- |||||||||| Journal: Epineural optogenetic activation of nociceptors initiates and amplifies inflammation. (Pubmed Central) - Mar 10, 2021
It also led to immune reactions in the skin in the absence of inflammation and potentiation of established inflammation, a consequence of the antidromic activation of nociceptor peripheral terminals. These results reveal a link between nociceptors and immune cells, which might have implications for the treatment of inflammation.
- |||||||||| Journal: WISP1 and TLR4 on Macrophages Contribute to Ventilator-Induced Lung Injury. (Pubmed Central) - Feb 9, 2021
TLR4 and WISP1, especially the former one, on macrophages could contribute to releasing of pro-inflammatory cytokines during ventilator-induced lung injury. Injurious mechanical ventilation may result in an immune response which is similar to that of infection.
- |||||||||| Journal: VEGF-PLGA controlled-release microspheres enhanced angiogenesis in encephalomyosynangiosis-based chronic cerebral hypoperfusion. (Pubmed Central) - Feb 7, 2021
We speculated that this enhancement of cerebral blood flow was attributed to more angiogenesis induced by combination of VEGF microspheres and EMS, which verified by more collateral circulation with cerebral angiography and higher expression of CD31 or α-SMA. Our study demonstrated that combinating VEGF-PLGA controlled-release microspheres could significantly promote angiogenesis in EMS-based CCH rats model, providing new ideas for clinical treatment of CCH.
- |||||||||| Review, Journal: Application of quercetin flavonoid based hybrid nanocomposites: A review. (Pubmed Central) - Jan 12, 2021
This quercetin flavonoid based hybrid nanocomposites seemed to show a significant effect on In vitro and some animal model processes along with attenuating lipid peroxidation, platelet aggregation, and capillary permeability actions. This review mainly focused on the hybrid nanoscience of quercetin bioflavonoid and its application in numerous biological, material fields with a future perspective.
- |||||||||| Journal: Research advances on the molecular mechanisms of vascular permeability in sepsis (Pubmed Central) - Dec 22, 2020
Recent studies have shown that various factors and mediators involved in the regulation of vascular permeability in sepsis are expected to become targets for clinical treatment of sepsis. In this paper, we have reviewed the research advances on some molecules which are significantly associated with vascular permeability in sepsis, such as vascular endothelial growth factor, angiopoietin, sphingosine-1-phosphate, heparin-binding protein, and Slit2.
- |||||||||| Journal: Severe acute pancreatitis: Capillary permeability model linking systemic inflammation to multiorgan failure. (Pubmed Central) - Dec 16, 2020
P=N/A
Changing capillary permeability to allow loss of NAPP in this model predicts loss of plasma oncotic pressure and reduced vascular volume, hypotension with pre-renal azotemia and acute kidney dysfunction, pancreas necrosis, and pulmonary edema from capillary leak in the lung with acute respiratory distress syndrome. Sequential biomarker analysis in humans with or without MOF is consistent with this model.
- |||||||||| sevoflurane / Generic mfg.
Preclinical, Journal: Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device. (Pubmed Central) - Dec 16, 2020
Because previous experimental and clinical research suggested potential benefits of halogenated volatiles, such as sevoflurane or isoflurane, for lung alveolar epithelial injury and inflammation, two pathophysiologic landmarks of diffuse alveolar damage during ARDS, we designed an animal model to understand the mechanisms of the effects of halogenated agents on lung injury and repair...Although this model induced a marked decrease in arterial oxygenation with altered alveolar-capillary permeability, it is reproducible and is characterized by a rapid onset, good stability over time, and no fatal complications. We have developed a piglet model of acid aspiration that reproduces most of the physiological, biological, and pathological features of clinical ARDS, and it will be helpful to further our understanding of the potential lung-protective effects of halogenated agents delivered through devices used for inhaled ICU sedation.
- |||||||||| Review, Journal: Endothelial Damage in Acute Respiratory Distress Syndrome. (Pubmed Central) - Dec 2, 2020
In this review, we will discuss the underlying pathology of endothelial dysfunction leading to ARDS and emerging therapies. Furthermore, we will present a brief overview demonstrating that endotheliopathy is an important feature of hospitalised patients with coronavirus disease-19 (COVID-19).
- |||||||||| Journal: Design, synthesis and biological activity of a novel ethylenediamine derivatives as H receptor antagonists. (Pubmed Central) - Sep 25, 2020
In vitro assay, the biological activities showed that the target compounds have good properties in inhibiting mast cell degranulation and releasing histamine and β-aminohexidase, such as the compounds 5c, 5g, 5k, 5l and 5o, especially of compound 5k to mast cell degranulation is IC = 0.0106 ± 0.001 μmol⋅L, histamine release was IC = 0.0192 ± 0.005 μmol⋅L and β-hexosaminidase release was IC = 0.0455 ± 0.002 μmol⋅Lin vitro. At the same time, in vivo biological activities assay results showed that have a good Histamie induce bronchospasm effect with relatively long duration and good protective effect in vivo, among which the protective effect of compound 5k was 79.74 ± 0.30%, compounds 5c, 5g, 5k, 5l and 5o could inhibit the capillary permeability of increasing which were caused by histamine.
- |||||||||| Clinical, Journal: Associations of MTA1 expression with CT features, pathology and prognosis of elderly patients with non-small cell lung cancer. (Pubmed Central) - Sep 18, 2020
Moreover, the patients with high expression of MTA1 had significantly shorter survival time and a remarkably lower 5-year survival rate than those with low expression of MTA1 (P<0.05). In conclusion, MTA1 plays a certain role in the occurrence and development of NSCLC in elderly patients and has an association with their prognosis, which can provide references for the treatment and prognosis of NSCLC, with important clinical significance.
- |||||||||| [VIRTUAL] Not All Worsening Ascites Is Due to Decompensated Liver Cirrhosis () - Sep 15, 2020 - Abstract #ACG2020ACG_1512;
After a thorough evaluation with imaging modalities (if possible) and even in the absence of suggestive symptoms, upper and lower endoscopic evaluation may be warranted. If the endoscopies fail to reveal a source, diagnostic laparoscopy may be indicated in certain cases.
- |||||||||| Clinical, Review, Journal: Hypoalbuminemia: Pathogenesis and Clinical Significance. (Pubmed Central) - Aug 20, 2020
After the age of 30 years, muscle mass and function slowly decrease, but this loss is accelerated by comorbidity and associated with decreasing serum albumin levels. Nutrition support cannot fully prevent, but slows down, this chain of events, especially when combined with physical exercise.
- |||||||||| Journal: Imaging correlates of the Blood Brain Barrier disruption in HIV associated neurocognitive disorder and therapeutic implications. (Pubmed Central) - Aug 13, 2020
This study indicates that HAND in the context of viral suppression is associated with BBB disruption and the DCE MR derived K-trans metric is a very sensitive parameter to identify the BBB disruption. The finding of region specific BBB disruption rather than globally and the lack of correlation with blood markers of neuroinflammation suggest that HIV and not systemic inflammation is driving the BBB disturbance and that the BBB disruption is a consequence of HIV already in the brain as opposed to HIV first causing BBB disruption then brain disease.
- |||||||||| Preclinical, Journal: Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress. (Pubmed Central) - Aug 7, 2020
The finding of region specific BBB disruption rather than globally and the lack of correlation with blood markers of neuroinflammation suggest that HIV and not systemic inflammation is driving the BBB disturbance and that the BBB disruption is a consequence of HIV already in the brain as opposed to HIV first causing BBB disruption then brain disease. In senescent SAMP8 mice, dietary supplementation with SDP attenuated cognitive decline and prevented changes in brain markers of neuroinflammation and oxidative stress.
- |||||||||| Preclinical, Journal: Effect of preconditioned Mesenchymal Stromal Cells on early microvascular disturbance in a mouse sepsis model. (Pubmed Central) - Jul 29, 2020
We showed that MSC-IFNγ have a beneficial effect on microcirculation, by increasing the flow of White Blood Cells (WBC) and the percentage of venules containing flowing WBC, by significantly reducing the adhesion of WBC and by increasing the average of red blood cell velocity (VRBC). In conclusion, our results suggest that intravenous injection of preconditioned MSC-IFNγ improves microvascular hemodynamics in early phases of sepsis.
- |||||||||| Journal: Compromised angiogenesis and vascular Integrity in impaired diabetic wound healing. (Pubmed Central) - Jul 21, 2020
Together, these studies provide novel information about the complexity of the perturbation of angiogenesis in diabetic wounds. Targeting factors responsible for wound resolution and vascular pruning, as well those that affect pericyte recruitment, maturation, and stability may have the potential to improve diabetic skin wound healing.
- |||||||||| [VIRTUAL] Interdisciplinary and Multimodal Management of Peripheral Edema to Improve Cancer Patients Functional Status () - Jul 14, 2020 - Abstract #ACRM2020ACRM_256;
We will spotlight a case series of cancer patients who underwent multicomponent compression bandaging, a standard technique recommended for lymphedema and chronic venous insufficiency, for bilateral lower extremity edema of multifactorial origin refractory to systemic medications.11 We will also briefly discuss the difference between generalized venous edema and lymphedema, how they are similarly managed, and various challenges involved in management of these types of edema. Finally, we will provide a literature reviewbased summary and recommendations for treating lymphedema and generalized peripheral venous edema with use of an interdisciplinary and multimodal approach along with outcome measurements to assess effective edema management.
- |||||||||| Biomarker, Journal: Impaired albumin function: A novel potential indicator for liver function damage? (Pubmed Central) - Jul 10, 2020
In this review, we summarize the factors affecting albumin function and discuss the clinical significance of impairments in albumin function in various liver diseases. Key messagesThe importance of albumin depends not only on its concentration, but also on its various physiological functions.Impaired albumin function has been reported in a variety of liver diseases, and is associated with disease severity and prognosis, thereby proposing the concept of "effective albumin concentration".Albumin dysfunction occurs earlier than other conventional indicators, and albumin dysfunction may be a new biomarker of early impairment in liver function.Many exogenous and endogenous factors lead to post-translational modifications of albumin, which alters the three-dimensional structure of albumin, resulting in a decrease in its biological activity.
- |||||||||| ceftriaxone / Generic mfg.
[VIRTUAL] Postictal Pulmonary Edema - A Forgotten Entity (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6884;
She presented to the emergency room in a postictal state following a grand mal seizure after missing two doses of regularly-prescribed levetiracetam...She initially received inhaled tranexamic acid for concern for diffuse alveolar haemorrhage and vancomycin, levofloxacin, and ceftriaxone empirically and then continued on azithromycin for concern for atypical pneumonia...It has been postulated that pulmonary venoconstriction secondary to intracranial hypertension and sympathetic stimulation causes pulmonary edema by increasing pulmonary capillary hydrostatic pressure. Increased pulmonary capillary permeability is also implicated, but the mechanism is yet to be completely delineated.
- |||||||||| [VIRTUAL] There's No Cap for This Leak: A Case of Systemic Capillary Leak Syndrome (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6834;
Our patient had two prior episodes of AKI and rhabdomyolysis likely secondary to recurrent episodes of SCLS. Early recognition is critical as some evidence suggests that prophylaxis with theophylline, terbutaline, or intravenous immunoglobulin can reduce mortality and the incidence of subsequent attacks in some patients.
- |||||||||| VentaProst (epoprostenol inhalation) / Aerogen Pharma
[VIRTUAL] Pulmonary Edema Following Naloxone Administration for Opioid Overdose: A Case Series (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6727;
Nine of ten patients required ICU admission, seven were intubated and mechanically-ventilated, four received inhaled epoprostenol for refractory hypoxemia, and one patient was supported with veno-venous extracorporeal membrane oxygenation (ECMO). In our experience, naloxone associated pulmonary edema, while ultimately a self-limited condition, is frequently life-threatening and can demand substantial critical care resources to manage.
- |||||||||| ceftriaxone / Generic mfg.
[VIRTUAL] Uremic Lung in Young with IgA Nephropathy (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_4622;
Initiated Ceftriaxone...There may be hemorrhagic diathesis secondary to platelet dysfunction of advanced kidney disease. It is important to note that pulmonary symptoms and radiographic findings are reversible with hemodialysis.
- |||||||||| [VIRTUAL] The Goosechase: Pericardial Tamponade as a Sympathetic Response to Iatrogenic Duodenal Hematoma (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_4286;
These exudates, often pleural or pericardial in nature, are felt to be caused by changes in capillary permeability, changes in lymphatic flow, or diaphragmatic penetration in the setting of local inflammation. A diagnosis of exclusion, consider the diagnosis of sympathetic pericardial tamponade in the setting of an unexplained pericardial effusion and intraabdominal pathology.
- |||||||||| sirolimus / Generic mfg.
Preclinical, Journal: Successful Reversal of Ovarian Hyperstimulation Syndrome in a mouse model by Rapamycin, a mTOR Pathway Inhibitor. (Pubmed Central) - Jun 26, 2020
Further study showed the functional roles of the mTOR signaling pathway in the hyperstimulation-induced ovarian extracellular matrix (ECM) remodeling as the expression of α2M, a broad proteolytic inhibitor in both ovary and serum was dramatically decreased after rapamycin treatment. Since a single injection of rapamycin during superovulation had no side effects on ovulation and early embryonic development, we propose rapamycin may be a good candidate to lower and prevent the risk of OHSS in future.
- |||||||||| [VIRTUAL] SPECT/CT Localization of Incidental Diverticular Bleed After Radioiodine (i131) Therapy for Metastatic Thyroid Cancer () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_2182;
We propose that the isolated focus of radioiodine activity in the sigmoid colon associated with transient self-limited bleed could be either related to preexisting diverticulitis leading to I131 accumulation secondary to hyperemia, increased vascular capillary permeability, and subsequent aggravation of colonic mucosa resulting in a transient bleed or due to incidental nonspecific pooling of radioiodine in a colonic diverticulum resulting in secondary mucosal irritation with subsequent minor bleeding. To our knowledge this is the first reported case of SPECT/CT localization of radioiodine to an isolated colonic diverticular bleed in a patient status post I131 therapy for metastatic papillary thyroid cancer.
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