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67 Companies | 59 Products |
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59 Products | |
344 Diseases | |
343 Trials |  |
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- | ibuprofen / Generic mfg.
Preclinical, Journal, IO Biomarker: Research on protective mechanism of ibuprofen in myocardial ischemia-reperfusion injury in rats through the PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Sep 21, 2020
Ib can activate the PI3K/Akt/mTOR signaling pathway, reduce the release of inflammatory factors and apoptosis, and alleviate the myocardial I/R injury in myocardial cells in rats.
- | Preclinical, Journal: 3-n-butylphthalide inhibits the apoptosis of nerve cells in rats with cerebral small vessel disease via the PI3K/Akt pathway. (Pubmed Central) - Sep 21, 2020
NBP can improve the morphology of brain tissue cells and the learning and memory abilities, and inhibit the apoptosis of nerve cells in VaD model rats with CSVD. The possible underlying mechanism may be related to the activation of the PI3K/Akt signaling pathway.
- | Journal: MicroRNA-328-3p inhibits the tumorigenesis of bladder cancer through targeting ITGA5 and inactivating PI3K/AKT pathway. (Pubmed Central) - Sep 21, 2020
The possible underlying mechanism may be related to the activation of the PI3K/Akt signaling pathway. MiR-328-3p inhibited tumorigenesis of BC through targeting ITGA5 and inactivating the PI3K/AKT pathway.
- | sevoflurane / Generic mfg.
Journal: Sevoflurane downregulates insulin-like growth factor-1 to inhibit cell proliferation, invasion and trigger apoptosis in glioma through the PI3K/AKT signaling pathway. (Pubmed Central) - Sep 21, 2020
These effects are regulated by IGF-1, an upstream gene of the PI3K/AKT signaling pathway. These findings may be significant for the selection of anesthetic agents in glioma surgery to improve the prognosis of patients.
- | Preclinical, Journal: MiR-126 promotes endothelial cell apoptosis by targeting PI3K/Akt in rats with lower limb arteriosclerosis obliterans. (Pubmed Central) - Sep 21, 2020
These findings may be significant for the selection of anesthetic agents in glioma surgery to improve the prognosis of patients. In rats with lower limb arteriosclerosis obliterans (ASO), miR-126 represses the PI3K/Akt signaling pathway to accelerate endothelial cell apoptosis.
- | Journal: Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumor suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells. (Pubmed Central) - Sep 21, 2020
Inhibition of the checkpoint response was dependent on activation of the phosphatidylinositol 3-kinase (PI3K) pathway. These findings highlight the synergistic effect of the loss of APC and infection with genotoxin-producing bacteria in promoting a microenvironment conducive to malignant transformation.
- | Preclinical, Journal: Glutamine administration promotes hepatic glucose homeostasis through regulating the PI3K/Akt pathway in high-fat diet-induced obese mice with limb ischemia. (Pubmed Central) - Sep 21, 2020
Administration of Gln increased protein expression associated with PI3K-Akt signaling pathway, while reducing G6PC and FOXO1 expression in the hepatocytes that may promote glycogen synthesis and inhibit gluconeogenesis. These findings suggest that obese mice treated with Gln-containing high-fat diet may normalize blood glucose and improve IR in response to limb ischemia.
- | Journal: Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling. (Pubmed Central) - Sep 21, 2020
Deficiency of MTMR7 by morpholino in neonatal testis caused excessive SSC proliferation, which was attributable to the aberrant PI3K/AKT signaling activation. Altogether, our study demonstrates that MTMR7 maintains SSC homeostasis by inhibiting PI3K/AKT signaling activation.
- | Journal: PI3K-AKT-mTOR signaling pathway: the intersection of allergic asthma and cataract. (Pubmed Central) - Sep 21, 2020
Considering that they are all induced by immune imbalance, inflammation, etc., there may be some correlation in the mechanism, and many clues showed that both diseases are associated with activation of the PI3K-AKT-mTOR signaling pathway. Therefore, we hypothesized that the PI3K-AKT-mTOR signaling pathway produces inflammatory or immune imbalance based on allergy leading to cataract.
- | Journal: GANT61 and Curcumin loaded PLGA Nanoparticles for GLI-1 and PI3K/Akt Mediated Inhibition in Breast Adenocarcinoma. (Pubmed Central) - Sep 21, 2020
The nanoparticles induced cytotoxic effects to breast cancer cells at a mid-minimal dosage followed by cell death via autophagy and apoptosis, reduction in their target protein expression along with compromising the self-renewal property of CSCs as revealed by their in vitro cell studies. The dual drug NPs thus provides a novel perspective on the aid of existing anti-cancer nano-medicine therapies to target a heterogeneous tumor mass effectively.
- |||||| Trodelvy (sacituzumab govitecan-hziy) / Immunomedics, Everest Medicines
Clinical: Smart chemotherapies (ADC) appear as major players’ #ESMO20 (ie IMMU-132, etc). A HER3 directed ADC demonstrated a 25% ORR in heavily pretreated EGFR #lcsm (86% with osi, 90% CT, 40% PD(L)1) including EGFR C797S, MET ampl, HER2 mut, BRAF fusion, PI3K mut patients. ILD was 5.3%. (Twitter) - Sep 21, 2020
- [VIRTUAL] Neuroprotective propensity of marmelosin against 6-OHDA-induced cognitive impairment and apoptosis via upregulation of PI3K/Akt pathway () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_490;
The results suggest that marmelosin significantly reversed 6-OHDA-induced cognitive impairment and apoptosis by regulating the PI3K/Akt pathway. Thus, it could be utilized as a promising neuroprotective agent for treatment of PD.
- ||| VS-6766 / Verastem, Copiktra (duvelisib) / Verastem
Yes! CKI27, Ro5126766, ch5126766, VS-6766.. I guess intermittent dosing, just like what's being done with Duvelisib (PI3K) now, is improving toxic profile. And dosing / schedule is what did a trick. 4% TEAE, all grade 1 or 2 is an outstanding accomplishment by @udai_banerji (Twitter) - Sep 20, 2020
- | quercetin (LY294002) / Eli Lilly
Journal, IO Biomarker: Study on mechanism of curcumin in treatment of acute pancreatitis based on regulation of PI3K-Akt signaling pathway by miR-198 (Pubmed Central) - Sep 20, 2020
The above effects could be weakened by miR-198 antagonist and PI3 K-Akt signal pathway inhibitor LY294002. In conclusion, curcumin has an ideal effect on acute pancreatitis, and its mechanism may be mediated by miR-198-PI3 K-Akt axis.
- |||||| @Amgen @VerastemOncolog @danwpaterson Can it be this easy? 😎 1.AMG510 / VS-6766 (RAS /RAF /MEK /ERK) +/- Defactinib (FAK) 2. AMG510 / Vs-5584 (PI3K mTOR) https://t.co/VDN8PpYoQW (Twitter) - Sep 20, 2020
- | Need shp2 or pi3k pathway inhibition due to rapid resistance development. Then a/e will become cumulative and combo impractical.. (Twitter) - Sep 20, 2020
- | Journal: SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway. (Pubmed Central) - Sep 20, 2020
Our study uncovered the mechanism through which SHP2 regulates breast cancer proliferation. SHP2 may therefore potentially serve as a therapeutic target for breast cancer.
- || ◇SOLAR-1のOS PIK3CA変異をもつ進行再発HR+/HER2-乳がんへのAlperisib（PI3K阻害薬）+FUL vs FULのphase3。 統計的な差はなかったが、mOSは39.3ヶ月vs30.8ヶ月。化学療法導入までの期間も10ヶ月近く延長。 んー、正直思ってたよりすごい。エベロリムスとだいぶ違う。 https://t.co/KlpuVA1eww #ESMO20 (Twitter) - Sep 20, 2020
- | Preclinical, Journal: Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. (Pubmed Central) - Sep 19, 2020
Western blot results revealed that inotilone affected the protein expression of MMPs, nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, anti-oxidant enzymes, mitogen activated protein kinase (MAPK), focal adhesion kinase (FAK), phosphoinositide-3 kinase (PI3K)-AKT, and nuclear factor (NF)κB. Therefore, we propose that inotilone is a potential therapeutic candidate against metastatic lung cancer cells.
- || Clinical, Journal: A novel small-molecule PI3K/Akt signaling inhibitor, W934, exhibits potent antitumor efficacy in A549 non-small-cell lung cancer. (Pubmed Central) - Sep 19, 2020
Oral administration of W934 inhibited the tumor growth in a dose-dependent manner. Hereby, W934 might be considered as a potential therapeutic drug candidate for non-small-cell lung cancer treatment.
- ||| Oral session on metastatic breast cancer in few minutes at #ESMO2020 ; update on IO in TNBC and PI3K inh in HR+ mBC (Twitter) - Sep 19, 2020
- | Journal: MicroRNA-191-5p promotes the development of osteosarcoma via targeting EGR1 and activating the PI3K/AKT signaling pathway. (Pubmed Central) - Sep 19, 2020
Hereby, W934 might be considered as a potential therapeutic drug candidate for non-small-cell lung cancer treatment. MiR-191-5p promoted the development of OS via targeting EGR1 and positively regulated the PI3K/AKT signaling pathway.
- | Journal: PI3K/ Akt/ mTOR pathway as a therapeutic target for colorectal cancer: A review of preclinical and clinical evidence. (Pubmed Central) - Sep 19, 2020
MiR-191-5p promoted the development of OS via targeting EGR1 and positively regulated the PI3K/AKT signaling pathway. Inhibitors of the PI3K/mTOR pathway has been successful for the treatment of primary and metastatic colorectal cancers, rendering the pathway as a promising clinical cancer therapeutic target.
- | Journal, IO Biomarker: DAla2GIP antagonizes HO-induced chondrocyte apoptosis and inflammatory factor secretion. (Pubmed Central) - Sep 19, 2020
Further, molecular biology experiments confirmed that DAla2GIP inhibited the HO mediated inflammation vis up-regulating the expressions of Sox9 and Col2a1 and inhibiting PI3K/Akt/NF-κB pathway. The results demonstrate that DAla2GIP has protective properties in HO-induced chondrocyte injury, this finding shows that novel GIP analogues have the potential as a novel therapeutic for osteoarthritis patients.
- | Journal: Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts. (Pubmed Central) - Sep 19, 2020
Further, we found that in contrast to WT, conditioned media derived from YF osteoclasts promoted increased numbers of alkaline phosphatase (ALP)-positive colonies, and increased expression of osteogenic markers in WT calvarial cultures. Cumulatively, our results suggest that the Cbl-PI3K interaction regulates Cathepsin K secretion required for proper bone resorption, and secretion of factors which promote osteogenesis.
- || fulvestrant / Generic mfg.
PK/PD data, Preclinical, Journal: Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy. (Pubmed Central) - Sep 19, 2020
The use of clinically unachievable exposure levels of fulvestrant as a benchmark in preclinical development of SERDs may negatively impact the selection of those molecules that are advanced for clinical development. Further, these studies suggest that antagonist efficacy, as opposed to SERD activity, is likely to be the primary driver of clinical response.
- | cisplatin / Generic mfg.
Journal: Sinomenine sensitizes human gastric cancer cells to cisplatin through negative regulation of PI3K/AKT/Wnt signaling pathway. (Pubmed Central) - Sep 19, 2020
These data suggested that SIN sensitizes human gastric cancer cells to cisplatin through negative regulation of PI3K/AKT/Wnt signaling pathway. In conclusion, SIN and cisplatin exerted synergistic antitumor effects in gastric cancer cells and might constitute a promising therapeutic approach for gastric cancer.
- | Journal: miRNA-103 promotes chondrocyte apoptosis by down-regulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis. (Pubmed Central) - Sep 19, 2020
In conclusion, SIN and cisplatin exerted synergistic antitumor effects in gastric cancer cells and might constitute a promising therapeutic approach for gastric cancer. Our studies suggest that miRNA-103 contributes to chondrocyte apoptosis, promoting OA progression by down-regulation of PI3K/AKT pathway through the reduction in SPHK1 activity.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Co-targeting CK2α and YBX1 suppresses tumor progression by coordinated inhibition of the PI3K/AKT signaling pathway. (Pubmed Central) - Sep 19, 2020
Further results demonstrated that CK2α could interact with YBX1 and PI3K/AKT antagonist decreased cell resistance to doxorubicin induced by co-activation of CK2α and YBX1. These results indicated that combined inhibition of CK2α and YBX1 showed synergistic effects in inactivating the PI3K/AKT signaling pathway and may be one of the mechanisms involved in tumor growth and migration.
- | Journal: MicroRNA-139-5p modulates the growth and metastasis of malignant melanoma cells via the PI3K/AKT signaling pathway by binding to IGF1R. (Pubmed Central) - Sep 19, 2020
The study validates that miR-139-5p could suppress malignant melanoma progression through the repression of the PI3K/AKT signaling pathway by down-regulating IGF1R. Therefore, miR-139-5p could pave a new way for the treatment of malignant melanoma.
- | sirolimus / Generic mfg.
Journal: Inhibition of Growth of TSC2-Null Cells by a PI3K/mTOR Inhibitor but Not by a Selective MNK1/2 Inhibitor. (Pubmed Central) - Sep 19, 2020
In contrast, a PI3K/mTOR inhibitor omipalisib blocked the phosphorylation of Akt and both S6K/S6 and 4E-BP/eIF4E branches, and additively decreased the growth of TSC2-null cells with rapamycin. Omipalisib, or another inhibitor of both major mTORC1 growth pathways and pAkt, might provide therapeutic options for TSC2-deficient cancers including, but not limited to, LAM.
- | Journal: Infiltrating Macrophages Induced Stem-cell-like Features Through PI3K/AKT/GSK3β Signaling to Promote Neurofibroma Growth. (Pubmed Central) - Sep 18, 2020
Omipalisib, or another inhibitor of both major mTORC1 growth pathways and pAkt, might provide therapeutic options for TSC2-deficient cancers including, but not limited to, LAM. Our results revealed a new mechanism of infiltrating macrophages contributing to neurofibroma progression, and targeting this newly identified signaling may help to treat neurofibroma.
- | Journal: A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis. (Pubmed Central) - Sep 18, 2020
However, further in vitro and in vivo experiments are warranted to validate the current findings with system biology tools. Our current approach provides a new strategy in predicting formulation rationale when developing new dietary supplements.
- | Piqray (alpelisib) / Novartis
Journal: Alpelisib to treat breast cancer. (Pubmed Central) - Sep 18, 2020
Although clinical activity has been observed independently of PIK3CA mutation status, clinical improvement has been mostly seen in a higher proportion of patients with PIK3CA-mutated tumors. In this review I share current data on alpelisib in breast cancer treatment.
- |||| Ibrance (palbociclib) / Pfizer, Kisqali (ribociclib) / Novartis
1932MO - #PI3K mutacion predice menor PFS a #palbociclib o #ribociclib en pacientes #BCSM usando biopsia liquida y asociando alto Ki67 #ESMO20 @aaoncoclinica @gaicoinforma (Twitter) - Sep 18, 2020
- | everolimus / Generic mfg., paclitaxel / Generic mfg.
Journal: Synergistic Anti-Tumor Activity by Targeting Multiple Signaling Pathways in Ovarian Cancer. (Pubmed Central) - Sep 18, 2020
Furthermore, the triple combination also synergistically increased the anti-tumor activity of paclitaxel, both in vitro and in vivo. Taken together, our results demonstrate that simultaneous inhibition of several signaling pathways results in better anti-tumor activity compared to inhibiting any of these signaling pathways alone.
- || Clinical, Review, Journal: Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence. (Pubmed Central) - Sep 18, 2020
In this article, we review the laboratory-based evidence of the critical role of PI3K/Akt/mTOR pathway in AML, and outcomes from current clinical studies using PI3K/Akt/mTOR inhibitors. Based on these results, we discuss the putative mechanisms of resistance to PI3K/Akt/mTOR inhibition, offering rationale for potential candidate combination therapies incorporating PI3K/Akt/mTOR inhibitors for precision medicine in AML.
- | Journal: PLAC8 inhibits oral squamous cell carcinogenesis and epithelial-mesenchymal transition via the Wnt/β-catenin and PI3K/Akt/GSK3β signaling pathways. (Pubmed Central) - Sep 18, 2020
Furthermore, β-catenin helped to repress PLAC8 expression by regulating the Wnt/β-catenin and PI3K/Akt/GSK3β signaling pathways in OSCC cells. Collectively, the results of the present study suggest that PLAC8 acts as a tumor suppressor in OSCC by downregulating β-catenin.
- | Journal: MicroRNA-23b-3p promotes pancreatic cancer cell tumorigenesis and metastasis via the JAK/PI3K and Akt/NF-κB signaling pathways. (Pubmed Central) - Sep 18, 2020
These results suggested that miR-23b-3p enhances PC cell tumorigenesis and metastasis, at least, partially via the JAK/PI3K and Akt/NF-κB signaling pathways. Therefore, targeting miR-23b-3p or the JAK/PI3K and Akt/NF-κB signalings may be potential therapeutic strategy against PC.
- | Journal: Resveratrol inhibits proliferation and promotes apoptosis via the androgen receptor splicing variant 7 and PI3K/AKT signaling pathway in LNCaP prostate cancer cells. (Pubmed Central) - Sep 18, 2020
Taken together, the present results suggested that Res suppresses the proliferation of prostate cancer cells, promotes apoptosis and inhibits the expression of AR mRNA and protein. These effects likely resulted from inhibition of ARV7 and the AKT signaling pathway.
- [VIRTUAL] Endothelium-Specific Reduction in Mitochondrial ROS Induces Coronary Angiogenesis in Ischemic Myocardium via Activation of PI3k/Akt/ERG, ERK1/2, and Jag-1 Signaling (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_339;
These effects likely resulted from inhibition of ARV7 and the AKT signaling pathway. Taken together, these results suggest that decreased mito-ROS in ECs improves post-MI cardiac function by inducing coronary angiogenesis through activation of PI3k/Akt/ERG, ERK1/2, and Jag-1 signaling.
- NVP-AEW541 / Novartis
[VIRTUAL] Maresin 1 Induces Cardiomyocyte Hypertrophy Through RORα/IGF-1/PI3K/Akt Pathway (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_252;
In conclusion, MaR1 is a novel lipid mediator that induces physiological cardiomyocyte hypertrophy by activating RORα/IGF-1/PI3K/Akt pathway. Thus, MaR1 could coordinate the resolving process and tissue recovery in myocardial inflammation.
- | quercetin (LY294002) / Eli Lilly
Preclinical, Journal: Acute-on-chronic liver disease enhances phenylephrine-induced endothelial nitric oxide release in rat mesenteric resistance arteries through enhanced PKA, PI3K/AKT and cGMP signalling pathways. (Pubmed Central) - Sep 17, 2020
Phe-induced NO release was determined in the presence/absence of either H89 (protein kinase -PK- A inhibitor) or LY 294002 (PI3K inhibitor)...Alpha-1 adrenoceptor, eNOS, PI3K and AKT expressions were unchanged, but sGC subunit expression, eNOS and AKT phosphorylation and the activities of PKA and PKG were higher in MRA from LC animals. In summary, these mechanisms may help maintaining splanchnic vasodilation and hypotension observed in decompensated LC.
- | Journal: EMP1 regulates cell proliferation, migration, and stemness in gliomas through PI3K-AKT signaling and CD44. (Pubmed Central) - Sep 17, 2020
Subsequently, we investigated the function of EMP1 on glioma stem cells and found that it regulates the expression of CD44 in such cells to promote stemness. Taken together, the new strategies for the treatment of glioma may be provided by these finding, thereby improving the prognosis associated with it.
- | Zolinza (vorinostat) / Merck (MSD)
Journal, IO Biomarker: Hydroxamic Acid Derivatives of β-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways. (Pubmed Central) - Sep 17, 2020
Compound 12b enhanced the acetylation levels of histone H3 and α-tubulin and induced greater cancer cell apoptosis than the FDA-approved HDAC inhibitor SAHA by regulating expression of apoptotic proteins Bax, Bcl-2, and caspase 3...Finally, 12b significantly inhibited PI3K/Akt/mTOR signaling, an important cell-growth-promoting pathway aberrantly activated in many cancers. Together, the results suggest that these hydroxamic-acid-containing β-carboline derivatives may be new leads for the discovery of agents for the treatment of human carcinoma cancers.
- | Journal: LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathway. (Pubmed Central) - Sep 17, 2020
The present study demonstrates autophagy inhibition is involved in the adenosine-induced cytotoxicity in HepG2 cells, the cytotoxicity can be synergized by OE MEG3 via downregulated ILF3 to activate PI3K/Akt/mTOR and inactivate the beclin-1 signaling pathway. In conclusion, MEG3 and inhibition of autophagy might be potential targets for augmenting adenosine-induced cytotoxicity in hepatoma.
- | Journal: miR-21 regulates the proliferation and apoptosis of ovarian cancer cells through PTEN/PI3K/AKT. (Pubmed Central) - Sep 17, 2020
The suppression of miR-21 increases PTEN expression, inhibits PI3K/AKT activity, promotes cell apoptosis, and reduces cell proliferation. This finding provides new leads to the future treatment of ovarian cancer.
- | Journal: Upregulation of the lncRNA MEG3 improves cognitive impairment, alleviates neuronal damage, and inhibits activation of astrocytes in hippocampus tissues in Alzheimer's disease through inactivating the PI3K/Akt signaling pathway. (Pubmed Central) - Sep 17, 2020
This finding provides new leads to the future treatment of ovarian cancer. Our study highlights that upregulation of the lncRNA MEG3 improves cognitive impairment, alleviates neuronal damage, and inhibits activation of astrocytes in hippocampus tissues in AD through inhibiting the PI3K/Akt signaling pathway.
- | Preclinical, Journal: The effect of miR-579 on the PI3K/AKT pathway in human glioblastoma PTEN mutant cell lines. (Pubmed Central) - Sep 17, 2020
Furthermore, the Western blot analysis showed that miR-579 could downregulate the AKT1 and Rheb protein expression. Overall, our findings propose that miR-579 functions as a novel tumor suppressor gene in GBM by regulating the PI3K/AKT signaling pathway and may serve as a therapeutic target for clinical therapy of glioblastoma multiform.