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- | Journal: miRNA‑205‑5p functions as a tumor suppressor by negatively regulating VEGFA and PI3K/Akt/mTOR signaling in renal carcinoma cells. (Pubmed Central) - Mar 24, 2020
Moreover, overexpression of miR‑205‑5p inhibited RCC growth in vivo in a mouse xenograft model. Overall, miR‑205‑5p functions as a tumor suppressor in RCC by targeting VEGFA and the PI3K/Akt signaling pathway, providing a potential therapeutic target for the treatment of ccRCC.
- | Biomarker, Journal: Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways. (Pubmed Central) - Mar 24, 2020
Together, this study demonstrates that PAPP-A activates the macrophage signaling pathway (IGF-I/PI3K/Akt), which drives the expression and production of inflammatory cytokines known to contribute to the initiation and progression of ACS. These findings indicate that PAPP-A may play a proinflammatory role in the pathophysiology of ACS and serve as a potential therapeutic target.
- | Journal: The bovine Lactoferrin-Osteopontin complex increases proliferation of human intestinal epithelial cells by activating the PI3K/Akt signaling pathway. (Pubmed Central) - Mar 24, 2020
AH was resistant to in vitro gastrointestinal digestion, co-localized with both LF and OPN receptors as revealed by confocal microscopy, and stimulated proliferation of HIECs by activating PI3K/Akt signaling. In conclusion, forming a LF-OPN complex may help both proteins to resist digestion and increase the capacity to promote intestinal development in infants.
- | Journal: Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling. (Pubmed Central) - Mar 24, 2020
In conclusion, forming a LF-OPN complex may help both proteins to resist digestion and increase the capacity to promote intestinal development in infants. This study identified circRNAs expression profile in gliomas and revealed that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling, which may provide new therapeutic approach for gliomas.
- | Journal: CDCA5 functions as a tumor promoter in bladder cancer by dysregulating mitochondria-mediated apoptosis, cell cycle regulation and PI3k/AKT/mTOR pathway activation. (Pubmed Central) - Mar 24, 2020
In conclusion, CDCA5 plays a pivotal role in the proliferation of BC cells. A better understanding of CDCA5 may provide new insights into its role as a therapeutic target for BC.
- | dactolisib (RTB101) / resTORbio
Journal: Inhibition of the PI3K-AKT-mTOR pathway suppresses the adipocyte-mediated proliferation and migration of breast cancer cells. (Pubmed Central) - Mar 24, 2020
Furthermore, BEZ235 a dual inhibitor of PI3K and mTOR significantly decreased the adipocyte-mediated the proliferation and migration of breast cancer cells. Adipocyte-derived conditioned media enhance the proliferation and migration of breast cancer cells through the PI3K-AKT-mTOR pathway, supporting the importance of heterotypic interactions between breast cancer cells and adipocytes in the tumor microenvironment.
- | quercetin (LY294002) / Eli Lilly
Journal: Integrin β1 in Adipose-Derived Stem Cells Accelerates Wound Healing via Activating PI3K/AKT Pathway. (Pubmed Central) - Mar 23, 2020
Adipocyte-derived conditioned media enhance the proliferation and migration of breast cancer cells through the PI3K-AKT-mTOR pathway, supporting the importance of heterotypic interactions between breast cancer cells and adipocytes in the tumor microenvironment. Integrin β1 can promote the migration and endothelial-like differentiation of ADSCs by activating PI3K/AKT pathway and then enhance the function of ADSCs in promoting wound healing.
- | Opdivo (nivolumab) / BMS, Aliqopa (copanlisib) / Bayer, Yervoy (ipilimumab) / BMS
Biomarker, New P1/2 trial, Checkpoint inhibition, IO biomarker, Metastases: Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN (clinicaltrials.gov) - Mar 23, 2020
P1/2, N=102, Not yet recruiting, Sponsor: National Cancer Institute (NCI)
- | dactolisib (RTB101) / resTORbio
Journal: Folate-dactolisib conjugates for targeting tubular cells in polycystic kidneys. (Pubmed Central) - Mar 23, 2020
In conclusion, folate conjugates were successfully prepared by platinum(II) coordination chemistry and accumulated in a target-specific manner in kidney cells and polycystic kidneys. The folate conjugate of dactolisib thus may have potential for targeted therapy of polycystic kidney disease.
- | metformin / Generic mfg.
Journal: Metformin INHIBITS β-Catenin PHOSPHORYLATION ON SER-552 through an AMPK/PI3K/AKT Pathway in colorectal cancer cells. (Pubmed Central) - Mar 22, 2020
The Wnt/β-catenin pathway, which plays a central role in intestinal homeostasis and sporadic colorectal cancer development, is regulated by phosphorylation cascades that are dependent and independent of Wnt. Here we report that a non-canonical Ser phosphorylation in β-catenin, which promotes its nuclear accumulation and transcriptional activity, is blocked by metformin via AMPK-mediated PI3K/Akt signaling inhibition.
- | bleomycin / Generic mfg., BMS
Journal: Microvesicles derived from human Wharton's Jelly mesenchymal stem cells ameliorate acute lung injury partly mediated by hepatocyte growth factor. (Pubmed Central) - Mar 22, 2020
The rat model of ALI was established by intratracheal instillation of bleomycin (BLM)...Intriguingly, these effects were completely abrogated by PI3K inhibitor. The therapeutic effect of MSC-MVs in ALI was partly mediated through HGF mRNA.
- | Journal: Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway. (Pubmed Central) - Mar 22, 2020
The therapeutic effect of MSC-MVs in ALI was partly mediated through HGF mRNA. Our studies revealed that Sirt1 ameliorates MSU-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway.
- | Biomarker, Journal: Profilin 2 Promotes Proliferation and Metastasis of Head and Neck Cancer Cells by Regulating PI3K/AKT/β-catenin Signaling Pathway. (Pubmed Central) - Mar 22, 2020
Collectively, these results suggest that PFN2 promotes the proliferation and metastasis of HNSC by activating the PI3K/Akt/β-catenin signaling pathway. Although further validation is needed, we speculate that PFN2 plays a crucial role in HNSC and may be a promising therapeutic target and prognostic biomarker.
- | Preclinical, Journal: LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro. (Pubmed Central) - Mar 22, 2020
Although further validation is needed, we speculate that PFN2 plays a crucial role in HNSC and may be a promising therapeutic target and prognostic biomarker. ZFAS1 might play an oncogenic role in NPC and facilitate cell proliferation and invasion via the PI3K/AKT signaling pathway in NPC cells.
- | Trisenox (arsenic trioxide) / Teva, Medsenic, buparlisib (BKM120) / Novartis, Adlai Nortye
Journal: Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO). (Pubmed Central) - Mar 22, 2020
Real-time PCR analysis also revealed that probably down-regulation of survivin coupled with up-regulation of forkhead family transcription factors is responsible for the enhancive effect of drugs in this cell line. Conclusively, this study shed lights on the effect of PI3K inhibition in chemo-sensitivity of MCF-7 cells, disclosing that combination of BKM120 and ATO could be a promising therapeutic approach in BC.
- | Journal, IO Biomarker: CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway. (Pubmed Central) - Mar 22, 2020
Additionally, CD28 deficiency significantly ameliorated blast exposure-induced increases of p-PI3K and p-Akt and ameliorated the decrease in the p-FoxO1 expression. Our results suggest that CD28 deficiency has a protective effect on blast exposure-induced lung injury, which might be associated with the PI3K/Akt/FoxO1 signaling pathway.
- | sirolimus / Generic mfg.
Journal: NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway. (Pubmed Central) - Mar 22, 2020
Analysis of the mechanism indicated that PI3K/AKT/mTOR pathway was involved in autophagy-mediated apoptosis upon NUPR1 knockdown. In summary, our results demonstrate that NUPR1 silencing suppresses autophagy activities and induces autophagy-mediated apoptosis in MM cells through the PI3K/AKT/mTOR pathway, which exhibits potential as a treatment strategy for MM.
- | Journal, IO Biomarker: LncRNA ZFAS1/miR-589 regulates the PTEN/PI3K/AKT signal pathway in the proliferation, invasion and migration of breast cancer cells. (Pubmed Central) - Mar 21, 2020
Moreover, PTEN is one of the gene targets of miR-589. In conclusion, this study indicated that ZFAS1 inhibited the proliferation, invasion and migration of breast cancer cells by targeting miR-589 through regulating the PTEN/PI3K/AKT signal pathway.
- | Preclinical, Journal: Eriodictyol exerts potent anticancer activity against A549 human lung cancer cell line by inducing mitochondrial-mediated apoptosis, G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signalling pathway. (Pubmed Central) - Mar 21, 2020
Additionally, eriodictyol effectively inhibited the mTOR/PI3K/Akt signalling pathway in a dose-dependent manner. Based on the above findings, we conclude that eriodictyol exerts its anticancer activity through induction of mitochondrial apoptosis and G2/M cell cycle arrest and inhibition of the TOR/PI3K/Akt cascade, indicating that it may have potential as a lead compound in the treatment of lung cancer, provided further in depth studies are done.
- | paclitaxel / Generic mfg.
Journal, BRCA Biomarker: Comparing PI3K/Akt Inhibitors Used in Ovarian Cancer Treatment. (Pubmed Central) - Mar 21, 2020
AZD8835 and AZD8186 inhibited Akt phosphorylation while AZD5363 augmented its phosphorylation on Ser473...AZD8835 and AZD5363 sensitized chemoresistant ovarian cancer cells to cisplatin and paclitaxel treatment...AZD compounds did not change the mRNA expression of BRCA1/BRCA in ovarian cancer cells, but AZD8835 inhibited BRCA1/BRCA2 mRNA expression and p-ERK protein expression in OVCAR-8 cells with the KRAS mutation. This study highlights the importance of PI3K/Akt in ovarian tumor progression and chemoresistance and the potential application of AZD compounds, especially AZD8835 and AZD5363, as therapeutic agents for the treatment of ovarian cancer.
- | Journal: Long non-coding RNA LINC00152 acts as a sponge of miRNA-193b-3p to promote tongue squamous cell carcinoma progression. (Pubmed Central) - Mar 21, 2020
Mechanistically, LINC00152 was determined to be localized in the cytoplasm and acted as a microRNA (miR)-193b-3p sponge, and LINC00152 knockdown or miR-193b-3p mimics both inhibited PI3K signaling pathway activation and downstream AKT phosphorylation; therefore, promoting TSCC progression in vitro. Overall, the results of the present study suggested that increased LINC00152 expression in TSCC tissues may act as a sponge of miR-193b-3p to promote cancer progression in vitro.
- | Journal: Hepatitis B virus upregulates cellular inhibitor of apoptosis protein 2 expression via the PI3K/AKT/NF-κB signaling pathway in liver cancer. (Pubmed Central) - Mar 21, 2020
The present data demonstrates that HBV-infection induces cIAP2 expression in the liver by activation of the PI3K/AKT/NF-κB signaling pathway through promoting the binding of NF-κB to cIAP2 promoter, which may lead to carcinogenesis. The findings from the present study provide more information for understanding HBV-induced liver cancer and also offer a potential target for treatment or diagnosis of this disease.
- | Journal: Curcumol inhibits the proliferation and metastasis of melanoma via the miR-152-3p/PI3K/AKT and ERK/NF-κB signaling pathways. (Pubmed Central) - Mar 21, 2020
The decrease in c-MET, P13K and p-AKT protein expression following curcumol treatment in mouse melanoma B16 cells was notably attenuated by the miR-152-3p inhibitor. Taken together, our findings suggested that curcumol attenuated melanoma progression and concomitantly suppressed ERK/NF-κB signaling and promoted miR-152-3p expression to inactivate the c-MET/PI3K/AKT signaling pathway.
- | Journal: ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway. (Pubmed Central) - Mar 21, 2020
ClpP silencing significantly inhibited proliferation, migration, invasion, and promoted apoptosis of BC cells, which resulted in suppression of the Src/PI3K/Akt signaling pathway. The gain-of-function assay confirmed partial these results.
- || U0126 / Promega, SP600125 / BMS
Clinical, Journal: Ephrin A1 promotes proliferation of bovine endometrial cells with abundant expression of proliferating cell nuclear antigen and cyclin D1 changing the cell population at each stage of the cell cycle. (Pubmed Central) - Mar 20, 2020
Furthermore, tunicamycin-induced endoplasmic reticulum (ER) stress was inactivated by ephrin A1 treatment of BEND cells. Our findings suggest that ephrin A1 promotes the development of BEND cells and likely enhances uterine capacity and maintenance of pregnancy by activating MAPK and PI3K signaling cascades and by restoring ER stress.
- | quercetin (LY294002) / Eli Lilly
Preclinical, Journal: Suppression of SEMA6C promotes preantral follicles atresia with decreased cell junctions in mice ovaries. (Pubmed Central) - Mar 20, 2020
And the LY294002, a PI3K inhibitor, could reverse the effect of low SEMA6C expression on cell junctions in preantral follicles. Our findings revealed that Sema6c was involved in follicle development, and the suppression of SEMA6C led to cell junction defection by activating the PI3K/AKT pathway, which might also provide valuable information for understanding premature ovarian failure and ovarian aging.
- | Journal: Tumor suppressor miR-139-5p targets Tspan3 and regulates the progression of acute myeloid leukemia through the PI3K/Akt pathway. (Pubmed Central) - Mar 20, 2020
In addition, we found that miR-139-5p suppressed the phosphoinositide 3-kinase (PI3K)/Akt pathway in AML cells by targeting Tspan3. In conclusion, our study concluded that miR-139-5p suppressed the leukemogenesis in AML cells by targeting Tspan3 through inactivation of the PI3K/Akt pathway, providing a better understanding of AML progression.
- | cisplatin / Generic mfg.
Journal, IO Biomarker: TLR2 protects cisplatin-induced acute kidney injury associated with autophagy via PI3K/Akt signaling pathway. (Pubmed Central) - Mar 20, 2020
Mechanistically, TLR2 inhibited autophagy via activating PI3K/Akt signaling pathway in renal tubular epithelial cells after the cisplatin treatment. Take together, these results suggest that TLR2 may protect cisplatin-induced AKI by activating autophagy via PI3K/Akt signaling pathway.
- | Journal: Epstein-Barr virus LMP2A utilizes Syk and PI3K to activate NF-κB in B-cell lymphomas to increase MIP-1α production. (Pubmed Central) - Mar 20, 2020
Finally, based on the finding that an NF-κB inhibitor decreased MIP-1α RNA/protein in LMP2A-positive cells, we are the first to demonstrate that LMP2A increases the nuclear localization of the NF-κB p65 subunit using DNA-binding assays and confocal microscopy in human B cells. These findings not only have implications for the treatment of HL, but also other LMP2A-expressing B-cell tumors that overexpress NF-κB.
- | Ibrance (palbociclib) / Pfizer
Journal: PI3K/mTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer. (Pubmed Central) - Mar 20, 2020
More importantly, low-dose combination was dramatically effective in inhibiting tumor growth in a xenograft model. Thus, combined PI3K/mTOR and CDK4/6 inhibition is a highly promising novel approach for the treatment of aggressive, therapy-resistant thyroid cancer.
- | quercetin (LY294002) / Eli Lilly
Journal: bFGF overexpression adipose derived mesenchymal stem cells improved the survival of pulmonary arterial endothelial cells via PI3k/Akt signaling pathway. (Pubmed Central) - Mar 20, 2020
With the administration of LY294002, the bFGF induced HPAECs survival and PI3k/Akt signaling activation were successfully blocked. The present study demonstrated that bFGF transfected ASCs improved the survival of HPAECs by activating the PI3k/Akt pathway.
- | Biomarker, Journal: MicroRNA-204 inhibits the proliferation and metastasis of breast cancer cells by targeting PI3K/AKT pathway. (Pubmed Central) - Mar 19, 2020
The present study demonstrated that bFGF transfected ASCs improved the survival of HPAECs by activating the PI3k/Akt pathway. We conclude that miR-204 regulates the proliferation and metastasis of the breast cancer cells and as such may prove to be an important therapeutic target.
- | Journal: In vitro and in vivo human gastric cancer inhibition by Trifolirhizin is facilitated via autophagy, mitochondrial mediated programmed cell death, G2/M phase cell cycle arrest and inhibition of m-TOR/PI3K/AKT signalling pathway. (Pubmed Central) - Mar 19, 2020
We conclude that miR-204 regulates the proliferation and metastasis of the breast cancer cells and as such may prove to be an important therapeutic target. In conclusion, it can be safely stated that Trifolirhizin has the potential to be developed as a potent anticancer agent against gastric carcinoma provided further in depth evaluation of this compound is performed.
- | Journal: Vitamins D and E Stimulate the PI3K-AKT Signalling Pathway in Insulin-Resistant SK-N-SH Neuronal Cells. (Pubmed Central) - Mar 19, 2020
The combination of vitamins D and E only showed significant increase in GLUT4, p-AKT, reduced ROS as well as GSK3β and TAU. Thus, the universal role of vitamin D, E alone and in combinations could be the potential nutritional agents in restoring the sensitivity of neuronal cells towards insulin and delaying the pathophysiological progression of AD.
- | Journal: Expression of Concern: Shikonin inhibits proliferation, migration, invasion and promotes apoptosis in NCI-N87 cells via inhibition of PI3K/AKT signal pathway. (Pubmed Central) - Mar 19, 2020
Thus, the universal role of vitamin D, E alone and in combinations could be the potential nutritional agents in restoring the sensitivity of neuronal cells towards insulin and delaying the pathophysiological progression of AD. No abstract available
- | Journal: Expression of Concern: Ras-PI3K pathway promotes osteosarcoma progression via regulating VRK1-mediated H2A phosphorylation at threonine 120. (Pubmed Central) - Mar 19, 2020
No abstract available No abstract available
- | Journal: Expression of Concern: Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson's disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation. (Pubmed Central) - Mar 19, 2020
No abstract available No abstract available
- | Journal: Expression of Concern: Upregulation of lncRNA HAGLROS enhances the development of nasopharyngeal carcinoma via modulating miR-100/ATG14 axis-mediated PI3K/AKT/mTOR signals. (Pubmed Central) - Mar 19, 2020
No abstract available No abstract available
- | Journal: Expression of Concern: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/AKT/mTOR/p70S6K pathway. (Pubmed Central) - Mar 19, 2020
No abstract available No abstract available
- | Preclinical, Journal, IO Biomarker: Omega-3PUFA Attenuates MNU-Induced Colorectal Cancer in Rats by Blocking PI3K/AKT/Bcl-2 Signaling. (Pubmed Central) - Mar 19, 2020
Furthermore, The effects of Omega-3PUFA on cell proliferation and apoptosis were inhibited by blocking PI3K/AKT signaling. Omega-3PUFA can attenuate MNU-induced colorectal cancer in rats by blocking PI3K/AKT/Bcl-2 signaling, which suggests that Omega-3PUFA may be a potent agent for CRC treatment.
- | quercetin (LY294002) / Eli Lilly
Biomarker, Journal: Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 Is a Potential Prognostic Biomarker and Promotes Cell Progression in Prostate Cancer. (Pubmed Central) - Mar 19, 2020
Importantly, the PI3K inhibitor LY294002 strongly inhibited the expression of LETM1, pPI3K-p85, and pAkt (Thr308, Ser473) in PCa cells. These results indicate that LETM1 expression is associated with cancer cell stemness, promotes EMT-like changes and cell proliferation and is a potential prognostic biomarker for PCa.
- | Zykadia (ceritinib) / Novartis, pictilisib (GDC-0941) / Roche
Journal: Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer. (Pubmed Central) - Mar 19, 2020
We have joined the two drugs through a new, pH-sensitive linker where the resulting codrugs are hydrolytically stable at lower pH (pH 6.4) but rapidly cleaved at higher pH (pH 7.4). Compound (19), which was designed for optimal lung retention, demonstrated clean liberation of the drug payloads in vitro and represents a novel approach to targeted lung delivery.
- ZNF582 methylation level may predict radiotherapy efficacy and radiotherapy inhibits cervical cancer cell proliferation by de-methylation of ZNF582 (Metro Toronto Convention Centre - Hall E) - Mar 19, 2020 - Abstract #SGO2020SGO_2508;
The level of ZNF582 methylation in Pap smear before treatment and the changes in ZNF582 methylation levels were related to the efficacy of radiotherapy. Radiotherapy can upregulate its mRNA expression by demethylation of ZNF582, and the high expression of ZNF582 gene can inhibit the proliferation of cervical cancer cells by inhibiting the PI3K/AKT signaling pathway.
- AZD8835 / AstraZeneca
Stability and preclinical efficacy of patient-derived xenograft (PDX) models in endometrial cancer and uterine sarcoma (Metro Toronto Convention Centre - Hall E) - Mar 19, 2020 - Abstract #SGO2020SGO_2347;
PDXs of uterine cancer, established by subrenal capsule implantation, had histopathological and genetic similarity and stability. In addition, this technique is useful in identifying and applying suitable targeted therapies in specific uterine cancer groups.
- ZNF582 methylation level may predict radiotherapy efficacy and radiotherapy inhibits cervical cancer cell proliferation by de-methylation of ZNF582 (Metro Toronto Convention Centre - Hall E) - Mar 19, 2020 - Abstract #SGO2020SGO_1876;
The level of ZNF582 methylation in Pap smear before treatment and the changes in ZNF582 methylation levels were related to the efficacy of radiotherapy. Radiotherapy can upregulate its mRNA expression by demethylation of ZNF582, and the high expression of ZNF582 gene can inhibit the proliferation of cervical cancer cells by inhibiting the PI3K/AKT signaling pathway.
- AZD8835 / AstraZeneca
Stability and preclinical efficacy of patient-derived xenograft (PDX) models in endometrial cancer and uterine sarcoma (Metro Toronto Convention Centre - Hall E) - Mar 19, 2020 - Abstract #SGO2020SGO_1715;
PDXs of uterine cancer, established by subrenal capsule implantation, had histopathological and genetic similarity and stability. In addition, this technique is useful in identifying and applying suitable targeted therapies in specific uterine cancer groups.
- ZNF582 methylation level may predict radiotherapy efficacy and radiotherapy inhibits cervical cancer cell proliferation by de-methylation of ZNF582 (Metro Toronto Convention Centre - Hall E) - Mar 19, 2020 - Abstract #SGO2020SGO_1219;
The level of ZNF582 methylation in Pap smear before treatment and the changes in ZNF582 methylation levels were related to the efficacy of radiotherapy. Radiotherapy can upregulate its mRNA expression by demethylation of ZNF582, and the high expression of ZNF582 gene can inhibit the proliferation of cervical cancer cells by inhibiting the PI3K/AKT signaling pathway.
- AZD8835 / AstraZeneca
Stability and preclinical efficacy of patient-derived xenograft (PDX) models in endometrial cancer and uterine sarcoma (Metro Toronto Convention Centre - Hall E) - Mar 19, 2020 - Abstract #SGO2020SGO_1058;
PDXs of uterine cancer, established by subrenal capsule implantation, had histopathological and genetic similarity and stability. In addition, this technique is useful in identifying and applying suitable targeted therapies in specific uterine cancer groups.
- ZNF582 methylation level may predict radiotherapy efficacy and radiotherapy inhibits cervical cancer cell proliferation by de-methylation of ZNF582 (Metro Toronto Convention Centre - Hall E) - Mar 19, 2020 - Abstract #SGO2020SGO_584;
The level of ZNF582 methylation in Pap smear before treatment and the changes in ZNF582 methylation levels were related to the efficacy of radiotherapy. Radiotherapy can upregulate its mRNA expression by demethylation of ZNF582, and the high expression of ZNF582 gene can inhibit the proliferation of cervical cancer cells by inhibiting the PI3K/AKT signaling pathway.
- AZD8835 / AstraZeneca
Stability and preclinical efficacy of patient-derived xenograft (PDX) models in endometrial cancer and uterine sarcoma (Metro Toronto Convention Centre - Hall E) - Mar 19, 2020 - Abstract #SGO2020SGO_423;
PDXs of uterine cancer, established by subrenal capsule implantation, had histopathological and genetic similarity and stability. In addition, this technique is useful in identifying and applying suitable targeted therapies in specific uterine cancer groups.