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- | Journal: miR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway. (Pubmed Central) - Nov 26, 2020
We show that Akt is activated by IGF2BP3 and is essential for IGF2BP3-induced cell development. Together, our results indicate that miR-9-5p could regulate the proliferation and differentiation of myoblasts by targeting IGF2BP3 through IGF-2 and that this activity results in the activation of the PI3K/Akt signaling pathway in skeletal muscle cells.
- | Journal: Limb ischemic preconditioning ameliorates renal microcirculation through activation of PI3K/Akt/eNOS signaling pathway after acute kidney injury. (Pubmed Central) - Nov 26, 2020
Together, our results indicate that miR-9-5p could regulate the proliferation and differentiation of myoblasts by targeting IGF2BP3 through IGF-2 and that this activity results in the activation of the PI3K/Akt signaling pathway in skeletal muscle cells. Collectively, the results demonstrate that LIPC ameliorates CM-induced renal vasocontraction and is mediated by activation of PI3K/Akt/eNOS signaling pathway.
- |||||| Jakafi (ruxolitinib) / Incyte, parsaclisib (INCB50465) / Incyte
Enrollment open: To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304) (clinicaltrials.gov) - Nov 26, 2020
P3, N=212, Recruiting, Sponsor: Incyte Corporation
Collectively, the results demonstrate that LIPC ameliorates CM-induced renal vasocontraction and is mediated by activation of PI3K/Akt/eNOS signaling pathway. Not yet recruiting --> Recruiting
- [VIRTUAL] PHARMACOLOGICAL INHIBITION OF EZRINA REDUCES THE VIABILITY, CLONOGENICITY AND ACTIVATION OF THE PI3K / AKT / MTOR ROUTE IN ACUTE MYELOID LEUKEMIA CELLULAR MODELS () - Nov 26, 2020 - Abstract #HEMO2020HEMO_265;
Both compounds inhibited the activation of the PI3 / AKT / mTOR pathway even in the presence of the leukemogenic mutations FLT3-ITD and KITN822K, which are known to activate this pathway constitutively, suggesting that ezrine may act as a key effector in the transduction of oncogenic signals and downstream signaling pathways. Support: FAPESP, CAPES and CNPq.
- |||| VS-5584 / Verastem, VS-6766 / Verastem, Copiktra (duvelisib) / Secura Bio, Yakult Honsha
*Pi3k mToR VS-5584 has promising potential as antiviral and platelet (activation, aggregation, adhesion) platform. Duvelisib Covid trial data will show if the concept works. *RAF /MEK RO5126766 is another promising antiviral concept. Links in photos🔽🔽 https://t.co/SzBskUlfdQ (Twitter) - Nov 25, 2020
- | Journal: Role of the PI3K and Hippo pathways in follicle activation after grafting of human ovarian tissue. (Pubmed Central) - Nov 25, 2020
This study supports the hypothesis that follicle activation may occur as an early event after transplantation, with follicle growth and death both contributing to the burnout phenomenon. This is the first time that the effectors of the PI3K and Hippo pathways have been investigated in grafted human ovarian tissue and their role in burnout documented.
- | Journal: Mechanism of Action of Acupotomy in Inhibiting Chondrocyte Apoptosis in Rabbits with KOA through the PI3K/Akt Signaling Pathway. (Pubmed Central) - Nov 25, 2020
PI3K and Akt expression levels were negatively correlated with chondrocyte apoptosis in the knee joint of rabbits in all groups. Inhibiting chondrocyte apoptosis in the knee joint of KOA rabbits by upregulating the PI3K/Akt signaling pathway may be a possible mechanism of acupotomy in treating KOA.
- | Journal: Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway. (Pubmed Central) - Nov 25, 2020
In addition, phosphatidylinositol 3'-kinase / protein kinase B (PI3K/AKT) signal pathway was suppressed by ISL treatment, and the epithelial marker E-cadherin was upregulated when the mesenchymal markers Vimentin and N-cadherin were downregulated. In brief, our findings suggest that isoliquiritigenin could be a promising agent for preventing hepatocellular carcinoma tumorigenesis and metastasis.
- | Journal: Echinacoside‑induced nitric oxide production in endothelial cells: Roles of androgen receptor and the PI3K‑Akt pathway. (Pubmed Central) - Nov 25, 2020
Furthermore, the ECH‑induced phosphorylation of the Akt at Ser473 was abrogated by 5 µM wortmannin (a PI3K inhibitor). These data indicated that ECH stimulated NO production via the AR‑dependent activation of eNOS in HUVECs, and that the PI3K/Akt pathway may be involved in eNOS phosphorylation induced by ECH.
- | Journal: Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells. (Pubmed Central) - Nov 25, 2020
Furthermore, both inhibition of PI3K/AKT/HIF-1α and attenuation of glycolysis significantly blocked Vitamin K2-induced AMPK activation and subsequently prevented autophagic cell death. Collectively, these findings reveal that Vitamin K2 could induce metabolic stress and trigger AMPK-dependent autophagic cell death in bladder cancer cells by PI3K/AKT/HIF-1α-mediated glycolysis promotion.
- Copiktra (duvelisib) / Secura Bio, Yakult Honsha
[VIRTUAL] Cutaneous Toxicities of PI3K Inhibitors: A Series of Two Cases and Review of the Literature () - Nov 25, 2020 - Abstract #FCDC2020FCDC_210;
Though one patient was able to later continue on therapy, both patients experienced recurrence with repeat exposure to duvelisib, establishing a notable temporal correlation. Thus, these cases contribute a novel presentation of adverse reactions to PI3K inhibitors to existing literature.
- |||| Piqray (alpelisib) / Novartis
Clinical: Impact of alpelisib (PI3K inh) on OS in pts with PIK3CAmut/HR+/Her2- mBC: mOS ↗️ 7.9 m, not sign mOS ↗️ 14 m in pts with liver/lung mets median time to chemo increased by 8 months Large impact observed in aggressive disease to be confirmed in new PhIII https://t.co/sV5bj3DQgX (Twitter) - Nov 24, 2020
- || Erbitux (cetuximab) / Eli Lilly, EMD Serono, buparlisib (BKM120) / Novartis, Adlai Nortye
Clinical, Journal, Combination therapy: A pilot study of the pan-class I PI3K inhibitor buparlisib in combination with cetuximab in patients with recurrent or metastatic head and neck cancer. (Pubmed Central) - Nov 22, 2020
Based on this pilot study, buparlisib at 100 mg daily plus cetuximab proved to be well-tolerated. Patients previously treated with cetuximab monotherapy showed benefit from this combination.
- | Journal: Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells. (Pubmed Central) - Nov 22, 2020
However, there was no significant difference in NFκB pathway, in which the normalised NFκB p105 (Ser933) phosphorylation remained constant in any treatment conditions in this study. This suggests that ethanol induced CYP2E1 expression by activating PI3K p85 (Tyr458) pathway, but not the NFκB p105 (Ser933) pathway in HepG2 cells.
- | Journal: Long noncoding RNA OR3A4 promotes the migration and invasion of melanoma through the PI3K/AKT signaling pathway. (Pubmed Central) - Nov 22, 2020
The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/18739.
- | Herceptin (trastuzumab) / Roche, AUM302 / AUM Biosci
Preclinical, Journal: Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer. (Pubmed Central) - Nov 22, 2020
The combination of trastuzumab and IBL-302 significantly increased the anti-proliferative effect in HER2+ breast cancer cell line, and matched trastuzumab-resistant line, relative to testing either drug alone. We thus believe that the novel PIM and PI3K/mTOR inhibitor, IBL-302, represents an exciting new potential treatment option for breast cancer, and that it should be considered for clinical investigation.
- | Journal: Testosterone Promotes the Proliferation of Chicken Embryonic Myoblasts Via Androgen Receptor Mediated PI3K/Akt Signaling Pathway. (Pubmed Central) - Nov 22, 2020
However, T-induced proliferation was attenuated by AR, PI3K, and Akt-specific inhibitors. These data indicated that the pro-proliferative effect of T was regulated though AR in response to the activation of PI3K/Akt signalling pathway.
- | buparlisib (BKM120) / Novartis, Adlai Nortye
Journal: Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy. (Pubmed Central) - Nov 22, 2020
Targeted therapies, especially those inhibiting PI3K, display promising effects in multiple chordoma cell line and xenograft models. Nevertheless, the limited effects of PI3K, EGFR, and CDK targeting agents in other models reveal the presence of resistance mechanisms, which motivates future research to both identify biomarkers of response and develop combination therapies.
- | Journal, IO Biomarker: MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling. (Pubmed Central) - Nov 22, 2020
These findings indicate that the MTH1 inhibitor TH287 mediates an array of anticancer effects in GCa cells through its effects on mitochondrial function and PI3K/AKT signaling. Collectively, these data highlight the promise of TH287 as a novel therapeutic option for GCa cells.
- | Journal: Inhibition of PTEN Gene Expression by Small Interfering RNA on PI3K/Akt/FoxO3a Signaling Pathway in Human Nasopharyngeal Carcinoma. (Pubmed Central) - Nov 22, 2020
The growth rate of HK-1 cells in the siPTEN group was significantly higher than the siNC group (P < .05), while the apoptosis rate was significantly lower than that of the siNC group (P < .05). Small interfering RNA can inhibit the expression of PTEN in HK-1 cells, and PTEN can participate in the development of NPC by affecting PI3K/Akt/FoxO3a signaling pathway.
- | Journal: Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting β-catenin translocation to the nucleus through activating PI3K/Akt pathway. (Pubmed Central) - Nov 22, 2020
Further mechanistic studies confirmed that AGK promoted the stemness of NPC cells through activating the PI3K/Akt pathway, and thus enhancing β-catenin accumulation in nucleus. This study demonstrates a novel AGK/PI3K/Akt/β-catenin axis involving in NPC cell stemness.
- | Journal: Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate. (Pubmed Central) - Nov 21, 2020
Together, our results indicate that AC protects OGD-injured NSCs by protecting mitochondrial structure and function. The results of the present study provide insight into the mechanisms underlying the protective effects of AC on NSCs.
- | Journal: D-Lactate Increases Cytokine Production in Bovine Fibroblast-Like Synoviocytes via MCT1 Uptake and the MAPK, PI3K/Akt, and NFκB Pathways. (Pubmed Central) - Nov 21, 2020
In addition, we observed that the inhibition of the p38, ERK1/2, PI3K/Akt, and NF-κB pathways reduced the production of IL-8 and IL-6. In conclusion, our results suggest that D-lactate induces an inflammatory response; this study contributes to the literature by revealing a potential key role of D-lactate in the polysynovitis of cattle with ARA.
- | Journal: CD276 Promotes Vasculogenic Mimicry Formation in Hepatocellular Carcinoma via the PI3K/AKT/MMPs Pathway. (Pubmed Central) - Nov 21, 2020
CD276 may promote VM formation by activating the PI3K/AKT/MMPs pathway and inducing the EMT process in HCC. CD276 may serve as a promising candidate for the anti-VM treatment of HCC.
- | Journal: Cytochrome C Oxidase Assembly Factor 1 Homolog Predicts Poor Prognosis and Promotes Cell Proliferation in Colorectal Cancer by Regulating PI3K/AKT Signaling. (Pubmed Central) - Nov 21, 2020
These findings demonstrate that COA1 promotes CRC cell proliferation and inhibits apoptosis by regulating the PI3K/AKT signaling pathway. Our results implicate COA1 as a potential oncogene involved in tumor growth and progression of CRC.
- | Preclinical, Journal, IO biomarker: Curcumin Improves the Renal Autophagy in Rat Experimental Membranous Nephropathy via Regulating the PI3K/AKT/mTOR and Nrf2/HO-1 Signaling Pathways. (Pubmed Central) - Nov 21, 2020
In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model. The results provide a scientific basis that curcumin could significantly alleviate the development of MN by inducing autophagy and alleviating renal oxidative stress through the PI3K/AKT/mTOR and Nrf2/HO-1 pathways.
- | PF-573228 / Pfizer
Journal: Artesunate alleviates myocardial ischemia/reperfusion-induced myocardial necrosis in rats and hypoxia/reoxygenation-induced apoptosis in H9C2 cells via regulating the FAK/PI3K/Akt pathway. (Pubmed Central) - Nov 21, 2020
Furthermore, after inhibitor PF573228 was added, Art inhibited apoptosis in H9C2 cells via activation of the FAK/PI3K/AKT signaling pathway in vitro...Art exerted an inhibitory effect on cardiomyocyte apoptosis by activating the FAK/PI3K/AKT signaling pathway. Therefore, Art may serve as an alternative treatment for MI/R injury.
- | cimetidine / Generic mfg.
Journal: Cimetidine promotes STUB1-mediated degradation of tumoral FOXP3 by activating PI3K-Akt pathway in gastric cancer. (Pubmed Central) - Nov 21, 2020
Furthermore, Cimetidine promoted STUB1 expression by activating PI3K/Akt pathway, and the inhibition of PI3K/Akt pathway rescued the decline of FOXP3 by suppressing the upregulation of STUB1. Cimetidine suppressed GC development by promoting STUB1-mediated ubiquitination/degradation of endogenous FOXP3 through the activation of the PI3K/Akt pathway.
- | Journal: Long non-coding RNA TRPM2-AS sponges microRNA-138-5p to activate epidermal growth factor receptor and PI3K/AKT signaling in non-small cell lung cancer. (Pubmed Central) - Nov 21, 2020
Our results suggested that TRPM2-AS can increase the levels of EGFR via sponging miR-138-3p; this promoted NSCLC cell proliferation, migration, and invasion in vitro, and exacerbated tumors in vivo. These findings highlight TRPM2-AS/miR-138-5p as a potential target for reducing drug resistance in patients with NSCLC.
- | Journal, IO Biomarker: A Biodegradable Mg-Based Alloy Inhibited the Inflammatory Response of THP-1 Cell-Derived Macrophages Through the TRPM7-PI3K-AKT1 Signaling Axis. (Pubmed Central) - Nov 21, 2020
Mechanically, the activities of AKT and AKT1 were increased by extract or MgCl with LPS and were blocked by a PI3K inhibitor, whereas siRNA TRPM7 inhibited only AKT1. Together, our results demonstrated the degradation products of Mg-based alloy, especially magnesium, and resolved inflammation by activation of the TRPM7-PI3K-AKT1 signaling pathway, which may be a potential advantage or target to promote biodegradable Mg-based alloy applications.
- | Journal: Involvement of intracellular caveolin-1 distribution in the suppression of antigen-induced mast cell activation by cationic liposomes. (Pubmed Central) - Nov 21, 2020
Meanwhile, cationic liposomes suppressed the translocation of caveolin-1 to the plasma membrane and the colocalization of caveolin-1 with PI3K p85 also at the plasma membrane. This finding provides new information for the development of therapies using cationic liposomes against allergies.
- | quercetin (LY294002) / Eli Lilly
Journal, IO Biomarker: CCN5 inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells. (Pubmed Central) - Nov 21, 2020
Further, LY294002, a PI3K/AKT antagonist, was employed to explore the mechanism underlying the effects of CCN5 in the regulation of OSCC...Finally, xenograft analysis showed that CCN5 represses tumorigenesis of OSCC cells. These findings together suggest that CCN5 functions as a tumor suppressor for OSCC cell development through inactivation of PI3K/AKT signaling pathway, providing a potential candidate for OSCC therapy.
- | quercetin (LY294002) / Eli Lilly
Journal: The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K. (Pubmed Central) - Nov 21, 2020
Finally, a molecular docking study demonstrated that Rg5 could bind to the active pocket of PI3K. Collectively, our results revealed that Rg5 could be a potential therapeutic agent for breast cancer treatment.
- | quercetin (LY294002) / Eli Lilly
Journal: The protective effects of PI3K/Akt pathway on human nucleus pulposus mesenchymal stem cells against hypoxia and nutrition deficiency. (Pubmed Central) - Nov 21, 2020
Collectively, our results revealed that Rg5 could be a potential therapeutic agent for breast cancer treatment. PI3K/Akt signal pathway may have protective effects on human nucleus pulposus-derived mesenchymal stem cells against hypoxia and nutrition deficiency.
- | Journal: Wnt/beta-catenin and PI3K/Akt/mtor Signaling Pathways in Glioblastoma: Two main targets for drug design: A Review. (Pubmed Central) - Nov 21, 2020
Understanding the mechanisms of GBM's invasion, represented by invasion and migration, is an important tool in designing effective therapeutic interventions. This review will investigate two main signaling pathways in GBM: PI3K/Akt/mTOR and Wnt/beta-catenin signaling pathways.
- | quercetin (LY294002) / Eli Lilly
Journal: Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. (Pubmed Central) - Nov 21, 2020
Human first-trimester EECs promoted their own migration and invasion through the autocrine mechanism with CXCL12/CXCR4 axis involvement by activating PI3K/AKT signaling. This study contributes to a better understanding of the epithelium function mediated by chemokine and chemokine receptor during normal pregnancy.
- | Journal: Asiatic Acid Interferes with Invasion and Proliferation of Breast Cancer Cells by Inhibiting WAVE3 Activation through PI3K/AKT Signaling Pathway. (Pubmed Central) - Nov 21, 2020
Asiatic acid could significantly inhibit the growth of MDA-MB-231 (F10) xenografted tumors in nude mice (p < 0.05). Asiatic acid interferes with the ability of breast cancer cells to invade and proliferate by inhibiting WAVE3 expression and activation and the mechanism of action may be related to the PI3K/AKT signaling pathway.
- | Preclinical, Journal: Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-κB, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways. (Pubmed Central) - Nov 21, 2020
Asiatic acid interferes with the ability of breast cancer cells to invade and proliferate by inhibiting WAVE3 expression and activation and the mechanism of action may be related to the PI3K/AKT signaling pathway. Collectively, our results have shown the possible protective mechanism of morin, a potential therapeutic agent for AC-induced testicular toxicity.
- |||| #angiosarcoma genomic signature separates head & neck (high TMB) from breast (myc, PI3K and RAS) primary tumors by @AndreaEspejoMD @SylvesterCancer #CTOS2020 (Twitter) - Nov 21, 2020
- ||| Aliqopa (copanlisib) / Bayer
Clinical, PK/PD data: Live at #ESMOAsia20 pharmacokinetics of pan PI3K inhibitor copanlisib in Chinese iNHL patients comparable to non-Chinese patients. Safety was also comparable and ORR was 50% (DCR = 100%) (Twitter) - Nov 20, 2020
- | volagidemab (REMD-477) / Amgen, REMD Bio
Enrollment open: Glucagon Receptor Inhibition to Enable Breast Cancer Patients to Benefit From PI3K Inhibitor Therapy (REMD-477) (clinicaltrials.gov) - Nov 20, 2020
P1, N=9, Recruiting, Sponsor: Duke University
Collectively, our results have shown the possible protective mechanism of morin, a potential therapeutic agent for AC-induced testicular toxicity. Not yet recruiting --> Recruiting
- | Journal: Beneficial role of microRNA-328-3p in fracture healing by enhancing osteoblastic viability through the PTEN/PI3K/AKT pathway. (Pubmed Central) - Nov 19, 2020
The expression of phosphorylated-AKT was elevated in osteoblasts by miR-328-3p overexpression, but this effect was abolished by overexpressing PTEN. Thus, the present study revealed that miR-328-3p may accelerate fracture healing by promoting osteoblastic viability through the PTEN/PI3K/AKT pathway.
- | Journal: [Corrigendum] STMN1, a prognostic predictor of esophageal squamous cell carcinoma, is a marker of the activation of the PI3K pathway. (Pubmed Central) - Nov 19, 2020
Furthermore, they apologize to the readership of the Journal for any inconvenience caused. [the original article was published in Oncology Reports 39: 834-842, 2018; DOI: 10.3892/or.2017.6145].
- | Journal: CADM1 inhibits ovarian cancer cell proliferation and migration by potentially regulating the PI3K/Akt/mTOR pathway. (Pubmed Central) - Nov 19, 2020
In conclusion, CADM1 inhibits ovarian cancer cell proliferation and migration by potentially regulating the PI3K/Akt/mTOR signaling pathway. CADM1 could be a potential therapeutic target for ovarian cancer.
- | irinotecan / Generic mfg.
Journal: Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway. (Pubmed Central) - Nov 19, 2020
However, its role in chemosensitivity to oxaliplatin (L-OHP) remains unclear...However, both PI3K inhibitor (LY294002) and activator (IGF-1) could not medicate CES2 expression. These findings indicated that CES2 may be utilized as a novel biomarker and therapeutic target for L-OHP resistance in CRC treatment.
- | Journal: miR-20b and miR-451a Are Involved in Gastric Carcinogenesis through the PI3K/AKT/mTOR Signaling Pathway: Data from Gastric Cancer Patients, Cell Lines and Ins-Gas Mouse Model. (Pubmed Central) - Nov 19, 2020
Loss-of-function experiments revealed that down-regulation of miR-20b and up-regulation of miR-451a expression exhibits an anti-tumor effect in vitro (miR-20b: reduced viability, colony formation, increased apoptosis rate, and miR-451a: reduced colony forming ability). To summarize, the present study identified that expression of miR-20b and miR-451a are deregulated in vitro and in vivo and have a tumor suppressive role in GC through regulation of the PI3K/AKT/mTOR signaling pathway.
- || Clinical, Review, Journal: Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma? (Pubmed Central) - Nov 19, 2020
Clinical responses, including complete remissions (especially in follicular lymphoma patients), are also observed in the very few clinical studies performed in patients that are affected by relapsed/refractory lymphomas or chronic lymphocytic leukemia. In this review, we summarize the literature on dual PI3K/mTOR inhibitors focusing on the lymphoma setting, presenting both the three compounds still in clinical development and those with a clinical program stopped or put on hold.
- | Preclinical, Journal: Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. (Pubmed Central) - Nov 19, 2020
Addition of chloroquine that suppressed autophagic flux to 2D GBM cultures increased CBD-induced cell death, presenting proof for the protective autophagy...Suppression of JNK activation partially reduced CBD-induced cell death in 3D GBM cultures. In contrast, co-treatment of CBD-targeted cells with inhibitors of PI3K-AKT-NF-κB, IKK-NF-κB or JAK2-STAT3 pathways killed surviving GBM cells in both 2D and 3D cultures, potentially improving the therapeutic ratio of GBM.
- | Journal: Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - Nov 19, 2020
On the contrary, MiR-206 inhibitors reversed the inhibitory effects of curcumin on cell migration, invasion and the phosphorylation level of mTOR and AKT. In conclusion, curcumin inhibited cell invasion and migration in NSCLC by elevating the expression of miR-206 which further suppressed the activation of the PI3K/AKT/mTOR pathway.
- | Journal: SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway. (Pubmed Central) - Nov 18, 2020
In vivo HSC-specific SPOCK1 knockdown following lentivirus administration dramatically ameliorated thioacetamide (TAA)-induced collagen deposition in rat livers. Collectively, our study indicates that SPOCK1 is crucial for hepatic fibrosis and it might be a promising therapeutic target.