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23 News |  |
- | dizocilpine (MK801) / Merck (MSD)
Journal: Astrocyte ?-adrenergic receptor activity regulates NMDA receptor signaling of medial prefrontal cortex pyramidal neurons. (Pubmed Central) - Jan 12, 2024
Here we show that ?-AR activity increases astrocyte process volume in the medial prefrontal cortex (mPFC), an emotion processing region of the brain, and reduces NMDAR activity associated with glutamate spillover in an astrocyte-dependent manner. Our study provides a novel mechanism by which impaired norepinephrine signaling and astrocyte ?-AR activity in the mPFC may contribute to the excessive extrasynaptic NMDAR activity observed in certain psychiatric and neurodegenerative disorders.
- | carvedilol / Generic mfg., atenolol / Generic mfg.
Preclinical, Journal: Comparative cardioprotective effects of carvedilol versus atenolol in a rat model of cardiorenal syndrome type 4. (Pubmed Central) - Feb 5, 2022
Carvedilol has superior cardioprotective effects than atenolol in a rat model of CRS type 4. These protective effects are mediated through modulating cardiac βARs/β-arrestin2/PIP2/DAG as well as abating cardiac apoptotic signaling pathways (caspase3/pS473 protein kinase B (Akt)).
- | Journal: Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells. (Pubmed Central) - Jan 28, 2022
Studies with skeletal muscle-specific mutant mice demonstrated that these metabolic improvements required activation of skeletal muscle β-adrenergic receptors and the stimulatory G protein, G. Unbiased transcriptomic and metabolomic analyses showed that chronic β-adrenergic receptor stimulation caused metabolic reprogramming of skeletal muscle characterized by enhanced glucose utilization. These findings strongly suggest that agents targeting skeletal muscle metabolism by modulating β-adrenergic receptor-dependent signaling pathways may prove beneficial as antidiabetic drugs.
- | rosuvastatin / Generic mfg.
Journal: Rosuvastatin Reduces L-Type Ca Current and Alters Contractile Function in Cardiac Myocytes via Modulation of β-Adrenergic Receptor Signaling. (Pubmed Central) - Jan 27, 2022
Finally, we examined the effect of RSV during β-adrenergic receptor stimulation by isoproterenol and observed that RSV significantly suppresses the β-adrenergic responses in both L-type Ca currents and contraction parameters. In conclusion, RSV modulates the β-adrenergic signaling cascade and thereby mimics the impact of β-adrenergic receptor blockers in adult ventricular myocytes through modulation of the AC-cAMP-PKA pathway.
- | Journal: Estrogen Attenuates Chronic Stress-Induced Cardiomyopathy by Adaptively Regulating Macrophage Polarizations via β-Adrenergic Receptor Modulation. (Pubmed Central) - Oct 20, 2021
However, this adaptive immunomodulation is hampered when βAR is inhibited. Taken together, the outcomes of this study show that E confers cardioprotection to prevent CSC via adaptive immunomodulation of macrophage phenotypes, and βAR-mediated signaling is crucial for the polarizations of CD86+ to CD206+ macrophages.
- [VIRTUAL] Gender Differences and Aging on Beta-Adrenergic Receptor Subtypes Expression and Function in Murine Left Ventricular Myocytes (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_6282;
Aging is associated with LV myocyte β1-AR downregulation and β3-AR upregulation. Sex affects age-related β1-AR downregulation, with males exhibiting a more profound decrease with increasing age.
- || Avastin (bevacizumab) / Roche
Review, Journal: β adrenergic receptor modulated signaling in glioma models: promoting β adrenergic receptor-β arrestin scaffold-mediated activation of extracellular-regulated kinase 1/2 may prove to be a panacea in the treatment of intracranial and spinal malignancy and extra-neuraxial carcinoma. (Pubmed Central) - Feb 17, 2021
Treatment with β adrenergic agonists also clearly reduce tumoral neoangiogenesis, which may represent a putatively useful mechanism to adjuvantly amplify the effects of bevacizumab...We suggest generating compounds and targeted mutations of the β adrenergic receptor favoring β arrestin binding and scaffold facilitated activation of ERK1/2 may hold potential promise and therapeutic benefit in adjuvantly treating most or all cancers. We hope our discussion will generate fruitful research endeavors seeking to exploit these mechanisms.