PI3K inhib 
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  • ||||||||||  Copiktra (duvelisib) / Verastem
    Journal:  Antitumor effects of duvelisib on Epstein-Barr virus-associated lymphoma cells. (Pubmed Central) -  Aug 9, 2019   
    However, duvelisib did not induce a remarkable change in the expression of EBV latent genes. These results may indicate that there is therapeutic potential for duvelisib administration in the treatment of EBV-associated B cell lymphomas and other B cell malignancies.
  • ||||||||||  cisplatin / generics
    Journal:  Apoptin-derived peptide reverses cisplatin resistance in gastric cancer through the PI3K-AKT signaling pathway. (Pubmed Central) -  Aug 9, 2019   
    Additionally, AdP inhibited the expression of p85, AKT, p-p85, p-AKT, multidrug resistance 1 (MDR1), and aryl hydrocarbon nuclear translocator (ARNT) in the PI3K/AKT/ARNT signaling pathway, which promoted apoptosis and necrosis in GC cells. AdP promoted apoptosis in CDDP-resistant GC cells by suppressing the PI3K/AKT/ARNT signaling pathway and might be considered a candidate agent for the clinical treatment of cisplatin-resistant GC.
  • ||||||||||  Biomarker, Journal:  miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway. (Pubmed Central) -  Aug 8, 2019   
    Further study demonstrated that expression of KIF26B was negative correlated with miR-450b-5p level in HCC tissues, and miR-450b-5p could inhibit cell viability, proliferation rate and invasion ability of HCC cells via targeted inhibiting KIF26B. Our study demonstrated that miR-450-5p/KIF26B/AKT axis is critical for progression of HCC, and might provide novel prognostic biomarker and therapeutic target for HCC.
  • ||||||||||  Journal:  New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound. (Pubmed Central) -  Aug 8, 2019   
    A comparison of the p110α-YXY-4F and apo p110α complexes showed that YXY-4F induced additional space by promoting a flexible conformational change in residues Ser773 and Ser774 in the PI3Kα ATP catalytic site. Specifically, residue 773(S) in PI3Kα is quite different from that of PI3Kβ (D), γ (A), and δ (D), which might guide further optimization of substituents around the NH group and phenyl group to improve the selectivity and potency of PI3Kα.
  • ||||||||||  Preclinical, Journal:  Caffeine inhibits angiogenesis in human glioblastoma cells via HIFs modulation. (Pubmed Central) -  Aug 7, 2019   
    Our results have indicated that this psychostimulant drug significantly reduced HIF-1α and VEGF expression in GBM cells exposed to hypoxia. This effect is mediated through inhibition of PI3K/Akt and MAPK/ERK signaling pathways both implied in HIFs regulation.
  • ||||||||||  Journal:  HER2 amplification in tumors activates PI3K/Akt signaling independent of HER3. (Pubmed Central) -  Aug 7, 2019   
    In contrast to activation of oncogenes by mutation, activation by overexpression was quantitative in nature: weak intrinsic activities were strengthened by overexpression, with additional gains observed through further increases in expression. Collectively, these data show that progressive functional gains by HER2 can increase its repertoire of activities such as the activation of PI3K and overcome its dependeny on HER3.
  • ||||||||||  gedatolisib (PF-05212384) / Celcuity
    Trial completion date, Trial primary completion date, Metastases:  An Initial Safety Study of Gedatolisib Plus PTK7-ADC for Metastatic Triple-negative Breast Cancer (clinicaltrials.gov) -  Aug 6, 2019   
    P1,  N=18, Recruiting, 
    BS and HTHX also promoted nerve regeneration, and this effect involved the ERK pathway. Trial completion date: Jan 2020 --> Jun 2020 | Trial primary completion date: Aug 2019 --> Jan 2020
  • ||||||||||  Journal:  Role of PI3K-Akt and MAPK Signaling in Uranyl Nitrate-Induced Nephrotoxicity. (Pubmed Central) -  Aug 3, 2019   
    All these changes were found to be time-dependent. The result of the current study suggests that uranyl nitrate induces acute renal injury by activation of apoptosis through JNK pathway, while the early activation of signaling molecules Akt and ERK promotes the tubular cell proliferation and cell survival.
  • ||||||||||  Journal:  A peptide derived from phosphoinositide 3-kinase inhibits endocytosis and influenza virus infection. (Pubmed Central) -  Aug 3, 2019   
    PI3K lacking this sequence failed to translocate to endosomes, and expression of the peptide comprising this PI3K-derived sequence inhibited clathrin-independent endocytosis, influenza virus internalization, and infection. Moreover, treatment of cells with this peptide in an arginine-rich, cell-penetrating form successfully suppressed influenza virus infection in vitro and ex vivo, making this peptide a potential therapeutic agent against influenza virus infection.Key words: signal transduction, endocytosis, endosome, imaging, influenza virus.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  AKT2 contributes to increase ovarian cancer cell migration and invasion through the AKT2-PKM2-STAT3/NF-κB axis. (Pubmed Central) -  Aug 3, 2019   
    ...The expressions of p-PI3K, p-AKT2, and PKM2 were increased when stimulated by epidermal growth factor (EGF); however, these expressions were blocked when inhibited the PI3K by LY294002...Taken together, AKT2 increases the migration and invasion of ovarian cancer cells in vitro and promotes lung metastasis in nude mice through PKM2-mediated elevation of STAT3 expression and NF-κB activation. In conclusion, we highlight a novel mechanism of the AKT2-PKM2-STAT3/NF-κB axis in the regulation of ovarian cancer progression, and our work suggested that both AKT2 and PKM2 may be potential targets for the treatment of ovarian cancer.
  • ||||||||||  Copiktra (duvelisib) / Verastem
    Clinical, Journal:  Duvelisib: First Global Approval. (Pubmed Central) -  Aug 3, 2019   
    Clinical development for various haematological malignancies is ongoing worldwide, as well as preclinical development for solid tumours in the USA. This article summarizes the milestones in the development of duvelisib leading to these first approvals for CLL/SLL and FL.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress. (Pubmed Central) -  Aug 3, 2019   
    Finally, the decreased p-AKT and p-mTOR expressions caused by I/R injury were upregulated by GB and inhibition of PI3K/AKT/mTOR pathway by LY294002 abolished the protective effects of GB on I/R injury, indicating that GB activated PI3K/AKT/mTOR pathway during I/R injury. GB protected against myocardial I/R injury through inhibiting ER stress-induced apoptosis via PI3K/AKT/mTOR signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  TGF‑β1 promotes the osteoinduction of human osteoblasts via the PI3K/AKT/mTOR/S6K1 signalling pathway. (Pubmed Central) -  Aug 3, 2019   
    ...Alterations in the expression of osteogenesis‑ and migration‑associated genes were evaluated following pre‑treatment with a PI3K/AKT inhibitor (LY294002) and an mTOR/S6K1 inhibitor (rapamycin), with or without TGF‑β1...The present study demonstrated that TGF‑β1 promoted the proliferation, differentiation and migration of human hFOB1.19 osteoblasts, and revealed that TGF‑β1 affected the biological activity of osteoblasts via the PI3K/AKT/mTOR/S6K1 signalling pathway. Our findings may provide novel insight to aid the development of bone tissue engineering methods for the treatment of bone injury.
  • ||||||||||  Preclinical, Journal:  Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells. (Pubmed Central) -  Aug 1, 2019   
    Finally, we demonstrated that econazole significantly suppressed A549 tumor growth in nude mice. Our findings suggest that econazole is a new PI3K inhibitor and a potential drug that can be used in lung cancer treatment alone or in combination with cisplatin.
  • ||||||||||  Journal:  Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. (Pubmed Central) -  Aug 1, 2019   
    Our findings suggest that econazole is a new PI3K inhibitor and a potential drug that can be used in lung cancer treatment alone or in combination with cisplatin. This study identifies a tumor suppressor pathway that prevents the survival of cancer cells following therapies targeting the PI3K-Akt pathway, providing insight into the mechanisms by which tumor cells persist as minimal residual disease and eventually recur.