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67 Companies | 59 Products |
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344 Diseases | |
343 Trials |  |
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- ||||| Preclinical: @DrMarkAwad on molecular features of MET exon 14 mut NSCLC in 1.387 samples (2.3%). METex14 tumors have higher PD-L1 exp and lower TMB vs METwt NSCLC. Acquired resistance MET mut found IN 25% of paired samples, MET amp in 8% and EGFR/HER2, KRAS, PI3K alt. @ASCO20 @OncoAlert (Twitter) - May 29, 2020
- | Journal: FoxD2-AS1 promotes glioma progression by regulating miR-185-5P/HMGA2 axis and PI3K/AKT signaling pathway. (Pubmed Central) - May 29, 2020
lncRNA FOXD2-AS1 acted as a sponge of miR-185-5p and influenced the PI3K/Akt signaling pathway through regulating HMGA2. LncRNA FOXD2-AS1 modulated HMGA2 and PI3K/Akt downstream signaling through sponging miR-185-5p, thereby promoting tumorigenesis and progression of glioma.
- | Journal: ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways. (Pubmed Central) - May 29, 2020
Compared with the inhibition of ITGA6 or RPSA alone, the downregulation of both ITGA6 and RPSA weakened invasion and metastasis to a greater extent and led to the simultaneous downregulation of p-AKT and p-ERK1/2. Our research indicates that the development of drugs targeting both ITGA6 and RPSA may be an effective strategy for the treatment of pancreatic cancer.
- ||| Have seen TNBC with pi3k, Will single agent Alp work in that setting? (Twitter) - May 29, 2020
- | Preclinical, Journal: Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin. (Pubmed Central) - May 29, 2020
Therefore, murine obesity and dyslipidemia induce renal tissue senescence and impairs kidney function, which is alleviated by chronic senolytic treatment. These findings implicate senescence in loss of kidney function in murine dyslipidemia and obesity, and support further studies of senolytic therapy in obesity.
- | Nutlin-3 / EMD Serono
Journal: A novel anti-cancer mechanism of Nutlin-3 through downregulation of Eag1 channel and PI3K/AKT pathway. (Pubmed Central) - May 29, 2020
Finally, we demonstrated that the decrease in Eag1 channel activity induced by Nutlin-3 treatment exerts anticancer activity by inhibiting the PI3K/AKT pathway. Our study therefore fills the gap between p53 pathway and its cellular function mediated by Eag1, shedding light on the new anti-cancer mechanism of Nutlin-3.
- High KRAS Signaling Is Associated with Favorable Tumor Immune Microenvironment and Better Survival in Triple-negative Breast Cancer Patients () - May 29, 2020 - Abstract #ASBrS2020ASBrS_358;
In conclusion, our results implied that enrichment of genes related with KRAS signaling was associated with improved OS in whole and TN breast cancer patients and better DFS in TN patients. Also, KRAS_SIGNALING_UP high group was found to associate with high infiltration of anti-cancer immune cells and low pro-cancer immune cells, which may explain the favorable role of KRAS signaling in TN breast cancer.
- How Effective Is Neoadjuvant Endocrine Therapy (NET) in Downstaging the Axilla and Achieving Breast-conserving Surgery (BCS)? () - May 29, 2020 - Abstract #ASBrS2020ASBrS_152;
Although nodal pCR is more frequent than breast pCR, NET is more likely to be successful in de-escalating breast surgery than axillary surgery if rules developed for neoadjuvant chemotherapy (NAC) are applied to N+ patients, and nodal pCR is required to avoid axillary lymph node dissection. However, with a nodal pCR rate of 12%, NET remains an option for downstaging cN+ patients not eligible for NAC.
- | quercetin (LY294002) / Eli Lilly
Journal: PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis. (Pubmed Central) - May 29, 2020
PI3K/Akt pathway was associated with TNF-α-induced activation of OA FLS, which may involve in the pathogenesis of osteoarthritis. Anti-Cadherin-11 therapy in CIOA mice could attenuate the pathological changes of OA joints.
- | capivasertib (AZD5363) / Otsuka, AstraZeneca
Preclinical, Journal: Combination Effect of Notch1 and PI3K/AKT/mTOR Signaling Pathways Inhibitors on T-ALL Cell Lines. (Pubmed Central) - May 29, 2020
Interaction of AZD5363 as an inhibitor of PI3k/AKT/mTOR and Compound E as an inhibitor of Notch1 signaling pathway was investigated in a T-ALL pre-clinical model...Cytotoxicity of drug combination increased in all T-ALL cell lines compared to each as a single drug. Simultaneous inhibition of Notch1 and PI3K/AKT signaling pathways as a possible treatment of T-ALL, provides a basis for future investigations.
- | Spherazole (itraconazole) / RA Chem, JW Pharma, Spherics, itraconazole / Generic mfg.
Journal: Itraconazole induces regression of infantile hemangioma via down-regulation of the PDGF-D/PI3K/Akt/mTOR pathway. (Pubmed Central) - May 29, 2020
Importantly, itraconazole significantly reduced platelet-derived growth factor D (PDGF-D) level, resulting in suppression of PDGFR-β activation and inhibition of its downstream effectors, such as PI3K, Akt, 4E-BP1 and p70S6K, which are important for cellular growth and survival of IH. In conclusion, our results suggest that PDGF-D is a target of itraconazole in IH.
- | Journal: Critical role for PI3Kγ-dependent neutrophil reactive oxygen species in WKYMVm-induced microvascular hyperpermeability. (Pubmed Central) - May 28, 2020
Pharmacological scavenging PI3Kγ-dependent ROS in the tissue eliminated the discrepancy in hyperpermeability between different PI3K transgenic mice and alleviated WKYMVm-induced microvascular leakage in all mouse strains tested. In conclusion, our study uncovers the critical role for PI3Kγ-dependent ROS generation by neutrophils in formyl peptide-induced microvascular hyperpermeability during neutrophil recruitment.
- | Preclinical, Journal: Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3β signaling pathway. (Pubmed Central) - May 28, 2020
The results of mechanistic investigations indicated that the antidepressant-like action of IRN was mediated, at least in part, by enhancing neurotrophins and attenuating neuroinflammation via modulating the PI3K/Akt/GSK-3β pathway.-Xian, Y.-F., Ip, S.-P., Li, H.-Q., Qu, C., Su, Z.-R., Chen, J.-N., Lin, Z.-X. Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3β signaling pathway.
- | Journal: Low-dose triple drug combination targeting the PI3K/AKT/mTOR pathway and the MAPK pathway is an effective approach in ovarian clear cell carcinoma. (Pubmed Central) - May 28, 2020
Finally, this low-dose triple drug combination treatment significantly reduced tumor growth in two genetically characterized OCCC patient-derived xenograft (PDX) models without resulting in weight loss in these mice. The effectiveness and tolerability of this combined therapy in PDX models warrants clinical exploration of this treatment strategy for OCCC and might be applicable to other cancer types with a similar genetic background.
- | Biomarker, Journal: Spliceosome Component SF3B1 as Novel Prognostic Biomarker and Therapeutic Target for Prostate Cancer. (Pubmed Central) - May 28, 2020
Antitumor actions of pladienolide-B involved: (1) inhibition of PI3K/AKT and JNK signaling pathways, (2) modulation of tumor markers and splicing variants (AR-v7/In1-ghrelin), and (3) regulation of key components of mRNA homeostasis-associated machineries (spliceosome/SURF/EJC). Altogether, our results demonstrated that SF3B1 is overexpressed and associated with malignant features in PCa, and its inhibition reduces PCa aggressiveness, suggesting that SF3B1 could represent a novel prognostic biomarker and a therapeutic target in PCa.
- | Journal: Upregulation of miR-519 enhances radiosensitivity of esophageal squamous cell carcinoma trough targeting PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - May 28, 2020
Altogether, our results demonstrated that SF3B1 is overexpressed and associated with malignant features in PCa, and its inhibition reduces PCa aggressiveness, suggesting that SF3B1 could represent a novel prognostic biomarker and a therapeutic target in PCa. These observations elucidated that upregulated miR-519 is closely correlated with the radiosensitivity of ESCC cells, which may contribute to finding a new promising target for improving the efficiency of radiotherapy in patients with ESCC.
- | quercetin (LY294002) / Eli Lilly, U0126 / Promega
Journal, PARP Biomarker, IO Biomarker: NO donor inhibits proliferation and induces apoptosis by targeting PI3K/AKT/mTOR and MEK/ERK pathways in hepatocellular carcinoma cells. (Pubmed Central) - May 28, 2020
These observations elucidated that upregulated miR-519 is closely correlated with the radiosensitivity of ESCC cells, which may contribute to finding a new promising target for improving the efficiency of radiotherapy in patients with ESCC. PABA/NO induced apoptosis through inhibition of PI3K/Akt/mTOR and MEK/ERK pathway in hepatocellular carcinoma cells.
- | Journal: Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways. (Pubmed Central) - May 28, 2020
Moreover, sinulariolide altered the protein expressions of E-cadherin and N-cadherin in the cytosol and Snail in the nuclei of AGS and NCI-N87 cells, which indicated that sinulariolide can avert the EMT process. These findings suggested that sinulariolide is a potential chemotherapeutic agent for development as a new drug for the treatment of gastric cancer.
- | Estybon (rigosertib) / Onconova, SymBio, Knight Therap
Journal: Rigosertib potently protects against colitis-associated intestinal fibrosis and inflammation by regulating PI3K/AKT and NF-κB signaling pathways. (Pubmed Central) - May 28, 2020
These findings suggested that sinulariolide is a potential chemotherapeutic agent for development as a new drug for the treatment of gastric cancer. This study clearly demonstrates the anti-proliferative, anti-inflammatory and anti-fibrotic effects of RGS in colitis that may have implications for the treatment of colitis and colitis-associated cancer.
- | Biomarker, Journal: IGF-1 promotes multiple myeloma progression through PI3K/Akt-mediated epithelial-mesenchymal transition. (Pubmed Central) - May 28, 2020
This study clearly demonstrates the anti-proliferative, anti-inflammatory and anti-fibrotic effects of RGS in colitis that may have implications for the treatment of colitis and colitis-associated cancer. IGF-1-induced mesenchymal phenotype contributed to MM progression via the PI3K/Akt pathway regulation.
- | metformin / Generic mfg., cisplatin / Generic mfg.
Journal, PARP Biomarker, IO Biomarker: Metformin enhances the sensitivity of colorectal cancer cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway. (Pubmed Central) - May 28, 2020
Moreover, NAC could recover the downregulation of p-PI3K and p-Akt treated with combination of metformin and cisplatin, which subsequently activated the PI3K/Akt signaling pathway. Taken together, our results demonstrated that metformin enhanced the sensitivity of CRC cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway.
- | Preclinical, Journal: The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice. (Pubmed Central) - May 28, 2020
These distinct age- and function-dependent impacts would be in agreement with the distinct cortical and limbic deficits in the Akt signaling in the brain we have recently described in these same animals. The elicitation of age- and neuronal-dependent specific patterns suggests that fine-tuning the intensity of the PKB/Akt signal that enables diverse physiological response has also its in vivo translation into the negative valence system and age is a key regulatory factor.
- ||| defactinib (VS-6063) / Verastem
Does this suggest that Defactinib (FAK PYK2) might attenuate some AEs with PI3K inhibitors? https://t.co/dLaPorMFK5 (Twitter) - May 28, 2020
- | cisplatin / Generic mfg.
Journal: SIK2 Promotes Cisplatin Resistance Induced by Aerobic Glycolysis in Breast Cancer Cells through PI3K/AKT/mTOR Signaling Pathway. (Pubmed Central) - May 28, 2020
When LY294002 was used to inhibit PI3K/AKT/mTOR signaling pathway, the effect of pcDNA3.1-SIK2 on aerobic glycolysis of breast cancer cells could be reversed. SIK2 can promote cisplatin resistance caused by aerobic glycolysis of breast cancer cells through PI3K/AKT/mTOR signaling pathway, which may be a new target to improve cisplatin resistance of breast cancer cells.
- | quercetin (LY294002) / Eli Lilly, A 443654 / AbbVie
Journal: MT1-MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching-inhibited invasion of bone-marrow-derived mesenchymal stem cells. (Pubmed Central) - May 27, 2020
In addition, the upregulation of Akt phosphorylation by a pharmacological activator (SC79) increased MT1-MMP expression and suppressed mechanical stretching-reduced BMSC invasion. Taken together, our results suggest that mechanical stretching inhibits BMSC invasion by downregulating MT1-MMP expression by suppressing the PI3K/Akt signaling pathway.
- | Biomarker, Journal: LINC00520 targeting miR-27b-3p regulates OSMR expression level to promote acute kidney injury development through the PI3K/AKT signaling pathway. (Pubmed Central) - May 27, 2020
Taken together, our results suggest that mechanical stretching inhibits BMSC invasion by downregulating MT1-MMP expression by suppressing the PI3K/Akt signaling pathway. Overexpression of LINC00520 contributes to the aggravation of AKI by targeting miR-27b-3p/ OSMR.
- | Journal: Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses. (Pubmed Central) - May 27, 2020
In contrast, SOS1/2 acquired a substantial role in ROS formation, PIP accumulation, and ERK activation in primed cells. These results suggest that SOS1/2 signaling plays a key role in determining the responsiveness of neutrophils in regions of inflammation.
- | Journal: Human umbilical cord-derived mesenchymal stem cells enhanced HK-2 cell autophagy through MicroRNA-145 by inhibiting the PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - May 27, 2020
Furthermore, hUC-MSCs enhanced autophagy and inhibited phosphorylation of PI3K/AKT/mTOR in AOPP-treated HK-2 cells, which was then partially rescued using miR-145 knockdown in the hUC-MSCs co-culture system. In conclusion, our study showed that hUC-MSCs enhanced autophagy in AOPP-treated HK-2 cells mediated by miR-145 via inhibition of the PI3K/AKT/mTOR pathway, which indicated that hUC-MSCs might serve as a prospective therapy for AKI.
- | Preclinical, Journal, IO Biomarker: Scutellarin exerts protective effects against atherosclerosis in rats by regulating the Hippo-FOXO3A and PI3K/AKT signaling pathways. (Pubmed Central) - May 27, 2020
When Mst1 was overexpressed or phosphoinositide 3-kinases suppressed, the effects of scutellarin were significantly blocked. In conclusion, the results of the present study suggest that scutellarin exerts protective effects against AS by inhibiting endothelial cell injury and apoptosis by regulating the Hippo-FOXO3A and PI3K/AKT signal pathways.
- | Journal: Targeting of SPP1 by microRNA-340 inhibits gastric cancer cell epithelial-mesenchymal transition through inhibition of the PI3K/AKT signaling pathway. (Pubmed Central) - May 27, 2020
Overexpression of miR-340 or the silencing of SPP1 inhibited GC cell proliferation, invasion, migration, and EMT process, but promoted apoptosis of GC cells. Typically, targeting of SPP1 by miR-340 may contribute to the inhibition of proliferation, migration, invasion, and EMT of GC cells via suppression of PI3K/AKT signaling pathway.
- | Journal: PRMT5 is upregulated by B-cell receptor signaling and forms a positive-feedback loop with PI3K/AKT in lymphoma cells. (Pubmed Central) - May 27, 2020
Co-targeting PRMT5 and AKT by their specific inhibitors is lethal to DLBCL cell lines and primary cancer cells. Therefore, this study provides a mechanistic rationale for clinical trials to evaluate PRMT5 and AKT inhibitors for DLBCL.
- | Journal: Phosphoinositide-3 kinase gamma regulates caspase-1 activation and leukocyte recruitment in acute murine gout. (Pubmed Central) - May 27, 2020
It is necessary for regulating caspase-1 activation and for mediating neutrophil migration and activation. Drugs that impair PI3Kγ function may be useful to control acute gout inflammation.
- | Journal: Hierarchical clustering of PI3K and MAPK pathway proteins in breast cancer intrinsic subtypes. (Pubmed Central) - May 27, 2020
In 32 ER+/HER2+, 37 ER-/HER2+ and 74 triple-negative breast cancer patients, subgroups were identified with preferentially activated (A) and preferentially not activated (N) proteins. These subgroups likely reflect tumors with differences in biological behavior as well as treatment outcome.
- | Preclinical, Journal: Corrigendum to "The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo" [Phytomedicine 23 (2016) 818-827]. (Pubmed Central) - May 27, 2020
These subgroups likely reflect tumors with differences in biological behavior as well as treatment outcome. No abstract available
- DOWNREGULATION OF VMP1 PROMOTES ENDOMETRIAL STROMAL CELL MIGRATION AND INVASION THROUGH ACTIVATING PI3K/AKT/MMP2 PATHWAY IN ENDOMETRIOSIS () - May 27, 2020 - Abstract #WCE2020WCE_464;
- | Journal: Niao Du Kang Mixture Increases the Expression of mir-129-5p to Relieve Renal Fibrosis. (Pubmed Central) - May 27, 2020
NDK mixture can significantly improve renal function and improve renal fibrosis in UUO model rats. Furthermore, NDK mixture can inhibit the expression of PDPK1 by upregulating the expression of mir-129-5p and then inhibiting the PI3K/AKT pathway to improve renal fibrosis.
- ||||| MEN1611 / Menarini, Piqray (alpelisib) / Novartis, Herceptin (trastuzumab) / Roche
Clinical: The wonders of #precisionmedicine Stunning response to alpelisib+trastuzumab in highly pretreated HER2+ MBC patient B-PRECISE01 trial of PI3K-inhibitor MEN1611 + trastuzumab (+- fulv) ongoing in @IEOufficiale, PI @curijoey @OncoAlert #bcsm (Twitter) - May 27, 2020
- ||| parsaclisib (INCB50465) / Incyte
Enrollment open, Trial completion date, Trial primary completion date: CIBI376A201: IBI376 in Patients With Relapsed or Refractory Follicular Lymphoma/Marginal Zone Lymphoma (clinicaltrials.gov) - May 26, 2020
P2, N=120, Recruiting, Sponsor: Innovent Biologics (Suzhou) Co. Ltd.
Furthermore, NDK mixture can inhibit the expression of PDPK1 by upregulating the expression of mir-129-5p and then inhibiting the PI3K/AKT pathway to improve renal fibrosis. Not yet recruiting --> Recruiting | Trial completion date: Sep 2024 --> Jun 2023 | Trial primary completion date: Jun 2022 --> Jul 2021
- | Preclinical, Journal: Enhanced Cardiac Phosphoinositide 3-Kinase (p110α) using Gene Therapy Attenuates Cardiac Remodeling in Type 2 Diabetic Mice. (Pubmed Central) - May 26, 2020
This cardioprotection occurred in combination with reduced LV ROS levels and an associated decrease in markers of endoplasmic reticulum stress. Together, the findings demonstrate that cardiac-selective increases in PI3K(p110α), via rAAV6-caPI3K, attenuates diabetic cardiomyopathy in a mouse model of T2D.
- ||||||| ME-401 / MEI, Kyowa Hakko Kirin
Clinical data, Video: Join us on June 2 for an #MEIP post- #ASCO20 Investor & Analyst virtual event! Tune into the video webcast to learn more about the updated #PI3K ME-401 clinical data and hear guest speaker @DrMatasar of #MSKBergen @sloan_kettering #lymsm (Twitter) - May 26, 2020
- | gemcitabine / Generic mfg.
Journal: Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells. (Pubmed Central) - May 25, 2020
The triggering of gemcitabine (GEM) drug resistance in pancreatic cancer by the receptor for advanced glycation end products (RAGE) has been demonstrated...Notably, quercetin showed a dramatic effect similar to RAGE silencing that effectively attenuated RAGE expression to facilitate cell cycle arrest, autophagy, apoptosis, and GEM chemosensitivity in MIA Paca-2 cells, suggesting that an additional reaction occurred under combined quercetin and GEM treatment. In conclusion, the results demonstrated that the molecular mechanisms of quercetin in regulating apoptosis and autophagy-related pathways and increasing GEM chemosensitivity in pancreatic cancer cells involved inhibition of RAGE expression.
- | Journal: miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer. (Pubmed Central) - May 24, 2020
miR-145 may inhibit Th9 cell differentiation through the PI3K/Akt/mTOR/p70S6K/HIF-1α pathway. These findings suggest a novel therapeutic target for malignant ascites from liver cancer.
- || Review, Journal: Radiosensitising Cancer Using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or Mammalian Target of Rapamycin (mTOR) Inhibitors. (Pubmed Central) - May 24, 2020
We recommend that future in vitro and in vivo research in this field should focus on dual PI3K/mTOR inhibitors. Early clinical trials are needed to assess the feasibility and efficacy of these dual inhibitors in combination with radiotherapy in brain, lung, head and neck, breast, prostate and rectal cancer patients.
- | quercetin (LY294002) / Eli Lilly
Journal: Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT/miR-129-5p axis. (Pubmed Central) - May 23, 2020
Combining TSAIII and PI3K inhibitors, LY294002 synergically reduced the migration and invasion of 786-O and A-498 cells, as well as decreased the CTSC expression in both the cell types...In conclusion, our findings reveal that TSAIII inhibits the metastatic properties of RCC cells, contributing to the inhibition of PI3K/AKT and the increase of miR-129-5p and the subsequent downregulation of CTSC. This suggests that TSAIII has significant antimetastatic activity against RCC cells and may be beneficial to RCC treatments.
- | Journal: LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway. (Pubmed Central) - May 23, 2020
Our results showed that LAMB3 could mediate cell cycle arrest and apoptosis in PDAC cells and alter the proliferative, invasive, and metastatic behaviors of PDAC by regulating the PI3K/Akt signaling pathway. LAMB3 may be a novel therapeutic target for the treatment of PDAC in the future.
- | quercetin (LY294002) / Eli Lilly, AG1478 / IDT Australia, PD98059 / Wayne State University
Journal, IO Biomarker: HS restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling. (Pubmed Central) - May 23, 2020
The beneficial effects of NaHS during PC were inhibited by EGFR knockdown, AG1478 (EGFR inhibitor), PD98059 (ERK1/2 inhibitor) or LY294002 (PI3K inhibitor). These results suggest that exogenous HS restores PC-mediated cardioprotection by up-regulating HB-EGF/EGFR signaling, which activates the ERK1/2-c-myc (and fos and c-jun) and PI3K-Akt- GSK-3β pathways in the aged cardiomyocytes.
- ||||| Clinical: Excellent presentation on targeting PI3K/AKT/mTOR in advanced ER+ HER2- #breastcancer by @FAndreMD at #ESMOBreast20: two possible solutions to improve safety (& therefore compliance) @myESMO (Twitter) - May 23, 2020
- || buparlisib (BKM120) / Novartis, Adlai Nortye
Clinical, P1 data, Journal: Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma. (Pubmed Central) - May 23, 2020
This is the first clinical trial to combine a PI3K inhibitor with radiotherapy in NSCLC and investigate the effects of PI3K inhibition on tumour hypoxia. This combination was well tolerated and PI3K inhibition reduced hypoxia, warranting investigation into whether this novel class of radiosensitisers can improve radiotherapy outcomes.
- || doxorubicin hydrochloride / Generic mfg.
Clinical, Journal: IL-10 knockdown with siRNA enhances the efficacy of Doxorubicin chemotherapy in EBV-positive tumors by inducing lytic cycle via PI3K/p38 MAPK/NF-kB pathway. (Pubmed Central) - May 23, 2020
Most importantly, IL-10 knockdown synergized with chemotherapeutic agent Doxorubicin to kill EBV associated tumor cells in vitro and repress EBV-positive tumor growth in vivo. Our results suggest that inhibition of IL-10 has the potential to serve as a new supplemental strategy for the treatment of EBV-associated tumors.