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- | Journal: Neuropeptide oxytocin facilitates its own brain-to-periphery uptake. (Pubmed Central) - Apr 4, 2025
Both the osmotic challenge and oxytocin neuronal activation elicit a local rise in neurohypophyseal capillary permeability in an oxytocin-signaling-dependent manner. We propose that oxytocin-dependent neurovascular coupling facilitates its efficient uptake into the blood circulation, suggesting a self-perpetuating stimulus-secretion-uptake mechanism for peripheral hormone transfer.
- | Journal: Low-pressure exposure influences the development of HAPE. (Pubmed Central) - Apr 3, 2025
Furthermore, hypoxia and hypobaria act synergistically and stimulate inflammation in ICR mice. Therefore, we suggest that hypobaria plays an important role in the pathogenesis of HAPE.
- | Journal: Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption. (Pubmed Central) - Mar 20, 2025
Our study indicates that disordered para vascular drainage, a marker for glymphatic system and BBB damage may contribute to neurocognitive impairment (NCI) among patients with PASC. The DTI-ALPS index, which does not require contrast injection, has the potential to serve as a non-invasive biomarker.
- || doxorubicin hydrochloride / Generic mfg.
Review, Journal: The Effects of Polyphenols on Doxorubicin-Induced Nephrotoxicity by Modulating Inflammatory Cytokines, Apoptosis, Oxidative Stress, and Oxidative DNA Damage. (Pubmed Central) - Mar 17, 2025
In addition, epidemiological studies have suggested that the intake of polyphenols may be associated with a reduced risk of DOX-induced nephrotoxicity by modulating inflammatory cytokines, apoptosis, oxidative stress, and oxidative DNA damage. Therefore, in the present review, we examined the influence of polyphenols on DOX-induced nephrotoxicity.
- || Biomarker, Review, Journal: Biomarkers of lung congestion and injury in acute heart failure. (Pubmed Central) - Mar 17, 2025
With deregulation of fluid handling and gas exchange pathways, SPs become sensitive markers of lung injury. We report the pathobiology of lung damage; the pathophysiological and clinical implications of alveolar SPs along with the newest evidence for some classical HF biomarkers that have also shown to reflect a vascular and/or a tissue lung-related activity.
- || Review, Journal: Systemic capillary leak syndrome: a nosological entity that the nephrologist must be aware of. (Pubmed Central) - Mar 9, 2025
The nephrologist must be aware of the potential and serious complications linked to this pathology, including the need for kidney replacement therapy. This review aims to increase awareness of systemic capillary leak syndrome in the nephrology community.
- | Journal: Physiopathology of High-Altitude Pulmonary Edema. (Pubmed Central) - Mar 7, 2025
This article presents a view of the physiopathology of HAPE by merging available data in humans exposed to high altitude with data from animal experimental approaches. A model is also presented to characterize HAPE nonsusceptible versus susceptible individuals based on the efficiency of alveolar-capillary oxygen uptake and estimated morphology of the air-blood barrier.
- | Journal: Primed Mesenchymal Stem Cells by IFN-? and IL-1? Ameliorate Acute Respiratory Distress Syndrome through Enhancing Homing Effect and Immunomodulation. (Pubmed Central) - Feb 20, 2025
signaling. In conclusion, in early-phase ARDS, primed MSCs displayed enhanced homing capabilities, improved lung function, and reduced inflammation.
- | Journal: Image-guided patient-specific prediction of interstitial fluid flow and drug transport in solid tumors. (Pubmed Central) - Feb 15, 2025
The patient-specific data were subsequently incorporated into a computational fluid dynamics (CFD) model to simulate individualized tumor perfusion and drug transport maps. The results on interstitial fluid flow demonstrated noticeable heterogeneity of interstitial fluid pressure and velocity within the tumor, along with heterogeneous drug penetration profiles among different tumors, even with a similar drug administration regimen.
- | Journal: A Case Report of Systemic Capillary Leak Syndrome: When More Than One Inciting Factor Exists, the Question Is Who Pulls the Trigger? (Pubmed Central) - Feb 11, 2025
We report herein a case of idiopathic SCLS in a 38-year-old male patient with a history of previous immunization, following COVID-19 infection, who was also diagnosed with a myeloproliferative neoplasm (MPN). To our knowledge, this is the first case where SCLS coexists with an MPN, leading to a legitimate question: Who pulls the trigger?
- | Journal: Dengue Hemorrhagic Fever Presenting With Pericardial Effusion and Cardiac Tamponade: A Case Report. (Pubmed Central) - Feb 3, 2025
After receiving empirical antibiotics, platelet transfusions, and close supervision, the patient's health improved, and the pericardial drain was removed on the fifth day of hospitalization. Since myocarditis and pericardial effusion are uncommon but hazardous cardiac symptoms in dengue fever, it is critical to detect and treat these disorders in patients with severe dengue fever to limit the illness's morbidity and mortality.
- | Preclinical, Journal: Overexpression of Parkin promotes the protective effect of mitochondrial autophagy on the lung of rats with exertional heatstroke. (Pubmed Central) - Jan 28, 2025
The expression of Pink1, MFN2, PTEN-L, and p62 decreased, whereas the expression of PTEN was not significantly different from that in the EHS group (P >0.05). Pink1/Parkin-mediated mitophagy dysfunction is one of the mechanisms underlying ALI in rats with EHS, and activation of Parkin overexpression-mediated mitophagy can alleviate ALI caused by EHS.
- A CASE OF KWASHIORKOR AFTER BARIATRIC SURGERY LEADING TO LARGE PERICARDIAL EFFUSION IN A YOUNG LATIN FEMALE - Josue Ocasio Tapia (Board no. 265; South Hall) - Jan 27, 2025 - Abstract #ACC2025ACC_7551;
Kwashiorkor is rare in developed countries, but must be taken into account in the appropriate clinical scenario and after careful history taking. Timely interventions such as thyroid hormone and albumin replacement can effectively reverse potentially fatal conditions.
- EXPLORING VASCULAR PERMEABILITY AS A POTENTIAL IMAGING BIOMARKER OF INFLAMMATION IN WOMEN WITH ISCHEMIA WITH NO OBSTRUCTIVE CORONARY ARTERIES - Ana Iribarren (Board no. 67; South Hall) - Jan 27, 2025 - Abstract #ACC2025ACC_6161;
These data support the hypothesis that increased vascular permeability may be linked to aortic stiffness in women with INOCA. More work is needed to confirm and extend these findings in a larger cohort
- A RARE AND INTERESTING CASE OF HYPOPITUITARISM AND RADIATION-INDUCED CONSTRICTIVE PERICARDITIS PRESENTING AS NEW DECOMPENSATED HEART FAILURE WITH PERICARDIAL EFFUSION - Kevin S. Tang (Board no. 254; South Hall) - Jan 27, 2025 - Abstract #ACC2025ACC_437;
RICP and hypopituitarism may both case heart failure through various mechanisms. Timely recognition and treatment of underlying causes are essential to reversing cardiac disease.
- | Biomarker, Journal: Biomarkers. (Pubmed Central) - Jan 12, 2025
This may imply regional BBB vulnerability of BF or another ongoing process such as hyperactivation or inflammation, suggesting a link between BBB dysfunction and early pathological changes in the BF area. Verification of these results on larger dataset is necessary before any further conclusions can be made.
- | Preclinical, Journal: Acetaminophen Overdose Reveals PAR4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium in Mice. (Pubmed Central) - Dec 24, 2024
Low-expressing PAR4 can react similarly to high-expressing PAR1 in APAP-overdosed hepatic ECs, demonstrating that PAR4 is a potent thrombin receptor. Additionally, these receptors are functionally redundant but act divergently in their expression and ability to influence transcription in hepatic ECs.
- || Review, Journal: Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients. (Pubmed Central) - Dec 17, 2024
It has been shown in both in vitro animal experiments and in humans that extracorporeal hemoadsorption can reduce circulating levels of cytokines and may also remove toxic proteins that directly take part in endothelium and glycocalyx damage. The current review aims to summarize current knowledge, put recent findings into context, and introduce the hypothesis of "endothelial protection with hemoadsorption" in critically ill patients.
- | Retrospective data, Journal: Single-Cell Meta-Analysis Uncovers the Pancreatic Endothelial Cell Transcriptomic Signature and Reveals a Key Role for NKX2-3 in PLVAP Expression. (Pubmed Central) - Nov 27, 2024
We defined a validated transcriptomic signature of pancreatic ECs and uncovered their intratissue transcriptomic heterogeneity. We showed that NKX2-3 acts upstream of PLVAP and provided a single-cell online resource that can be further explored by the community: https://vasconcelos.shinyapps.io/pancreatic_endothelial/.
- | Journal: VEGFR1 TK signaling protects the lungs against LPS-induced injury by suppressing the activity of alveolar macrophages and enhancing the anti-inflammatory function of monocyte-derived macrophages. (Pubmed Central) - Nov 14, 2024
Treatment with placental growth factor (PlGF), an agonist for VEGFR1, protected the lung against LPS-induced ALI associated with increased MDMs. These results suggest that VEGFR1 TK signaling prevents LPS-induced ALI by suppressing the pro-inflammatory activity of AMs and enhancing the anti-inflammatory function of MDMs.
- | tamoxifen / Generic mfg.
Journal: Latrophilin-2 Deletion in Cardiomyocyte Disrupts Cell Junction, Leading to D-CMP. (Pubmed Central) - Nov 13, 2024
The embryonic lethality resulting from Lphn2 deletion necessitates the establishment of cardiomyocyte-specific, tamoxifen-inducible Lphn2 knockout mice, which was achieved by crossing Lphn2?flox/flox mice with mice having MerCreMer (tamoxifen-inducible Cre [Cyclization recombinase] recombinase) under the ?-myosin heavy chain promoter...Lphn2 is a critical regulator of heart integrity by controlling mitochondrial functions and cell-to-cell junctions in cardiomyocytes. Its deficiency leads to D-CMP, which can be rescued by activators of the p38-MAPK pathway.
- | Journal: Bronchoalveolar Lavage and Oleic Acid Two-hit Model for Inducing Acute Respiratory Distress Syndrome in Swine Models. (Pubmed Central) - Nov 5, 2024
This promising new model has the capacity to successfully replicate human ARDS which is a well-known and notoriously multifactorial pathogenic process to reproduce experimentally for an extended period of time. The "two-hit model" is a viable and appropriate model for the research of novel treatments for ARDS.
- | Journal: The effect of VEGF and KDR gene variants on Crimean-Congo hemorrhagic fever. (Pubmed Central) - Nov 5, 2024
The KDR?-?604?T?>?C variant's allele and genotype distribution were not significantly different between the patients and controls. This study suggests the VEGF 936?C?>?T variant is a genetic marker of sensitivity to CCHF among the Turkish population and may help protect against the disease.
- Radiogenomics during neoadjuvant therapy with aromatase inhibitors: integrating dynamic magnetic resonance data and molecular biology (Halls 2-3) - Nov 1, 2024 - Abstract #SABCS2024SABCS_269;
- | thapsigargin / University of Nottingham, Pirbright Institute
Journal: Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability. (Pubmed Central) - Oct 23, 2024
This study suggests the VEGF 936?C?>?T variant is a genetic marker of sensitivity to CCHF among the Turkish population and may help protect against the disease. Rap1A knockdown, unlike Rap1B, significantly increased store-operated calcium entry in response to a GPCR (G-protein-coupled receptor) agonist, ATP (500
- | Preclinical, Journal: Male Akita diabetic mice develop underactive bladder independent of NLRP3 that can be prevented with blood glucose control. (Pubmed Central) - Oct 14, 2024
Deleting NLRP3 did not affect voiding function. Male Akita mice develop an underactive-like bladder, independent of NLRP3, which can be prevented with glucose control.
- || garadacimab (CSL312) / CSL Behring
Review, Journal: Targeting factor XIIa for therapeutic interference with hereditary angioedema. (Pubmed Central) - Sep 27, 2024
Of these, garadacimab, an FXIIa-targeted inhibitory monoclonal antibody, is the most advanced and has shown potential as a novel long-term prophylactic treatment for patients with HAE in clinical trials. The evidence from these trials is summarized and discussed, and we propose areas for future research where targeting FXIIa may have therapeutic potential beyond HAE.
- | Journal: Ac2-26 Reduced Lung Injury After Cardiopulmonary Bypass via the AKT1/GSK3?/eNOS Pathway. (Pubmed Central) - Sep 26, 2024
Ac2-26 significantly reduced lung injury and inflammation after CPB. The protective effect of Ac2-26 mainly depended on the AKT1/GSK3?/endothelial nitric oxide synthase pathway.
- | Journal: In Memoriam: C. Charles Michel, BA (Hons), MA, BM BCh, DPhil, FRCP, 23 March 1938-19 July 2024. (Pubmed Central) - Sep 24, 2024
The protective effect of Ac2-26 mainly depended on the AKT1/GSK3?/endothelial nitric oxide synthase pathway. No abstract available
- | Panzem (2-methoxyestradiol) / CASI
Preclinical, Journal: The Essential Role of PGF2?/PTGFR in Molding Endometrial Breakdown and Vascular Dynamics, Regulated by HIF-1? in a Mouse Menstrual-like Model. (Pubmed Central) - Sep 15, 2024
Our study provides evidence that PGF2?/PTGFR plays a vital role in endometrial breakdown via vascular changes that are regulated by HIF-1? during menstruation.
- | Preclinical, Journal: Sulfated polysaccharide from Apostichopus japonicus viscera exhibits anti-inflammatory properties in vitro and in vivo. (Pubmed Central) - Sep 15, 2024
SCVP-2's anti-inflammatory capacity was confirmed in acute inflammation models, including xylene-induced ear swelling and acetic acid-induced peritoneal capillary permeability, and in high-fat diet-induced systemic low-grade chronic inflammation. In conclusion, SCVP-2 exhibits significant anti-inflammatory activity, suggesting its potential for development as a functional food ingredient or therapeutic agent for inflammation-related diseases.
- RE-EXPANSION PULMONARY EDEMA AFTER UNCOMPLICATED THORACENTESIS (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6628;
Our patient only met one of the most reported risk factors with the fluid collection having been present for >72 hours at the time of thoracentesis. He exhibited no signs of discomfort during the procedure, but unfortunately did develop this rare yet often deadly complication.
- INTRAPLEURAL CORTICOSTEROID FOR RECURRENT INFLAMMATORY PLEURAL EFFUSION AFTER LUNG TRANSPLANT: A CASE SERIES (Convention Center Exhibit Hall: Rapid Fire Area 4D) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6453;
He exhibited no signs of discomfort during the procedure, but unfortunately did develop this rare yet often deadly complication. These cases shed light on the efficacy of intrapleural triamcinolone as a therapeutic modality, offering insights into its potential as an innovative solution for symptomatic exudative lymphocytic predominant pleural effusions.
- aspirin / Generic mfg.
DYSPNEA AND DISTRESS: MATERNAL RESPIRATORY COLLAPSE IN SEVERE PREECLAMPSIA IN THE POSTPARTUM PERIOD (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6441;
Awareness of the physiological mechanisms can perhaps lead to preventative measures such as judicious use of tocolytics and IV fluids antepartum and strict blood pressure control. Other risk fators include advanced maternal age, multiparity and chronic hypertension
- NEGATIVE PRESSURE PULMONARY EDEMA AFTER LARYNGEAL MASK AIRWAY IN A PATIENT WITH DAILY VAPING USE (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6394;
Other risk fators include advanced maternal age, multiparity and chronic hypertension Given the growing incidence of vaping among patients, it is especially important for clinicians to be aware of NPPE to optimize treatment and reduce post-operative complications.
- | tamoxifen / Generic mfg.
Journal: ROLE OF CASPASE-1/CASPASE-11-HMGB1-RAGE/TLR4 SIGNALING IN THE EXACERBATION OF EXTRAPULMONARY SEPSIS INDUCED LUNG INJURY BY MECHANICAL VENTILATION. (Pubmed Central) - Sep 4, 2024
EC HMGB1-/- mice are deficient in HMGB1 owing to endothelial cells, resulting in a distinct pulmonary protective mechanism independent of the inflammatory response and more relevant to the improvement of alveolar-capillary permeability. iHMGB1-/- mice, which are systemically HMGB1-deficient, share both of these lung-protective mechanisms.
- | Retrospective data, Journal: Risk factors for post-colorectal endoscopic submucosal dissection bleeding and efficacy of carbazochrome sodium sulfonate: A multicenter retrospective cohort study. (Pubmed Central) - Aug 11, 2024
CSS administration is ineffective in preventing post-colorectal ESD bleeding in both the general population and individuals at a high risk for such bleeding. Our results indicate the necessity to reconsider the application of CSS for preventing post-colorectal ESD bleeding.
- Yellow Urticaria (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_5194;
Our results indicate the necessity to reconsider the application of CSS for preventing post-colorectal ESD bleeding. Although it is an infrequent occurrence, it is noteworthy to recognize this sign, which in all reported cases has occurred in the context of hyperbilirubinemia in potentially serious underlying pathologies.
- || Emla-cream / Akorn, AstraZeneca, lidocaine topical / Generic mfg.
Review, Journal: EMLA cream in burns: A systematic review of safety, analgesic efficacy, and effects on burn pathophysiology. (Pubmed Central) - Aug 1, 2024
Current data on EMLA use in the management of procedural pain in small burns are sparse but suggest that EMLA is safe and effective in adults. Further clinical pharmacokinetic studies are warranted, especially for application on larger burn areas.
- atovaquone/proguanil / Generic mfg., lorazepam / Generic mfg.
SEVERE MALARIA COMPLICATED BY NONCARDIOGENIC PULMONARY EDEMA: WHEN HYPOPARASITEMIA PROVIDES FALSE REASSURANCE (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5570;
This case highlights the importance of assessing different prognostic markers when treating for malaria in order to provide adequate therapy in a timely manner. Similarly, it warrants being vigilant with volume repletion given high risk of pulmonary edema in setting of increased capillary permeability[3].
- | Journal: Atypical Hemorrhages Secondary to Dengue Infection and Cardiopulmonary Resuscitation: Subcutaneous Thrombin Injection as a Salvage Technique for Refractory Femoral Artery Hemorrhage. (Pubmed Central) - Jul 19, 2024
We describe a case of severe dengue hemorrhagic fever presenting with atypical hemorrhage from both the psoas muscle and the femoral arterial puncture sites. These were successfully treated with
- CHANGES IN FLUID DISTRIBUTION AND HAEMODYNAMICS IN THE EARLY PHASE OF ACUTE PANCREATITIS (Poster Stage 4) - Jul 18, 2024 - Abstract #UEGW2024UEGW_2420;
Our data provide physiological rationale for emerging evidence regarding more restricitive fluid resuscitation. Personalized- and goal directed therapy may be a promising novel way in the transition from necessary fluid resuscitation to harmful fluid volume accumulation in the early phase of AP.
- | Journal: Pulmonary Vascular Permeability and Extravascular Lung Water Index in Patients with Liver Cirrhosis and Septic Shock. (Pubmed Central) - Jul 13, 2024
Higher levels of PVPID2 and pEVLWID2 are associated with higher 28-day mortality rates in cirrhotic patients with septic shock. PVPI and pEVLWI may be useful to guide fluid management in this clinical setting.
- || Review, Journal: Fluid Responsiveness and Management in Obstetrics using Point-of-Care Ultrasound. (Pubmed Central) - Jul 6, 2024
The expert review synthesizes current evidence and practice guidelines, suggesting integrating POCUS as a fundamental aspect of fluid management in obstetrics. It calls for ongoing research to enhance techniques and validate their use in broader clinical settings, aiming to improve outcomes for pregnant patients and their babies by preventing complications associated with both under- and over-resuscitation.
- Dynamic contrast enhanced MRI reveals impaired blood brain barrier in basal forebrain region in patients with Alzheimers disease: A pilot study (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_4107;
Our pilot data show regional BBB dysfunction in NBM region in patients with MCI due to AD.This may imply regional BBB vulnerability of BF or another ongoing process such as hyperactivation or inflammation, suggesting a link between BBB dysfunction and early pathological changes in the BF area. Verification of these results on larger dataset is necessary before any further conclusions can be made.
- | metformin / Generic mfg.
Preclinical, Journal: Metformin attenuates lung ischemia-reperfusion injury and necroptosis through AMPK pathway in type 2 diabetic recipient rats. (Pubmed Central) - May 15, 2024
Verification of these results on larger dataset is necessary before any further conclusions can be made. Metformin attenuates lung I/R injury and necroptosis through AMPK pathway in type 2 diabetic lung transplant recipient rats.
- COMBINATION OF PLATELET PARAMETERS AND MONOCYTE FLUORESCENCE TO ASSES AND PREDICT SEVERE DENGUE IN A PEDIATRIC POPULATION.A SINGLE PEDIATRIC HOSPITAL EXPERIENCE (Grand Hall) - May 9, 2024 - Abstract #ISLH2024ISLH_51;
MPV may predicts the evolution to a severe phase before it occurs, and both (IPF% and MPV) could be combined and help to manage the Mild Dengue patients. We plan to confirm in a prospective study the utility of these parameters to manage Dengue infection in hospitalized children and once confirmed to try to treat the patients preventing its complication to a severe disease.
- | Journal: Vaporization of perfluorocarbon attenuates sea-water-drowning-induced acute lung injury by deactivating the NLRP3 inflammasomes in canines. (Pubmed Central) - May 6, 2024
(IL-1?), and interleukin-18 (IL-18) by enhancing the expression of HO-1 and NRF1. Our results suggest that the vaporization of PFCs could attenuate SD-ALI by deactivating NLRP3 inflammasomes via the HO-1/NRF1 pathway.
- | Journal: Da-Cheng-Qi decoction improves severe acute pancreatitis capillary leakage syndrome by regulating tight junction-associated proteins. (Pubmed Central) - May 6, 2024
DCQD also upregulated claudin 5, occludin, and ZO-1 expression in vitro (p < 0.05). DCQD can improve capillary permeability in both in vivo and in vitro models of SAP by upregulating expression of claudin 5, occludin, and ZO-1, but not JAM-C.
- thyroxine / Generic mfg.
Myxedema Heart Unveiled - Profound Hypothyroidism With a Large Pericardial Effusion (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1829;
Given his thyroid function tests, Endocrinology was consulted, and he was started on Liothyronine and IV Levothyroxine...Dramatic response to thyroid hormone supplementation is usually seen. Pericardiocentesis is beneficial when the diagnosis is in doubt or in case of cardiac tamponade.