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67 Companies | 59 Products |
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- | Journal: Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation. (Pubmed Central) - Nov 6, 2019
This observation establishes a relation between PI3K signalling and iron homeostasis in glioma cells. It also implies that activated PI3K controls ferritin expression to ensure availability of adequate iron required for cell proliferation.
- | Journal: miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway. (Pubmed Central) - Nov 6, 2019
Most importantly, treatment of LY29004 (an inhibitor of the PI3k/Akt pathway) can attenuate miR-142-5p osteoclastogenesis effects, while the inhibition effects of LY29004 on the osteoclastogenesis were abolished by knockdown of FoxO1. Taken together, our findings demonstrated that miR-142-5p promotes the osteoclastogenesis of BMMs through PI3k/Akt/FoxO1 pathway via targeting PTEN.
- | Journal: K-Ras-PI3K/AKT pathway regulates H1.4 through PKA to promote the occurrence and development of osteosarcoma cancer. (Pubmed Central) - Nov 6, 2019
Ras-PI3K/AKT signal pathway decreased H1.4 through down-regulation of PKA while up-regulation of MDM2 in MG-63 cells. Highlights H1.4 is regulated by K-Ras-PI3K/AKT in MG-63 cells; Overexpression of H1.4 regulates MG-63 cell growth; H1.4 regulates Ras downstream factors; K-Ras-PI3K/AKT activity induces PKA degradation to down-regulate H1.4; K-Ras-PI3K/AKT activity involves in PKA degradation via MDM2.
- | Journal: Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3β pathway. (Pubmed Central) - Nov 6, 2019
Our experiments revealed that upregulation of OGFRP1 may enhance the progression of endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3β pathway. OGFRP1 may be of significance in illustrating the biology of endometrial cancer.
- | quercetin (LY294002) / Eli Lilly
Journal: FGF10 Enhances Peripheral Nerve Regeneration via the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant Response. (Pubmed Central) - Nov 5, 2019
The inhibition of the PI3K/Akt pathway by the specific inhibitor LY294002 partially reversed the therapeutic effects of FGF10 both in vivo and in vitro. Thus, from our perspective, FGF10 may be a promising therapeutic drug for repairing sciatic nerve damage through countering excessive oxidative stress-induced SC apoptosis.
- ORAI2 promotes tumorigenesis and metastasis in gastric cancer via activation of the PI3K/Akt and FAK/MAPK/ERK pathways () - Nov 5, 2019 - Abstract #NCRI2019NCRI_149;
Q-PCR and IHC revealed STIMs as promising SOC partners of ORAI2, while IF and FRAP illustrated ORAI2 to be responsible for FA dynamics. Functional assays evidenced that ORAI2 could promote cell motility, tumor formation and metastasis in both cell lines and mice.
- || WATCH: Dr. Smith on PI3K Inhibitors in CLL #cllsm #leukemia @GWCancer https://t.co/MaWVqWPCzq (Twitter) - Nov 5, 2019
- | Journal: Correction: Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S BTK Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma. (Pubmed Central) - Nov 4, 2019
Functional assays evidenced that ORAI2 could promote cell motility, tumor formation and metastasis in both cell lines and mice. No abstract available
- | Journal: The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer. (Pubmed Central) - Nov 4, 2019
Mechanistically, PI3K and Akt inhibitors reversed impaired the effect of PEAK1 function on cell proliferation, migration, and invasion. Our results provide compelling evidence that the PEAK1-PPP1R12B axis inhibits colorectal tumorigenesis and metastasis through deactivation of the Grb2/PI3K/Akt pathway, which might provide a novel therapeutic strategy for CRC treatment.
- | Journal, IO Biomarker: Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway. (Pubmed Central) - Nov 3, 2019
The results support the idea that flaccidoxide-13-acetate-induced apoptosis is mediated by mitochondrial dysfunction, ER stress, and activation of both the p38 and JNK pathways, and also relies on inhibition of PI3K/AKT signaling. These findings imply that flaccidoxide-13-acetate has potential in the development of chemotherapeutic agents for human bladder cancer.
- | MK-2206 / Merck (MSD), Zyclara (imiquimod) / Mochida, Mylan, Bausch Health, quercetin (LY294002) / Eli Lilly
Journal: Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via PI3K-Akt Pathways. (Pubmed Central) - Nov 2, 2019
Furthermore, topical use of anti-psoriatic calcipotriol effectively decreased expression of CRNN, inhibited the Akt activation and improved the IMQ-stimulated psoriasis-like pathologies. Taken together, these results suggest that induced expression of CRNN may contribute to the pathogenesis of psoriasis.
- | clozapine / generics
Preclinical, Journal: Clozapine attenuates mitochondrial burdens and abnormal behaviors elicited by phencyclidine in mice via inhibition of p47 ; Possible involvements of phosphoinositide 3-kinase/Akt signaling. (Pubmed Central) - Nov 2, 2019
Taken together, these results suggest that induced expression of CRNN may contribute to the pathogenesis of psoriasis. Our results suggest that p47 gene mediates phencyclidine-induced mitochondrial burdens and abnormal behaviors, and that the interactive modulation between p47 and phosphoinositide 3-kinase/Akt is important for the understanding on the pharmacological mechanism of clozapine.
- | Journal: LncRNA ST3Gal6-AS1/ST3Gal6 axis mediates colorectal cancer progression by regulating α-2, 3 sialylation via PI3K/Akt signaling. (Pubmed Central) - Nov 2, 2019
ST3Gal6-AS1 expression was negatively correlated with tumor size, lymphatic metastasis, distant metastasis and tumor stage in CRC patients. Collectively, these data indicated that ST3Gal6-AS1, ST3Gal6, PI3K/Akt, and Foxo1 formed a positive feedback loop, which might play a key role in CRC progression.
- | Journal: Gentisyl Alcohol Inhibits Proliferation and Induces Apoptosis via Mitochondrial Dysfunction and Regulation of MAPK and PI3K/AKT Pathways in Epithelial Ovarian Cancer Cells. (Pubmed Central) - Nov 2, 2019
Moreover, gentisyl alcohol up-regulated signal transduction of MAPK and PI3K/AKT pathways. Collectively, our results demonstrated the possibility of gentisyl alcohol as a novel therapeutic agent for human ovarian cancer.
- | Journal: Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathway. (Pubmed Central) - Nov 2, 2019
Collectively, our results demonstrated the possibility of gentisyl alcohol as a novel therapeutic agent for human ovarian cancer. This present work puts insights into the crucial effects of the miR-134/NOS3 axis in myocardial H/R injury, delivering a potential therapeutic technology in future.
- | sirolimus / Generic mfg.
Journal: Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy. (Pubmed Central) - Nov 1, 2019
In vitro, NRK-52E cells were divided into four groups: normal glucose (NG), high glucose (HG), HG+DHM, and HG+rapamycin (autophagy inhibitor)...In addition, DHM promoted autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway. In conclusion, DHM promotes autophagy and attenuates RIF by regulating the miR-155-5p/PTEN signaling and PI3K/AKT/mTOR signaling pathway in DN.
- | Journal, IO Biomarker: MicroRNA-520a-3p inhibits cell growth and metastasis of non-small cell lung cancer through PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - Oct 31, 2019
In conclusion, DHM promotes autophagy and attenuates RIF by regulating the miR-155-5p/PTEN signaling and PI3K/AKT/mTOR signaling pathway in DN. Our study suggested that miR-520a-3p could suppress the NSCLC proliferation, migration and invasion through PI3K/AKT/mTOR signaling pathway.
- | quercetin (LY294002) / Eli Lilly
Preclinical, Journal: Bi S -Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo. (Pubmed Central) - Oct 31, 2019
Moreover, the mechanism studies also demonstrate that Bi S -Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway. The results demonstrate that the newly synthesized multifunctional nanoplatform paves a new avenue for accurate therapy of photothermal-resistant cancer.
- | Preclinical, Journal: Effect of PI3K/PKB signal pathway inhibitor wortmannin pretreatment on intestinal barrier function in severe acute pancreatitic rats. (Pubmed Central) - Oct 31, 2019
The results demonstrate that the newly synthesized multifunctional nanoplatform paves a new avenue for accurate therapy of photothermal-resistant cancer. The PI3K/PKB signal pathway may involve SAP-related intestinal injuries and WT may relieve SAP intestinal injuries through the PI3K/PKB pathway.
- | Journal: Effects of MiR-21 on proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis through PTEN/PI3K/AKT signaling pathway. (Pubmed Central) - Oct 31, 2019
The PI3K/PKB signal pathway may involve SAP-related intestinal injuries and WT may relieve SAP intestinal injuries through the PI3K/PKB pathway. No abstract available
- | quercetin (LY294002) / Eli Lilly
Preclinical, Journal: DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice. (Pubmed Central) - Oct 31, 2019
PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3. These findings suggest that histone methylation, especially H3K27me3 deposition is a novel mechanism and therapeutic target for retinal degenerative diseases, similar to H3K27me3-mediated ataxia-telangiectasia in Atmmouse.
- | Journal, BRCA Biomarker: Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts. (Pubmed Central) - Oct 31, 2019
Apart from this, it was shown for the first time that Sei-1 could directly regulate the expression of BRCA1. Our results suggest that the PI3K/Akt/BRCA1-Abraxas pathway is responsible for the formation of DMs induced by Sei-1.
- | trimetazidine / generics
Journal, IO Biomarker: Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy. (Pubmed Central) - Oct 31, 2019
The effect of TMZ on autophagy was repressed by LY294002. TMZ protected against MI/R injury by inhibiting excessive autophagy via activating the AKT/mTOR pathway.
- | Journal: Discovery of new Phosphoinositide 3-kinase delta (PI3Kδ) inhibitors via virtual screening using crystallography-derived pharmacophore modelling and QSAR analysis. (Pubmed Central) - Oct 31, 2019
TMZ protected against MI/R injury by inhibiting excessive autophagy via activating the AKT/mTOR pathway. Crystallography-based pharmacophores were successfully combined with QSAR analysis for the identification of novel PI3Kδ inhibitors.
- | Journal: PI3K activity in dendritic cells exerts paradoxical effects during autoimmune inflammation. (Pubmed Central) - Oct 31, 2019
Thus, PI3K-AKT signaling in DCs acts in a paradoxical manner. While attenuating EAE associated T1 and T17 responses, it impairs health during autoimmune inflammation.
- | Journal: Concentrate Growth Factors Regulate Osteogenic Dysfunction of MC3T3-E1 Cells Induced by High Glucose Through PI3K/Akt Signaling Pathway. (Pubmed Central) - Oct 30, 2019
While attenuating EAE associated T1 and T17 responses, it impairs health during autoimmune inflammation. It was concluded that the soluble factors released by CGF could significantly attenuate high glucose-mediated MC3T3-E1 cells osteogenic dysfunction through the PI3K/Akt pathway.
- |||||| bimiralisib (PQR309) / PIQUR
P2 data: Great collaboration with @FayeJohnso from bench to bedside. NOTCH1 LOF mutations in squamous cancer of head neck can be associated with salutary response to the PI3K/mTOR inhibitor bimiralisib, presented at #targets19. Phase 2 study for NOTCH1 HNSCC enrolling @MDAndersonNews (Twitter) - Oct 30, 2019
- | cisplatin / Generic mfg.
Preclinical, Journal: Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR-424-3p and targeting PTEN/PI3K/Akt pathway. (Pubmed Central) - Oct 30, 2019
Dual-luciferase reporter assay demonstrated that PTEN is a target gene of miR-424-3p, and overexpression of miR-424-3p or silencing of PTEN partially attenuated the effects of baicalein on A549 and H460 cells. Taken together, we concluded that baicalein inhibits cell growth and increases cisplatin sensitivity to A549 and H460 cells via down-regulation of miR-424-3p and targeting the PTEN/PI3K/Akt pathway.
- | MK-2206 / Merck (MSD), U0126 / Promega
Journal: CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways. (Pubmed Central) - Oct 30, 2019
The oncogenic effects induced by CRLF1 were suppressed by treating the cells with the MEK inhibitor U0126 or the AKT inhibitor MK-2206. These results suggest that CRLF1 enhances cell proliferation and metastasis in PTC and thus may therefore be a potential therapeutic target for PTC.
- | Journal: PI3K signaling in chronic obstructive pulmonary disease: mechanisms, targets, and therapy. (Pubmed Central) - Oct 30, 2019
PI3Ks have thus emerged as promising alternative drug targets for COPD and a wide array of pan-isoform and isoform-selective inhibitors have been tested in preclinical models and are currently being evaluated in clinical studies. Here, we summarize the recent knowledge on the involvement of PI3K enzymes in the pathophysiology of COPD, and we will discuss the most recent results arising from the preclinical as well as the clinical testing of PI3K inhibitors as novel therapeutics for COPD.
- | Zydelig (idelalisib) / Gilead
Journal, Checkpoint inhibition: Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors. (Pubmed Central) - Oct 29, 2019
The PI3Kδ inhibitor idelalisib has proven highly effective in the clinical treatment of chronic lymphocytic leukemia and the potential to extend the use of PI3Kδ inhibitors to nonhematological cancers is being evaluated...PI3Kδ inactivation antagonized the antitumor effects of tumor vaccines and checkpoint blockade therapies intended to boost the CD8+ T cell response. These findings provide insights into mechanisms by which PI3Kδ inhibition promotes antitumor immunity and demonstrate that the mechanism is distinct from that mediated by immune checkpoint blockade.
- ||||| P2 data: Great collaboration with @FayeJohnso from bench to bedside. NOTCH1 LOF mutations in squamous cancer of head neck can be associated with salutary response to the PI3K/mTOR inhibitor bimeralisib, presented at #targets19. Phase 2 study for NOTCH1 HNSCC enrolling @MDAndersonNews (Twitter) - Oct 29, 2019
- | Journal: MicroRNA 375 modulates hyperglycemia-induced enteric glial cell apoptosis and Diabetes-induced gastrointestinal dysfunction by targeting Pdk1 and repressing PI3K/Akt pathway. (Pubmed Central) - Oct 29, 2019
Hyperglycemia can increase the expression of microRNA375 and damage EGC survival through PI3K/Akt pathway. MicroRNA375 specific inhibition can prevent hyperglycemia induced EGC damage and diabetes-induced gastrointestinal dysfunction.
- | fluorouracil / generics
Journal: Verbascoside: Identification, Quantification, and Potential Sensitization of Colorectal Cancer Cells to 5-FU by Targeting PI3K/AKT Pathway. (Pubmed Central) - Oct 29, 2019
Additionally, 5-FU combined to VER was capable of significantly reducing PI3K and p-AKT/total AKT ratio. Overall, these results suggest a potential role of VER as an adjuvant treatment to decrease the resistance of CRC cells to 5-FU possibly by targeting the PI3K/AKT pathway.
- | Journal: Discovery of Potent, Efficient and Selective Inhibitors of Phosphoinositide 3-Kinase δ Through a Deconstruction and Regrowth Approach. (Pubmed Central) - Oct 29, 2019
Overall, these results suggest a potential role of VER as an adjuvant treatment to decrease the resistance of CRC cells to 5-FU possibly by targeting the PI3K/AKT pathway. A deconstruction of previously reported PI3Kδ inhibitors and subsequent regrowth led to the identification of a privileged fragment for PI3Kδ which was exploited to deliver a potent, efficient and selective lead series with a novel binding mode observed in the PI3Kδ crystal structure.
- | quercetin (LY294002) / Eli Lilly
Journal, IO Biomarker: PM-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway. (Pubmed Central) - Oct 29, 2019
PM exposure could cause the myocardial ADRB2 hypermethylation and activate the β2AR/PI3K/Akt pathway, resulted in PM-induced cardiomyocytes apoptosis and cardiac dysfunction. Our study suggested that the ADRB2 demethylation or ADRB2/β2AR activation may serve as a potential pathway to prevent cardiac dysfunction induced by PM exposure.
- | Journal: Dihydroartemisinin suppresses glycolysis of LNCaP cells by inhibiting PI3K/AKT pathway and downregulating HIF-1α expression. (Pubmed Central) - Oct 29, 2019
Our study suggested that the ADRB2 demethylation or ADRB2/β2AR activation may serve as a potential pathway to prevent cardiac dysfunction induced by PM exposure. Experimental validation results indicate that DHA treatment can inhibit the LNCaP cell proliferation and induce apoptosis, which may be related to glycolysis inhibition.
- | Journal: Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway. (Pubmed Central) - Oct 29, 2019
Experimental validation results indicate that DHA treatment can inhibit the LNCaP cell proliferation and induce apoptosis, which may be related to glycolysis inhibition. In conclusion, resveratrol supplementation during CIH upregulates autophagy by targeting the PI3K/AKT/mTOR pathway, which appears to be beneficial for resisting cardiac hypertrophy.
- | Clinical, Journal, BRCA Biomarker, PARP Biomarker, PD(L)-1 Biomarker, IO Biomarker: Update Breast Cancer 2019 Part 5 - Diagnostic and Therapeutic Challenges of New, Personalised Therapies in Patients with Advanced Breast Cancer. (Pubmed Central) - Oct 29, 2019
Now other anti-HER2 therapies are being developed (e.g. margetuximab, DS-8201a, pyrotinib) which can overcome other resistance mechanisms in the HER2 signalling pathway...The PARP inhibitor therapy for HER2-negative patients with a germ line mutation in BRCA1 or BRCA2 was also associated with an improved overall survival in a subgroup. These promising new study results are summarised in this review.
- Kisqali (ribociclib) / Novartis
Targeting the RB pathway in medulloblastoma (Ballroom Lawn) - Oct 29, 2019 - Abstract #SNO2019SNO_595;
We are currently evaluating the combination of brain penetrant compounds in Group 3 MB PDOXs. The identification of potent drug combinations should provide new therapeutic options for the treatment of Group 3 MB, one of the most difficult to treat.
- Rosette-forming glioneuronal tumor is defined by FGFR1 activating alterations with frequent accompanying PI3K and MAPK pathway mutations (Ballroom Lawn) - Oct 29, 2019 - Abstract #SNO2019SNO_581;
Whereas pilocytic astrocytoma and ganglioglioma are characterized by solitary activating MAP kinase pathway alterations (e.g. BRAF fusion or mutation), RGNT are genetically more complex with dual PI3K-Akt-mTOR and Ras-Raf-MAPK pathway activation. Rare anaplastic examples may show additional ATRX and/or CDKN2A inactivation.
- buparlisib (BKM120) / Novartis, Adlai Nortye
PI3K inhibition in conjunction with the ketogenic diet reduces growth and neuroinflammation in pediatric high-grade glioma (Ballroom Lawn) - Oct 29, 2019 - Abstract #SNO2019SNO_444;
We measured pro-inflammatory cytokines in glioma cells treated with BKM-120 and phenformin in comparison to vehicle-treated cells to determine their effect on neuro-inflammation. We also applied conditioned medium from glioma cells treated with BKM-120 and phenformin to cortical neurons to measure oxidative stress. We found that phenformin reduced the production of pro-inflammatory cytokines, including TNF-alpha, IFN-gamma, IL-1beta, and IL-6, by BKM-120-treated glioma cells. Cortical neurons treated with conditioned medium from BKM-120- and phenformin-treated glioma cells exhibited less oxidative stress than those treated with BKM-120 alone. Our results demonstrate that lowering glucose utilization and insulin feedback increases efficacy of PI3K inhibition and decreases neuro-inflammation. By using the ketogenic diet to reduce systemic glucose levels, this strategy may enhance efficacy and reduce morbidity of PI3K inhibitors in this population.
- GDC-0084 / Kazia
Phase 2 study to evaluate the safety, pharmacokinetics and clinical activity of PI3K/mTOR inhibitor GDC-0084 in GBM patients with unmethylated O6-methylguanine-methyltransferase (MGMT) promoter status (Ballroom Lawn) - Oct 29, 2019 - Abstract #SNO2019SNO_344;
By using the ketogenic diet to reduce systemic glucose levels, this strategy may enhance efficacy and reduce morbidity of PI3K inhibitors in this population. GDC-0084 displays a safety profile consistent with previous data in recurrent high-grade glioma but appears better tolerated in the newly diagnosed GBM setting. An MTD of 60mg is identified.
- temozolomide / Generic Mfg., Afinitor (everolimus) / Novartis
PI3K/mTOR Pathway Activation Selected Phase II Study of Everolimus (RAD001) With and Without Temozolomide in the Treatment of Adult Patients with Supratentorial Low-Grade Glioma [NCT NCT02023905] (Ballroom Lawn) - Oct 29, 2019 - Abstract #SNO2019SNO_339;
P2
In summary, everolimus was well tolerated in previously untreated low-grade gliomas. However, it failed to meet primary outcome of extending PFS in this population.
- | quercetin (LY294002) / Eli Lilly
Journal: Perfluorooctane sulfonate mediates secretion of IL-1β through PI3K/AKT NF-кB pathway in astrocytes. (Pubmed Central) - Oct 29, 2019
In addition, pretreatment with AKT inhibitor LY294002 could obviously attenuate PFOS-induced NF-κB activation and IL-1β secretion. Taken together, these results indicated that PFOS could facilitate reactive astrocytosis and the secretion of pro-inflammatory cytokines through AKT-dependent NF-κB signaling pathway.
- | Journal: MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN. (Pubmed Central) - Oct 29, 2019
In conclusion, the data we collected could define an original mechanism of PI3K/AKT hyperactivation and sketch the regulatory role of miR-494-3p in suppressing the expression of PTEN. Therefore, targeting miR-494-3p could provide an effective therapeutic method for the treatment of the disease.
- | Review, Journal: Class-Switch Recombination (CSR)/Hyper-IgM (HIGM) Syndromes and Phosphoinositide 3-Kinase (PI3K) Defects. (Pubmed Central) - Oct 29, 2019
Previously reported forms of CSR/HIGM syndromes are briefly reviewed and compared to the phosphoinositide 3-kinase (PI3K) pathway defects. Diseases involving the PI3K pathway represent a distinctive subset of CSR/HIGM syndromes, presenting with their own characteristic clinical and laboratory attributes as well as individual therapeutic approaches.
- | cisplatin / generics
Journal: The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways. (Pubmed Central) - Oct 28, 2019
Maltol also suppressed the expression of Bax and caspase 3 by inhibiting the p53 activity in HEK293 cells. Overall, maltol may serve as a valuable potential drug to prevent cisplatin-induced nephrotoxicity, and the underlying molecular mechanisms of maltol action may involve intracellular AMPK/PI3K/Akt and p53 signaling pathways.
- | Biomarker, Journal: Phosphoinositide 3-kinase-delta could be a biomarker for eosinophilic nasal polyps. (Pubmed Central) - Oct 28, 2019
Furthermore, CRS patients possessing NP with higher p110δ expression displayed more eosinophils in NP tissue and blood, higher levels of IL-5 in NP tissue, and more severe features of the disease. Therefore, PI3K-δ may contribute to the formation of NP, especially eosinophilic NP associated with more severe clinical presentations and radiological features.
- | Journal: WDR13 promotes the differentiation of bovine skeletal muscle-derived satellite cells by affecting PI3K/AKT signaling. (Pubmed Central) - Oct 28, 2019
The results showed that activation of WDR13 inhibited the PI3K/AKT signaling pathway and enhanced cell differentiation. These data suggest that WDR13 can promote the differentiation of bovine MDSCs by affecting the PI3K/AKT signaling pathway.