- |||||||||| Januvia (sitagliptin) / Merck (MSD)
Journal: Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury. (Pubmed Central) - Apr 24, 2024
We previously reported that DPP4 inhibition by sitagliptin attenuates lipopolysaccharide (LPS)-induced lung injury in mice...In summary, this study demonstrated that genetic deficiency of Dpp4 attenuates inflammatory responses but not permeability in LPS-induced lung injury in mice, potentially through differential functional roles of CD26/DPP4 expression in resident cellular components of the lung. CD26/DPP4 may be a potential therapeutic target for ARDS and warrants further exploration to precisely identify the multiple functional effects of CD26/DPP4 in ARDS pathophysiology.
- |||||||||| Review, Journal: Mechanisms of Myocardial Edema Development in CVD Pathophysiology. (Pubmed Central) - Feb 24, 2024
The study of molecular, genetic, and mechanical changes in the myocardium during edema may contribute to the development of new approaches to the diagnosis and treatment of this condition. This review was conducted to describe the main mechanisms of myocardial edema development at the molecular and cellular levels and to identify promising targets for the regulation of this condition based on articles cited in Pubmed up to January 2024.
- |||||||||| Selzentry (maraviroc) / ViiV Healthcare
CCR5 Drives NK Cell Mediated Airway Damage in an Endotoxin-induced Model of Acute Lung Injury (San Diego Convention Center, Room 1A-B (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_7365;
In a treatment trial, 24 hours preceding ALI, a group of animals were given intraperitoneal 10 mg/kg of the allosteric CCR5 inhibitor,Maraviroc or 10 mg/kg of vehicle control...Our results demonstrate that CCR5 dependent trafficking facilitates NK cell-associated airway damage in LPS-induced ALI. CCR5 inhibition may be a potential therapeutic strategy to mitigate this pathology.
- |||||||||| hydrochlorothiazide / Generic mfg., furosemide / Generic mfg., spironolactone / Generic mfg.
Characterizing Outpatient Diuretic Therapy in Children With Bronchopulmonary Dysplasia (San Diego Convention Center, Area G (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3978;
Just under half of our study population was on diuretic therapy in the outpatient setting, with chlorothiazide being the most commonly prescribed. Subjects on diuretic therapy were more likely to be on supplemental oxygen in the outpatient setting, but diuretic status was not associated with age of weaning supplemental oxygen.
- |||||||||| Post-Operative Outcomes of ARDS after VATS: The Seismic Shift in ARDS Clinical Practice Guidelines (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3587;
Our case highlights the need for early recognition of ARDS and the shift in the guidelines, which has provided clinicians the scientific endorsement for the early use of corticosteroids in managing this challenging disease. This intervention is likely to be foundational in the propagation of more favourable ARDS outcomes of varying etiologies.
- |||||||||| fentanyl citrate / Generic mfg., buprenorphine/naloxone sublingual film / Generic mfg., naloxone nasal spray / Generic mfg.
No-lax-zone: Side Effects That Can Steal Your Breath Away (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1610;
Although left ventricular dysfunction likely played a role, it underscores the importance of recognizing and managing this adverse effect, particularly with the increasing availability of intranasal naloxone. Raising awareness among patients and healthcare providers about the potential complications associated with naloxone is vital to ensure safe and effective opioid overdose management.
- |||||||||| methimazole / Generic mfg.
Methimazole-Induced Hypothyroidism Presenting as Recurrent Thoracic Cavity Effusions and Ascites (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1512;
This was evident in our case with the patient's history of dialysis dependence and hyperthyroidism from Grave's disease, which did not provide sufficient explanation for her recurrent serosal effusions. In the appropriate patient, thyroid function analysis is crucial in identifying medication-induced hypothyroidism as correction of thyroid hormone levels prevents future effusions.
- |||||||||| A Breath-Taking Triad, Rare Case of Pseudo-Meigs Syndrome in a Patient With Benign Leiomyoma (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1497;
Tumor resection results in resolution of ascites and pleural effusions and saves patients from unnecessary thoracentesis and paracentesis. Eliminating the iatrogenic risks of these procedures, such as pneumothorax, bleeding, infection, and bowel perforation.
- |||||||||| furosemide / Generic mfg., methamphetamine / Generic mfg., bumetanide / Generic mfg.
Neurogenic Pulmonary Edema in the Setting of Intracerebral Hemorrhage: A Case Report (San Diego Convention Center, Room 5A-B (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_771;
Case Report: A 40-year-old male with a history of hypertension and methamphetamine use presented with stroke-like symptoms, including right facial droop, right upper extremity weakness, and slurred speech...Despite treatment with furosemide, methylprednisolone, and breathing treatment administration, his respiratory distress worsened, requiring intubation...Empiric antibiotics and intravenous bumetanide were initiated...Our case underscores the importance of maintaining clinical suspicion, prompt recognition, and early intervention of NPE. We also aim to contribute to the limited existing knowledge regarding the diagnosis of NPE.
- |||||||||| Journal: Fe-Capsaicin Nanozymes Attenuate Sepsis-Induced Acute Lung Injury via NF-?B Signaling. (Pubmed Central) - Jan 12, 2024
The nanoparticles showed non-cytotoxicity, when studying these biological activities. Fe-CAP NPs could alleviated inflammation by inhibiting the expression of pro-inflammatory factors in macrophages, increasing the expression of anti-inflammatory factors, and alleviating lung tissue damage.
- |||||||||| Thrombotic Complications of Ovarian Hyperstimulation Syndrome (North 120 D Ballroom) - Jan 9, 2024 - Abstract #ISC2024ISC_1700;
We found very few thrombotic events shortly after OHSS diagnosis using two large datasets. The low rate of outcome events after OHSS seen in each of our population-level analyses increases the reliability of these study results.
- |||||||||| methamphetamine / Generic mfg., nitroglycerin / Generic mfg.
ACUTE RESPIRATORY FAILURE SECONDARY TO SUSPECTED NALOXONE-INDUCED PULMONARY EDEMA () - Jan 4, 2024 - Abstract #SCCM2024SCCM_1964;
Treatment is similar to sympathetic crashing acute pulmonary edema (SCAPE) with nitroglycerin boluses and high-rate infusions with non-invasive or invasive ventilation for airway support...While a vape-induced lung injury may have contributed to earlier respiratory symptoms, it has not been linked to SCAPE-like symptoms. NPE requires increased education for healthcare providers due to severity of illness.
- |||||||||| CAPILLARY LEAK SYNDROME CAUSED BY CALCIUM CHANNEL BLOCKER TOXICITY SUCCESSFULLY TREATED WITH ECMO () - Jan 4, 2024 - Abstract #SCCM2024SCCM_1012;
The mechanism by which CCB toxicity can cause capillary leak syndrome is not fully understood, but may be caused by selective precapillary arteriolar dilation and possibly L type calcium channel modulation of vascular endothelium permeability. This is a rare case of capillary leak syndrome resulting in distributive shock, ARDS, and severe end organ damage which was successfully treated with ECMO.
- |||||||||| Journal: Posterior Reversible Leukoencephalopathy With Hemorrhagic Features: A Case Series. (Pubmed Central) - Dec 29, 2023
Conclusion Patients with PRES and hemorrhagic features had a lower use of corticosteroids and a higher presence of restrictive lesions on neuroimaging. Further studies are needed to better understand the clinical implications and management of PRES with hemorrhagic manifestations.
- |||||||||| irbesartan / Generic mfg.
Preclinical, Journal: Irbesartan eases lipopolysaccharide-induced lung injury In Vitro and In Vivo. (Pubmed Central) - Dec 27, 2023
In addition, LPS-stimulated lung tissue damage, pulmonary edema, inflammatory response as well as lung capillary permeability in vivo were all reversed following IRB treatment. Collectively, IRB treatment might elicit protective behaviors against LPS-triggered ALI.
- |||||||||| Review, Journal: Capillary leak and endothelial permeability in critically ill patients: a current overview. (Pubmed Central) - Dec 20, 2023
While currently available treatment options are limited, we further review understanding of fluid resuscitation and experimental approaches to target endothelial permeability. Despite the improved understanding of CLS pathophysiology, efforts are needed to develop uniform diagnostic criteria, associate clinical consequences to these criteria, and delineate treatment options.
- |||||||||| Review, Journal: Dynamic Contrast-Enhanced Study in the mpMRI of the Prostate-Unnecessary or Underutilised? A Narrative Review. (Pubmed Central) - Nov 24, 2023
Moreover, there have been numerous scientific discussions about abandoning the intravenous application of gadolinium-based contrast as a routine part of MRI examination of the prostate. In this review, we summarised the recent literature on the advantages and disadvantages of DCE-MRI, focusing on an overview of currently available data on bpMRI and mpMRI, as well as on studies providing information on the potential better usability of DCE-MRI in improving the sensitivity and specificity of mpMRI examinations of the prostate.
- |||||||||| Preclinical, Journal: THE WOUND HEALING POTENTIAL OF THE ENDEMIC PLANT (Pubmed Central) - Nov 13, 2023
In this review, we summarised the recent literature on the advantages and disadvantages of DCE-MRI, focusing on an overview of currently available data on bpMRI and mpMRI, as well as on studies providing information on the potential better usability of DCE-MRI in improving the sensitivity and specificity of mpMRI examinations of the prostate. Inflammatory cytokines were significantly inhibited in the LPS-induced FR cell line, with the highest effect seen on IL-6 (34.5
- |||||||||| pentoxifylline / Generic mfg.
Review, Journal: Cardiogenic Pulmonary Edema in Emergency Medicine. (Pubmed Central) - Oct 31, 2023
Patients with persistent symptoms and diuretic resistance might benefit from additional approaches (i.e., beta-agonists and pentoxifylline). This paper reviews the pathophysiology, clinical presentation, and management of CPE.
- |||||||||| Zontivity (vorapaxar) / Merck (MSD)
Journal: Tubulovascular protection from protease-activated receptor-1 depletion during AKI-to-CKD transition. (Pubmed Central) - Oct 23, 2023
This paper reviews the pathophysiology, clinical presentation, and management of CPE. Our findings elucidate a detrimental role of PAR-1 in vascular dysfunction and profibrotic responses upon tissue injury during AKI-to-CKD transition and provide an attractive therapeutic strategy for post-injury repair in AKI.
- |||||||||| Avastin (bevacizumab) / Roche
Journal: A Novel Multi-Model High Spatial Resolution Method for Analysis of DCE MRI Data: Insights from Vestibular Schwannoma Responses to Antiangiogenic Therapy in Type II Neurofibromatosis. (Pubmed Central) - Sep 28, 2023
Twelve patients with neurofibromatosis type II-related vestibular schwannoma (20 tumours) undergoing bevacizumab therapy were imaged at 1.5 T both before and at 90 days following treatment...Both the capillary permeability-surface area product (PS) and the extravascular extracellular fraction (v) significantly differentiated the 'responder' and 'non-responder' tumour groups at 90 days (p < 0.05 and p < 0.001, respectively). These results highlight that this novel DCE-MRI analysis approach can be used to evaluate tumour microvascular changes during treatment and the need for future larger clinical studies investigating its role in predicting antiangiogenic therapy response.
- |||||||||| A CRISIS FROM COLOMBIA (Convention Center Exhibit Hall) - Sep 15, 2023 - Abstract #CHEST2023CHEST_6583;
- |||||||||| Journal: Thyroid Accumulation of 99mTc-DTPA in Graves Disease. (Pubmed Central) - Sep 13, 2023
This should be cautiously distinguished from 99mTc-pertechnetate uptake, considering that the salivary glands, oral cavity, and stomach were not visualized. Our case demonstrates that augmentation of blood supply, enhancement of capillary permeability, and accumulation of inflammatory exudate may be involved in the pathological process of Graves disease.
- |||||||||| Journal, Machine learning: Machine learning decision tree models for multiclass classification of common malignant brain tumors using perfusion and spectroscopy MRI data. (Pubmed Central) - Aug 24, 2023
In hierarchical order of importance, the root node (Cho/NAA) in the decision tree algorithm was primarily based on the proliferative, infiltrative, and neuronal destructive characteristics of the tumor, the internal node (PSRmax), on tumor tissue capillary permeability characteristics, and the end node (Lac/Cr or Cho/Cr), on tumor energy glycolytic (Warburg effect), or on membrane lipid tumor metabolism. Our study shows potential implementation of machine learning decision tree model algorithms based on a hierarchical, convenient, and personalized use of perfusion and spectroscopy MRI data for multiclass classification of these brain tumors.
- |||||||||| chlorogenic acid / Jiuzhang Biotech
Preclinical, Journal: Qualitative and quantitative analyses of chemical constituents in vitro and in vivo and systematic evaluation of the pharmacological effects of Tibetan medicine Zhixue Zhentong capsules. (Pubmed Central) - Aug 2, 2023
Quantitative analysis of the six main metabolites, shanzhiside methyl ester, chlorogenic acid, 8-O-acetyl shanzhiside methyl ester, forsythin B, luteoloside, and verbascoside, was extensively performed...The established method is simple and reproducible and can help improve the quality control level of ZXZTCs as a medicinal product. Evaluating the hemostatic, analgesic, and anti-inflammatory activities of ZXZTCs can help reveal its mechanism.
- |||||||||| Protein-Losing Enteropathy: An Isolated Presentation of Lupus Nephritis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3131;
She had 1 prior hospital admission with a similar complaint and was diagnosed with a UTI, colitis, anemia, and unspecified fever, and was treated with a course of cefuroxime...Patient was started on high dose steroid taper, hydroxychloroquine, azathioprine, and lisinopril with subsequent improvement...Endoscopic biopsies aid in excluding other disease processes, but may not may not define the etiopathogenesis of protein-loss enteropathy, and in many cases, they are normal or show nonspecific findings. Early and aggressive steroid and immunosuppressant therapy is necessary to improve prognosis.
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