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  • ||||||||||  Journal:  The role of a small molecule in the modulation of cell death signal transduction pathways. (Pubmed Central) -  Oct 8, 2019   
    Future experiments will aim to further characterize how DN1 modulates signal transduction pathways to inhibit pyroptotic cell death in LT-sensitive macrophages. DN1 represents a novel chemical probe to investigate host cellular mechanisms that mediate cell death in response to pathogenic agents.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Overcoming Target Driven Fratricide for T Cell Therapy. (Pubmed Central) -  Oct 8, 2019   
    The first focused upon the inclusion of a Phosphoinositol-3-Kinase inhibitor (LY294002) into the production process...By means of targeted inhibition of NKG2D expression or generic inhibition of enzyme function, target-driven CAR T fratricide can be overcome. These strategies have been incorporated into on-going clinical trials to enable a highly efficient and reproducible manufacturing process for NKG2D-CAR T cells.
  • ||||||||||  Avastin (bevacizumab) / Roche, paclitaxel / Generic Mfg.
    Review, Journal:  PI3K/AKT/mTOR inhibitors for advanced or recurrent endometrial cancer. (Pubmed Central) -  Oct 8, 2019   
    In a recurrent disease setting, mTOR inhibitors may result in improved progression-free survival, but we found no clear benefit in overall survival or tumour response rate. We await the publication of at least five ongoing studies investigating the role of PI3K/AKT/mTOR inhibitors in advanced or recurrent endometrial cancer before any conclusions can be drawn on their use.
  • ||||||||||  Journal:  Hypothalamic dopamine signaling regulates brown fat thermogenesis. (Pubmed Central) -  Oct 5, 2019   
    We further demonstrate that, as early as 3 months after onset of treatment, patients treated with the D2R agonist cabergoline experience an increase in energy expenditure that persists for one year, leading to total body weight and fat loss through a prolactin-independent mechanism. Our results may provide a mechanistic explanation for how clinically used D2R agonists act in the CNS to regulate energy balance.
  • ||||||||||  Journal:  MFG-E8 reverses microglial-induced neurotoxic astrocyte (A1) via NF-κB and PI3K-Akt pathways. (Pubmed Central) -  Oct 4, 2019   
    In the current study, we constructed an Aβ42-activated microglia-conditioned medium to induce A1 astrocytic activation via secretion of interleukin 1α, tumor necrosis factor, and complement component 1q in vitro, and indicated the regulatory role of milk fat globule epidermal growth factor 8 (MFG-E8) on A1/A2 astrocytic alteration through the downregulation of nuclear factor-κB and the upregulation of PI3K-Akt. This study showed that MFG-E8 suppressed A1 astrocytes and holds great potential for the treatment of AD.
  • ||||||||||  MK-2206 / Merck (MSD), dactolisib (RTB101) / Novartis, PureTech
    Journal:  Inhibition of esophageal cancer growth through the suppression of PI3K/AKT/mTOR signaling pathway. (Pubmed Central) -  Oct 3, 2019   
    The enhanced efficacy of the combination was associated with the inhibition of phosphorylation ATK on both Thr308 and Ser473. The combination of MK2206 and BEZ235 exhibits potent antitumor effects and may have important clinical applications for esophageal SCC treatment.
  • ||||||||||  quercetin (LY294002) / Eli Lilly, SP600125 / Celgene
    Mechanisms underlying human placental CD34+-derived natural killer cell cytotoxicity against glioblastoma (Prince George's Exhibition Halls AB) -  Oct 2, 2019 - Abstract #SITC2019SITC_566;    
    Our results demonstrate the importance of PI3K and JNK pathways in mediating PNK cytotoxicity to GBM cell line targets. These data combined with our receptor profiling on PNK cells establish the rationale for further investigating receptor-ligand interactions that directly modulate PI3K and JNK activity.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury. (Pubmed Central) -  Oct 2, 2019   
    Collectively, these findings identified that UBIAD1 protects against OGD/R-induced multiple subcellular organelles injury through PI3K/AKT Pathway.  These results suggest that apoM possesses protective properties against LPS-induced organ injuries and could potentially be introduced as a novel therapy for the severe conditions that are consequent to sepsis.
  • ||||||||||  Review, Journal:  The versatile role of curcumin in cancer prevention and treatment: A focus on PI3K/AKT pathway. (Pubmed Central) -  Oct 2, 2019   
    Considered to be the key signaling pathway, the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway therefore represents a key target for cancer therapeutics. In the current review, we focus upon curcumin's targeting of PI3K/AKT in different malignancies to effect inhibition of cancer development and progression.
  • ||||||||||  sirolimus / generics
    Preclinical, Journal:  Exogenous H S exerts biphasic effects on porcine mammary epithelial cells proliferation through PI3K/Akt-mTOR signaling pathway. (Pubmed Central) -  Oct 2, 2019   
    Moreover, constitutive activation of Akt pathway via transfection of Akt-CA completely eliminated the inhibition of PMECs proliferation and mTOR signaling pathway, and the change of proliferative genes expression induced by 600 µM NaHS. In conclusion, our findings provided evidence that exogenous H S supplied by NaHS exerted biphasic effects on PMECs proliferation, with stimulation at lower doses and suppression at high dose, through the intracellular PI3 K/Akt-mTOR signaling pathway.
  • ||||||||||  tyrphostin (AG 490) / EMD Serono, Yissum Research Development Company, quercetin (LY294002) / Eli Lilly, PD98059 / Wayne State University
    Preclinical, Journal:  Specific effects of neuregulin-1β on the communication between DRG neurons and skeletal muscle cells in vitro. (Pubmed Central) -  Oct 2, 2019   
    These data imply that NRG-1β is essential for the nerve-muscle communication by enhancing growth and modifying phenotypes of the two different kinds of cells. The specific effects produced by NRG-1β add novel interpretation for nerve-muscle communication between sensory neurons and SKM cells.
  • ||||||||||  Wnt11 combines PI3K and Rho / ROCK signaling in the invasion of breast cancer (M8) -  Sep 30, 2019 - Abstract #DGHO2019DGHO_1537;    
    Our findings suggest that irisin is a novel therapeutic agent for pancreatic cancer. Taken together, our results identified WNT11 as an important tumor protein regulating breast cancer metastasis through integration of PI3K and Rho/Rock signaling.
  • ||||||||||  Rituxan (rituximab) / Roche, Biogen
    Follicular lymphoma (Hall A7) -  Sep 30, 2019 - Abstract #DGHO2019DGHO_1009;    
    Many other drugs, including immunotherapies and CAR-T cell therapies, are under investigation. The identification of patients with high medical need and new drugs will improve the therapeutic options in future.
  • ||||||||||  Campath (alemtuzumab) / Sanofi
    T-cell lymphoma (R10) -  Sep 30, 2019 - Abstract #DGHO2019DGHO_898;    
    The current management of most PTCL is based on chemotherapy and stem cell transplantation concepts. In the near future, more effective treatments may lead to better therapy outcomes in many PTCL entities.