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- | Preclinical, Journal: Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice. (Pubmed Central) - Aug 21, 2019
PNS promoted liver regeneration through activation of PI3K/AKT/mTOR and upregulated the AKT/Bad cell pathways in mice.
- | Journal: Tumor-associated macrophages affect the biological behavior of lung adenocarcinoma A549 cells through the PI3K/AKT signaling pathway. (Pubmed Central) - Aug 20, 2019
Western blot analysis indicated that the expression levels of phosphorylated (p)-PI3K and p-AKT proteins were significantly upregulated in the TAMs coculture group compared with that of the blank control group. In summary, the present study demonstrated that TAMs may promote the proliferation, invasion and migration of lung adenocarcinoma A549 cells in vitro, perhaps through the activation of the PI3K/AKT signaling pathway.
- GLUCOCORTICOIDS DECREASE APOPTOSIS AND AUTOPHAGY OF HEPATOCYTES VIA PI3K/AKT/MTOR SIGNALING PATHWAY IN AUTOIMMUNE HEPATITIS (E-Poster Terminal 1) - Aug 18, 2019 - Abstract #UEGW2019UEGW_3779;
We provided evidence that underlying mechanisms of hepatocytes involved in the progression of AIH. Glucocorticoids could ameliorate Con A-induced liver injury by regulating autophagy and apoptosis on hepatocytes via PI3K/AKT/mTOR signaling pathway.
- MIR-23B-3P PROMOTES PANCREATIC CANCER CELL TUMORIGENESIS AND METASTASIS THROUGH THE PTEN/PI3K/AKT SIGNALING PATHWAY (Poster Exhibition - Hall 7) - Aug 18, 2019 - Abstract #UEGW2019UEGW_1373;
These results suggest that miR-23b-3p enhances PC cell tumorigenesis and metastasis at least partially through the PTEN/PI3K/Akt signaling pathway. Therefore, targeting miR-23b-3p or PTEN/PI3K/Akt signaling may be a potential therapeutic strategy against PC.
- GLUCOCORTICOIDS DECREASE APOPTOSIS AND AUTOPHAGY OF HEPATOCYTES VIA PI3K/AKT/MTOR SIGNALING PATHWAY IN AUTOIMMUNE HEPATITIS (Poster Exhibition - Hall 7) - Aug 18, 2019 - Abstract #UEGW2019UEGW_1317;
We provided evidence that underlying mechanisms of hepatocytes involved in the progression of AIH. Glucocorticoids could ameliorate Con A-induced liver injury by regulating autophagy and apoptosis on hepatocytes via PI3K/AKT/mTOR signaling pathway.
- | Clinical, Review, Journal: Androgen blockade based clinical trials landscape in triple negative breast cancer. (Pubmed Central) - Aug 17, 2019
Research in investigating androgen-blockade based combination therapy in this aggressive tumor has demonstrated promising benefit in preclinical studies, and comparable clinical trials of combined strategies with CDK4/6 inhibitors, PI3K inhibition, chemotherapy, and immunotherapy, are ongoing. Accordingly, clinical interpretation of AR-related biological interactions, aiming at combined blockade of the signaling pathways may pave a new way for endocrine-based therapy in the treatment of TNBC.
- | Journal: Selenoprotein-U (SelU) knockdown triggers autophagy through PI3K-Akt-mTOR pathway inhibition in rooster Sertoli cells. (Pubmed Central) - Aug 17, 2019
However SelU attenuation did not induce apoptosis in rooster SCs. Taken together, we conclude that SelU is essential for the survival and normal functioning of SCs.
- | Review, Journal: PI3K pathway in prostate cancer: All resistant roads lead to PI3K. (Pubmed Central) - Aug 17, 2019
In addition, we describe the molecular mechanisms by which prostate cancer cells become resistant to PI3K pathway inhibitors. This review will be helpful in translating biological knowledge into therapeutic strategies for the treatment of prostate cancer and provide insight into overcoming therapeutic challenges associated with prostate cancer.
- | Review, Journal: The next generation of PI3K-Akt-mTOR pathway inhibitors in breast cancer cohorts. (Pubmed Central) - Aug 17, 2019
The problems hindering the development of drugs targeting the PI3K pathway are examined, which have created problems for their use as monotherapies. PI3K pathway inhibitor combinations therefore remains a dynamic research area, and their role in combination with immunotherapies and epigenetic therapies is also inspected.
- | Journal: DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway. (Pubmed Central) - Aug 17, 2019
Furthermore, DRAM1 regulated the activation of IGF-1 receptor. Thus, our results identify that the class I PI3K-Akt-rpS6 pathway is regulated by DRAM1 and may provide new insight into the potential role of DRAM1 in human cancers.
- | cisplatin / generics
Journal, IO Biomarker: Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway. (Pubmed Central) - Aug 17, 2019
GPX1 overexpression blocks cisplatin-induced ROS intracellular accumulation, activates PI3K-AKT pathway by increased AKT phosphorylation, and further leads to cisplatin resistance in NSCLC cells. Inhibition of NF-κB signaling may be an alternative approach for restoring cisplatin sensitivity for NSCLC cells resistant to cisplatin-based chemotherapy.
- | Journal: miR-3691-5p promotes hepatocellular carcinoma cell migration and invasion through activating PI3K/Akt signaling by targeting PTEN. (Pubmed Central) - Aug 17, 2019
Recuse assays showed that restoration of PTEN reversed the effects of miR-3691-5p on HCC cell migration and invasion through decreasing PI3K/Akt signaling. Our results demonstrated that miR-3691-5p contributes to HCC cell migration and invasion through activating PI3K/Akt signaling by targeting PTEN.
- | Journal: ENKUR acts as a tumor suppressor in lung adenocarcinoma cells through PI3K/Akt and MAPK/ERK signaling pathways. (Pubmed Central) - Aug 17, 2019
Silencing of ENKUR in LAD cells also promoted tumorigenesis in nude mice model and caused epithelial to mesenchymal transition (EMT). Furthermore, using western blot and co-immunoprecipitation analyses, we demonstrated that ENKUR interacts with PI3K directly and is possibly involved in the PI3K/Akt and MAPK/ERK signaling pathways.
- | Journal: MicroRNA-326 Functions as a Tumor Suppressor in Breast Cancer by Targeting ErbB/PI3K Signaling Pathway. (Pubmed Central) - Aug 17, 2019
In addition, EMT markers RT-qPCR, scratch, and Transwell assays showed inhibited cellular migration and invasion following miR-326 upregulation. Altogether, our results revealed that miR-326 play a tumor-suppressive role in breast cancer through inhibiting ErbB/PI3K pathway and miR-326 may serve as a potential therapeutic target for the treatment of patients with breast cancer.
- | quercetin (LY294002) / Eli Lilly
Preclinical, Journal: Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. (Pubmed Central) - Aug 17, 2019
When compared to the commercial PI3K inhibitor LY294002, the anti-inflammatory effects appeared to be quite similar. The results reveal hitherto unknown anti-inflammatory effects of natural stilbenoids and suggest that those effects may be mediated via inhibition of the PI3K/Akt pathway.
- | Biomarker, Journal, BRCA Biomarker, PD(L)-1 Biomarker, IO Biomarker: Prognostic value of androgen receptor and FOXA1 co-expression in non-metastatic triple negative breast cancer and correlation with other biomarkers. (Pubmed Central) - Aug 17, 2019
AR + /FOXA1 + expression defines a luminal-like TNBC subgroup affected with a worse outcome compared to other TNBC and a higher risk of late recurrences. This subgroup appears enriched in PIK3CA mutations, suggesting a role for PI3K inhibitors in this subgroup.
- | Journal: Pelargonidin induces antitumor effects in human osteosarcoma cells via autophagy induction, loss of mitochondrial membrane potential, G2/M cell cycle arrest and downregulation of PI3K/AKT signalling pathway. (Pubmed Central) - Aug 17, 2019
This subgroup appears enriched in PIK3CA mutations, suggesting a role for PI3K inhibitors in this subgroup. Taken together, these results indicated that pelargonidin may prove a potential lead drug for the treatment of osteosarcoma.
- | Journal: Antiproliferative activity of Farnesol in HeLa cervical cancer cells is mediated via apoptosis induction, loss of mitochondrial membrane potential (ΛΨm) and PI3K/Akt signalling pathway. (Pubmed Central) - Aug 17, 2019
Taken together, these results indicated that pelargonidin may prove a potential lead drug for the treatment of osteosarcoma. In brief, this study showed that farnesol -a naturally occurring sesquiterpene- exerts powerful antiproliferative activity via apoptosis induction, loss of MMP and downregulation of the expression levels of PI3K, p-PI3K and p-Akt proteins.
- | Journal, IO Biomarker: Galangin induced antitumor effects in human kidney tumor cells mediated via mitochondrial mediated apoptosis, inhibition of cell migration and invasion and targeting PI3K/ AKT/mTOR signalling pathway. (Pubmed Central) - Aug 17, 2019
In brief, this study showed that farnesol -a naturally occurring sesquiterpene- exerts powerful antiproliferative activity via apoptosis induction, loss of MMP and downregulation of the expression levels of PI3K, p-PI3K and p-Akt proteins. In conclusion, Galangin could prove a useful new molecule in the treatment of kidney carcinoma.
- | MK-2206 / Merck (MSD), quercetin (LY294002) / Eli Lilly, Acomplia (rimonabant) / Sanofi
Journal: Anandamide Induces Platelet Nitric Oxide Synthase through AMP-Activated Protein Kinase. (Pubmed Central) - Aug 17, 2019
SR144528, an antagonist of type 2 cannabinoid receptor (CB2), has a less-potent effect, suggesting that the CB1 receptor is overall involved in the AEA effect. In conclusion, we show that the CaMKKβ/AMPKα pathway, downstream of the PI3K/AKT pathway, is activated by AEA in human platelets and leads to increase NO levels producing beneficial effects during ischemic conditions and contributing to extend platelet survival.
- | Journal: MiR-203a functions as a tumor suppressor in bladder cancer by targeting SIX4. (Pubmed Central) - Aug 17, 2019
We established negative correlation between SIX4 expression and miR-203a expression in bladder cancer tissues, and SIX4 silencing caused effects similar to miR-203a up-regulation Furthermore, SIX4 over-expression diminished the effects of miR-203a on bladder cancer cells in vitro. In summary, our study determined that miR-203a down-regulation is closely related to tumorigenesis in bladder cancer; thus suggesting that miR-203a is a potential prognostic marker and a potential target in bladder cancer treatment.
- | quercetin (LY294002) / Eli Lilly
Journal: Klotho protein inhibits H2O2-induced oxidative injury in endothelial Cells via regulation of PI3K/Akt/Nrf2/HO-1 Pathways. (Pubmed Central) - Aug 17, 2019
Klotho protein also activated phosphorylation of AKT, whereas the addition of LY294002, a pharmacological inhibitor of PI3K, blocked KL (klotho protein)-induced Nrf2/HO-1 activation and cytoprotection. Klotho protein enhanced the antioxidant defense ability of the cells by activating the PI3K/AKT pathway, which upregulated the expression of NRF2/HO-1, thereby inhibiting H2O2-induced oxidative damage.
- | Journal: LncRNA SNHG20 promotes tumorigenesis and cancer stemness in glioblastoma via activating PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Aug 16, 2019
At last, rescue assays validated that PI3K/Akt/mTOR signaling pathway involved in the glioblastoma progression mediated by SNHG20. Taken together, this study revealed that SNHG20 regulated PI3K/Akt/mTOR signaling pathway to promote tumorigenesis and stemness of glioblastoma.
- | vincristine / generics
Journal: Wnt5a modulates vincristine resistance through PI3K/Akt/GSK3β signaling pathway in human ovarian carcinoma SKOV3/VCR cells (Pubmed Central) - Aug 16, 2019
Meanwhile, LY294002 (PI3K inhibitor) decreased the protein expression levels of MDR1, β-catenin and Survivin, as well as the phosphorylation levels of Akt and GSK3β in SKOV3/VCR cells (P < 0.05). These results suggest that WNT5A gene silencing reverses VCR resistance in SKOV3/VCR cells possibly through blocking the PI3K/Akt/GSK3β/β-catenin signaling pathway, and thus down-regulating the protein expression levels of MDR1 and Survivin.
- | Journal: Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition. (Pubmed Central) - Aug 16, 2019
We further found that DADS blocked EMT via targeting the Rac1-mediated PAK1-LIMK1-Cofilins signaling. Rac1 is a potential target molecule for the inhibitory effect of DADS on EMT and invasion and metastasis of colon cancer cells.
- | Journal, IO Biomarker: Long non-coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway. (Pubmed Central) - Aug 16, 2019
The results of western blot analysis suggested that the levels of phosphorylated phosphoinositide-3 kinase (PI3K) and phosphorylated AKT were attenuated by H19 silencing. These results suggest that lncRNA H19 exerts an oncogenic function in TC, in part through the PI3K/AKT pathway.
- | Journal: Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling. (Pubmed Central) - Aug 16, 2019
To sum up, the research indicated that OA promoted autophagy through inhibition of PI3K/AKT/mTOR pathway. OA alleviated diabetic renal fibrosis by increasing autophagy through regulation of miR-142-5p/PTEN via PI3K/AKT/mTOR pathway in NRK-52E cells.
- | MK-2206 / Merck (MSD), quercetin (LY294002) / Eli Lilly
Journal, IO Biomarker: Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy. (Pubmed Central) - Aug 15, 2019
In addition, LY-294002 (a PI3K inhibitor) and MK2206 (an Akt inhibitor) significantly blocked the protective effect of TBN against OGD-induced death of cortical neurons. Taken together, the multifunctional mechanisms including scavenging free radicals, blocking calcium overload, maintaining mitochondrial function and activating the PI3K/Akt/p-GSK3β cell survival pathway were possibly involved in the neuroprotective effects of TBN, making it a promising clinical candidate for the treatment of ischemic stroke.
- | Journal: Predictive value of EGFR-PI3K-pAKT-mTOR-pS6 pathway in sinonasal squamous cell carcinomas. (Pubmed Central) - Aug 15, 2019
This study reveals that the absence of pS6 overexpression is associated with better clinical outcomes. Therefore, pS6 expression could be considered as an unfavourable prognostic marker.
- | Preclinical, Journal: Quinone-fused pyrazoles through regio-selective 1,3-dipolar cycloadditions: synthesis of tricyclic scaffolds and in vitro cytotoxic activity evaluation on glioblastoma cancer cells. (Pubmed Central) - Aug 15, 2019
In vitro studies confirmed the potent anti-cancer capability, showing interesting IC50 values down to 2.5 μM on three different glioblastoma cell lines. Their cytotoxic activity was finally positively correlated to their ability of inhibiting PI3K/mTOR kinases, which are responsible for the regulation of diverse cellular processes in human cancer cells.
- | metformin / generics
Journal: Blood and skin-derived Sezary cells: differences in proliferation-index, activation of PI3K/AKT/mTORC1 pathway and its prognostic relevance. (Pubmed Central) - Aug 15, 2019
Moreover, CNV of PTEN, PDCD4, and P70S6K, evaluated individually or in combination, are associated with reduced survival of SS patients. These data shed light on effects in vivo of skin-SS cells interaction underlying the prognostic and therapeutic relevance of mTORC1 pathway in SS.
- | Preclinical, Journal: PI3K/Akt and Nrf2/HO-1 pathways involved in the hepatoprotective effect of verapamil against thioacetamide toxicity in rats. (Pubmed Central) - Aug 15, 2019
In conclusion, the calcium channel blocker, verapamil, that is used widely as antihypertensive exhibits a valuable hepatoprotective effect. The protection partially rests on activation of Nrf2/HO-1 and PI3K/Akt pathways.
- | cisplatin / generics
Journal: [6]-Gingerol enhances the cisplatin sensitivity of gastric cancer cells through inhibition of proliferation and invasion via PI3K/AKT signaling pathway. (Pubmed Central) - Aug 15, 2019
The combination treatment inhibited cell migration and invasion ability and decreased cyclin D1, cyclin A2, matrix metalloproteinase-9, p-PI3K, AKT, and p-AKT protein expressions and increased P21 and P27 mRNA levels. Our study demonstrates that [6]-gingerol enhances the cisplatin sensitivity of gastric cancer cells and that the mechanisms involve G1 phase arrest, migration and invasion suppression via PI3K/AKT signaling pathway.
- | Journal: ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway. (Pubmed Central) - Aug 15, 2019
Furthermore, western blot analysis demonstrated that the effects of ZNF692 were mediated by upregulating cyclin D1, cyclin‑dependent kinase 2 (CDK2) and matrix metalloproteinase‑9 (MMP‑9) and by downregulating p27Kip1 through the phosphoinositide 3‑kinase/AKT signaling pathway. Collectively, these data indicated that ZNF692 may serve as a novel oncogene and a potential treatment target in COAD patients.
- | epirubicin / generics
Journal: Isoforms S and L of MRPL33 from alternative splicing have isoform‑specific roles in the chemoresponse to epirubicin in gastric cancer cells via the PI3K/AKT signaling pathway. (Pubmed Central) - Aug 15, 2019
In conclusion, the results of the present study revealed that isoforms S and L of MRPL33, which arise from alternative splicing, exhibited opposing roles in the chemoresponse to epirubicin in gastric cancer via the PI3K/AKT signaling pathway. These findings may contribute to the development of potential therapeutic strategies for the resensitization of patients with gastric cancer to epirubicin treatment.
- | Journal: Functional role of SGK3 in PI3K/Pten driven liver tumor development. (Pubmed Central) - Aug 15, 2019
These findings may contribute to the development of potential therapeutic strategies for the resensitization of patients with gastric cancer to epirubicin treatment. Altogether, our data suggest that SGK3 plays a role in transducing helical domain mutant PIK3CA signaling during liver tumor development.
- | quercetin (LY294002) / Eli Lilly, SB202190 / Amgen
Clinical, Journal: Prostaglandin E receptors differentially regulate the output of proinflammatory cytokines in myometrial cells from term pregnant women. (Pubmed Central) - Aug 15, 2019
The inhibitors of adenylyl cyclase and PKA prevented EP and EP stimulation of IL-1β and TNFα output, whereas PLC and PKC inhibitors blocked EP- and EP-induced TNFα output but not IL-1β output. Our data suggest that PGE receptors exhibit different effects on the output of various cytokines in myometrium, which can subtly modulate the inflammatory microenvironment in myometrium during pregnancy.
- | Journal: Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade. (Pubmed Central) - Aug 15, 2019
TGF-β-induced morphological changes and induction of invasive ability of tumor cells was also found to be abrogated by BSN treatment. Finally, BSN not only suppressed constitutive, but also inducible phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) phosphorylation in tumor cells.
- | quercetin (LY294002) / Eli Lilly
Journal: Ghrelin modulates intracellular signalling pathways that are critical for podocyte survival. (Pubmed Central) - Aug 15, 2019
...While PI3K inhibitor (LY294002) was without effect on cell survival or P38 MAPK activation, it inhibited ghrelin induced ERK1/2 phosphorylation...Of note, podocytes contribute to the formation and the maintenance of the glomerular filtration barrier and thus are important for normal renal function. Therefore, ghrelin secretion in the context of obesity could be involved in the aetiology of kidney injury, a well-known hallmark found in obese patients.
- | Journal: Effectiveness and mechanism of pure platelet-rich plasma on osteochondral injury of talus (Pubmed Central) - Aug 15, 2019
Western blot detection showed that the relative expression of PI3K, pAKT, and p-c-Jun protein in group B was significantly higher than those in groups A and C ( P0.05). P-PRP is superior to L-PRP for osteochondral injury of talus, which may be related to the inhibition of PI3K/AKT/AP-1 signaling pathway in the osteoblast, thereby reducing the secretion of MMP-9.
- | Journal: The Comparison of RhoC and PI3K Gene Expression on the Breast Cancer Tissue and Benign Tumour Tissue. (Pubmed Central) - Aug 14, 2019
P-PRP is superior to L-PRP for osteochondral injury of talus, which may be related to the inhibition of PI3K/AKT/AP-1 signaling pathway in the osteoblast, thereby reducing the secretion of MMP-9. This study concluded that expression of RhoC affects the expression of PI3K so that the thing this is what causes the proliferation and began to provide support aggressive cancer cells in the breast.
- || WATCH: Dr. Abedin on PI3K Inhibitors in CLL #leukemia https://t.co/g3NBU76Vuj (Twitter) - Aug 13, 2019
- |||| CDZ173 / Novartis
$NVS sells CDZ173/leniolisib, one of the most advanced PI3K inhibitors, to Pharming for non-oncology use https://t.co/VFk387P029 (Twitter) - Aug 13, 2019
- | quercetin (LY294002) / Eli Lilly
Journal: Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility. (Pubmed Central) - Aug 11, 2019
Mechanistically, cotreating with miR-21-5p and LY294002, a PI3K inhibitor, suppressed these effects...Finally, mathematical simulations predicted the translational capacity for miR-21-5p treatment to restore calcium handling in mature ischemic adult human cardiomyocytes.miR-21-5p plays a key role in hMSC-exo-mediated effects on cardiac contractility and calcium handling, likely via PI3K signaling. These findings may open new avenues of research to harness the role of miR-21-5p in optimizing future stem cell-based cardiotherapies.
- | ketamine / generics, memantine / generics
Journal: Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3β pathway. (Pubmed Central) - Aug 10, 2019
Additionally, ketamine significantly (P<0.005) suppressed IL-1β, TNF-α, IL-6, caspase-6 and p21WAF1/CIP1, p53 expression and up-regulated the PI3K/AKT/GSK-3β expression in the group of iso-induced rats. We can conclude that ketamine prevented the cognitive impairment induced by isoflurane anesthesia through anti-apoptotic, anti-inflammatory, and antioxidant effects via the PI3K/AKT/GSK-3β pathway.
- | Journal: Interleukin-22 secreted by cancer-associated fibroblasts regulates the proliferation and metastasis of lung cancer cells via the PI3K-Akt-mTOR signaling pathway. (Pubmed Central) - Aug 10, 2019
Finally, we also identified a panel of critical genes with differential expression between A549 cells treated with and without IL-22. In summary, our results demonstrate a novel regulatory function of IL-22 secreted by CAFs in NSCLC and provide a potential therapeutic target for treating lung cancer.
- |||| NF1 mutations are observed consistently in around 10% of HR+ mBC resistant to endocrine therapy. We must NOT forget metastatic Breast Cancer when it will be time to develop RAS inhibitors (and until then combo PI3K/MEK inh) (Twitter) - Aug 10, 2019
- | quercetin (LY294002) / Eli Lilly
Biomarker, Journal: Inhibition of Ca -activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling. (Pubmed Central) - Aug 9, 2019
Mechanistically, ANO1 knockdown attenuated phosphorylation of PI3K/Akt, and inhibition of PI3K/Akt signaling by specific inhibitor LY294002 resulted in suppression of ovarian cancer cells growth promoted by ANO1 expression...Taken together, our findings demonstrate that ANO1 overexpression is involved in the pathogenesis of human epithelial ovarian cancer. Inhibition of ANO1 upregulation or inactivating PI3K/Akt signaling may have therapeutic potential for epithelial ovarian cancer, and the detection of ANO1 expression level in PBMCs from patients may also serve as a biomarker for diagnosis and prognosis of epithelial ovarian cancers.
- | venlafaxine / generics, carvedilol / generics
Journal, PARP Biomarker: Venlafaxine and carvedilol ameliorate testicular impairment and disrupted spermatogenesis in rheumatoid arthritis by targeting AMPK/ERK and PI3K/AKT/mTOR pathways. (Pubmed Central) - Aug 9, 2019
They also modulated the AMPK/ERK signaling via lowering of p-AMPK and upregulation of p-ERK1/2 and the PI3K/AKT/mTOR transduction by enhancing the PI3Kp110α, p-AKT and p-mTOR protein expression. Together, the present work demonstrates the beneficial effects of venlafaxine and carvedilol in RA testicular dysfunction and impaired spermatogenesis via modulation of AMPK/ERK and PI3K/AKT/mTOR signaling and intervention with the testicular oxidative stress, inflammation and apoptosis.
- | Journal, IO Biomarker: Trametenolic acid B protects against cerebral ischemia and reperfusion injury through modulation of microRNA-10a and PI3K/Akt/mTOR signaling pathways. (Pubmed Central) - Aug 9, 2019
Further studies in vitro and in vivo indicated TAB could efficiently reduce OGD/R-damaged SH-SY5Y cell and cerebral I/R rat serum ROS, LDH and MDA levels, elevate SOD, GSH-Px and CAT activities, downregulate miR-10a mRNA and Bax, cytochrome C, cleaved-caspase-3 and cleaved-caspase-9 protein expressions, upregulate p-PIK3CA, p-Akt, p-mTOR, Bcl-2, pro-caspase-9 and pro-caspase-3 protein expressions and p-PIK3CA/PIK3CA, p-Akt/Akt, p-mTOR/mTOR ratios (P < 0.05 or P < 0.01, respectively). Our present study indicated that TAB possessed neuroprotective property against ODG/R and I/R injury by suppressing miR-10a expression, activating PI3K/Akt/mTOR signaling pathway, thereby reducing mitochondrial-mediated apoptosis, which provided a new insight for interpreting the underlying mechanisms of TAB' neuroprotective effect and a candidate agent to treat cerebral I/R injury.