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344 Diseases | |
343 Trials |  |
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- | chloroquine phosphate / Generic mfg.
Preclinical, Review, Journal: Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis. (Pubmed Central) - Feb 14, 2020
In addition, YFSJF-induced autophagy is mediated by the PI3K-AKT-mTOR pathway, and knockdown of PI3K by siRNA up-regulated the expression of autophagy-related genes and down-regulated the expression of collagen in human lung fibroblasts (HLF). Our findings provide a detailed understanding that YFSJF-antifibrotic effects are mainly mediated by triggering autophagy, and suppressing phosphorylation of the PI3K-AKT-mTOR pathway is required for YFSJF-curative effect.
- | biglycan (TVN-102) / Tivorsan
Journal: Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the Phosphatidylinositol 3-Kinases (PI3K)/Akt/Nuclear Factor kappa B (NF-κB) Signaling Pathway. (Pubmed Central) - Feb 14, 2020
In cells that overexpressed BGN, inhibition of the PI3K/Akt pathway by LY294002 increased the sensitivity of human WERI-Rb-1 retinoblastoma cells to rapamycin. CONCLUSIONS Overexpression of BGN induced rapamycin resistance in WERI-Rb-1 retinoblastoma cells by activating PI3K/Akt/NF-kappaB signaling.
- | Preclinical, Journal: Urolithin A targets the PI3K/Akt/NF-κB pathways and prevents IL-1β-induced inflammatory response in human osteoarthritis: in vitro and in vivo studies. (Pubmed Central) - Feb 14, 2020
In vivo, in a surgically induced mouse OA model, UA-induced protective effects in OA development could be detected. In summary, this research suggested that UA may be adopted as a new therapeutic agent for the treatment of OA.
- | quercetin (LY294002) / Eli Lilly
Journal, IO Biomarker: Silencing of Tenascin-C Inhibited Inflammation and Apoptosis Via PI3K/Akt/NF-κB Signaling Pathway in Subarachnoid Hemorrhage Cell Model. (Pubmed Central) - Feb 14, 2020
The TNC gene silencing relieved neuronal apoptosis and neuroinflammation by activating the PI3K/Akt/ NF-κB signaling pathway. TNC-induced neuroinflammation would be a new target to improve outcome after SAH.
- | Review, Journal: Interplay Among PI3K/AKT, PTEN/FOXO and AR Signaling in Prostate Cancer. (Pubmed Central) - Feb 14, 2020
Indeed, the cross talk between PI3K/AKT and other pathways, such as AR, WNT, and ERK signaling pathways is known to play essential roles in disease progression and drug resistance in prostate cancer. Therefore, co-targeting the PI3K/AKT signaling pathway and its cooperating pathways may be critical for improving the anti-cancer efficacy of PI3K/AKT inhibitors in the clinic.
- | Preclinical, Journal: Phosphoinositide 3-kinase inhibitor AS605240 ameliorates streptozotocin-induced Alzheimer's disease like sporadic dementia in experimental rats. (Pubmed Central) - Feb 13, 2020
Further, the increased Aβ protein expression levels in brain tissue were markedly restored with AS605240 treatment. In conclusion, our study demonstrated that AS605240 exhibited immense potential in attenuating STZ-induced sporadic AD features in rats and may be developed as a therapeutic agent in the treatment and management of sporadic AD.
- | low molecular weight dextran sulfate (ILB) / TikoMed
Preclinical, Journal: Anti-Inflammatory Effects of Huangqin Decoction on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through Regulation of the Gut Microbiota and Suppression of the Ras-PI3K-Akt-HIF-1α and NF-κB Pathways. (Pubmed Central) - Feb 13, 2020
HQD ameliorates DSS-induced colitis through regulation of the gut microbiota, and suppression of Ras-PI3K-Akt-HIF-1α and NF-κB pathways. Our results suggested that HQD may be a potential candidate for treatment of UC.
- | Mozobil (plerixafor) / Sanofi
Journal: AMD3100 Attenuates Post-Traumatic Osteoarthritis by Maintaining Transforming Growth Factor-β1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3 via the Phosphatidylinositol 3-Kinase/Akt Pathway. (Pubmed Central) - Feb 13, 2020
In conclusion, inhibition of the CXCL12a/CXCR4 signaling axis maintained TIMP-3 expression via the PI3K/Akt pathway. Our findings provide insight into the mechanism by which AMD3100 prevents OA.
- | Journal: Epstein-Barr Virus Latent Membrane Protein 1 Regulates Host B Cell MicroRNA-155 and Its Target FOXO3a via PI3K p110α Activation. (Pubmed Central) - Feb 13, 2020
Notably, we demonstrate a novel mechanism in which LMP1 supports the regulation of miR-155 and its target FOXO3a in B cells through activation of PI3K p110α. This mechanism expands on the previously established mechanisms by which LMP1 regulates miR-155 and FOXO3a and may represent both rational therapeutic targets and biomarkers for EBV+ B cell lymphomas.
- | sirolimus / Generic mfg.
Preclinical, Journal: Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model. (Pubmed Central) - Feb 13, 2020
Moreover, rapamycin (Rapa) was used to inhibit the mTOR pathway to observe the catalpol mechanism on neuronal cell activity to promote axonal growth, and the proteins related with PI3K/AKT/mTOR pathway were detected by Western blot assay...Catalpol can also reversed proteins reduced by Rapa related with PI3K/AKT/mTOR pathway. These results suggested that catalpol might contribute to internal neuronal cell activity and axonal regeneration by regulating PI3K/AKT/mTOR pathway.
- dactolisib (RTB101) / Novartis, PureTech
Pretargeted delivery of PI3K/mTOR small-molecule inhibitor-loaded nanoparticles for treatment of non-Hodgkin lymphoma (Freedom Ballroom E/F, Philadelphia 201 Hotel) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_17389;
Comprehensive in vivo studies using Namalwa and Raji mouse models confirm that the dual Ab pretargeted system effectively inhibits tumors growth, improves survival, and reduces the systemic side effects of BEZ235. Our data demonstrate that a novel NP-enabled pretargeted system consolidates the use of kinase inhibition with Ab-directed targeted therapy and improves the therapeutic window of small molecule inhibitors.
- GDC-0077 / Roche
From Bench to Bedside and Back Again: The Journey to the Discovery of GDC-0077 (Grand Ballroom B, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_11428;
While many of these inhibitors have struggled to balance clinical responses with adequate safety profiles, several conclusions have been drawn from the clinical and preclinical data to guide the discovery of improved next generation molecules. Genentech's history and learnings from research with PI3K inhibitors will be summarized and focus particularly on the data and observations that contributed to the design and discovery of GDC-0077, a highly selective PI3Ka inhibitor that selectively degrades p110a and is currently in clinical trials.
- quercetin (LY294002) / Eli Lilly
Protective effect of piceatannol against oxidative stress-induced apoptosis in ARPE-19 cells and its mechanism (102B, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_10101;
LY294002 (PI3K inhibitor) dramatically blocked piceatannol-mediated increasing of Nrf2 nuclear translocation, HO-1 expression, and cytoprotective activity, indicating the involvement of PI3K/Akt pathway in the cytoprotective effect of piceatannol. The results from this suggest the potential of piceatannol in reducing the risk of age-related macular degeneration.
- PI3K Inhibitors for the treatment of venous and lymphatic malformations via topical formulations (Exhibit Hall A, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_8995;
Venthera has developed representative compounds of this series for topical delivery medication to treat VMs and LMs. However, further development efforts led to the design and preparation of several successful formulations that enhanced the skin permeation and improved physical properties to achieve better topical delivery.This presentation will highlight the progress on the development of new medication with suitable formulations aiming to provide a new topical treatment for VMs and LMs.
- New strategies towards developing steroid-based inhibitors of the inositol 5’-phosphatase SHIP (Exhibit Hall D, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_4130;
Current steroid scaffolds being investigated include pregnane, cholestane, and androstane derivatives. Progress towards paralog selective and potent small molecule SHIP inhibitors will be discussed.
- PI3K Inhibitors for the treatment of venous and lymphatic malformations via topical formulations (Exhibit Hall D, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_4083;
Venthera has developed representative compounds of this series for topical delivery medication to treat VMs and LMs. However, further development efforts led to the design and preparation of several successful formulations that enhanced the skin permeation and improved physical properties to achieve better topical delivery.This presentation will highlight the progress on the development of new medication with suitable formulations aiming to provide a new topical treatment for VMs and LMs.
- |||| Clinical: Vicky Makker @mskcc there is an open window of opportunity keto trial in endometrial cancer patients. Also pi3k and keto opening soon!! (Twitter) - Feb 12, 2020
- ||| Clinical: Not an onc. but #metaplastic DX 2012 Stage 4 2014 after AC/T and Rads-Normal Diet. DAE trial- Pi3k mutation- keto does have personal benefits and I do try to stay low fat but not perfect.Need to focus on balance of electrolytes. Maintenance low dose Afintor- NED (Twitter) - Feb 11, 2020
- |||| PD(L)-1 Biomarker, IO Biomarker: My father’s cancer progressed rapidly (~9-fold increase) on liver and spread to lungs and kidneys within 4 weeks of a-pd-1. Mutations: amplified ERBB2 and TSC1 nonsense. The combo mutations completely overwhelm P53 thru amplified PI3K/AKT/mTOR signaling, enabling cell cycling. (Twitter) - Feb 10, 2020
- | Preclinical, Journal: Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats. (Pubmed Central) - Feb 10, 2020
Meanwhile, the ovarian expression in the L-Arg group in terms of p-AKT, p-FoxO3a, and LC3-II on PD19 were significantly (p < 0.05) upregulated, while the expressions of PTEN and cleaved Caspase-3 were (p < 0.05) downregulated as a result of NOS/NO generation, respectively. Therefore, the results suggest that NOS is possibly involved in the maturation of follicular development to puberty via the PI3K/ AKT/FoxO3a pathway, through follicular autophagia and apoptosis mechanisms.
- | Journal: Ubiquitin specific peptidase 49 inhibits non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling. (Pubmed Central) - Feb 9, 2020
Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K/AKT signaling by stabilizing PTEN in NSCLC cells. In conclusion, we demonstrated that USP49 was functional in NSCLC cells, and inhibited NSCLC cell growth by suppressing PI3K/AKT signaling, suggesting that USP49 could be as a novel target for NSCLC therapy.
- Campath (alemtuzumab) / Sanofi
[VIRTUAL] UK EXPERIENCE IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) FOR ACTIVATING PI3K MUTATIONS (ePoster Area) - Feb 8, 2020 - Abstract #EBMT2020EBMT_1291;
All received serotherapy (Alemtuzumab=10, ATG= 4)... HSCT is a curative treatment for patients with activating PI3K mutation but almost a third of patients developed GF requiring an additional procedure.
- | Journal: Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3. (Pubmed Central) - Feb 8, 2020
Knocking down eEF2K also led to a striking decrease in the phosphorylation of PI3K/Akt and STAT3, indicating inactivation of these tumorigenic pathways. Taken together, our data suggest that eEF2K contributes to angiogenesis and tumor progression in HCC via SP1/KLF5-mediated VEGF expression, as well as the subsequent stimulation of PI3K/Akt and STAT3 signaling.
- | Sutent (sunitinib) / Pfizer
Journal: HP-1 inhibits the progression of ccRCC and enhances sunitinib therapeutic effects by suppressing EMT. (Pubmed Central) - Feb 8, 2020
The HP-1-induced enhancement of sunitinib effects on tumor growth were also observed in vivo in a xenograft mouse model. Overall, these results indicated that HP-1 exerted antitumor effects against clear cell renal cell carcinoma (ccRCC) and enhanced the therapeutic efficacy of sunitinib.
- | quercetin (LY294002) / Eli Lilly
Journal: Lipoxin A ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial-mesenchymal transition. (Pubmed Central) - Feb 8, 2020
Overall, these results indicated that HP-1 exerted antitumor effects against clear cell renal cell carcinoma (ccRCC) and enhanced the therapeutic efficacy of sunitinib. LipoxinA attenuates lung injury via stimulating epithelial cell proliferation, reducing epithelial cell apoptosis and inhibits epithelial-mesenchymal transition.
- | metformin / Generic mfg., sirolimus / Generic mfg.
Journal: MicroRNA‑212 facilitates the motility and invasiveness of esophageal squamous carcinoma cells. (Pubmed Central) - Feb 8, 2020
These data suggest that miR‑212 activates multiple signaling cascades and facilitates ESCC cell motility and invasion by promoting the epithelial‑mesenchymal transition and degrading the ECM. Berberine may be a potential therapeutic agent against metastasis in patients with ESCC, who express high levels of miR‑212.
- | quercetin (LY294002) / Eli Lilly
Preclinical, Journal, IO Biomarker: Inhibition of microRNA-141-3p Reduces Hypoxia-Induced Apoptosis in H9c2 Rat Cardiomyocytes by Activating the RP105-Dependent PI3K/AKT Signaling Pathway. (Pubmed Central) - Feb 8, 2020
RP105 short-interfering RNA (siRNA) was constructed, and LY294002 was used to inhibit the PI3KA/AKT pathway...The protective effect of miR-141-3p inhibition in hypoxic H9c2 cells was abolished by the absence of RP105 and inhibition of PI3K/AKT. CONCLUSIONS Inhibition of miR-141-3p reduced hypoxia-induced apoptosis in H9c2 cardiomyocytes in vitro by activating the RP105-dependent PI3K/AKT signaling pathway.
- | Journal: Phosphoinositide 3-kinase inhibition in the treatment of hormone receptor-positive breast cancer. (Pubmed Central) - Feb 8, 2020
CONCLUSIONS Inhibition of miR-141-3p reduced hypoxia-induced apoptosis in H9c2 cardiomyocytes in vitro by activating the RP105-dependent PI3K/AKT signaling pathway. No abstract available
- | Journal, IO Biomarker: Effects of HOXA1 Gene Antisense Oligonucleotides on Growth of Esophageal Cancer Cells (Pubmed Central) - Feb 8, 2020
Antisense oligodeoxynucleotides of HOXA1 gene can inhibit the proliferation, invasion and migration of esophageal cancer cells, and induce apoptosis. The mechanism is related to the inhibition of PI3K/AKT signaling pathway.
- || Review, Journal, IO Companion Diagnostic: PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer. (Pubmed Central) - Feb 8, 2020
Such combined approaches could potentially be used as neoadjuvant therapies, limiting the development of resistance to treatments or sensitizing cells to other therapeutics. To determine which drugs should be combined with PIM inhibitors for each patient, it will be key to develop companion diagnostics that predict response to each co-targeted option, hopefully providing a personalized medicine pathway for subsets of prostate cancer patients in the future.
- | Journal: Degeneration of the intestinal microbial community in PI3Kγ-knockout mice. (Pubmed Central) - Feb 8, 2020
PI3Kγ dysfunction led to degeneration of the intestinal microbial community and might alter the synthesis of some antibiotics, bile acids, and thiamine. The usage of PI3Kγ inhibitors for inflammation and cardiovascular diseases might lead to knock-on effect on our organism through intestinal microbiota.
- | Journal: Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types. (Pubmed Central) - Feb 7, 2020
Both compounds exhibited anti-proliferative/anti-migratory effects on HeLa and MCF7 but not in MDA-MB-231 cells. These results indicate that inhibition of SHP2 and its downstream pathways by the two compounds might be a promising strategy for cancer therapy in some but not all cancer types.
- || P1 data, Journal: Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor. (Pubmed Central) - Feb 7, 2020
Conclusion CLR457 clinical development was terminated due to poor tolerability and limited antitumor activity. These results emphasize the difficulty of achieving a wide therapeutic index when targeting all class I PI3K-isoforms.
- | quercetin (LY294002) / Eli Lilly
Journal: Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. (Pubmed Central) - Feb 7, 2020
However, with the addition of PI3K-Akt-mTOR pathway-specific inhibitor LY294002, the expression of PI3K, P-Akt, P-mTOR, RUNX2, COL1, ALP, OCN, and P1NP decreased. The results indicated that the PI3K-Akt-mTOR pathway played a positive regulatory role in the process of orthosilicic acid-mediated osteogenesis in vitro.
- || Biomarker, Clinical, Journal: A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth. (Pubmed Central) - Feb 7, 2020
We find EGFR, AKT1 and CSMD1 copy number aberrations, but not PIK3CA mutations, to be associated with responsiveness to PI3K-targeted drugs. Further, we reveal PI3Kα inhibition to be almost globally tumoristatic in HNSCC xenografts regardless of PIK3CA mutational status, emphasizing its potential as a stabilizing neoadjuvant therapy for HNSCC patients.
- || WATCH: Dr. Kaplan on the Use of PI3K Inhibitors in #FollicularLymphoma #lymphoma @UCSFCancer https://t.co/RWx7idR4L7 (Twitter) - Feb 7, 2020
- || Clinical, Journal: Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma. (Pubmed Central) - Feb 7, 2020
Both the ubiquitin proteasome system (UPS) and the PI3K/Akt/mTOR signaling pathways have been implicated in the pathogenesis, and treatment of MM and different lines of evidence suggest a close cross talk between these central cell-regulatory signaling networks. In this review, we outline the interplay between the UPS and mTOR pathways and discuss their implications for the pathophysiology and therapy of MM.
- | Omeprazole RBX (omeprazole) / Generic mfg.
Journal: Proton pump inhibitors promote the growth of androgen-sensitive prostate cancer cells through ErbB2, ERK1/2, PI3K/Akt, GSK-3β signaling and inhibition of cellular prostatic acid phosphatase. (Pubmed Central) - Feb 7, 2020
Specifically, omeprazole (OME) promoted cell cycle progression, increased c-Myc expression, ErbB2 activity and PSA secretion...In vivo, OME promoted tumor growth in mice bearing LNCaP xenografts. Our results indicate that PPIs display tumorigenic activities in PCa cells, suggesting that their long-term administration in patients should be carefully monitored.
- | Journal: The role of PI3K/Akt signaling pathway in non-physiological shear stress-induced platelet activation. (Pubmed Central) - Feb 7, 2020
The inhibition of PI3K signaling can attenuate the adhesion of unsheared platelets (baseline) on collagen and vWF, while had no impact on adhesion of NPSS-sheared platelets on collagen and vWF. This study confirmed the important role of PI3K/Akt signaling pathway in NPSS-induced platelet activation.
- | Journal: Inhibition of IGF-1-PI3K-Akt-mTORC2 in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis. (Pubmed Central) - Feb 7, 2020
Our results show that LR disruption by psychosine de-sensitizes cells to extracellular growth factors by inhibiting signal transmission from the plasma membrane to intracellular compartments. This mechanism serves also as a mechanistic model to understand how alterations of the membrane architecture by the progressive accumulation of lipids undermines cell function, with potential implications in other genetic sphingolipidoses and adult neurodegenerative conditions.
- | Preclinical, Journal: Reduction of the PI3K/Akt related signaling activities in skeletal muscle tissues involves insulin resistance in intrauterine growth restriction rats with catch-up growth. (Pubmed Central) - Feb 7, 2020
Catch-up growth IUGR rats were positively correlated with insulin resistance and underwent more remarkable alterations of the PI3K, PTEN and GLUT4 expressions. Our results demonstrated that rats born IUGR developed insulin resistance later in life, which was likely mediated by reductions of the PI3K/Akt related signaling activities, particularly in those with excess catch-up growth.
- | Zydelig (idelalisib) / Gilead
Journal: Idelalisib inhibits osteoclast differentiation and pre-osteoclast migration by blocking the PI3Kδ-Akt-c-Fos/NFATc1 signaling cascade. (Pubmed Central) - Feb 7, 2020
It may be possible to expand the clinical use of idelalisib for controlling osteoclast differentiation. Together, the present results contribute to our understanding of the clinical value of PI3Kδ as a druggable target and the efficacy of related therapeutics including osteoclastogenesis.
- | gefitinib / Generic mfg.
Journal: Gadolinium chloride promotes proliferation of HEK293 human embryonic kidney cells by activating EGFR/PI3K/Akt and MAPK pathways. (Pubmed Central) - Feb 7, 2020
Gd exposure also upregulated the mRNA levels of TGFβ-1, TGFβR1, TNFα, TIMP-1 and integrin αV, β1 which could also be attenuated by the inhibition of Akt and ERK signaling. Our study provides new clues for the etiological role of Gd in the pathogenesis of nephrogenic systemic fibrosis, and suggests the inhibition of EGFR/Akt/ERK signaling as a potential treatment strategy.
- | Preclinical, Journal: The circular RNA hsa-circ-0072309 plays anti-tumour roles by sponging miR-100 through the deactivation of PI3K/AKT and mTOR pathways in the renal carcinoma cell lines. (Pubmed Central) - Feb 7, 2020
circRNA stimulated the down-regulation of miR-100, which was low-expressed in tumour tissue and whose overproduction abolished the impacts of circRNA on these elements mentioned above. The hsa-circ-0072309 played anti-tumour roles by targeting miR-100 by blocking the PI3K/AKT and mTOR cascades in the CAKI-1 and ACHN cell lines.
- | Journal: Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice. (Pubmed Central) - Feb 7, 2020
Moreover, knockout of GNMT promoted the Akt activation as well as the Angptl8 expression. These results suggested that GNMT might be involved in insulin-induced Angptl8 expression in HFD-mediated metabolic syndrome.
- | Mekinist (trametinib) / Novartis, buparlisib (BKM120) / Novartis, Adlai Nortye, trametinib
Journal: Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors. (Pubmed Central) - Feb 7, 2020
Combined treatment also more effectively increased apoptosis, and inhibited tumor growth in vivo. This suggests a clinical potential of combined treatment to overcome ceased treatment activity which is often seen after monotherapies, and strongly encourages the evaluation of the treatment strategy on melanoma patients with brain metastases.
- | Journal: ROCK1 promotes migration and invasion of non‑small‑cell lung cancer cells through the PTEN/PI3K/FAK pathway. (Pubmed Central) - Feb 7, 2020
More importantly, the interruption of the PTEN/PI3K/FAK pathway markedly rescued the inhibition of cell migration and invasion mediated by ROCK1 knockdown. Taken together, these results suggest a novel role for ROCK1 in cell migration and invasion by inhibiting cell adhesion ability, and indicate that ROCK1 may be of value as a therapeutic target for the treatment of NSCLC.
- | JQ-1 / Roche
Journal: Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway. (Pubmed Central) - Feb 7, 2020
In addition, treatment with siBrd4 or JQ1 induced apoptosis by activating AKT downstream target genes involved in apoptosis. In conclusion, these results suggest that Brd4 has great potential as a therapeutic target, and JQ1 has notable anti‑tumor effects against GBM which may be mediated via the VEGF/PI3K/AKT signaling pathway.
- | Journal: Antiproliferative and pro‑apoptotic effects of Cyclocarya paliurus polysaccharide and X‑ray irradiation combination on SW480 colorectal cancer cells. (Pubmed Central) - Feb 7, 2020
The present study demonstrated that the combination of CPP with X‑ray irradiation suppressed SW480 cell proliferation and promoted cell apoptosis compared with the control, CPP and 8 Gy groups. The underlying mechanisms may involve inhibition of PI3K/Akt signaling.
- | Journal: Long noncoding RNA HAGLROS promotes the process of mantle cell lymphoma by regulating miR-100/ATG5 axis and involving in PI3K/AKT/mTOR signal. (Pubmed Central) - Feb 7, 2020
Our findings point out that expression of HAGLROS is increased in mantle cell lymphoma cells and may function as an oncogene in mantle cell lymphoma. HAGLROS may promote tumour development by regulating miR-100/ATG5/PI3K/AKT/mTOR axis.