SEA suggested an association between AM phenotype and lung inflammation. However, functions of AMs in the pathogenesis of SEA remain to be elucidated.
- | Journal: S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. (Pubmed Central) - Jan 29, 2022
In addition, administration of S1PC elevated the M2c/M1 macrophage ratio in senescence-accelerated mice. These findings suggest that S1PC may help improve atherosclerosis due to its anti-inflammatory effect to promote IL-10-induced M2c macrophage polarization.
- | Journal: Is There Any Evidence of Monocytes Involvement in Alzheimer's Disease? A Pilot Study on Human Postmortem Brain. (Pubmed Central) - Jan 29, 2022
In contrast to studies on animal models, we observed only a quite low level of myeloid monocytes associated with AD pathology. Furthermore, we provide evidence associating early microglial reactions carried out in particular by pro-inflammatory cells with early effects on tangle- and plaque-positive vulnerable brain regions.
- | Journal, PD(L)-1 Biomarker, IO biomarker: Platelet lysate converts M (IFNγ+LPS) macrophages in CD206 TGF-β arginase M2-like macrophages that affect fibroblast activity and T lymphocyte migration. (Pubmed Central) - Jan 28, 2022
Our results demonstrate that PL dampens the macrophage secretion of pro-inflammatory cytokines and induces the release of arginase, TGF-? and VEGF that may affect angiogenesis and tissue regeneration, thus facilitating the wound healing process.
- | Journal: Macrophages expressing uncoupling protein 1 increase in adipose tissue in response to cold in humans. (Pubmed Central) - Jan 28, 2022
A high percentage of CD163 macrophages in SC WAT expressed UCP1, and these UCP1 expressing CD163 macrophages were significantly increased by cold treatment in SC WAT of lean subjects. In conclusion, our results suggest that CD163 macrophages are involved in some aspect of the tissue remodeling that occurs during SC WAT beiging in humans after cold treatment, but they are likely not direct mediators of the beiging process.
- | Preclinical, Journal: HIF-1α activator DMOG inhibits alveolar bone resorption in murine periodontitis by regulating macrophage polarization. (Pubmed Central) - Jan 27, 2022
DMOG treatment promoted the number of HIF-1α-positive cells in periodontal tissues. This study demonstrated the cell-specific roles of DMOG in macrophage polarization in vitro and provided insight into the mechanism underlying the protective effect of DMOG in a model of periodontitis.
- | Journal: Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function. (Pubmed Central) - Jan 27, 2022
In addition, biofilm carbohydrates reduce the association of the DC-SIGN ligand Lewis, but not fucose, to human monocyte-derived dendritic cells (moDCs), and alter moDC morphology without affecting early cytokine production in response to lipopolysaccharide or P. aeruginosa cultures. This work identifies the presence of ligands for three important C-type lectins within P. aeruginosa biofilm structures and purified biofilm carbohydrates and highlights the potential for these receptors to impact immunity to P. aeruginosa infection.
- | Journal: Water extract of Cayratia albifolia C.L.Li root relieves zymosan A-induced inflammation by restraining M1 macrophage polarization. (Pubmed Central) - Jan 27, 2022
This study provides further evidence that CAC significantly reduces zymA induced infectious inflammation. In addition, this novel data revealed that CAC restrained M1 rather than promoting M2 macrophages polarization via multi-target inhibitory effects, based on its potentially active components.
- | Preclinical, Journal: Role of M2 Macrophage Exosomes in Osteogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells under High-Glucose and High-Insulin (Pubmed Central) - Jan 27, 2022
High glucose and high insulin had inhibitory effect on the osteogenic differentiation potential of BMSCs. After intervention with M2-exo, the Hedgehog signaling pathway in BMSCs was activated and the osteogenic differentiation potential was enhanced, suggesting that M2-exo might have therapeutic potentials for the treatment of diabetic bone disease.
- | Preclinical, Journal: Transplantation of Fibroblast Sheets with Blood Mononuclear Cell Culture Exerts Cardioprotective Effects by Enhancing Anti-Inflammation and Vasculogenic Potential in Rat Experimental Autoimmune Myocarditis Model. (Pubmed Central) - Jan 26, 2022
Histological analysis revealed that QQ+F sheet transplantation promoted revascularization and mitigated fibrosis by limiting LV remodeling. Therefore, autologous QQMNC-modified F-sheets may be a beneficial therapeutic option for EAM.
- | Journal: C-Reactive Protein Is an Indicator of the Immunosuppressive Microenvironment Fostered by Myeloid Cells in Hepatocellular Carcinoma. (Pubmed Central) - Jan 26, 2022
The combination of serum CRP with TAMs or TANs in both the nontumor and intratumor regions could represent a powerful criterion for predicting patient prognoses. Serum CRP could serve as an indicator of an immunosuppressive TME in HCC, which could be of potential clinical application for treatment strategies targeting the TME.
- | Journal: Tumor-derived adenosine promotes macrophage proliferation in human hepatocellular carcinoma. (Pubmed Central) - Jan 21, 2022
Tumor-derived adenosine functions synergistically with autocrine GM-CSF released from activated Mφ, which promotes Mφ proliferation. Thus, selective modulation of Mφ accumulation at the source may provide a novel strategy for cancer therapy.
- | Journal: Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer. (Pubmed Central) - Jan 21, 2022
A diverse set of myeloid cells are present within the PDAC tumor microenvironment and are distributed heterogeneously across patient tumors. Not only the densities but also the spatial locations of myeloid immune cells are associated with patient outcomes, highlighting the potential role of spatially-resolved myeloid cell subtypes as quantitative biomarkers for PDAC prognosis and therapy.
- | Journal: Effects of Anti-Inflammatory Nanofibers on Urethral Healing. (Pubmed Central) - Jan 21, 2022
AIF-PA1 treatment enhances the healing process, contributing to earlier, complete urethral healing, and increased angiogenesis. Further studies are needed to elucidate the specific mechanism of inflammatory response modulation on angiogenesis and overall urethral healing.
- | Journal: Ginsenoside Rb2 Alleviated Atherosclerosis by Inhibiting M1 Macrophages Polarization Induced by MicroRNA-216a. (Pubmed Central) - Jan 21, 2022
Our findings indicated that Rb2 might be a potential therapeutic molecule for atherosclerosis by attenuating the atherosclerosis plaque lesion, lipid accumulation, and M1 macrophages polarization by targeting miR-216a. Given that accumulation of foam cells in the intima takes place chronically, the role of Rb2 in atherosclerosis progression needs further investigation.
- DECORIN DEFICIENCY EXACERBATES PERITONEAL INFLAMMATION AND FIBROSIS IN A MURINE MODEL OF PERITONEAL DIALYSIS (Poster Area (Virtual)) - Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_1253;
Given that accumulation of foam cells in the intima takes place chronically, the role of Rb2 in atherosclerosis progression needs further investigation. Our data suggest that decorin may ameliorate PDF-induced peritoneal fibrosis through its effects on FN and inflammatory cell infiltration.
- PRELIMINARY STUDY ON THE REGULATORY EFFECT OF HIGH GLUCOSE ON MACROPHAGE POLARIZATION THROUGH miR-125b (Poster Area (Virtual)) - Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_1031;
Inhibiting the expression of miR-125b can partially reverse the macrophages induced by high glucose stimulation to the pro-inflammatory type change. While this process may be achieved by up-regulating IRF4, PPAR, and down-regulating IRF5.
- SELF-ASSEMBLED PRO-APOPTOTIC GLYCOL-PEPTIDE BIVA-PK AMELIORATES RENAL FIBROSIS AFTER ISCHEMIA-REPERFUSION INJURY BY TARGETING M2 MACROPHAGES (Poster Area (Virtual)) - Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_1024;
While this process may be achieved by up-regulating IRF4, PPAR, and down-regulating IRF5. BIVA-PK ameliorated renal fibrosis through the specific elimination of M2 macrophages in renal interstitium and remodeled the local immune microenvironment, which suggests a potential therapeutic usage of BIVA-PK in renal fibrosis induced by IRI.
- | Preclinical, Journal: Polarization of macrophages in the trigeminal ganglion of rats with pulpitis. (Pubmed Central) - Jan 20, 2022
The trend of M2 macrophages was opposite to that of M1 macrophages in the TG during the process of pulpitis induced by CFA, which is consistent with the expression of macrophage-related cytokines. Macrophage polarization in the TG may participate in the neuroinflammation response induced by dental pulpitis.
- | Journal: Translocator protein regulate polarization phenotype transformation of microglia after cerebral ischemia-reperfusion injury. (Pubmed Central) - Jan 20, 2022
On the contrary, overexpression of TSPO inhibited M1 polarization, promoted M2 polarization, and significantly improved cell viability. In summary, TSPO plays a neuroprotective role in CIRI by inhibiting M1 polarization and promoting M2 polarization, which suggests that TSPO may have the potential to serve as a therapeutic target for stroke.
- | Journal: Bone marrow mesenchymal stem cell-derived exosomes improve renal fibrosis by reducing the polarisation of M1 and M2 macrophages through the activation of EP2 receptors. (Pubmed Central) - Jan 20, 2022
Compared to the lipopolysaccharide (LPS) group and the LPS + exosome + Ah6809 group, the lipopolysaccharide (LPS) + exosome group and the LPS + butaprost group showed a significant decrease in α-SMA expression, a decrease in the number of F4/80 CD86 and F4/80 CD206 cells, a decrease in interleukin (IL)-6 and an increase in IL-10 levels. Therefore, we conclude that BM-MSCs can reduce the polarization of M1 and M2 macrophages by activating EP2 receptors, thereby ameliorating renal fibrosis.
- || Clinical, Journal: The expression of IL17RA on sputum macrophages in asthma patients. (Pubmed Central) - Jan 19, 2022
This may be related to the Th2-dependent environment in asthma and increased concentrations of IL-25 and IL-13 as well as eosinophils in the airways. To our knowledge, our study provides the first data on a possible link between immunological reaction orchestrating CD206 + expressing sputum macrophages and IL-25 via IL17RA pathway in the asthmatic airways.
- | Journal: A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL-40 - IL-13 Receptor α2 Axis. (Pubmed Central) - Jan 19, 2022
In GCA, a GM-CSF-skewed, CD206+MMP9+ macrophage subset expresses high levels of YKL-40 which may stimulate tissue destruction and angiogenesis through IL-13Rα2 signaling. Targeting YKL-40 or GM-CSF may inhibit macrophages that are currently insufficiently suppressed by glucocorticoids.
- | Journal: Irf1- and Egr1-activated transcription plays a key role in macrophage polarization: A multiomics sequencing study with partial validation. (Pubmed Central) - Jan 19, 2022
Targeting YKL-40 or GM-CSF may inhibit macrophages that are currently insufficiently suppressed by glucocorticoids. Through multiomic analyses of epigenetic sequencing and RNA-seq with partial validation, the current study found that Irf1- and Egr1-induced transcription plays key roles in M1 and M2 macrophage polarization, respectively.
- | Interleukin 22 subunit alpha receptor / Merck (MSD)
Journal: Novel circulating and tissue monocytes as well as macrophages in pancreatitis and recovery. (Pubmed Central) - Jan 19, 2022
We identified several novel monocyte/macrophage subsets with unique phenotype and functional characteristics that are associated with AP, recovery, and SAP. Our findings highlight differential innate immune responses during AP progression and recovery that can be leveraged for future disease monitoring and targeting.
- | Journal: STAT3 is over-activated within CD163 bone marrow macrophages in both Multiple Myeloma and the benign pre-condition MGUS. (Pubmed Central) - Jan 18, 2022
By immunohistochemistry, bone marrow levels of pSTAT3 were increased specifically within CD163 cells in both MGUS and MM patients.In conclusion, macrophage-related inflammatory changes, including activation of STAT3, were present already at the MGUS stage, at similar levels as in MM. Specific increase in pSTAT3 levels within CD163 cells supports that the CD163 scavenger receptor may be a useful target for future delivery of STAT3-inhibitory drugs to TAMs in MM patients.
- | Journal: Natural killer T cell/IL-4 signaling promotes bone marrow-derived fibroblast activation and M2 macrophage-to-myofibroblast transition in renal fibrosis. (Pubmed Central) - Jan 18, 2022
Thus, this study revealed a novel role of NKT cells in the bone marrow-derived fibroblasts activation and M2MMT during renal fibrosis. Targeting NKT cell/IL-4 signaling may be an effective treatment for renal fibrosis.
- | Preclinical, Journal: The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with Tc-Tilmanocept SPECT. (Pubmed Central) - Jan 18, 2022
This result correlated with reduced tumor growth and collagen content, as well as an increase in CD8 cells in the TME. Tc-Tilmanocept SPECT imaging might represent an innovative non-invasive strategy to quantify CD206 tumor-associated macrophages as a biomarker of anti-GRP94 therapy efficacy and TNBC tumor aggressiveness.
- | Journal, PD(L)-1 Biomarker, IO biomarker: Colorectal Cancer-Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD-L1 Expression in Tumor-Associated Macrophages. (Pubmed Central) - Jan 18, 2022
Further studies reveal that CRC-derived miR-21-5p and miR-200a synergistically induces macrophage M2 like polarization and PD-L1 expression by regulating the PTEN/AKT and SCOS1/STAT1 pathways, resulting in decreased CD8 T cell activity and increased tumor growth. This study suggests that inhibiting the secretion of specific sEV-miRNAs from CRC and targeting PD-L1 in TAMs may serve as novel methods for CRC treatment as well as a sensitization method for anti-PD-L1 therapy in CRC.
- | Preclinical, Journal: Intrauterine inflammation induced white matter injury protection by fibrinogen-like protein 2 deficiency in perinatal mice. (Pubmed Central) - Jan 15, 2022
Intrauterine inflammation induces WMI leading to severe neurological sequelae. FGL2 plays an important role in the progression of WMI induced by intrauterine inflammation.FGL2 deficiency can protect against WMI by inhibiting p38 MAPK and JNK phosphorylation, regulating microglia polarization, and reducing inflammation response.FGL2 could be a novel molecular target for protecting against WMI induced by intrauterine inflammation.
- | Journal: Neutrophilic asthma features increased airway classical monocytes. (Pubmed Central) - Jan 15, 2022
We observed an increase in classical and CD206 monocytes in sputum in neutrophilic asthma, suggesting co-recruitment of monocytes and neutrophils to the airways in asthma. Our data suggest further investigation of how airway monocyte dysregulation impacts on asthma-related disease activity is merited.
- | Journal, IO biomarker: Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway. (Pubmed Central) - Jan 15, 2022
The data indicated that DLBCL-derived exosomes could trigger macrophages polarization into a pro-survival M2-like phenotype, which was at least partially through the GP130/STAT3 signaling pathway. Collectively, this study showed that DLBCL-derived exosomes could promote macrophages transformation to protumor M2-like phenotype in the tumor microenvironment.
- | Mekinist (trametinib) / Novartis, AT9283 / Otsuka
Journal: Production of NOS2 and inflammatory cytokines is reduced by selected protein kinase inhibitors with partial repolarization of HL-60 derived and human blood macrophages. (Pubmed Central) - Jan 15, 2022
Our results suggest that the repolarization of macrophages cannot be achieved by inhibiting their signaling pathways; nevertheless, the expression of certain polarization markers was decreased, therefore a "depolarization" could be observed both in M1 and M2 polarized cells. Selected protein kinase inhibitors of M1 polarization, decreasing NOS 2 and inflammatory cytokines may be potential candidates for therapeutical trials against inflammatory diseases.
- | Journal: Contemporary update of SPECT tracers and novelties in radioguided surgery: a perspective based on urology. (Pubmed Central) - Jan 14, 2022
For example, the impact of targeted radiotracers on prostate specific membrane antigen (PSMA), CD206 receptor-targeted agents (99mTc-tilmanocept), and hybrid tracers adding fluorescence to radioguidance (ICG-99mTc-nanocolloid) as well as targeting hypoxiainduced carbonic anhydrase IX (CAIX) will be covered. Furthermore, future outlooks on the implementation of gold nanoparticles (AuNP's), but also technical advances in improved radiotracer detection by hybrid gamma devices will be discussed.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Mifepristone regulates macrophage-mediated natural killer cells function in decidua. (Pubmed Central) - Jan 14, 2022
Our data suggest that mifepristone, which regulates NK cells function through macrophages, was associated with the changes in TGF-β1 secreted by macrophages. This may be one of the mechanisms of mifepristone acting as contraceptive and abortion drugs at the maternal-fetal interface.
- | Journal: Transglutaminase 2 mediates lung inflammation and remodeling by transforming growth factor beta 1 via alveolar macrophage modulation. (Pubmed Central) - Jan 14, 2022
This result suggests that TG2 mediates TGF-β1-induced M2-like polarization but does not contribute to TGF-β1-induced M1 polarization. In conclusion, TG2 regulates macrophage modulation and plays an important role in TGF-β1-induced lung inflammation, destruction, and fibrosis.
- | Preclinical, Journal: Hepatoprotective effect of genistein against dimethylnitrosamine-induced liver fibrosis in rats by regulating macrophage functional properties and inhibiting the JAK2/STAT3/SOCS3 signaling pathway. (Pubmed Central) - Jan 14, 2022
In conclusion, TG2 regulates macrophage modulation and plays an important role in TGF-β1-induced lung inflammation, destruction, and fibrosis. Taken together, our results showed that genistein could be improved liver fibrosis both in vivo and in vitro, probably through regulating the functional properties of macrophage and inhibiting the JAK2/STAT3/SOCS3 signaling pathway.
- | Journal: Interleukin-4 repairs wear particle induced osteolysis by modulating macrophage polarization and bone turnover. (Pubmed Central) - Jan 13, 2022
Interesting, slightly more bone formation and ALP + osteoblasts were seen in the IL-4 Del group than in the IL-4 Cont group although these differences were not statistically significant. The study is a proof of principle that osteolytic lesions can be repaired via modulation of macrophage polarization.
- | Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Journal, Combination therapy: Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity. (Pubmed Central) - Jan 13, 2022
The study is a proof of principle that osteolytic lesions can be repaired via modulation of macrophage polarization. These findings demonstrate the antitumor immune responses mediated by macrophage activation on local administration of poly(I:C)+R848 combination and support the intratumoral application of this therapy to patients with solid tumors in the clinic.
- | Preclinical, Journal: Hepatocyte growth factor ameliorates methylglyoxal-induced peritoneal inflammation and fibrosis in mouse model. (Pubmed Central) - Jan 12, 2022
Furthermore, HGF treatment reduces myofibroblast and macrophage infiltration, and attenuates the upregulated expression of proinflammatory and profibrotic genes in peritoneal tissues. HGF might be an effective approach to prevent the development of PF in patients undergoing PD.
- | Biomarker, Journal: Paraquat Mediates BV-2 Microglia Activation by Raising Intracellular ROS and Inhibiting Akt1 Phosphorylation. (Pubmed Central) - Jan 12, 2022
The Akt1 (S473E) partially attenuated the PQ induced increase in M1 phenotype, while ROS did not significantly change. These results indicated that PQ induced BV-2 microglia activation by increased ROS mediated Akt1 activation inhibition, leading to neuroinflammation.
- | Preclinical, Journal: C16, a novel sinomenine derivatives, promoted macrophage reprogramming toward M2-like phenotype and protected mice from endotoxemia. (Pubmed Central) - Jan 11, 2022
Furthermore, the results also showed that C16 showed anti-inflammatory effect by inhibiting LPS-induced p38, AKT and STAT1 phosphorylation and contributing ERK1/2 activation. C16 promoted macrophage reprogramming toward M2-like phenotype via p-p38/p-AKT or STAT1 signals pathway and C16 might be a valid candidate for inflammatory disease.
- | Journal: lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-κB Signaling. (Pubmed Central) - Jan 11, 2022
We proved that blocking the NF-κB pathway using antagonists greatly downregulated OSCC progression and M2 macrophage polarization induced by the overexpression of DCST1-AS1. To sum up, we reported that DCST1-AS1 plays an important role in modulating OSCC tumorigenicity and M2 macrophage polarization through regulating the NF-κB pathway.
- | Journal, IO biomarker: Dietary Sodium Nitrite Causes Similar Modifications to Splenic Inflammatory Gene Expression as a High-Fat Diet. (Pubmed Central) - Jan 11, 2022
These NaNO- or HFD-induced modifications were less profound in the liver and abdominal adipose tissues than in the spleen. These findings indicate that dietary NaNO has similar modulatory effects to HFD feeding on splenic inflammatory genes.