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  • ||||||||||  tamoxifen / Generic mfg.
    Journal:  Latrophilin-2 Deletion in Cardiomyocyte Disrupts Cell Junction, Leading to D-CMP. (Pubmed Central) -  Nov 13, 2024   
    The embryonic lethality resulting from Lphn2 deletion necessitates the establishment of cardiomyocyte-specific, tamoxifen-inducible Lphn2 knockout mice, which was achieved by crossing Lphn2?flox/flox mice with mice having MerCreMer (tamoxifen-inducible Cre [Cyclization recombinase] recombinase) under the ?-myosin heavy chain promoter...Lphn2 is a critical regulator of heart integrity by controlling mitochondrial functions and cell-to-cell junctions in cardiomyocytes. Its deficiency leads to D-CMP, which can be rescued by activators of the p38-MAPK pathway.
  • ||||||||||  Journal:  The effect of VEGF and KDR gene variants on Crimean-Congo hemorrhagic fever. (Pubmed Central) -  Nov 5, 2024   
    The KDR?-?604?T?>?C variant's allele and genotype distribution were not significantly different between the patients and controls. This study suggests the VEGF 936?C?>?T variant is a genetic marker of sensitivity to CCHF among the Turkish population and may help protect against the disease.
  • ||||||||||  garadacimab (CSL312) / CSL Behring
    Review, Journal:  Targeting factor XIIa for therapeutic interference with hereditary angioedema. (Pubmed Central) -  Sep 27, 2024   
    Of these, garadacimab, an FXIIa-targeted inhibitory monoclonal antibody, is the most advanced and has shown potential as a novel long-term prophylactic treatment for patients with HAE in clinical trials. The evidence from these trials is summarized and discussed, and we propose areas for future research where targeting FXIIa may have therapeutic potential beyond HAE.
  • ||||||||||  Journal:  Physiopathology of High-Altitude Pulmonary Edema. (Pubmed Central) -  Sep 27, 2024   
    This article presents a view of the physiopathology of HAPE by merging available data in humans exposed to high altitude with data from animal experimental approaches. A model is also presented to characterize HAPE nonsusceptible versus susceptible individuals based on the efficiency of alveolar-capillary oxygen uptake and estimated morphology of the air-blood barrier.
  • ||||||||||  Preclinical, Journal:  Sulfated polysaccharide from Apostichopus japonicus viscera exhibits anti-inflammatory properties in vitro and in vivo. (Pubmed Central) -  Sep 15, 2024   
    SCVP-2's anti-inflammatory capacity was confirmed in acute inflammation models, including xylene-induced ear swelling and acetic acid-induced peritoneal capillary permeability, and in high-fat diet-induced systemic low-grade chronic inflammation. In conclusion, SCVP-2 exhibits significant anti-inflammatory activity, suggesting its potential for development as a functional food ingredient or therapeutic agent for inflammation-related diseases.
  • ||||||||||  RE-EXPANSION PULMONARY EDEMA AFTER UNCOMPLICATED THORACENTESIS (Convention Center Exhibit Hall: Poster Area 3) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6628;    
    Our patient only met one of the most reported risk factors with the fluid collection having been present for >72 hours at the time of thoracentesis. He exhibited no signs of discomfort during the procedure, but unfortunately did develop this rare yet often deadly complication.
  • ||||||||||  INTRAPLEURAL CORTICOSTEROID FOR RECURRENT INFLAMMATORY PLEURAL EFFUSION AFTER LUNG TRANSPLANT: A CASE SERIES (Convention Center Exhibit Hall: Rapid Fire Area 4D) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6453;    
    He exhibited no signs of discomfort during the procedure, but unfortunately did develop this rare yet often deadly complication. These cases shed light on the efficacy of intrapleural triamcinolone as a therapeutic modality, offering insights into its potential as an innovative solution for symptomatic exudative lymphocytic predominant pleural effusions.
  • ||||||||||  aspirin / Generic mfg.
    DYSPNEA AND DISTRESS: MATERNAL RESPIRATORY COLLAPSE IN SEVERE PREECLAMPSIA IN THE POSTPARTUM PERIOD (Convention Center Exhibit Hall: Poster Area 3) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6441;    
    Awareness of the physiological mechanisms can perhaps lead to preventative measures such as judicious use of tocolytics and IV fluids antepartum and strict blood pressure control. Other risk fators include advanced maternal age, multiparity and chronic hypertension
  • ||||||||||  NEGATIVE PRESSURE PULMONARY EDEMA AFTER LARYNGEAL MASK AIRWAY IN A PATIENT WITH DAILY VAPING USE (Convention Center Exhibit Hall: Poster Area 3) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6394;    
    Other risk fators include advanced maternal age, multiparity and chronic hypertension Given the growing incidence of vaping among patients, it is especially important for clinicians to be aware of NPPE to optimize treatment and reduce post-operative complications.
  • ||||||||||  Biomarker, Review, Journal:  Biomarkers of lung congestion and injury in acute heart failure. (Pubmed Central) -  Aug 9, 2024   
    With deregulation of fluid handling and gas exchange pathways, SPs become sensitive markers of lung injury. We report the pathobiology of lung damage; the pathophysiological and clinical implications of alveolar SPs along with the newest evidence for some classical HF biomarkers that have also shown to reflect a vascular and/or a tissue lung-related activity.
  • ||||||||||  Yellow Urticaria (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_5194;    
    We report the pathobiology of lung damage; the pathophysiological and clinical implications of alveolar SPs along with the newest evidence for some classical HF biomarkers that have also shown to reflect a vascular and/or a tissue lung-related activity. Although it is an infrequent occurrence, it is noteworthy to recognize this sign, which in all reported cases has occurred in the context of hyperbilirubinemia in potentially serious underlying pathologies.
  • ||||||||||  atovaquone/proguanil / Generic mfg., lorazepam / Generic mfg.
    SEVERE MALARIA COMPLICATED BY NONCARDIOGENIC PULMONARY EDEMA: WHEN HYPOPARASITEMIA PROVIDES FALSE REASSURANCE (Convention Center Exhibit Hall: Poster Area 3) -  Jul 31, 2024 - Abstract #CHEST2024CHEST_5570;    
    This case highlights the importance of assessing different prognostic markers when treating for malaria in order to provide adequate therapy in a timely manner. Similarly, it warrants being vigilant with volume repletion given high risk of pulmonary edema in setting of increased capillary permeability[3].
  • ||||||||||  CHANGES IN FLUID DISTRIBUTION AND HAEMODYNAMICS IN THE EARLY PHASE OF ACUTE PANCREATITIS (Poster Stage 4) -  Jul 18, 2024 - Abstract #UEGW2024UEGW_2420;    
    Our data provide physiological rationale for emerging evidence regarding more restricitive fluid resuscitation. Personalized- and goal directed therapy may be a promising novel way in the transition from necessary fluid resuscitation to harmful fluid volume accumulation in the early phase of AP.
  • ||||||||||  Review, Journal:  Fluid Responsiveness and Management in Obstetrics using Point-of-Care Ultrasound. (Pubmed Central) -  Jul 6, 2024   
    The expert review synthesizes current evidence and practice guidelines, suggesting integrating POCUS as a fundamental aspect of fluid management in obstetrics. It calls for ongoing research to enhance techniques and validate their use in broader clinical settings, aiming to improve outcomes for pregnant patients and their babies by preventing complications associated with both under- and over-resuscitation.
  • ||||||||||  thyroxine / Generic mfg.
    Myxedema Heart Unveiled - Profound Hypothyroidism With a Large Pericardial Effusion (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_1829;    
    Given his thyroid function tests, Endocrinology was consulted, and he was started on Liothyronine and IV Levothyroxine...Dramatic response to thyroid hormone supplementation is usually seen. Pericardiocentesis is beneficial when the diagnosis is in doubt or in case of cardiac tamponade.
  • ||||||||||  Januvia (sitagliptin) / Merck (MSD)
    Journal:  Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury. (Pubmed Central) -  Apr 24, 2024   
    We previously reported that DPP4 inhibition by sitagliptin attenuates lipopolysaccharide (LPS)-induced lung injury in mice...In summary, this study demonstrated that genetic deficiency of Dpp4 attenuates inflammatory responses but not permeability in LPS-induced lung injury in mice, potentially through differential functional roles of CD26/DPP4 expression in resident cellular components of the lung. CD26/DPP4 may be a potential therapeutic target for ARDS and warrants further exploration to precisely identify the multiple functional effects of CD26/DPP4 in ARDS pathophysiology.
  • ||||||||||  Review, Journal:  Mechanisms of Myocardial Edema Development in CVD Pathophysiology. (Pubmed Central) -  Feb 24, 2024   
    The study of molecular, genetic, and mechanical changes in the myocardium during edema may contribute to the development of new approaches to the diagnosis and treatment of this condition. This review was conducted to describe the main mechanisms of myocardial edema development at the molecular and cellular levels and to identify promising targets for the regulation of this condition based on articles cited in Pubmed up to January 2024.
  • ||||||||||  Selzentry (maraviroc) / ViiV Healthcare
    CCR5 Drives NK Cell Mediated Airway Damage in an Endotoxin-induced Model of Acute Lung Injury (San Diego Convention Center, Room 1A-B (Upper Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_7365;    
    In a treatment trial, 24 hours preceding ALI, a group of animals were given intraperitoneal 10 mg/kg of the allosteric CCR5 inhibitor,Maraviroc or 10 mg/kg of vehicle control...Our results demonstrate that CCR5 dependent trafficking facilitates NK cell-associated airway damage in LPS-induced ALI. CCR5 inhibition may be a potential therapeutic strategy to mitigate this pathology.
  • ||||||||||  hydrochlorothiazide / Generic mfg., furosemide / Generic mfg., spironolactone / Generic mfg.
    Characterizing Outpatient Diuretic Therapy in Children With Bronchopulmonary Dysplasia (San Diego Convention Center, Area G (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_3978;    
    Just under half of our study population was on diuretic therapy in the outpatient setting, with chlorothiazide being the most commonly prescribed. Subjects on diuretic therapy were more likely to be on supplemental oxygen in the outpatient setting, but diuretic status was not associated with age of weaning supplemental oxygen.
  • ||||||||||  Post-Operative Outcomes of ARDS after VATS: The Seismic Shift in ARDS Clinical Practice Guidelines (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_3587;    
    Our case highlights the need for early recognition of ARDS and the shift in the guidelines, which has provided clinicians the scientific endorsement for the early use of corticosteroids in managing this challenging disease. This intervention is likely to be foundational in the propagation of more favourable ARDS outcomes of varying etiologies.
  • ||||||||||  fentanyl citrate / Generic mfg., buprenorphine/naloxone sublingual film / Generic mfg., naloxone nasal spray / Generic mfg.
    No-lax-zone: Side Effects That Can Steal Your Breath Away (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_1610;    
    Although left ventricular dysfunction likely played a role, it underscores the importance of recognizing and managing this adverse effect, particularly with the increasing availability of intranasal naloxone. Raising awareness among patients and healthcare providers about the potential complications associated with naloxone is vital to ensure safe and effective opioid overdose management.
  • ||||||||||  methimazole / Generic mfg.
    Methimazole-Induced Hypothyroidism Presenting as Recurrent Thoracic Cavity Effusions and Ascites (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_1512;    
    This was evident in our case with the patient's history of dialysis dependence and hyperthyroidism from Grave's disease, which did not provide sufficient explanation for her recurrent serosal effusions. In the appropriate patient, thyroid function analysis is crucial in identifying medication-induced hypothyroidism as correction of thyroid hormone levels prevents future effusions.
  • ||||||||||  A Breath-Taking Triad, Rare Case of Pseudo-Meigs Syndrome in a Patient With Benign Leiomyoma (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_1497;    
    Tumor resection results in resolution of ascites and pleural effusions and saves patients from unnecessary thoracentesis and paracentesis. Eliminating the iatrogenic risks of these procedures, such as pneumothorax, bleeding, infection, and bowel perforation.