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- | Journal: Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. (Pubmed Central) - Apr 10, 2020
In addition, we observed that co-treatment inhibited the PI3K/Akt/mTOR pathway more efficiently than their single treatments. Our study suggests that combination treatments of SLCP and berberine may be a promising strategy to reduce or prevent glioblastoma growth in comparison to individual treatments using either compound.
- | quercetin (LY294002) / Eli Lilly, silmitasertib (CX-4945) / Senhwa Biosciences, University of California
Journal: Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells. (Pubmed Central) - Apr 10, 2020
However, we found that the PI3K inhibitor LY294002 reduced GSK3β pS9, and concomitantly decreased Snail1 levels (a GSK3β target and Epithelial-to-Mesenchymal transition marker). The effects of LY294002 were observed also in CK2β-downregulated cells, suggesting that reducing GSK3β pS9 could be a strategy to control Snail1 levels in any situation where CK2β is defective, as possibly occurring in cancer cells.
- | Journal: miR-26a-5p protects against myocardial ischemia/reperfusion injury by regulating the PTEN/PI3K/AKT signaling pathway. (Pubmed Central) - Apr 9, 2020
Furthermore, miR-26a-5p effectively improved viability and inhibited apoptosis in cardiomyocytes upon I/R injury by inhibiting PTEN expression to activate the PI3K/AKT signaling pathway. miR-26a-5p could protect cardiomyocytes against I/R injury by regulating the PTEN/PI3K/AKT pathway, which offers a potential approach for myocardial I/R injury treatment.
- | Review, Journal: PI3K in stemness regulation: from development to cancer. (Pubmed Central) - Apr 9, 2020
There is also evidence that the stemness phenotype may become 'locked' and thus independent of the original PI3K activation, posing limitations for the success of PI3K monotherapy in cancer. Ongoing therapeutic developments for PI3K-associated cancers may therefore benefit from a better understanding of the pathway's two-layered and highly context-dependent regulation of cell growth versus stemness.
- || Review, Journal: Role of regulatory miRNAs of the PI3K/AKT signaling pathway in the pathogenesis of breast cancer. (Pubmed Central) - Apr 9, 2020
Therefore, identifying novel regulatory miRNAs for this oncogenic pathway and discovery of their related target genes may represent a promising therapeutic approach for breast cancer therapy. This review highlights the recent findings about the potential role of PI3K/AKT signaling regulatory miRNAs in breast cancer tumorigenesis.
- |||||| Copiktra (duvelisib) / Secura Bio, Yakult Honsha
New trial, HEOR, Real-world evidence, Real-world: Observational Trial of Real-World Treatment Utilization and Effectiveness of PI3K-inhibitors in CLL/SLL and FL (clinicaltrials.gov) - Apr 9, 2020
P, N=200, Not yet recruiting, Sponsor: Verastem, Inc.
- | Journal: Silencing of Long Non-Coding RNA-HCG18 Inhibits the Tumorigenesis of Gastric Cancer Through Blocking PI3K/Akt Pathway. (Pubmed Central) - Apr 9, 2020
In addition, silencing of lncRNA-HCG18 suppressed the growth of GC xenografts in mice. Silencing of lncRNA-HCG18 inhibited the tumorigenesis of GC through blocking the PI3K/Akt pathway, suggesting a novel therapeutic target for GC.
- | quercetin (LY294002) / Eli Lilly
Journal, IO Biomarker: Downregulation of RAGE Inhibits Cell Proliferation and Induces Apoptosis via Regulation of PI3K/AKT Pathway in Cervical Squamous Cell Carcinoma. (Pubmed Central) - Apr 9, 2020
Moreover, PI3K inhibitor LY294002 effectively inhibited activation of PI3K and AKT, and further repressed RAGE overexpression-induced cell proliferation and apoptosis inhibition. RAGE promotes the growth ability of cervical squamous cell carcinoma by inducing PCNA expression and inhibiting cell apoptosis via inactivation of the PI3K/AKT pathway.
- | Journal: Flufenamic Acid Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells by Antagonizing the PI3K/AKT Signaling Pathway. (Pubmed Central) - Apr 9, 2020
Mechanistically, FFA inhibited adipogenesis of human MSCs by inhibiting the PI3K/AKT pathway. The present study indicated that FFA could be used to inhibit adipogenesis of human MSCs in tissue engineering and diseases related to excessive adipogenic differentiation of MSCs.
- | flutamide / Generic mfg.
Journal: Crucial role of androgen receptor in resistance and endurance trainings-induced muscle hypertrophy through IGF-1/IGF-1R- PI3K/Akt- mTOR pathway. (Pubmed Central) - Apr 9, 2020
(3) The levels of IGF-1, IGF-1R and mTOR as well as the activities of PI3K and Akt were enhanced selectively (in the gastrocnemius of R rats and in the soleus of E rats), which were reduced by flutamide. AR exerted an essential role in both resistance training and endurance training-induced muscle hypertrophy, which was mediated at least partly through IGF-1/IGF-1R- PI3K/Akt- mTOR pathway.
- | Journal: miR-320/ELF3 axis inhibits the progression of breast cancer via the PI3K/AKT pathway. (Pubmed Central) - Apr 9, 2020
The luciferase reporter assay demonstrated the direct binding of miR-320 to the 3' untranslated region of ELF3 mRNA, which may further downregulate ELF3. Overall, the present results provided evidence that miR-320 may be a tumor suppressor in BC, and that the miR-320/ELF3 axis regulated tumor progression via the PI3K/AKT signaling pathway, which may represent a novel treatment strategy for BC.
- | Journal: RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling. (Pubmed Central) - Apr 9, 2020
Together, these findings suggest that RRM2 may act as a pro-metastatic factor to facilitate breast cancer metastasis by evoking cell invasion, migration and VEGF expression through the PI3K/AKT signaling pathway. This study may provide an attractive target for metastatic intervention in breast cancer.
- | quercetin (LY294002) / Eli Lilly
Journal: Fisetin Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via PI3K/Akt/CREB Signaling Pathway. (Pubmed Central) - Apr 9, 2020
More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002. These findings indicate that fisetin has potent neuroprotective effect and prevents HG-induced neurotoxicity by activation of PI3K/Akt/CREB pathway.
- || Review, Journal: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours. (Pubmed Central) - Apr 9, 2020
Numerous PI3K inhibitors have exhibited good results in preclinical studies, and some have been clinically tested in haematologic malignancies and solid tumours. In this review, we briefly summarize the results of research on the PI3K/AKT/mTOR pathway and discuss the structural composition, activation, communication processes, regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway in the pathogenesis of neurodegenerative diseases and tumours.
- | Journal: KRAS signaling enriched triple negative breast cancer is associated with favorable tumor immune microenvironment and better survival. (Pubmed Central) - Apr 9, 2020
In agreement, cytolytic activity score, interferon gamma response score, and lymphocyte infiltrating signature score, were all significantly elevated in KRAS-high TNBC. In conclusion, we found that patients with enrichment of KRAS signaling gene sets were associated with inflammation and favorable tumor immune microenvironment as well as improved survival in TNBC.
- | Preclinical, Journal, IO biomarker: DMAMCL exerts antitumor effects on hepatocellular carcinoma both in vitro and in vivo. (Pubmed Central) - Apr 9, 2020
In vivo, DMAMCL inhibits tumor growth in mice bearing xenograft HCC tumors without noticeable toxicity. In summary, DMAMCL exerts antitumor effects both in vitro and in vivo and therefore may be applied as a potential therapeutic agent for HCC.
- rivastigmine / Generic mfg.
[VIRTUAL] CHROMIUM PICOLINATE ATTENUATES COGNITIVE DEFICIT IN ICV-STZ RAT PARADIGM OF ALZHEIMER’S DISEASE: ROLE OF PI3K/AKT/GSK-3Β PATHWAY () - Apr 7, 2020 - Abstract #AATADPD2020AAT_ADPD_1135;
Rivastigmine (2 mg/kg) was used as standard drug...Conclusions Results revealed an improvement in insulin signaling evident by increased gene expression of IRS-1, PI3-K, AKT and decreased expression of GSK-3β. This decreased expression of GSK-3β might lead to decreased tau phosphorylation, reversing the AD symptoms.
- [VIRTUAL] BRAIN INSULIN RESISTANCE IN ALZHEIMER’S DISEASE: TARGETING PHOSPHOINOSITIDE 3-KINASE (PI3K)/AKT/GSK-3Β PATHWAY () - Apr 7, 2020 - Abstract #AATADPD2020AAT_ADPD_1092;
Conclusions Results revealed an improvement in insulin signaling evident by increased gene expression of IRS-1, PI3-K, AKT and decreased expression of GSK-3β. This decreased expression of GSK-3β might lead to decreased tau phosphorylation, reversing the AD symptoms
- [VIRTUAL] DESIGN AND SYNTHESIS OF NOVEL PI3K/MTOR DUAL INHIBITORS AND APPLICATIONS IN NEURODEGENERATIVE STUDIES () - Apr 7, 2020 - Abstract #AATADPD2020AAT_ADPD_1076;
Conclusions Ater being properly purified (CCC, TLC and / or HPLC), 13 unpublished compounds were synthesized and characterized by 1H NMR , 13C, gCOSY, gHMQC, gHMBC and ESI-MS techniques. Modeling studies confirmed affinity for one target (mTOR) and biological assays are now being performed.
- | Journal: BCL2L10/BECN1 modulates hepatoma cells autophagy by regulating PI3K/AKT signaling pathway. (Pubmed Central) - Apr 5, 2020
Based on Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PI3K/AKT signaling pathway was significantly upregulated in HCC. In conclusions, BCL2L10 had a low expression in HCC tissues and cells, which could release BECN1 to induce autophagy of hepatoma cells by downregulating PI3K/AKT signaling pathway.
- | cisplatin / Generic mfg.
Journal: Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway. (Pubmed Central) - Apr 4, 2020
Interestingly, pre-incubating the cells with either [D-Lys3]-GHRP-6 or LY294002 completely abolished the above-mentioned effect of AG in both control and Cis-treated cells. In conclusion, the findings of this study show that AG promotes cell survival of the OC cells and renders them resistat to Cis therapy, an effect that is mediated by the activation of PI3K/Akt/mTOR and activation of NF-κB, and requires GHS-R1a.
- | ME-401 / MEI, Kyowa Hakko Kirin
Preclinical, Journal: Absorption, Distribution, and Binding Profile of ME-401, a Potent and Selective Oral Small-Molecule Inhibitor of Phosphatidylinositol 3-Kinase δ (PI3Kδ) in Animal and B-Cell Lymphoma Models. (Pubmed Central) - Apr 4, 2020
These data support the capacity of ME-401 to be orally absorbed, distribute to target tissues, enter and accumulate in target cells, and bind to the target with high affinity to exert its mechanism of action. These characteristics underlie the high clinical potency seen in B-cell malignancies that may differentiate ME-401 from other PI3Kδ inhibitors currently approved or in development.
- | Journal: Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway. (Pubmed Central) - Apr 4, 2020
Notably, peptide 17, a YAP inhibitor, exerted a significant attenuating effect on OC progression by diminishing the activation of the PI3K/Akt/mTOR pathway in vitro as well as in vivo. Taken together, these findings demonstrated that targeting YAP attenuated OC progression and suggested the potential application of peptide 17 in OC therapy, thus providing new insights into improving the treatment of OC.
- | ABSK-091 / Abbisko Therap, buparlisib (BKM120) / Novartis, Adlai Nortye, dactolisib (RTB101) / resTORbio
Journal: Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines. (Pubmed Central) - Apr 3, 2020
On the whole, the findings of this study demonstrate that FGFR3 and PIK3CA mutations are uncommon in patients with NB. However, certain NB cell lines are rather sensitive to both FGFR and PI3K inhibitors alone, and even more so when the different drugs are used in combination.
- | Journal: Nerve growth factor-induced migration in oral and salivary gland tumour cells utilizes the PI3K/Akt signalling pathway: is there a link to perineural invasion? (Pubmed Central) - Apr 3, 2020
Phosphorylated Akt controls cancer cell migration and scattering. Blocking the Akt pathway may inhibit cell migration and therefore perineural invasion and metastasis.
- | Journal: MiR-203a-3p targets PTEN to promote hepatocyte proliferation by regulating PI3K/Akt pathway in BRL-3A cells. (Pubmed Central) - Apr 3, 2020
Overexpression of PTEN partially reversed the inhibition of PTEN and the activation of p-Akt/Akt induced by miR-203a-3p mimic. Our study revealed that miR-203a-3p might activate PI3K/Akt signaling pathway by inhibiting PTEN expression, thereby promoting cell proliferation.
- || Tecfidera (dimethyl fumarate) / Biogen
Clinical, Journal: IL-17 CD8 T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. (Pubmed Central) - Apr 3, 2020
Consequently, T-BET-deficiency in mice or inhibition of PI3K-AKT, STAT5 or reactive oxygen species prevents DMF-mediated Tc17 suppression. Overall, our data disclose a DMF-AKT-T-BET driven immune modulation and suggest putative therapy targets in MS and beyond.
- | Journal: MiR-616 plays oncogenic role in hepatocellular carcinoma progression through suppressing PTEN expression and activating PI3K/AKT pathway. (Pubmed Central) - Apr 3, 2020
The bioinformatics analysis and luciferase reporter assay suggested that PTEN was a targeted gene of miR-616. PTEN had the capacity to reverse the oncogenic function of miR-616 in HCC.MiR-616 activates PI3K/AKT pathway through suppressing PTEN expression, thus promoting the progression of HCC.
- | Journal, IO biomarker: Polygalasaponin F (PGSF) Inhibits Neuronal Apoptosis Induced by Oxygen-Glucose Deprivation and Reoxygenation through the PI3K/Akt Pathway. (Pubmed Central) - Apr 3, 2020
Data suggest PGSF might prevent OGD/R-induced injury via activation of PI3K/Akt signalling. The ability of PGSF to block the effects of OGD/R appears to involve regulation of Bcl-2, Bax and caspase-3, which are related to apoptosis.
- | docetaxel / Generic mfg.
Journal: Coadministration of chemotherapy and PI3K/Akt pathway treatment with multistage acidity/CathB enzyme-responsive nanocarriers for inhibiting the metastasis of breast cancer. (Pubmed Central) - Apr 2, 2020
The antitumor mechanistic studies confirmed that PPP-DA/NPs could down-regulate the expressions of Akt, MMP-9 and pro-caspase-3/9 protein, as indicated by western blot analysis. This multifunctional drug delivery system (DDS) is highly selective and effective in inhibiting tumor metastasis, which shows a great potential in inventing smart nanocarriers for targeted tumor-metastasis therapy.
- | Journal: Design, Synthesis and Preliminary Biological Evaluation of Benzylsulfone Coumarin Derivatives as Anti-Cancer Agents. (Pubmed Central) - Apr 2, 2020
Next, an in silico molecular docking study was conducted to evaluate the binding models of 5h and 5m towards PI3Kα and PI3Kβ. Collectively, the above findings suggested that compounds 5h and 5m might be promising PI3K inhibitors deserving further investigation for cancer treatment.
- | Journal: Astilbin protects chicken peripheral blood lymphocytes from cadmium-induced necroptosis via oxidative stress and the PI3K/Akt pathway. (Pubmed Central) - Apr 2, 2020
However, the most important our results was that ASB supplements remarkably attenuated the Cd-induced effects. We conclude that the Cd treatment promoted an imbalance of the antioxidant status and activated the PI3K/Akt pathway, leading to necroptosis in chicken peripheral blood lymphocytes, and that ASB was able to partially ameliorate the effect of Cd-induced necroptosis.
- || Tamoxis (tamoxifen) / Bioprofarma
Clinical, Journal: ER and PI3K Pathway Activity in Primary ER Positive Breast Cancer Is Associated with Progression-Free Survival of Metastatic Patients under First-Line Tamoxifen. (Pubmed Central) - Apr 2, 2020
In contrast, high PI3K, HH, and androgen receptor pathway activity was associated with shorter PFS, and high PI3K and TGFβ pathway activity with worse treatment response. Potential clinical utility of assessment of ER pathway activity lies in predicting response to hormonal therapy, while activity of PI3K, HH, TGFβ, and AR pathways may indicate failure to respond, but also opens new avenues for alternative or complementary targeted treatments.
- | Journal: ZEB1-AS1/miR-133a-3p/LPAR3/EGFR axis promotes the progression of thyroid cancer by regulating PI3K/AKT/mTOR pathway. (Pubmed Central) - Apr 2, 2020
Further investigation also indicated the oncogenic role of ZEB1-AS1 by mediating PI3K/AKT/mTOR pathway. ZEB1-AS1 could be an underlying biomarker in TC.
- | Journal: Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer. (Pubmed Central) - Apr 2, 2020
It enhanced the chemotherapeutic sensitivity and reduced the metastasis of gallbladder carcinoma. In conclusion, Bufalin can be used as a new promising anticancer drug for gallbladder cancer patients who are resistant to traditional chemotherapy.
- | quercetin (LY294002) / Eli Lilly
Journal: Effect of simulated microgravity induced PI3K-nos2b signalling on zebrafish cardiovascular plexus network formation. (Pubmed Central) - Apr 1, 2020
Moreover, specific phosphoinositide 3-kinase (PI3K) inhibitors such as LY294002 were also tested on zebrafish embryos under SM condition...Therefore, it can be concluded that SM affects zebrafish CVP network remodeling by enhancing angiogenesis. Additionally, the PI3K-nos2b signaling pathway is involved in this process.
- | Journal: PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Apr 1, 2020
In addition, PTEN inhibition is useful for protecting the neuron from apoptosis. The PTEN/Akt/mTOR signaling pathway is an important signaling pathway.
- | Journal: MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis. (Pubmed Central) - Apr 1, 2020
In conclusion, abrogation of PI3K/AKT signaling triggered by miR‑186‑5p/CXCL13 may contribute to ON pathogenesis. These results highlight the possible clinical value of miR‑186‑5p in treatment for non‑traumatic ON.
- | prazosin / Generic mfg.
Journal: Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling. (Pubmed Central) - Apr 1, 2020
Finally, dexmedetomidine ameliorated both the emotional and spatial cognitive disorders without alteration in locomotor activity. The present findings suggested that dexmedetomidine may protect the brain against SAE, and that the Hsp90/AKT pathway may be involved in this process.
- | Journal: MicroRNA‑195 suppresses rectal cancer growth and metastasis via regulation of the PI3K/AKT signaling pathway. (Pubmed Central) - Apr 1, 2020
It was also determined that the phosphorylation of PI3K and AKT were significantly inhibited in the mimic group. The tumor suppressive ability of miR‑195 in rectal cancer cell proliferation and metastasis was mediated by blocking IGF1 expression and inhibiting the PI3K/AKT pathway.
- | MK-2206 / Merck (MSD)
Journal: Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation. (Pubmed Central) - Apr 1, 2020
Moreover, NCSTN overexpression in Sk-hep1 cells activated the PI3K/Akt signalling pathway, and MK-2206, a PI3K/Akt inhibitor, reversed this activation according to Western blotting analysis. We suggest that NCSTN serves as an oncogene in HCC by promoting growth and inhibiting apoptosis via the PI3K/Akt pathway, providing a potential novel therapeutic target for HCC treatment.
- Piqray (alpelisib) / Novartis, metformin / Generic mfg., glimepiride / Generic mfg.
Phosphoinositide 3-Kinase (PI3K) Inhibitor Induced Hyperglycemia With Alpelisib (ENDOExpo) - Apr 1, 2020 - Abstract #ENDO2020ENDO_4263;
One purposed mechanism is the effect on AMP kinase pathway which may also affect the efficacy of metformin. Here, we present a case of new onset T2DM in the setting of HR-positive, HER-2 negative breast cancer effectively treated with metformin.
- | volagidemab (REMD-477) / Amgen, REMD Bio
New P1 trial: Glucagon Receptor Inhibition to Enable Breast Cancer Patients to Benefit From PI3K Inhibitor Therapy (REMD-477) (clinicaltrials.gov) - Apr 1, 2020
P1, N=9, Not yet recruiting, Sponsor: Duke University
- | quercetin (LY294002) / Eli Lilly
Preclinical, Journal, IO Biomarker: Inhibition of glycolytic metabolism in glioblastoma cells by Pt3glc combinated with PI3K inhibitor via SIRT3-mediated mitochondrial and PI3K/Akt-MAPK pathway. (Pubmed Central) - Mar 31, 2020
Most importantly, the levels of SIRT3 and phosphorylated p53 were also down-regulation, indicating that Pt3glc combinated with PI3K inhibitor could induced GBM cell death may act via the SIRT3/p53-mediated mitochondrial and PI3K/Akt-ERK pathways. Our findings thus provide rational evidence that the combination of Pt3glc with PI3K inhibitor, which target alternative pathways in GBM cells, may be a useful adjuvant therapy in glioblastoma treatment.
- | quercetin (LY294002) / Eli Lilly, U0126 / Promega
Journal: 1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways. (Pubmed Central) - Mar 31, 2020
Cell viability was further inhibited by the combination of EB30 with LY294002 (a specific PI3K inhibitor) or U0126 (a MEK inhibitor). The current study indicates that EB30 is a potential anticancer agent that induces cell apoptosis via suppression of the PI3K/Akt pathway and activation of the ERK1/2 pathway.
- | Journal, BRCA Biomarker, PARP Biomarker: Evaluating the potential of kinase inhibitors to suppress DNA repair and sensitise ovarian cancer cells to PARP inhibitors. (Pubmed Central) - Mar 31, 2020
We urge caution before combining these drugs clinically. (228 words).
- | Preclinical, Journal: CXCL8 gene silencing promotes neuroglial cells activation while inhibiting neuroinflammation through the PI3K/Akt/NF-κB-signaling pathway in mice with ischemic stroke. (Pubmed Central) - Mar 31, 2020
(228 words). Taken together, these findings highlight that functional suppression of CXCL8 promotes neuroglial activation and inhibits neuroinflammation by regulating the PI3K/Akt/NF-κB-signaling pathway in mice with ischemic stroke, which might provide new insight for ischemic stroke treatment.
- | Journal: PURB is a positive regulator of amino acid-induced milk synthesis in bovine mammary epithelial cells. (Pubmed Central) - Mar 31, 2020
We also demonstrated that PURB binds to the promoters of mTOR and SREBP-1c, and these bindings were increased by Met and Leu stimulation. In summary, our data reveal that PURB is required for amino acids to stimulate mTOR and SREBP-1c gene expression, and PURB is a positive regulator of amino acid-induced PI3K-regulated milk protein and fat synthesis in BMECs.
- | Preclinical, Journal: Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. (Pubmed Central) - Mar 31, 2020
In addition, LN was observed exerting protective effects in a surgical induced model of OA. To sum up, this study indicated LN could be applied as a promising therapeutic agent in the treatment of OA.
- | Preclinical, Journal: microRNA-186 inhibition of PI3K-AKT pathway via SPP1 inhibits chondrocyte apoptosis in mice with osteoarthritis. (Pubmed Central) - Mar 31, 2020
Our findings reveal a novel mechanism by which miR-186 inhibits chondrocyte apoptosis in OA by interacting with SPP1 and regulating PI3K-AKT pathway. Restoring miR-186 might be a future therapeutic strategy for OA.