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- | Journal: 16α-Hydroxytrametenolic acid from Poria cocos improves intestinal barrier function through glucocorticoid receptor mediated PI3K/Akt/NF-κB pathway. (Pubmed Central) - Oct 18, 2019
Moreover, HTA prevented NF-κB translocation into the nucleus and binding to its cis-element and suppressed LPS-induced downstream NO production, pro-inflammatory cytokines at both protein and mRNA expression levels. In conclusion, HTA from P. cocos improves intestinal barrier function through a GR mediated PI3K/Akt/NF-κB signaling pathway and may be potentially exploited as a supportive dietary therapeutic strategy for restoring gut health.
- | sirolimus / generics
Preclinical, Journal: Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety. (Pubmed Central) - Oct 18, 2019
It shows superiority in the suppression of cancer cell proliferation and demonstrates significant antitumor activity in an OVCAR-3 xenograft model at concentrations approximately eight times lower than PQR309 (1). The favorable pharmacokinetic profile and a minimal brain penetration promote PQR514 (4) as an optimized candidate for the treatment of systemic tumors.
- | Journal: Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells. (Pubmed Central) - Oct 18, 2019
Masking of GalNAc-DSLc4 with antibodies as well as PI3K inhibitor suppressed malignant properties of the transfectants. These results suggested that GalNAc-DSLc4 is involved in malignant properties of RCCs by forming a molecular complex with integrins in lipid rafts.
- | Journal: Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling. (Pubmed Central) - Oct 18, 2019
Mechanistically, we show that NGR1's mode of action is through inhibiting the activation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling. Taken together, this study identified NGR1 as a potential therapeutic agent for combating restenosis after PTA in cardiovascular diseases.
- | Journal: Estrogen promotes progression of hormone-dependent breast cancer through CCL2-CCR2 axis by upregulation of Twist via PI3K/AKT/NF-κB signaling. (Pubmed Central) - Oct 18, 2019
Our data show the hormonal regulation on CCL2-CCR2 axis is associated with enhanced Twist expression via activation of ERα and PI3K/AKT/NF-κB signaling. Thus, CCL2-CCR2 axis may represent as a novel therapeutic target eagerly needed for hormone-dependent breast cancer.
- | chloroquine phosphate / Generic Mfg., Nexavar (sorafenib) / Bayer, Amgen
Journal: Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells. (Pubmed Central) - Oct 18, 2019
Meanwhile, E5 was able to downregulate the PDGFRα/PI3K/AKT/mTOR pathway and to activate MAPK/ERK signaling pathway. Taken together, in addition to the possibility of E5 as a valuable drug candidate, the present study further supports the notion that targeted inhibition of PDGFRα is a promising therapeutic strategy for HCC.
- | Journal: The Telomerase and Alternative Lengthening of Telomeres Mechanisms Regulate Laryngeal Cancer Cell Apoptosis via the PI3K/Akt Pathway. (Pubmed Central) - Oct 18, 2019
Taken together, in addition to the possibility of E5 as a valuable drug candidate, the present study further supports the notion that targeted inhibition of PDGFRα is a promising therapeutic strategy for HCC. The inhibition of telomere-related genes inhibited the growth of laryngeal squamous cell carcinoma by promoting cell apoptosis via the PI3K/Akt pathway.
- | sirolimus / generics
Review, Journal: The Treatment of Activated PI3Kδ Syndrome. (Pubmed Central) - Oct 18, 2019
These treatments including conventional immunodeficiency therapies such as immunoglobulin replacement, antibiotic prophylaxis, and hematopoietic stem cell transplant. We also discuss the more targeted therapies of mTOR inhibition with sirolimus and selective PI3Kδ inhibitors.
- PI3K inhibitors in advanced breast cancer: What has changed? (Room 324) - Oct 18, 2019 - Abstract #ESMOAsia2019ESMO_ASIA_1024;
- | MEN1611 / Menarini
Preclinical, Journal: Melanocortin type 4 receptor-mediated inhibition of A-type K current enhances sensory neuronal excitability and mechanical pain sensitivity in rats. (Pubmed Central) - Oct 17, 2019
Chemical inhibition of phosphatidylinositol 3-kinase (PI3K) with wortmannin or of class I PI3Ks with the selective inhibitor CH5132799 prevented the MC4R-mediated I response...Additionally, α-MSH significantly increased the action potential firing rate of TG neurons and increased the sensitivity of rats to mechanical stimuli applied to the buccal pad area, and both effects were abrogated by I blockade. Taken together, our findings suggest that α-MSH suppresses I by activating MC4R, which is coupled sequentially to the G complex of the G protein and downstream class I PI3K-dependent p38α signaling, thereby increasing TG neuronal excitability and mechanical pain sensitivity in rats.
- | quercetin (LY294002) / Eli Lilly
Journal: Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine. (Pubmed Central) - Oct 17, 2019
Furthermore, using Atipamezole and LY294002, we found that dexmedetomidine significantly increased GLT-1 levels in astrocytes via activating α2 adrenergic receptor and PI3K/AKT pathway both in vitro and in vivo study. Overall, our present study indicated that dexmedetomidine had neuroprotective effects on ischemia stroke and upregulation of GLT-1 levels by PI3K/AKT dependent pathway might be the potential mechanism.
- | Journal: Inhibition of long non-coding RNA-AWPPH decreases osteosarcoma cell proliferation, migration and invasion. (Pubmed Central) - Oct 17, 2019
Furthermore, AWPPH downregulation significantly inhibited the PI3K/AKT pathway. The present study demonstrated that AWPPH was highly expressed in OS, and that AWPPH promoted OS cell proliferation and migration, and inhibited OS cell apoptosis, which may be mediated by PI3K/AKT pathway activation.
- |||| Piqray (alpelisib) / Novartis, Afinitor (everolimus) / Novartis
Agree convincing data for PI3K inhibition is lacking in lung cancer. But alpelisib has decent data in breast. Given lack of good treatment options, I think alpelisib (if available) + keto diet (if pt willing) is reasonable option to try. Gef+everolimus also seems worth a shot. (Twitter) - Oct 17, 2019
- | Journal: PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-β1 signaling to PI3Kγ/AKT/Rac1 pathway. (Pubmed Central) - Oct 16, 2019
The migration of hepatic stellate cells is regulated by PHP14. PHP14 is a mediator of TGF-β1 signaling to PI3Kγ/AKT/Rac1 pathway in hepatic stellate cells.
- ABTL0812 / Ability Pharma, SciClone, paclitaxel / Generic Mfg.
Preclinical evidences of the therapeutic potential of ABTL0812 in endometrial cancer () - Oct 16, 2019 - Abstract #ESGO2019ESGO_2015;
ABTL0812 efficacy was evaluated in tumor onset and progression in a tamoxifen-inducible PTEN-KO murine model and cell line- or patient-derived xenograft (PDX) models...ABTL0812 in vivo therapeutic benefit was confirmed, leading to a marked reduction in tumor growth (p<0.05), impairing the initial progression of endometrial tumorigenesis in PTEN-KO mouse model, and inhibiting tumor progression in PDX models, potentiating carboplatin-paclitaxel treatment...Collectively, we provided strong preclinical evidences of the therapeutic benefit of ABTL0812 as monotherapy or in combination with current first-line treatment in EC. Our findings present a novel and clinically applicable therapeutic strategy for EC and suggest the potential use of TRIB3 as a pharmacodynamic biomarker to monitor ABTL0812 treatment.
- Measuring functional PI3K and NFkB pathway activity to distinguish between short-term and long-term disease-free survivors of high grade serous ovarian cancer () - Oct 16, 2019 - Abstract #ESGO2019ESGO_1996;
The low PI3K/high FOXO and high NFkB activity of the favourable prognosis cluster may indicate apoptosis, while the high PI3K/low FOXO and low NFkB activity of the unfavourable prognosis cluster may indicate high cell division. Elucidating underlying mechanisms of HGSC aids our understanding of the disease and provides possible new leads for targeted therapies.
- Resibufogenin inhibits ovarian clear cell carcinoma (OCCC) growth in vivo, and migration of OCCC cells in vitro, by down-regulating the PI3K/AKT and actin cytoskeleton signaling pathways () - Oct 16, 2019 - Abstract #ESGO2019ESGO_1619;
- Post-transcriptional regulation of prognostic factor PD-L1 expression by 17β-estradiol via PI3K/Akt signaling pathway in endometroid cancer () - Oct 16, 2019 - Abstract #ESGO2019ESGO_1239;
Co-culture results shows that up-regulating PD-L1 expression and activating PD-1/PD-L1 pathway leads to inhibition of T cell activity. Conclusion Our results demonstrate a new role of estrogen in regulation of anti-cancer immunity, implying PD-L1 as a potential therapeutic target or an outcome parameter in anti-estrogen treatment of EC and estrogen- dependent cancer.
- paclitaxel / Generic Mfg.
Inhibition of phosphatidylinositol 3-kinase (PI3K) signaling synergistically potentiate antitumor efficiency of paclitaxel and overcome paclitaxel-mediated resistance in cervical cancer () - Oct 16, 2019 - Abstract #ESGO2019ESGO_839;
In addition, PI3K inhibition also suppressed tumor migration and invasive ability by targeting β-catenin, p-c-raf, matrix metalloproteinase-2 (MMP-2) and vascular endothelial cell growth factor (VEGF). Conclusion We suggest that a combination of a PI3K inhibitor with paclitaxel may enhance antitumor activity through a cascade of PI3K signaling events.
- | Piqray (alpelisib) / Novartis, buparlisib (BKM120) / Novartis, Adlai Nortye
Journal: Inhibition of the α-subunit of phosphoinositide 3-kinase (PI3K) in heart increases late sodium current and is arrhythmogenic. (Pubmed Central) - Oct 16, 2019
We conclude that inhibition of cardiac PI3K-α is arrhythmogenic by increasing INaL, and this effect is not seen with inhibition of other PI3K isoforms. These results highlight a mechanism underlying potential cardiotoxicity of PI3K-α inhibitors.
- | Clinical, Journal: Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology. (Pubmed Central) - Oct 16, 2019
Eighteen out of 295 herbs showed significant correlation with survival results (P < 0.05). Bioinformatics analysis indicated that the 18 herbs realize anti-CRC activity mainly through suppressing the proliferative activity of ERBB2, peroxisome proliferator-activated receptor gamma, and retinoid X receptor, suppressing angiogenesis via inhibition of VEGFR and VEGFA expression, inhibiting the phosphatidylinositol-3-kinase/AKT1 signaling pathway directly through SRC and AKT1, and reducing tumor necrosis factor-induced inflammation.
- | Clinical, Journal, Cancer stem cells: let-7i-5p, miR-181a-2-3p and EGF/PI3K/SOX2 axis coordinate to maintain cancer stem cell population in cervical cancer. (Pubmed Central) - Oct 16, 2019
In conclusion, this study highlights for the first time the contrasting role of let-7i-5p/ miR-181a-2-3p and EGF/PI3K/SOX2 axis in maintaining cervical CSCs. While the EGF pathway promotes CSC formation in cervical cancer by inducing SOX2, miR-181a-2-3p/let-7i-5p counteracts the EGF pathway by inhibiting SOX2, thereby reducing the CSC population.
- | quercetin (LY294002) / Eli Lilly
Journal: PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases. (Pubmed Central) - Oct 16, 2019
Interestingly, the broad-spectrum phosphoinositide 3-kinase (PI3K) inhibitor LY294002 proved to be 10-fold less effective against the resistant replicons...Instead, we demonstrated that both molecules impede HCV replication at least partially by an inhibitory effect on PI3Ks. Moreover, HCV is able to bypass PI3K inhibition by acquiring mutations in its genome.
- | AZD8835 / AstraZeneca
Journal: PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8 T-cell activity. (Pubmed Central) - Oct 16, 2019
Together these data reveal novel mechanisms by which PI3Kα/δ inhibitors interact with the immune system and validate the clinical compound AZD8835 as a novel immunoncology drug, independent of effects on tumor cells. These data support further clinical investigation of PI3K pathway inhibitors as immuno-oncology agents.
- Induction of the Intracellular Immunomodulator Toll-Interacting Protein (Tollip) Mediates Monophosphoryl Lipid A (MPLA)-Induced Protection Against Lipopolysaccharide in Medullary Thick Ascending Limb (MTAL) (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_4088;
Strategies targeted to manipulate Tollip expression may aid in protecting renal tubule function against infectious and inflammatory challenge. Funding NIDDK Support
- | Piqray (alpelisib) / Novartis
Journal: Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα. (Pubmed Central) - Oct 13, 2019
Moreover, BTF3 knockdown sensitizes ER+ breast cancer cells to the PI3Kα inhibitor BYL-719 in both in vitro and in vivo models. Together, our findings highlight a novel role of BTF3 in modulation of ERα-dependent transcriptional activity and its potential as a predictive marker for the response to PI3K-targeted therapy in ER+ breast cancer.
- | Journal: Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways. (Pubmed Central) - Oct 12, 2019
In addition, only RSV-LNCs inhibited MDA levels and SOD activity in parallel with blockade of the ERK and PI3K/Akt pathways following LPS provocation. Nanoformulation of RSV in biodegradable oil-core polymers is an effective strategy to improve the anti-ALI activity of RSV, suggesting that the modified-release formulation of this plant polyphenol may be of great value in clinical conditions associated with ALI and respiratory failure.
- | Journal: miR-132-3p inhibits tumor malignant progression by regulating LAPTM4B in breast cancer. (Pubmed Central) - Oct 12, 2019
Functionally, miR-132-3p suppressed the migration and invasion of breast carcinoma cells through LAPTM4B by mediating EMT signals, and partially reversed the carcinogenic effects of LAPTM4B by inhibiting the PI3K-AKT-mTOR signaling pathway. Taken together, these findings provide the first comprehensive analysis of miR-132-3p as a direct LAPTM4B-targeted miRNA, and shed light on miR-132-3p/LAPTM4B as a significant functional axis involved in the oncogenesis and metastasis of breast cancer.
- |||| Clinical: PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Kα inhibitors in breast cancer. https://t.co/UOuI3AdIsL (Twitter) - Oct 12, 2019
- | tyrphostin (AG 490) / EMD Serono, Yissum Research Development Company, quercetin (LY294002) / Eli Lilly, PD98059 / Wayne State University
Journal, IO Biomarker: Adropin reduces hypoxia/reoxygenation-induced myocardial injury via the reperfusion injury salvage kinase pathway. (Pubmed Central) - Oct 12, 2019
Furthermore, no significant difference was observed in phosphorylated-STAT3/total-STAT3 expression between the adropin and SI/R groups and Janus kinase 2 inhibitor AG490 did not significantly inhibit the protective role of adropin. These results indicate that adropin exerts a protective effect against SI/R injury through the RISK pathway instead of the survivor activating factor enhancement pathway.
- | Journal: MicroRNA-21-5p targeting PDCD4 suppresses apoptosis via regulating the PI3K/AKT/FOXO1 signaling pathway in tongue squamous cell carcinoma. (Pubmed Central) - Oct 12, 2019
This anti-apoptotic effect was achieved by regulating the PI3K/Akt/FOXO1 signaling pathway. These data represent the basis for a promising novel strategy for the treatment of TSCC.
- ||| Congratulations @LewCantleyWCMC!! We are so honored to have you on the scientific advisory board of @letswinpc 🏅 🎖 #pi3k #cancer #CancerResearch #gene #oncogene #pathway (Twitter) - Oct 12, 2019
- | Journal: MiR-182 affects renal cancer cell proliferation, apoptosis, and invasion by regulating PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - Oct 12, 2019
The decreasing level of miR-182 plays a role in enhancing mTOR expression and promoting renal carcinoma pathogenesis. Overexpression of miR-182 inhibited mTOR expression and weakened cell proliferation and invasion, which provides leads to the future therapy of renal cancer.
- | Journal: Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases. (Pubmed Central) - Oct 12, 2019
Here, we will discuss recent advances in the study of how PIPKs control specific cellular events through assembly and regulation of PI4,5Peffectors that mediate specific cellular processes. A focus will be on the roles of PIPKs in control of the phosphoinositide 3-kinase pathway and autophagy.
- | etoposide IV / Generic Mfg.
Journal: Dual inhibition of PI3K/mTOR signaling in chemoresistant AML primary cells. (Pubmed Central) - Oct 12, 2019
Remarkably, dual PI3K/mTOR inactivation was cytotoxic also to leukemia initiating cells. All together, our findings indicate that signaling activation profiling associated to gene expression can be very useful to stratify patients and improve therapy.
- | temozolomide / Generic Mfg.
Journal: A multi-targeted natural flavonoid myricetin impedes abnormal glioblastoma cell motility and invasiveness via suppressing lamellipodia and focal adhesions formation. (Pubmed Central) - Oct 11, 2019
All together, our findings indicate that signaling activation profiling associated to gene expression can be very useful to stratify patients and improve therapy. In conclusion, myricetin is a multi-targeted drug that has potent anti-migratory and anti-invasive effects on GBM cells via suppressing formation of lamellipodia and focal adhesions, suggesting that it may serve as an alternative option for GBM treatment.
- | quercetin (LY294002) / Eli Lilly
Journal: IL-1β promotes the nuclear translocaiton of S100A4 protein in gastric cancer cells MGC803 and the cell's stem-like properties through PI3K pathway. (Pubmed Central) - Oct 11, 2019
LY294002, a pharmacological inhibitor of Phosphoinositide 3-kinase (PI3K) reversed the above effects...Our study demonstrated that IL-1β promote the nuclear translocation of S100A4 protein in gastric cancer cells MGC803, which are PI3K dependent, suggesting the existence of IL-1β-PI3K-S100A4 pathway for the first time. The study also showed that IL-1β promoted stem-like properties of the cells through the new pathway.
- | chloroquine phosphate / Generic Mfg.
Journal: Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. (Pubmed Central) - Oct 11, 2019
Anti-oxidant (NAC) treatment did not rescue cells from death, indicating that oxidative stress is not the reason of cytotoxicity. Inhibition of autophagy by Atg5 siRNA and chloroquine even increased the toxicity of PFAAs, suggesting that PFAAs-autophagy was induced as the secondary effects of organelle damages and played a protective role during cell death.
- | cisplatin / generics
Journal: The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy. (Pubmed Central) - Oct 11, 2019
Introduction of STAT3-DN deprived the RAS-induced ERS, autophagy, oncogenicity, and cisplatin resistance, whereas introduction of p53 in STAT3-DN/RAS expressing cells induced additional tumor retardation and cisplatin sensitivity. Thus, our data provide strong evidence that the crosstalk between STAT3 and p53/RAS signaling controls ovarian cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy.
- | pilaralisib (SAR245408) / Sanofi
Clinical, P1 data, Journal: Phase I Trial of a Tablet Formulation of Pilaralisib, a Pan-Class I PI3K Inhibitor, in Patients with Advanced Solid Tumors. (Pubmed Central) - Oct 10, 2019
MTD was not determined. The recommended phase II dose for pilaralisib tablets, based on PK data, was 400 mg once daily.
- | MK-2206 / Merck (MSD), buparlisib (BKM120) / Novartis, Adlai Nortye
Journal: Positive Effects of PI3K/Akt Signaling Inhibition on PTEN and P53 in Prevention of Acute Lymphoblastic Leukemia Tumor Cells. (Pubmed Central) - Oct 9, 2019
In this study, we investigated the effects of dual targeting of PI3K/Akt pathway by combined inhibition with nvp-BKM-120 (PI3K inhibitor) and MK-2206 (Akt inhibitor) in relation with PTEN and P53 on apoptosis and proliferation of leukemia cells. This investigation suggested that inhibition of Akt and PI3K could be helpful in leukemia treatment.
- | Journal: Structural Perturbations due to Mutation (H1047R) in Phosphoinositide-3-kinase (PI3Kα) and Its Involvement in Oncogenesis: An in Silico Insight. (Pubmed Central) - Oct 9, 2019
Furthermore, a study of secondary structure elements and the electrostatic potential of the protein also gave a molecular insight into the change in interaction patterns of the protein with the plasma membrane. Our finding clearly indicates the role of mutation in oncogenesis and provides an insight into considering the structural aspects to handle this mutation.
- | quercetin (LY294002) / Eli Lilly
Journal: Ginsenoside-Rb3 inhibits endothelial-mesenchymal transition of cardiac microvascular endothelial cells. (Pubmed Central) - Oct 9, 2019
Our finding clearly indicates the role of mutation in oncogenesis and provides an insight into considering the structural aspects to handle this mutation. Rb3 inhibited EMT in CMVECs following CVB3 infection via the Pyk2-PI3K-AKT signaling pathway.
- | Journal: Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. (Pubmed Central) - Oct 9, 2019
Rb3 inhibited EMT in CMVECs following CVB3 infection via the Pyk2-PI3K-AKT signaling pathway. High-expressed miR-182 and low-expressed FOXO1 promoted proliferation and inhibiting apoptosis on liver fibrosis cells, stimulating the development of S. japonica-induced hepatic fibrosis through feeding back to PI3K / AKT signaling pathway.
- | dactolisib (RTB101) / Novartis, PureTech
Journal: Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease. (Pubmed Central) - Oct 9, 2019
Dual mTOR/PI3K inhibition with NVP-BEZ235 abrogated these pro-proliferative signals and normalized kidney morphology and function by blocking proliferation and fibrosis. Our findings suggest that multi-target PI3K/mTOR inhibition may represent a potential treatment for ADPKD.
- | Zydelig (idelalisib) / Gilead
Journal: Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses. (Pubmed Central) - Oct 9, 2019
In conclusion, PI3K inhibitors might cause a neutropenia-like susceptibility to infections in patients by leading to impaired PMN functionality. This should be considered when evaluating patients for infections treated with such inhibitors in daily clinical routine.
- Zydelig (idelalisib) / Gilead
Impact of comorbidities on outcome of therapy with idelalisib (IDELA), a phosphoinositide-3 kinase-delta inhibitor, in relapsed or refractory chronic lymphocytic leukemia (CLL) () - Oct 9, 2019 - Abstract #iwCLL2019IWCLL_1;
- | Journal: Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8 T Cell Survival, Differentiation, and Function. (Pubmed Central) - Oct 8, 2019
Despite uncontrolled EBV infection, many APDS/PASLI patients had normal or higher frequencies of EBV-specific CD8 T cells. In this review, we discuss data pertaining to CD8 T cell function in APDS/PASLI, including increased cell death, expression of exhaustion markers, and altered killing of autologous EBV-infected B cells, and how these and other data on PI3K provide insight into potential cellular defects that prevent clearance of chronic infections.
- | Journal: Schwann cells augment cell spreading and metastasis of lung cancer. (Pubmed Central) - Oct 8, 2019
In summary, SC can regulate the CXCL5/CXCR2/PI3K/AKT/GSK-3β/Snail-Twist pathway to promote EMT, invasiveness, and metastatic potential of lung cancer cells. Our results reveal a new role of the PNS in the functional organization of the tumor microenvironment and tumor progression.