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  • ||||||||||  ulinastatin injection / Generic mfg.
    Journal:  Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages. (Pubmed Central) -  May 29, 2021   
    Our previous study found that urinary trypsin inhibitor (ulinastatin, UTI) protected tight junctions (TJs) of lung endothelia via TNF-α inhibition, thereby alleviating pulmonary capillary permeability in septic rats...UTI markedly ameliorated the lung EB leakage, improved LIS, reduced the wet-to-dry ratio and revised the damaged TJs of PMVECs in CLP-rats. UTI effectively inhibits the conversion of M1 macrophage but increases M2, reduces the phagocytosis and migration, which helps to protect endothelia TJs and reduce pulmonary capillary permeability during sepsis.
  • ||||||||||  Journal:  Lymphatic flow modulation as adjunct therapy for septic shock. (Pubmed Central) -  May 15, 2021   
    Multiple studies in both humans and animals have shown nitric oxide to be a potent modulator of lymphatic function. The present study suggests a hypothetical adjunct therapy for patients with septic shock through the use of phosphodiesterase inhibitors, which may improve microcirculatory flow by decreasing interstitial fluid volume via increased lymphatic fluid drainage.
  • ||||||||||  Journal:  Sampling and Evaluating the Peripheral Nervous System. (Pubmed Central) -  May 5, 2021   
    Differentiating between axonal or myelin degeneration may not be possible from the examination of paraffin-embedded sections. A sampling strategy more consistent with known mechanisms of toxicity, atraumatic harvest of tissues, optimized fixation, and the use of resin and paraffin-embedded sections will greatly enhance the pathologist's ability to observe and characterize effects in the PNS.
  • ||||||||||  Journal:  α1-Antitrypsin. (Pubmed Central) -  Apr 27, 2021   
    However, studies have also highlighted the role of α1-antitrypsin in the modulation of inflammation and bacterial clearance. In light of the current SARS-CoV-2 pandemic, the identification of a treatment for acute respiratory distress syndrome is even more pertinent, and α1-antitrypsin has been implicated in the inflammatory response to SARS-CoV-2 infection.
  • ||||||||||  Journal:  Brown Spiders' Phospholipases-D with Potential Therapeutic Applications: Functional Assessment of Mutant Isoforms. (Pubmed Central) -  Apr 7, 2021   
    Both in vitro (sphingomyelinase activity and hemolysis) and in vivo (capillary permeability, dermonecrotic activity, and histopathological analysis) assays showed that the PLDs with mutations H12-H47, E32-D34, and Y228-Y229-W230 displayed only residual activities. Results indicate that these mutant toxins are suitable for use as antigens to obtain neutralizing antisera with enhanced properties since they will be based on the most deleterious toxins in the venom and without causing severe harmful effects to the animals in which these sera are produced.
  • ||||||||||  Journal:  Epineural optogenetic activation of nociceptors initiates and amplifies inflammation. (Pubmed Central) -  Mar 10, 2021   
    It also led to immune reactions in the skin in the absence of inflammation and potentiation of established inflammation, a consequence of the antidromic activation of nociceptor peripheral terminals. These results reveal a link between nociceptors and immune cells, which might have implications for the treatment of inflammation.
  • ||||||||||  Journal:  Diffusion kurtosis imaging in head and neck cancer: A correlation study with dynamic contrast enhanced MRI. (Pubmed Central) -  Mar 2, 2021   
    Future research should focus on a combination of these strategies to reduce edema and assess the effect on organ function and outcome following CPB. A weak to intermediate correlation was found between DKI parameters and both K and v. The kurtosis was associated to the intratumoral heterogeneity and complexity of the capillary permeability, expressed by En(K).
  • ||||||||||  Journal:  WISP1 and TLR4 on Macrophages Contribute to Ventilator-Induced Lung Injury. (Pubmed Central) -  Feb 9, 2021   
    TLR4 and WISP1, especially the former one, on macrophages could contribute to releasing of pro-inflammatory cytokines during ventilator-induced lung injury. Injurious mechanical ventilation may result in an immune response which is similar to that of infection.
  • ||||||||||  Journal:  VEGF-PLGA controlled-release microspheres enhanced angiogenesis in encephalomyosynangiosis-based chronic cerebral hypoperfusion. (Pubmed Central) -  Feb 7, 2021   
    We speculated that this enhancement of cerebral blood flow was attributed to more angiogenesis induced by combination of VEGF microspheres and EMS, which verified by more collateral circulation with cerebral angiography and higher expression of CD31 or α-SMA. Our study demonstrated that combinating VEGF-PLGA controlled-release microspheres could significantly promote angiogenesis in EMS-based CCH rats model, providing new ideas for clinical treatment of CCH.
  • ||||||||||  Review, Journal:  Application of quercetin flavonoid based hybrid nanocomposites: A review. (Pubmed Central) -  Jan 12, 2021   
    This quercetin flavonoid based hybrid nanocomposites seemed to show a significant effect on In vitro and some animal model processes along with attenuating lipid peroxidation, platelet aggregation, and capillary permeability actions. This review mainly focused on the hybrid nanoscience of quercetin bioflavonoid and its application in numerous biological, material fields with a future perspective.
  • ||||||||||  Journal:  Research advances on the molecular mechanisms of vascular permeability in sepsis (Pubmed Central) -  Dec 22, 2020   
    Recent studies have shown that various factors and mediators involved in the regulation of vascular permeability in sepsis are expected to become targets for clinical treatment of sepsis. In this paper, we have reviewed the research advances on some molecules which are significantly associated with vascular permeability in sepsis, such as vascular endothelial growth factor, angiopoietin, sphingosine-1-phosphate, heparin-binding protein, and Slit2.
  • ||||||||||  Journal:  Severe acute pancreatitis: Capillary permeability model linking systemic inflammation to multiorgan failure. (Pubmed Central) -  Dec 16, 2020   
    P=N/A
    Changing capillary permeability to allow loss of NAPP in this model predicts loss of plasma oncotic pressure and reduced vascular volume, hypotension with pre-renal azotemia and acute kidney dysfunction, pancreas necrosis, and pulmonary edema from capillary leak in the lung with acute respiratory distress syndrome. Sequential biomarker analysis in humans with or without MOF is consistent with this model.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device. (Pubmed Central) -  Dec 16, 2020   
    Because previous experimental and clinical research suggested potential benefits of halogenated volatiles, such as sevoflurane or isoflurane, for lung alveolar epithelial injury and inflammation, two pathophysiologic landmarks of diffuse alveolar damage during ARDS, we designed an animal model to understand the mechanisms of the effects of halogenated agents on lung injury and repair...Although this model induced a marked decrease in arterial oxygenation with altered alveolar-capillary permeability, it is reproducible and is characterized by a rapid onset, good stability over time, and no fatal complications. We have developed a piglet model of acid aspiration that reproduces most of the physiological, biological, and pathological features of clinical ARDS, and it will be helpful to further our understanding of the potential lung-protective effects of halogenated agents delivered through devices used for inhaled ICU sedation.
  • ||||||||||  Review, Journal:  Endothelial Damage in Acute Respiratory Distress Syndrome. (Pubmed Central) -  Dec 2, 2020   
    In this review, we will discuss the underlying pathology of endothelial dysfunction leading to ARDS and emerging therapies. Furthermore, we will present a brief overview demonstrating that endotheliopathy is an important feature of hospitalised patients with coronavirus disease-19 (COVID-19).
  • ||||||||||  Journal:  Design, synthesis and biological activity of a novel ethylenediamine derivatives as H receptor antagonists. (Pubmed Central) -  Sep 25, 2020   
    In vitro assay, the biological activities showed that the target compounds have good properties in inhibiting mast cell degranulation and releasing histamine and β-aminohexidase, such as the compounds 5c, 5g, 5k, 5l and 5o, especially of compound 5k to mast cell degranulation is IC = 0.0106 ± 0.001 μmol⋅L, histamine release was IC = 0.0192 ± 0.005 μmol⋅L and β-hexosaminidase release was IC = 0.0455 ± 0.002 μmol⋅Lin vitro. At the same time, in vivo biological activities assay results showed that have a good Histamie induce bronchospasm effect with relatively long duration and good protective effect in vivo, among which the protective effect of compound 5k was 79.74 ± 0.30%, compounds 5c, 5g, 5k, 5l and 5o could inhibit the capillary permeability of increasing which were caused by histamine.
  • ||||||||||  Clinical, Journal:  Associations of MTA1 expression with CT features, pathology and prognosis of elderly patients with non-small cell lung cancer. (Pubmed Central) -  Sep 18, 2020   
    Moreover, the patients with high expression of MTA1 had significantly shorter survival time and a remarkably lower 5-year survival rate than those with low expression of MTA1 (P<0.05). In conclusion, MTA1 plays a certain role in the occurrence and development of NSCLC in elderly patients and has an association with their prognosis, which can provide references for the treatment and prognosis of NSCLC, with important clinical significance.
  • ||||||||||  [VIRTUAL] Not All Worsening Ascites Is Due to Decompensated Liver Cirrhosis () -  Sep 15, 2020 - Abstract #ACG2020ACG_1512;    
    After a thorough evaluation with imaging modalities (if possible) and even in the absence of suggestive symptoms, upper and lower endoscopic evaluation may be warranted. If the endoscopies fail to reveal a source, diagnostic laparoscopy may be indicated in certain cases.
  • ||||||||||  Clinical, Review, Journal:  Hypoalbuminemia: Pathogenesis and Clinical Significance. (Pubmed Central) -  Aug 20, 2020   
    After the age of 30 years, muscle mass and function slowly decrease, but this loss is accelerated by comorbidity and associated with decreasing serum albumin levels. Nutrition support cannot fully prevent, but slows down, this chain of events, especially when combined with physical exercise.
  • ||||||||||  Journal:  Imaging correlates of the Blood Brain Barrier disruption in HIV associated neurocognitive disorder and therapeutic implications. (Pubmed Central) -  Aug 13, 2020   
    This study indicates that HAND in the context of viral suppression is associated with BBB disruption and the DCE MR derived K-trans metric is a very sensitive parameter to identify the BBB disruption. The finding of region specific BBB disruption rather than globally and the lack of correlation with blood markers of neuroinflammation suggest that HIV and not systemic inflammation is driving the BBB disturbance and that the BBB disruption is a consequence of HIV already in the brain as opposed to HIV first causing BBB disruption then brain disease.
  • ||||||||||  Preclinical, Journal:  Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress. (Pubmed Central) -  Aug 7, 2020   
    The finding of region specific BBB disruption rather than globally and the lack of correlation with blood markers of neuroinflammation suggest that HIV and not systemic inflammation is driving the BBB disturbance and that the BBB disruption is a consequence of HIV already in the brain as opposed to HIV first causing BBB disruption then brain disease. In senescent SAMP8 mice, dietary supplementation with SDP attenuated cognitive decline and prevented changes in brain markers of neuroinflammation and oxidative stress.
  • ||||||||||  Preclinical, Journal:  Effect of preconditioned Mesenchymal Stromal Cells on early microvascular disturbance in a mouse sepsis model. (Pubmed Central) -  Jul 29, 2020   
    We showed that MSC-IFNγ have a beneficial effect on microcirculation, by increasing the flow of White Blood Cells (WBC) and the percentage of venules containing flowing WBC, by significantly reducing the adhesion of WBC and by increasing the average of red blood cell velocity (VRBC). In conclusion, our results suggest that intravenous injection of preconditioned MSC-IFNγ improves microvascular hemodynamics in early phases of sepsis.