- |||||||||| acetazolamide / generics, dalfampridine / generics
Journal: Aminopyridines and acetyl-DL-leucine: new therapies in cerebellar disorders. (Pubmed Central) - Apr 11, 2019
A new treatment option for cerebellar disease is the amino-acid acetyl-DL-leucine, which has significantly improved cerebellar symptoms in three case series. There are on-going randomized controlled trials for cerebellar ataxia (acetyl-DL-leucine vs placebo; ALCAT), cerebellar gait disorders (SR-form of 4-AP vs placebo; FACEG) and EA2 (sustained-release/SR-form of 4-AP vs acetazolamide vs placebo; EAT2TREAT), which will provide new insights into the pharmacological treatment of cerebellar disorders.
- |||||||||| Journal: Differential effect of Androctonus australis hector venom components on macrophage K channels: electrophysiological characterization. (Pubmed Central) - Mar 25, 2019
Unlike cloned K1.5 channels, Aah venom exerted a similar blocking effect on K1.3 compared to K current in LPS-activated macrophages, along with a hyperpolarizing shift in the voltage dependence of K1.3 inactivation, indicating a direct mechanism of current inhibition by targeting K1.3 subunits. The obtained results, demonstrating that Aah venom differentially targets K channels in macrophages, suggest differential outcomes for their inhibitions, and that further investigations of scorpion venom immunomodulatory potential are required.
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